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Nanoparticulate Systems for Growth Factor Delivery

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Abstract

The field of nanotechnology, which aims to control and utilize matter generally in 1–100 nm range, has been at the forefront of pharmaceutical development. Nanoparticulate delivery systems, with their potential to control drug release profiles, prolonging the presence of drugs in circulation, and to target drugs to a specific site, hold tremendous promise as delivery strategies for therapeutics. Growth factors are endogenous polypeptides that initiate intracellular signals to regulate cellular activities, such as proliferation, migration and differentiation. With improved understanding of their roles in physiopathology and expansion of their availability through recombinant technologies, growth factors are becoming leading therapeutic candidates for tissue engineering approaches. However, the outcome of growth factor therapeutics largely depends on the mode of their delivery due to their rapid degradation in vivo, and non-specific distribution after systemic administration. In order to overcome these impediments, nanoparticulate delivery systems are being harnessed for spatiotemporal controlled delivery of growth factors. This review presents recent advances and some disadvantages of various nanoparticulate systems designed for effective intact growth factor delivery. The therapeutic applications of growth factors delivered by such systems are reviewed, especially for bone, skin and nerve regeneration as well as angiogenesis. Finally, future challenges and directions in the field are presented in addition to the current limitations.

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Acknowledgements

The studies in authors’ labs have been financially supported by Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Council of Canada (NSERC) and Alberta Heritage Foundation for Medical Research (AHFMR). The authors would like to thank Mr. Guilin Wang for his contributions to nanoparticle technologies in the authors’ lab.

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Authors and Affiliations

  1. Department of Chemical and Materials Engineering, Faculty of Engineering, University of Alberta, #830, Chemical & Materials Engineering Building, Edmonton, Alberta, Canada, T6G 2G6

    Sufeng Zhang & Hasan Uludağ

  2. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada

    Hasan Uludağ

  3. Department of Biomedical Engineering, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada

    Hasan Uludağ

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  1. Sufeng Zhang
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  2. Hasan Uludağ
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Correspondence to Hasan Uludağ.

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Zhang, S., Uludağ, H. Nanoparticulate Systems for Growth Factor Delivery. Pharm Res 26, 1561–1580 (2009). https://doi.org/10.1007/s11095-009-9897-z

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