Abstract
Objective
To investigate the relationship of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values with renal function on 3T diffusion tensor imaging (DTI) in chronic kidney disease.
Materials and methods
Twenty healthy volunteers and 29 patients with CKD underwent DTI. The relationship among ADC, FA, and renal function was analyzed.
Results
Cortical and medullary ADC and FA values of patients with chronic kidney disease were lower than those of healthy volunteers (P = 0.000). Both the renal ADC and FA values correlated inversely with serum creatinine and blood urea nitrogen (P < 0.05).
Conclusion
DTI is a feasible and non-invasive means to reflect the severity of renal function damaged.
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Acknowledgements
This study is supported by Guangdong Science and Technology Program Grant number 2010B080701067.
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Wang, Wj., Pui, M.H., Guo, Y. et al. 3T magnetic resonance diffusion tensor imaging in chronic kidney disease. Abdom Imaging 39, 770–775 (2014). https://doi.org/10.1007/s00261-014-0116-y
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DOI: https://doi.org/10.1007/s00261-014-0116-y