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Dipeptidyl peptidase-4 inhibitors in cardioprotection: a promising therapeutic approach

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Abstract

Cardiovascular diseases are major killers in all developed societies and rapidly becoming the leading cause of morbidity and mortality in the developing world. Patients with diabetes mellitus are at particular risk of developing cardiovascular diseases. The present treatment options for management of diabetes have expanded since the development of glucagon-like peptide-1 agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors. There is a growing body of evidence that these agents may have cardioprotective effects even in patients who do not have diabetes. Here, we discuss this evidence as well as pathways that DPP-4 inhibitors target in the cardiovascular system. These agents over time will find an appropriate place in the management of cardiovascular diseases.

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Abbreviations

ADACP-2:

Adenosine deaminase complexing protein-2

AMPK:

Adenosine-monophosphate-activated protein kinase

BNP:

B-type natriuretic peptide

cGMP:

Cyclic guanosine monophosphate

CVDs:

Cardiovascular diseases

DPP-4:

Dipeptidyl peptidase-4

eNOS:

Nitric oxide synthase

G-CSF:

Granulocyte colony-stimulating factor

GIP:

Gastric inhibitory peptide

GLP-1:

Glucagon-like peptide-1

GLP-1R:

Glucagon-like peptide-1 receptor

LDLR:

Low density lipoprotein receptor

PYY:

Peptide YY

SDF-1α:

Stromal cell-derived factor-1α

TNF-α:

Tumor necrosis factor alpha

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Acknowledgments

This study was supported in part by funds from the Department of Veterans Affairs.

Conflict of interest

The authors declare that there is no duality of interest associated with this manuscript.

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Authors and Affiliations

  1. Division of Cardiology, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, AR, 72212, USA

    Yao Dai, Federico Mercanti, Zufeng Ding, Xianwei Wang & Jawahar L. Mehta

  2. Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China

    Yao Dai

  3. Department of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China

    Dongsheng Dai

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  1. Yao Dai
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  2. Dongsheng Dai
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  3. Federico Mercanti
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  4. Zufeng Ding
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  5. Xianwei Wang
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  6. Jawahar L. Mehta
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Correspondence to Jawahar L. Mehta.

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Communicated by Massimo Federici.

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Dai, Y., Dai, D., Mercanti, F. et al. Dipeptidyl peptidase-4 inhibitors in cardioprotection: a promising therapeutic approach. Acta Diabetol 50, 827–835 (2013). https://doi.org/10.1007/s00592-013-0496-4

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  • DOI: https://doi.org/10.1007/s00592-013-0496-4

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