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Role of autophagy in regulating the radiosensitivity of tumor cells

  • Review – Cancer Research
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Background

Autophagy is a metabolic response of cells to chemical and physical factors, such as nutrition or growth factor deprivation, proinflammatory state, hypoxia, accumulation of reactive oxygen species, presence of infectious agents, and DNA damage. Autophagy maintains the homeostasis of intracellular metabolism mainly by degrading cellular organelles and critical proteins. In a sense, autophagy protects cells from death. Radiotherapy is a powerful tool used to control tumor growth, and it can induce autophagy. The relationship between radiotherapy and autophagy is worthy of further investigation.

Methods

We searched various electronic databases including PubMed for peer-reviewed English-language articles and selected articles on the mechanism of autophagy, its role in cancer development and cancer treatment, and the relationship between the effect of radiation therapy and autophagy intensity.

Results

This review has recently shown that the sensitivity of tumor cells to radiation therapy can be increased by regulating autophagy.

Conclusion

The effects of autophagy vary, and autophagy provides various ways of enhancing radiosensitivity, including inhibition of autophagy, increase in autophagy, and altering the outcome of autophagy.

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Author notes

  1. Yong Xin, Fan Jiang and Chunsheng Yang contributed equally to this work.

Authors and Affiliations

  1. Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, China

    Yong Xin, Fan Jiang, Qiuyue Yan, Wenwen Guo, Qian Huang & Longzhen Zhang

  2. Department of Dermatology, Affiliated Huai’an Hospital of Xuzhou Medical, Huai’an, China

    Chunsheng Yang

  3. Department of Dermatology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, China

    Guan Jiang

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  1. Yong Xin
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  2. Fan Jiang
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Correspondence to Guan Jiang.

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We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work that there are no professional or other personal interests of any nature or kind in any products, services, and/or companies that could be construed as influencing the position presented.

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This article does not contain any studies with human participants or animals performed by any of the authors.

Funding

This research was supported by the National Natural Science Foundation of China (No. 81372916, No.81572976), the Science and Technology. Department of Jiangsu Province (No. BK20141142), Jiangsu Provincial Medical Talent Foundation.

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Xin, Y., Jiang, F., Yang, C. et al. Role of autophagy in regulating the radiosensitivity of tumor cells. J Cancer Res Clin Oncol 143, 2147–2157 (2017). https://doi.org/10.1007/s00432-017-2487-2

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