Abstract
Mycotoxins are the most frequently occurring natural contaminants in human and animal diet. Among them, deoxynivalenol (DON), produced by Fusarium, is one of the most prevalent and thus represents an important health risk. Recent detection methods revealed new mycotoxins and new molecules derivated from the “native” mycotoxins. The main derivates of DON are the acetylated forms produced by the fungi (3- and 15-acetyl-DON), the biologically “modified” forms produced by the plant (deoxynivalenol-3-β-d-glucopyranoside), or after bacteria transformation (de-epoxy DON, 3-epi-DON and 3-keto-DON) as well as the chemically “modified” forms (norDON A-C and DON-sulfonates). High proportions of acetylated and modified forms of DON co-occur with DON, increasing the exposure and the health risk. DON and its acetylated and modified forms are rapidly absorbed following ingestion. At the molecular level, DON binds to the ribosome, induces a ribotoxic stress leading to the activation of MAP kinases, cellular cell-cycle arrest and apoptosis. The toxic effects of DON include emesis and anorexia, alteration of intestinal and immune functions, reduced absorption of the nutrients as well as increased susceptibility to infection and chronic diseases. In contrast to DON, very little information exists concerning the acetylated and modified forms; some can be converted back to DON, their ability to bind to the ribosome and to induce cellular effects varies according to the toxin. Except for the acetylated forms, their toxicity and impact on human and animal health are poorly documented.
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Abbreviations
- Acetyl-DON:
-
Acetyl-deoxynivalenol
- 3-acetyl-DON:
-
3-Acetyl deoxynivalenol
- 15-acetyl-DON:
-
15-Acetyl deoxynivalenol
- CAT:
-
Catalase
- CDK:
-
Cyclin-dependent kinase
- D3G:
-
Deoxynivalenol-3-β-d-glucopyranoside
- DOM-1:
-
De-epoxy DON
- DON:
-
Deoxynivalenol
- DONS:
-
DON sulfate
- ERK1/2:
-
Extracellular signal-regulated kinase 1and 2
- Hck:
-
Hematopoietic cell kinase (Tyrosine protein kinase)
- IEC:
-
Intestinal epithelial cells
- IPEC:
-
Intestinal porcine epithelial cells
- GLUT5:
-
d-Fructose Transporter Glucose Transporter-5
- Ig:
-
Immunoglobulin
- iNOS:
-
Nitric oxide synthase
- JNK:
-
c-Jun N-terminal kinase
- MAP Kinase:
-
Mitogen-activated protein kinase
- NF-κB:
-
Nuclear factor-κB
- NO:
-
Nitric oxide
- PKR:
-
Protein kinase R
- ROS:
-
Reactive oxygen species
- RNS:
-
Reactive nitrogen species
- SGLT1:
-
d-Glucose/d-galactose sodium-dependent transporter
- SOD:
-
Superoxidase dismutase
- TEER:
-
Trans-epithelial electrical resistance
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Acknowledgments
AP was supported by a CIFRE fellowship (2012/0572, jointly financed by the BIOMIN holding GmBH, ANRT and INRA). This work was supported in part by the ANR (Agence Nationale de la Recherche) projects ImBio (ANR-13-CESA-0003-03) and CaDON(ANR-15-CE21-0001-02) and the Partenariat Hubert Curien project (PHC 35813XM).
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Payros, D., Alassane-Kpembi, I., Pierron, A. et al. Toxicology of deoxynivalenol and its acetylated and modified forms. Arch Toxicol 90, 2931–2957 (2016). https://doi.org/10.1007/s00204-016-1826-4
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DOI: https://doi.org/10.1007/s00204-016-1826-4