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Protection Against Chemotherapy-Induced Alopecia

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Abstract

Purpose

The goal is to provide an overview on the advances in protection against chemotherapy-induced alopecia (CIA).

Materials and Methods

The four major parts of this review are (a) overview of the hair follicle biology, (b) characteristics of CIA, (c) state-of-the-art animal models of CIA, and (d) experimental approaches on protection against CIA.

Results

The hair follicle represents an unintended target of cancer chemotherapy. CIA is a significant side effect that compromises the quality of life of patients. Overcoming CIA represents an area of unmet needs, especially for females and children. Significant progresses have been made in the last decade on the pathobiology of CIA. The pharmacological agents under evaluation include drug-specific antibodies, hair growth cycle modifiers, cytokines and growth factors, antioxidants, cell cycle or proliferation modifiers, and inhibitors of apoptosis. Their potential applications and limitations are discussed.

Conclusion

Multiple classes of agents with different action mechanisms have been evaluated in animal CIA models. Most of these protective agents have activity limited to a single chemotherapeutic agent. In comparison, calcitriol and cyclosporine A have broader spectrum of activity and can prevent against CIA by multiple chemotherapeutic agents. Among the three agents that have been evaluated in humans, AS101 and Minoxidil were able to reduce the severity or shorten the duration of CIA but could not prevent CIA.

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Abbreviations

Ara-C:

cytosine arabinoside

CIA:

chemotherapy-induced alopecia

EGF:

epidermal growth factor

FGF:

fibroblast growth factor

IRS:

inner root sheath

ORS:

outer root sheath

PTH:

parathyroid hormone

PTHrP:

PTH-related protein

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Acknowledgment

This work is supported in part by a research grant R43CA107998 from the National Cancer Institute, DHHS.

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Authors and Affiliations

  1. College of Pharmacy, The Ohio State University, Columbus, Ohio, USA

    Jie Wang & Jessie L.-S. Au

  2. James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio, USA

    Jessie L.-S. Au

  3. Optimum Therapeutics LLC, OSU Science Tech Village, Columbus, Ohio, USA

    Jie Wang & Ze Lu

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  1. Jie Wang
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  2. Ze Lu
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  3. Jessie L.-S. Au
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Correspondence to Jessie L.-S. Au.

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Wang, J., Lu, Z. & Au, J.LS. Protection Against Chemotherapy-Induced Alopecia. Pharm Res 23, 2505–2514 (2006). https://doi.org/10.1007/s11095-006-9105-3

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