Summary
Using a photochemical method silver was demonstrated in the brains of 1-, 14-, and 45-day-old rats which had been exposed to silver on gestational days 18 and 19. In the brain tissue of new-born rats, silver was found in the lysosomes of neurons and astroglia. Minor changes in the anatomic distribution of silver were observed between days 1 and 45. The pattern seen at day 45 was identical to that observed in silver-exposed adults.
At day 1, the choroid plexus and meninges were heavily loaded with silver both intra- and extracellularly. In particular, macrophage-like cells of the meningeal spaces contained large amounts of silver. In these structures, the silver had virtually disappeared by day 45.
Silver was always seen in basement membranes of the cerebral vessels.
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References
Bradbury M (1979) The concept of a blood-brain barrier, 1st edn. Wiley and Sons, Chichester New York Brisbane Toronto
Danscher G (1981 a) Histochemical demonstration of heavy metals. Histochemistry 71:1–16
Danscher G (1981 b) Localization of gold in biological tissue. Histochemistry 71:81–88
Danscher G (1981 c) Light and electron microscopic localization of silver in biological tissue. Histochemistry 71:177–186
Danscher G (1982a) Silver used as a marker of retrograde axonal transport. Neurosci Lett [Suppl] 10:129 (Abstr)
Danscher G (1982b) Exogenous selenium in the brain. Histochemistry 76:281–293
Dempsey EW, Wislocki GB (1955) An electron microscopic study of the blood-brain barrier in the rat, employing silver nitrate as a vital stain. J Biophys Biochem Cytol 1:245–256
Furchner JE, Richmond CR, Drake GA (1968) Comparative metabolism of radionucleides in mammals. IV. Retention of silver 110m in the mouse, rat, monkey and dog. Health Phys 15:505–514
Newton D, Holmes A (1966) A case of accidental inhalation of zine 65 and silver 110m. Radiat Res 29:403–412
Petering HG (1976) Pharmacology and toxicology of heavy metals: Silver. Pharmacol Ther 1:127–130
Reinhardt G, Geldmacher-v. Mallinckrodt M, Kittel H, Opitz O (1971) Akute tōdliche Vergiftung mit Silbernitrat als Folge eines Abtreibungsversuches. Arch Kriminol 148:69–78
Roberts WJ (1935) A new procedure for the detection of gold in animal tissues. Proc R Acad Sci (Amsterdam) 38:540–544
Rungby J, Danscher G (1983) Localization of exogenous silver in brain and spinal cord of silver exposed rats. Acta Neuropathol (Berl) 60:92–98
Scott KG, Hamilton JG (1950) The metabolism of silver in the rat with radio-silver used as an indicator. Univ Calif Berkeley Publ Pharmacol 19:241–262
Scott T, Norman PM (1980) Silver deposition in arteriolar basal laminae in the cerebral cortex of argyric rats. Acta Neuropathol (Berl) 52:253–256
Scott WL, Jr (1967) Silver uptake in brains of chronically gamma-irradiated rats: A study by neutron activation analysis. Radiat Res 31:522–528
Timm F (1958) Zur Histochemie der Schwermetalle. Das Sulfid-Silber-Verfahren. Dtsch Z Ges Gerichtl Med 46:706–711
Wislocki GB, Leduc EH (1952) Vital staining of the haematoencephalic barrier by silver nitrate and trypan blue, and cytological comparisons of the neurohypophysis, pineal body, area postrema, intercolumnar tubercle and supraoptic crest. J Comp Neurol 96:371–413
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Rungby, J., Danscher, G. Neuronal accumulation of silver in brains of progeny from argyric rats. Acta Neuropathol 61, 258–262 (1983). https://doi.org/10.1007/BF00691995
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DOI: https://doi.org/10.1007/BF00691995