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Innate immunity in the pathogenesis of psoriasis

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Abstract

Psoriasis is a common, immune-mediated inflammatory skin disorder. T helper(h)1 and Th17 lymphocytes contribute to the pathogenesis of psoriasis through the release of inflammatory cytokines that promote further recruitment of immune cells, keratinocyte proliferation and sustained inflammation. The innate immune system is the first line of defence against infection and plays a crucial role in the initiation of the adaptive immune response. The presence of innate immune cells and their products in psoriatic skin plaques suggests a role for innate immunity in this disease. In addition, the innate immune system can direct the development of pathogenic Th cells in psoriasis. In this article, we will summarise the role of the innate immune system in psoriasis with particular emphasis on the role of cytokines, signalling pathways and cells of the innate immune system.

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Acknowledgments

CS is supported by a Janssen Newman fellowship in Dermatology. BK has received unrestricted grants from Janssen, Abbot and Pfizer and acts as a consultant to MSD, Abbot, Janssen and Pfizer. AMT has received an unrestricted grant from Abbot and acts as a consultant to Abbot and Janssen.

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  1. Department of Dermatology, St. Vincent’s University Hospital, Dublin 4, Ireland

    Ann-Marie Tobin & Brian Kirby

  2. Department of Dermatology, Education and Research Centre, St Vincent’s University Hospital, Elm Park, Dublin 4, Ireland

    Cheryl M. Sweeney

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Correspondence to Cheryl M. Sweeney.

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Sweeney, C.M., Tobin, AM. & Kirby, B. Innate immunity in the pathogenesis of psoriasis. Arch Dermatol Res 303, 691–705 (2011). https://doi.org/10.1007/s00403-011-1169-1

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