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The role of mesenchymal stem cells in bone repair and regeneration

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European Journal of Orthopaedic Surgery & Traumatology Aims and scope Submit manuscript

Abstract

Despite the undisputed modern development of synthetic biomaterials that range from bioactive unresorbable to restorable materials, clinically applied osteoconduction bone substitutes still have limitations in the treatment of bone defects. These are the result of the physical and chemical properties of the utilized materials and the biological interactions associated with both local and general reactions of the organism. Mesenchymal stem cells constitute a promising treatment alternative in orthopedics. Preclinical studies regarding the use of mesenchymal stem cells have shown good therapeutic results. However, it is still necessary to advance further in this area and enable the treatment of patients with critically large bone defects. The aim of this review is to describe the role of mesenchymal stem cells in bone repair and regeneration, describe the techniques used in the clinical application of mesenchymal stem cells and outline future research endeavors in this area.

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Acknowledgments

This work was supported by Grant IGA MZ NT 13477-4. Dr. Šponer reports grants from Interní Grantová Agentura MZ ČR, during the conduct of the study. Dr. Kučera reports grants from Interní Grantová Agentura MZ ČR, during the conduct of the study. Dr. Diaz-Garcia has nothing to disclose. Dr. Filip reports grants from Interní Grantová Agentura MZ ČR, during the conduct of the study.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Faculty of Medicine in Hradec Králové, Charles University in Prague, 500 05, Hradec Králové, Czech Republic

    Pavel Šponer & Tomáš Kučera

  2. Department of Orthopaedic Surgery, University Hospital in Hradec Králové, 500 05, Hradec Králové, Czech Republic

    Pavel Šponer & Tomáš Kučera

  3. Department of Histology, Faculty of Medicine in Hradec Králové, Charles University in Prague, 500 05, Hradec Králové, Czech Republic

    Daniel Diaz-Garcia

  4. Department of Oncology and Radiotherapy, Faculty of Medicine in Hradec Králové, Charles University in Prague, 500 05, Hradec Králové, Czech Republic

    Stanislav Filip

Authors
  1. Pavel Šponer
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  2. Tomáš Kučera
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  3. Daniel Diaz-Garcia
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  4. Stanislav Filip
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Correspondence to Pavel Šponer.

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Šponer, P., Kučera, T., Diaz-Garcia, D. et al. The role of mesenchymal stem cells in bone repair and regeneration. Eur J Orthop Surg Traumatol 24, 257–262 (2014). https://doi.org/10.1007/s00590-013-1328-5

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  • DOI: https://doi.org/10.1007/s00590-013-1328-5

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