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Biosensing applications of clay-modified electrodes: a review

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Abstract

Two-dimensional layered inorganic solids, such as cationic clays and layered double hydroxides (LDHs), also defined as anionic clays, have open structures which are favourable for interactions with enzymes and which intercalate redox mediators. This review aims to show the interest in clays and LDHs as suitable host matrices likely to immobilize enzymes onto electrode surfaces for biosensing applications. It is meant to provide an overview of the various types of electrochemical biosensors that have been developed with these 2D layered materials, along with significant advances over the last several years. The different biosensor configurations and their specific transduction procedures are discussed.

Scheme of enzyme biosensors based on clay modified electrodes

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Acknowledgement

I would like to acknowledge Claude Forano (LMI, Clermont-Ferrand) and Serge Cosnier (DCM, Grenoble) for their respective contributions in the synthesis of Enz-LDHs biohybrids (Fig. 3) and in the development of biosensors based on LDHs.

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  1. Laboratoire des Matériaux Inorganiques (LMI, UMR UBP-CNRS 6002), Université Blaise Pascal (Clermont-Ferrand), 24, Avenue des Landais, 63177, Aubière cedex, France

    Christine Mousty

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Mousty, C. Biosensing applications of clay-modified electrodes: a review. Anal Bioanal Chem 396, 315–325 (2010). https://doi.org/10.1007/s00216-009-3274-y

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