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Nanobiotechnology and bone regeneration: a mini-review

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Abstract

The purpose of this paper is to review current developments in bone tissue engineering, with special focus on the promising role of nanobiotechnology. This unique fusion between nanotechnology and biotechnology offers unprecedented possibilities in studying and modulating biological processes on a molecular and atomic scale. First we discuss the multiscale hierarchical structure of bone and its implication on the design of new scaffolds and delivery systems. Then we briefly present different types of nanostructured scaffolds, and finally we conclude with nanoparticle delivery systems and their potential use in promoting bone regeneration. This review is not meant to be exhaustive and comprehensive, but aims to highlight concepts and key advances in the field of nanobiotechnology and bone regeneration.

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Acknowledgments

This project has received funding from the European Union’s Seventh Programme for research, technological development and demonstration under grant agreement No.278807.

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Authors and Affiliations

  1. Department of Traumatology, General Hospital Pula, Pula, Croatia

    Nadomir Gusić

  2. Department of Biotechnology, University of Rijeka, Rijeka, Croatia

    Alan Ivković & Jana Ivković

  3. Department of Orthopaedic Surgery, University Hospital Sveti Duh, Sveti Duh 64, 10000, Zagreb, Croatia

    Alan Ivković, Damir Hudetz & Saša Janković

  4. Department of Orthopaedic Surgery, St. Catherine’s Hospital, Zabok, Croatia

    Alan Ivković & Damir Hudetz

  5. Department of Orthopaedic Surgery, Care UK Northeast London NHS Treatment Centre, King George Hospital, Ilford, UK

    John VaFaye

  6. Department of Histology and Embryology, School of Medicine, University of Zagreb, Zagreb, Croatia

    Andreja Vukasović

Authors
  1. Nadomir Gusić
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  2. Alan Ivković
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  3. John VaFaye
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  4. Andreja Vukasović
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  5. Jana Ivković
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  6. Damir Hudetz
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  7. Saša Janković
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Correspondence to Alan Ivković.

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Nadomir Gusić and Alan Ivković contributed equally to this work

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Gusić, N., Ivković, A., VaFaye, J. et al. Nanobiotechnology and bone regeneration: a mini-review. International Orthopaedics (SICOT) 38, 1877–1884 (2014). https://doi.org/10.1007/s00264-014-2412-0

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  • DOI: https://doi.org/10.1007/s00264-014-2412-0

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