Abstract
A 24-year-old man injected himself intravenously with metallic mercury in a suicide attempt, and died 5 months later after cutting his wrists. The brain was removed at postmortem and 7-μm paraffin sections were cut from representative blocks. Dense deposits of mercury were found on autometallography in large cortical motor neurons, but in no other cerebral neurons. Smaller mercury deposits were found in the brain stem (in the mesencephalic trigeminal nucleus, noradrenergic neurons, and in neurons for extraocular muscles), the cerebellum (in the dentate nucleus) and in lateral motor neurons in the C2/3 spinal cord. Mercury deposits were found in glial cells in all regions. The finding that elemental mercury enters human cortical motor neurons in preference to other cerebral neurons raises the possibility that this neurotoxin may play a part in the pathogenesis of some human motor neuron diseases.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 14 February 1996 / Revised: 23 May 1996 / Accepted: 28 May 1996
Rights and permissions
About this article
Cite this article
Pamphlett, R., Waley, P. Uptake of inorganic mercury by the human brain. Acta Neuropathol 92, 525–527 (1996). https://doi.org/10.1007/s004010050556
Issue Date:
DOI: https://doi.org/10.1007/s004010050556