Abstract
Photosynthetic microorganisms convert carbon dioxide and solar radiation into interesting bioactive compounds not yet entirely explored. Several species of microalgae are known to be rich in colored high-valuable components that, although remarkable, are poorly explored as natural sources of pigments for cosmetics. Pigments associated to photosynthetic activity include chlorophyll, β-carotene, astaxanthin, xanthophylls, and phycobiliproteins, many of which have shown high potential as cosmetic actives due to their antioxidant, immune-enhancing, and anti-inflammatory properties. In the last decade, concern with a young and beautiful appearance has emerged, encouraging many consumers to use anti-aging cosmetics daily. As a result, the cosmetic market has been growing and evolving rapidly to meet consumer expectations. However, due to regular use and the sensitive nature of facial skin, local adverse reactions may often occur, such as irritation, sensitization, or photoreactions, and safety evaluation is mandatory prior to marketing. It is, therefore, understandable that new actives from natural sources, such as microalgae, are perceived as attractive alternatives for consumers who seek ingredients without allergenic potential. Thus, the cosmetic industry has recently started to explore the inclusion of compounds extracted from microalgae and cyanobacteria in innovative formulations. Herein, we revised nontraditional microalgae species for pigment production with cosmetic applications, indicating those that could also be considered potential ingredients for innovative cosmetics.
Key points
• Extraction methods for pigments from photosynthetic microorganisms were compiled.
• Innovative cosmeceuticals could be developed with natural pigments.
• Safety features of such natural pigments were also described.
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References
Aburai N, Ohkubo S, Miyashita H, Abe K (2013) Composition of carotenoids and identification of aerial microalgae isolated from the surface of rocks in mountainous districts of Japan. Algal Res 2(3):237–243. https://doi.org/10.1016/j.algal.2013.03.001
ALGATECH (2020) AstaPure® FucoVital™. https://www.algatech.com/. Accessed 26 Feb 2020
Apone F, Barbulova A, Colucci MG (2019) Plant and microalgae derived peptides are advantageously employed as bioactive compounds in cosmetics. Front Plant Sci 10:756. https://doi.org/10.3389/fpls.2019.00756
Ariede MB, Candido TM, Jacome ALM, Velasco MVR, Carvalho JCM, Baby AR (2017) Cosmetic attributes of algae - a review. Algal Res 25:483–487. https://doi.org/10.1016/j.algal.2017.05.019
Ariede MB, Morocho-Jácome AL, Candido TM, Lourenço FR, Kato ETM, Lima FV, Rosado C, Velasco MVR, de Carvalho JCM, Baby AR (2020) Is the Botryococcus braunii dry biomass an adjuvant for anti-UVB topical formulations? Sci Pharm 88:22–31. https://doi.org/10.3390/scipharm88020022
Avila-León IA, Matsudo MC, Ferreira-Camargo LS, Rodrigues-Ract JN, Carvalho JCM (2020) Evaluation of Neochloris oleoabundans as sustainable source of oil-rich biomass. Braz J Chem Eng 37:41–48. https://doi.org/10.1007/s43153-020-00011-3
Begum H, Yusoff FMD, Banerjee S, Khatoon H, Shariff M (2016) Availability and utilization of pigments from microalgae. Crit Rev Food Sci Nutr 56(13):2209–2222. https://doi.org/10.1080/10408398.2013.764841
Brandt U (2011) A two-state stabilization-change mechanism for proton-pumping complex I. Biochim Biophys Acta Bioenerg 1807:1364–1369. https://doi.org/10.1016/j.bbabio.2011.04.006
Bresaola MD, Morocho-Jácome AL, Matsudo MC, Carvalho JCM (2019) Semi-continuous process as a promising technique in Ankistrodesmus braunii cultivation in photobioreactor. J Appl Phycol 31:2197–2205. https://doi.org/10.1007/s10811-019-01774-0
Buono S, Langellotti AL, Martello A, Rinna F, Fogliano V (2014) Functional ingredients from microalgae. Food Funct 5:1669–1685. https://doi.org/10.1039/C4FO00125G
Caporgno MP, Taleb A, Olkiewicz M, Font J, Pruvost J, Legrand J, Bengoa C (2015) Microalgae cultivation in urban wastewater: nutrient removal and biomass production for biodiesel and methane. Algal Res 10:232–239. https://doi.org/10.1016/j.algal.2015.05.011
Caruana AMN, Amzil Z (2018) Microalgae and Toxins. In: Levine IA, Fleurence J (eds) Microalgae in health and disease prevention. Elsevier, pp 263–305
Cezare-Gomes EA, Mejia-da-Silva LC, Pérez-Mora LS, Matsudo MC, Ferreira-Camargo LS, Singh AK, de Carvalho JCM (2019) Potential of microalgae carotenoids for industrial application. Appl Biochem Biotechnol 188:602–634. https://doi.org/10.1007/s12010-018-02945-4
Chen B, Wan C, Mehmood MA, Chang JS, Bai F, Zhao X (2017) Manipulating environmental stresses and stress tolerance of microalgae for enhanced production of lipids and value-added products–a review. Bioresour Technol 244:1198–1206. https://doi.org/10.1016/j.biortech.2017.05.170
CODIF (2020) Dermochlorella D. http://www.codif-tn.com/en/principesactifs/dermochlorella-d/. Accessed 26 Feb 2020
Couteau C, Coiffard L (2018) Microalgal application in cosmetics. In: Levine I, Fleurence J (eds) Microalgae in health and disease prevention, first. Academic Press, pp 317–323
D’Alessandro EB, Antoniosi Filho NR (2016) Concepts and studies on lipid and pigments of microalgae: a review. Renew Sust Energ Rev 58:832–841. https://doi.org/10.1016/j.rser.2015.12.162
Daniel Jouvance (2019) Daniel Jouvance. https://www.danieljouvance.com/fr-fr/. Accessed 4 Dec 2019
Davinelli S, Nielsen ME, Scapagnini G (2018) Astaxanthin in skin health, repair, and disease: a comprehensive review. Nutrients 10:522. https://doi.org/10.3390/nu10040522
De Jesus Raposo MF, De Morais RMSC, De Morais AMMB (2013a) Health applications of bioactive compounds from marine microalgae. Life Sci 93:479–486. https://doi.org/10.1016/j.lfs.2013.08.002
De Jesus Raposo MF, De Morais RMSC, De Morais AMMB (2013b) Bioactivity and applications of sulphated polysaccharides from marine microalgae. Mar Drugs 11:233–252. https://doi.org/10.3390/md11010233
Delattre C, Pierre G, Laroche C, Michaud P (2016) Production, extraction and characterization of microalgal and cyanobacterial exopolysaccharides. Biotechnol Adv 34(7):1159–1179. https://doi.org/10.1016/j.biotechadv.2016.08.001
DIC (2020) Linablue®. https://www.dlt-spl.co.jp/business/pdf/linablue_en.pdf. Accessed 26 Feb 2020
DSM (2020) Pepha®-Ctive. https://www.dsm.com/personal-care/en_US/products/skin-bioactives/pepha-ctive.html. Accessed 26 Feb 2020
European Commission (2020) Cosmetic ingredient database. In: Cosmetics. https://ec.europa.eu/growth/sectors/cosmetics/cosing_en. Accessed 28 Feb 2020
GIVAUDAN (2020) Megassane®. https://www.givaudan.com/fragrances/active-beauty/products/megassane®. Accessed 26 Feb 2020
Grundman O, Richter H, Ini S (2018) Compositions comprising carotenoids and use thereof. US20180078521A1
Guihéneuf F, Stengel DB (2017) Interactive effects of light and temperature on pigments and n-3 LC-PUFA-enriched oil accumulation in batch-cultivated Pavlova lutheri using high-bicarbonate supply. Algal Res 23:113–125. https://doi.org/10.1016/j.algal.2017.02.002
Guihéneuf F, Stengel DB (2015) Towards the biorefinery concept: interaction of light, temperature and nitrogen for optimizing the co-production of high-value compounds in Porphyridium purpureum. Algal Res 10:152–163. https://doi.org/10.1016/j.algal.2015.04.025
Hallegraeff GM (2014) Harmful algae and their toxins: progress, paradoxes and paradigm shifts. In: Rossini GP (ed) Toxins and biologically active compounds from microalgae, 1st edn, vol 1. CRC Press-Taylor & Francis Group, Boca Raton, pp 3–20
Hamed I (2016) The evolution and versatility of microalgal biotechnology: a review. Compr Rev Food Sci Food Saf 15:1104–1123. https://doi.org/10.1111/1541-4337.12227
Hu J, Nagarajan D, Zhang Q, Chang JS, Lee DJ (2018) Heterotrophic cultivation of microalgae for pigment production: a review. Biotechnol Adv 36:54–67. https://doi.org/10.1016/j.biotechadv.2017.09.009
Ishika T, Moheimani NR, Bahri PA, Laird DW, Blair S, Parlevliet D (2017) Halo-adapted microalgae for fucoxanthin production: effect of incremental increase in salinity. Algal Res 28:66–73. https://doi.org/10.1016/j.algal.2017.10.002
Karpagam R, Jawaharraj K, Ashokkumar B, Sridhar J, Varalakshmi P (2018) Unraveling the lipid and pigment biosynthesis in Coelastrella sp. M-60: Genomics-enabled transcript profiling. Algal Res 29:277–289. https://doi.org/10.1016/j.algal.2017.11.031
Khanra S, Mondal M, Halder G, Tiwari ON, Gayen K, Bhowmick TK (2018) Downstream processing of microalgae for pigments, protein and carbohydrate in industrial application: a review. Food Bioprod Process 110:60–84. https://doi.org/10.1016/j.fbp.2018.02.002
Koller M, Muhr A, Braunegg G (2014) Microalgae as versatile cellular factories for valued products. Algal Res 6:52–63. https://doi.org/10.1016/j.algal.2014.09.002
Kozlova TA, Hardy BP, Levin DB (2018) The combined influence of 24-epibrassinolide and 3-indoleacetic acid on growth and accumulation of pigments and fatty acids in the microalgae Scenedesmus quadricauda (CPCC-158). Algal Res 35:22–32. https://doi.org/10.1016/j.algal.2018.08.009
Kulkarni S, Nikolov Z (2018) Process for selective extraction of pigments and functional proteins from Chlorella vulgaris. Algal Res 35:185–193. https://doi.org/10.1016/j.algal.2018.08.024
Levasseur W, Perré P, Pozzobon V (2020) A review of high value-added molecules production by microalgae in light of the classification. Biotechnol Adv 41:107545. https://doi.org/10.1016/j.biotechadv.2020.107545
Lima GM, Teixeira PCN, Teixeira CMLL, Filócomo D, Lage CLS (2018) Influence of spectral light quality on the pigment concentrations and biomass productivity of Arthrospira platensis. Algal Res 35:185–193. https://doi.org/10.1016/j.algal.2018.02.012
Lorencini M, Brohem CA, Dieamant GC, Zanchin NI, Maibach HI (2014) Active ingredients against human epidermal aging. Ageing Res Rev 15:100–115
Minatelli JA, Hill WS (2018) Method of treating photo-induced ocular fatigue and associated reduction in speed of ocular focus. US20180042978A1
Mourelle M, Gómez C, Legido J (2017) The potential use of marine microalgae and cyanobacteria in cosmetics and thalassotherapy. Cosmetics 4:1–14. https://doi.org/10.3390/cosmetics4040046
Novoveská L, Ross ME, Stanley MS, Pradelles R, Wasiolek V, Sassi JF (2019) Microalgal carotenoids: a review of production, current markets, regulations, and future direction. Mar Drugs 17:640. https://doi.org/10.3390/md17110640
Palombo P, Fabrizi G, Ruocco V, Ruocco E, Fluhr J, Roberts R, Morganti P (2007) Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Skin Pharmacol Physiol 20:199–210. https://doi.org/10.1159/000101807
Panis G, Carreon JR (2016) Commercial astaxanthin production derived by green alga Haematococcus pluvialis: a microalgae process model and a techno-economic assessment all through production line. Algal Res 18:175–190. https://doi.org/10.1016/j.algal.2016.06.007
Patel HM, Rastogi RP, Trivedi U, Madamwar D (2018) Structural characterization and antioxidant potential of phycocyanin from the cyanobacterium Geitlerinema sp. H8DM. Algal Res 32:372–383. https://doi.org/10.1016/j.algal.2018.04.024
Penna A, Galluzzi L (2014) Detection and identification of toxic microalgae by the use of innovative molecular methods. In: Rossini GP (ed) Toxins and biologically active compounds from microalgae, 1st edn, vol 1. CRC Press, Boca Raton, pp 51–74
Rao AR, Sindhuja HN, Dharmesh SM, Sankar KU, Sarada R, Ravishankar GA (2013) Effective inhibition of skin cancer, tyrosinase, and antioxidative properties by astaxanthin and astaxanthin esters from the green alga Haematococcus pluvialis. J Agric Food Chem 61:3842–3851. https://doi.org/10.1021/jf304609j
Rhodes L, Wood S (2014) Micro-algal and cyanobacterial producers of biotoxins. In: Rossini GP (ed) Toxins and biologically active compounds from microalgae, 1st edn, vol 1. CRC Press, Boca Raton, pp 21–50
Rodrigues RDP, Castro FC, Santiago-Aguiar RS, Rocha MVP (2018) Ultrasound-assisted extraction of phycobiliproteins from Spirulina (Arthrospira) platensis using protic ionic liquids as solvent. Algal Res 31:454–462. https://doi.org/10.1016/j.algal.2018.02.021
Ruiz Canovas E, Álvarez Mic X, Durany Turk O, Segura de Yebra J, Mercade Roca J (2017) Use of a carotenoid in the treatment or prevention of stress induced conditions. WO2017178456A1
Ruiz J, Olivieri G, De Vree J, Bosma R, Willems P, Reith JH, Eppink MHM, Kleinegris DMM, Wijffels RH, Barbosa MJ (2016) Towards industrial products from microalgae. Energy Environ Sci 9:3036–3043. https://doi.org/10.1039/c6ee01493c
Ryu BM, Himaya SWA, Kim S-K (2015) Applications of microalgae-derived active ingredients as cosmeceuticals. In: Kim S-W (ed) Handbook of marine microalgae: biotechnology advances, first. Academic Press, pp 309–315
Rzymski P, Niedzielski P, Kaczmarek N, Jurczak T, Klimaszyk P (2015) The multidisciplinary approach to safety and toxicity assessment of microalgae-based food supplements following clinical cases of poisoning. Harmful Algae 46:34–42. https://doi.org/10.1016/j.hal.2015.05.003
Safafar H, Van Wagenen J, Møller P, Jacobsen C (2015) Carotenoids, phenolic compounds and tocopherols contribute to the antioxidative properties of some microalgae species grown on industrial wastewater. Mar Drugs 13:7339–7356. https://doi.org/10.3390/md13127069
Saini DK, Chakdar H, Pabbi S, Shukla P (2020) Enhancing production of microalgal biopigments through metabolic and genetic engineering. Crit Rev Food Sci Nutr 60:391–405. https://doi.org/10.1080/10408398.2018.1533518
Sathasivam R, Ki JS (2018) A review of the biological activities of microalgal carotenoids and their potential use in healthcare and cosmetic industries. Mar Drugs 16:1–31. https://doi.org/10.3390/md16010026
Sathasivam R, Radhakrishnan R, Hashem A, Abd_Allah EF (2017) Microalgae metabolites: a rich source for food and medicine. Saudi J Biol Sci 26:709–722. https://doi.org/10.1016/j.sjbs.2017.11.003
Schurr R, Keuhnle A (2016) Improved heterotrophic production methods for microbial biomass and bioproducts. WO2018006068A1
Schurr RJ, Kuehnle AR (2018) Heterotrophic production methods for microbial biomass and bioproducts. US20180002711A1
Scoglio S (2018) Microcystins in water and in microalgae: do microcystins as microalgae contaminants warrant the current public alarm? Toxicol Rep 5:785–792. https://doi.org/10.1016/j.toxrep.2018.07.002
Sekar S, Chandramohan M (2008) Phycobiliproteins as a commodity: trends in applied research, patents and commercialization. J Appl Phycol 20:113–136. https://doi.org/10.1007/s10811-007-9188-1
Solovchenko A, Solovchenko O, Khozin-Goldberg I, Didi-Cohen S, Pal D, Cohen Z, Boussiba S (2013) Probing the effects of high-light stress on pigment and lipid metabolism in nitrogen-starving microalgae by measuring chlorophyll fluorescence transients: Studies with a δ5 desaturase mutant of Parietochloris incisa (Chlorophyta, Trebouxiophyceae). Algal Res 2:175–182. https://doi.org/10.1016/j.algal.2013.01.010
Stahl W, Sies H (2012) β-Carotene and other carotenoids in protection from sunlight. Am J Clin Nutr 96:1179–1184. https://doi.org/10.3945/ajcn.112.034819
Tominaga K, Fujishita M, Nobuko H (2018) Use of astaxanthin for reducing progression of damage caused to human skin. WO2018062427
Varela JC, Pereira H, Vila M, León R (2015) Production of carotenoids by microalgae: achievements and challenges. Photosynth Res 125:432–436. https://doi.org/10.1007/s11120-015-0149-2
Velasco MVR, Sauce R, Oliveira CA, Pinto CASO, Martinez RM, Baah S, Almeida TS, Rosado C, Baby AR (2018) Active ingredients, mechanisms of action and efficacy tests antipollution cosmetic and personal care products. Braz J Pharm Sci 54(spe):e01003. https://doi.org/10.1590/s2175-97902018000001003
Wang HMD, Chen CC, Huynh P, Chang JS (2015) Exploring the potential of using algae in cosmetics. Bioresour Technol 184:355–362. https://doi.org/10.1016/j.biortech.2014.12.001
Wanjari N, Waghmare J (2015) A review on latest trend of cosmetics-cosmeceuticals. Int J Pharm Res Rev 4:45–51
Yarkent Ç, Gürlek C, Oncel SS (2020) Potential of microalgal compounds in trending natural cosmetics: a review. Sustain Chem Pharm 17:100304. https://doi.org/10.1016/j.scp.2020.100304
Yeager DG, Lim HW (2019) What’s new in photoprotection: a review of new concepts and controversies. Dermatol Clin 37:149–157. https://doi.org/10.1016/j.det.2018.11.003
Zhang C, Chen X, Too HP (2020) Microbial astaxanthin biosynthesis: recent achievements, challenges, and commercialization outlook. Appl Microbiol Biotechnol 104:5725–5737. https://doi.org/10.1007/s00253-020-10648-2
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The authors would like to thank São Paulo Research Foundation (FAPESP), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and Mayla Santos Rodrigues, PhD in Pharmaceutical Technology and Biochemical Engineering, and Scientific Proof-reader for her help with the manuscript.
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This work was supported by FAPESP (Process 2015/11194-6) and CNPq (Process 305250/2019-1).
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A.L.M.J.: conceptualization, funding acquisition, and writing (original draft). N. R.: writing (original draft). R.M.M.: writing (original draft). J.C.M.C.: validation. T.S. A.: writing (original draft). J.G.C.: writing (original draft). C.R.: writing (review and editing). M.V.R.V.: writing (review and editing). A.R.B.: supervision, conceptualization, and writing (review and editing). All authors contributed to the discussion and approval of the final manuscript.
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Morocho-Jácome, A.L., Ruscinc, N., Martinez, R.M. et al. (Bio)Technological aspects of microalgae pigments for cosmetics. Appl Microbiol Biotechnol 104, 9513–9522 (2020). https://doi.org/10.1007/s00253-020-10936-x
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DOI: https://doi.org/10.1007/s00253-020-10936-x