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Disease Animal Models for Cancer Research

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Cancer Cell Culture

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2645))

Abstract

Despite nonanimal methods (NAMs) are more and more exploited and new NAMs are developed and validated, animal models are still used in cancer research. Animals are used at multiple levels, from understanding molecular traits and pathways, to mimicking clinical aspects of tumor progression, to drug testing. In vivo approaches are not trivial and involve cross-disciplinary knowledge: animal biology and physiology, genetics, pathology, and animal welfare.

The aim of this chapter is not to list and address all animal models used in cancer research. Instead, the authors would like to guide experimenters in the strategies to adopt in both planning and performing in vivo experimental procedures, including the choice of cancer animal models.

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Notes

  1. 1.

    https://retractionwatch.com/ last access on July 6, 2022.

  2. 2.

    https://www.humane-endpoints.info/en/why-humane-endpoints, Last access on July 6, 2022.

  3. 3.

    http://www.informatics.jax.org/, last access on July 6, 2022.

  4. 4.

    www.informatics.jax.org/humanDisease.shtml, last access on July 6, 2022.

  5. 5.

    https://phenome.jax.org/, last access on July 6, 2022.

  6. 6.

    https://rgd.mcw.edu/rgdweb/homepage/, last access on July 6, 2022.

  7. 7.

    http://pathbase.net/, las access on July 6, 2022.

  8. 8.

    https://www.syrcle.network/, last access on July 6, 2022.

  9. 9.

    https://www.ed.ac.uk/clinical-brain-sciences/research/camarades, last access on July 6, 2022.

  10. 10.

    https://preclinicaltrials.eu/, last access on July 6, 2022.

  11. 11.

    https://www.crd.york.ac.uk/prospero/, last access on July 6, 2022.

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Authors and Affiliations

  1. Universität Bern, Experimental Animal Center, Bern, Switzerland

    Sara Fuochi

  2. Netherlands Institute for Neuroscience - KNAW, Amsterdam, The Netherlands

    Viola Galligioni

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  1. Sara Fuochi
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  2. Viola Galligioni
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Correspondence to Viola Galligioni .

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Editors and Affiliations

  1. Trinity Translational Medicine Institute, Trinity Centre for Health Sciences, Dublin, Ireland

    Dania Movia

  2. Trinity Translational Medicine Institute, Trinity Centre for Health Sciences, Dublin, Ireland

    Adriele Prina-Mello

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Fuochi, S., Galligioni, V. (2023). Disease Animal Models for Cancer Research. In: Movia, D., Prina-Mello, A. (eds) Cancer Cell Culture. Methods in Molecular Biology, vol 2645. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3056-3_4

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