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Cytokine Pathways in Psoriasis and Psoriatic Arthritis

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Psoriatic Arthritis and Psoriasis

Abstract

Psoriatic disease is a systemic autoimmune disease mostly associated with skin and joint involvement (psoriatic arthritis). Strong evidences from clinical studies and experimental models suggest that both innate and adaptive immune responses are involved in its pathogenesis. Psoriatic disease used to be regarded as a Th1-driven disease, now there are substantial evidences to suggest regulatory role of Th17 cells as well in the pathogenesis of psoriasis and psoriatic arthritis. Cytokines play a critical role; besides IFN-γ and TNFα, IL-23/Th17 pathway plays a dominant role in the inflammatory and proliferative cascades of both the skin and joint tissues. Recently in a series of elegant experiments using mouse models and human tissues it has been demonstrated that IL-23 induced Th17 cytokines (IL-17 and IL-22) can contribute to all four pathologic events in a psoriatic disease: development of psoriatic plaque, pannus formation in the joint, joint erosion and new bone formation.

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Authors and Affiliations

  1. Division of Immunology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Ankit Saxena PhD

  2. Psoriasis Clinic and Division of Rheumatology, VA Medical Center Sacramento, Sacramento, CA, USA

    Smriti K. Raychaudhuri MD & Siba P. Raychaudhuri MD

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  1. Ankit Saxena PhD
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  2. Smriti K. Raychaudhuri MD
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  3. Siba P. Raychaudhuri MD
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Correspondence to Siba P. Raychaudhuri MD .

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Editors and Affiliations

  1. Faculty of Medicine, University of Sheffield, Sheffield, United Kingdom

    Adewale Adebajo

  2. Faculty of Medicine, University of Geneva, Geneva 14, Switzerland

    Wolf-Henning Boehncke

  3. Toronto Western Hospital, Toronto, Ontario, Canada

    Dafna D. Gladman

  4. Seattle Rheumatology Associates, Seattle, Washington, USA

    Philip J. Mease

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Saxena, A., Raychaudhuri, S.K., Raychaudhuri, S.P. (2016). Cytokine Pathways in Psoriasis and Psoriatic Arthritis. In: Adebajo, A., Boehncke, WH., Gladman, D., Mease, P. (eds) Psoriatic Arthritis and Psoriasis. Springer, Cham. https://doi.org/10.1007/978-3-319-19530-8_9

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