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The α-Lipoic acid derivative sodium zinc dihydrolipoylhistidinate reduces chemotherapy-induced alopecia in a rat model: A pilot study

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Abstract

Purpose

Alopecia is one of the most common side effects of chemotherapy for which treatments have not been developed. In the present study, we evaluated the effects of sodium zinc dihydrolipoylhistidinate (DHLHZn), a new derivative of the multifunctional antioxidant α-lipoic acid, to treat chemotherapy-induced alopecia.

Methods

Wistar rats (8 days old) were treated with cytosine arabinoside (AraC; 20 mg/kg by daily intraperitoneal injection; days 0–6) and DHLHZn (0%, 0.5%, or 1% topically applied in a white petrolatum base; days 0–12). A control group received daily saline injections (days 0–6) and topical application of white petrolatum (days 0–12). On day 12, we evaluated hair loss and histologic changes to scalp tissue for each group (n = 10).

Results

Rats treated with AraC and 0% DHLHZn cream exhibited complete hair loss; however, treatment with 0.5% or 1% DHLHZn significantly reduced chemotherapy-induced hair loss. Histological analysis revealed that AraC treatment promoted inflammatory cell infiltration of the hair follicles, but this inflammatory response was attenuated by DHLHZn.

Conclusions

Our findings demonstrate that DHLHZn attenuates chemotherapy-induced alopecia, indicating the potential use of this α-lipoic acid derivative as a therapeutic agent against this common side effect of chemotherapy.

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Authors and Affiliations

  1. Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan

    Satoshi Hagiwara, Hironori Koga & Takayuki Noguchi

  2. Department of Molecular Pathology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan

    Tomohisa Uchida & Masatsugu Moriyama

  3. Department of Gastroenterological Surgery, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan

    Masafumi Inomata, Fumitaka Yoshizumi & Seigo Kitano

Authors
  1. Satoshi Hagiwara
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  2. Tomohisa Uchida
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  3. Hironori Koga
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  4. Masafumi Inomata
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  5. Fumitaka Yoshizumi
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  6. Masatsugu Moriyama
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  7. Seigo Kitano
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  8. Takayuki Noguchi
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Hagiwara, S., Uchida, T., Koga, H. et al. The α-Lipoic acid derivative sodium zinc dihydrolipoylhistidinate reduces chemotherapy-induced alopecia in a rat model: A pilot study. Surg Today 41, 693–697 (2011). https://doi.org/10.1007/s00595-010-4481-z

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  • DOI: https://doi.org/10.1007/s00595-010-4481-z

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