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Evolving challenges to model human diseases for translational research

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Abstract

Animal models are a significant component of biomedical research and play an important role in translational studies. Traditionally, rodent models have been the mainstay and principal choice of researchers but in recent years, there have been significant changes in the landscape of animal modeling. For example, newer techniques have greatly expanded the use and successful application of large animal models such as pigs for translational studies. The evolving types and species of animal models can influence the research landscape in terms of facilities, expertise, reproducibility and funding streams, which creates new challenges for research studies. It is also important that investigators are prepared to address the necessity of their animal model research and capable to educate the public regarding its value.

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We would like to thank the Lamb Art Studio (www.faithlamb.com) for excellent assistance with graphic artwork.

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  1. Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA

    Amanda P. Beck

  2. Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA

    David K. Meyerholz

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  1. Amanda P. Beck
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Correspondence to Amanda P. Beck.

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Beck, A.P., Meyerholz, D.K. Evolving challenges to model human diseases for translational research. Cell Tissue Res 380, 305–311 (2020). https://doi.org/10.1007/s00441-019-03134-3

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