Summary
Forty randomly selected dogs, arranged into three groups according to age, were examined light and electron microscopically. Lafora-like inclusion bodies were found in all cases of aged dogs without neurological signs. They appeared as PAS positive, round bodies measuring up to 15μm in diameter. Typically they had central cores and radiating peripheral lines. Electronmicroscopically, the inclusions consisted of irregularly clustered, short branching filaments measuring about 80–120 Å in diameter or of electrondense homogeneous or granular central cores with filamentous peripheral areas and located both in the perikarya and neuronal processes. The inclusions were disseminated all over the brain and spinal cord. The thalamic nuclei, a circumscribed area dorsal to the aqueduct, and the molecular layer of the superior colliculus were the most severely affected. The frequency of the inclusions showed age-dependency; the inclusions were not found in dogs younger than 2 years, but were extensive in all dogs of more than 8 years of age. The occurrence of the inclusions may therefore represent an age-dependent phenomenon. The relationship between the present findings and Lafora's disease is discussed.
Similar content being viewed by others
References
Anraku, S., Kotorii, K., Shigaki, Y., Mae, A.: An autopsy case of Lafora-body disease with interesting clinical symptoms. Clin. Neurol.14, 445–453 (1974)
Anzil, A. P., Herrlinger, H., Blinzinger, K., Kronski, D.: Intraneuritic corpora amylacea: Demonstration in orbital cortex of elderly subjects by means of early postmortem brain sampling and electron microscopy. Virchows Arch. [Pathol. Anat.]346, 297–301 (1974)
Brion, S., Mikol, J.: Étude ultrastructurale de la maladie de Pick. A propos de trois cas. Rev. Neurol. (Paris)125, 273–286 (1971)
Cusick, P. K., Cameron, A. M., Parker, A. J.: Canine neuronal glycoproteinosis: Lafora's disease in the dog. J. Amer. Anim. Hosp. Ass.12, 518–521 (1976)
Dayan, A. D.: Comparative neuropathology of ageing. Studies on the brains of 47 species of vertebrates. Brain94, 31–42 (1971)
Duffy, P. E., Tennyson, V. M.: Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus caeruleus in Parkinson's disease. J. Neuropathol. Exp. Neurol.24, 398–414 (1965)
Gambetti, P., Di Mauro, S., Hirt, L., Blume, R. P.: Myoclonic epilepsy with Lafora bodies. Arch. Neurol.25, 483–493 (1971)
Greenfield, J. G., Bosanquet, F. D.: The brain-stem lesions in parkinsonism. J. Neurol. Neurosurg. Psychiatry16, 213–226 (1953)
Hartog Jager, W. A. den, Bethlem, J.: The distribution of lewy bodies in the central and autonomic nervous system in idopathic paralysis agitans. J. Neurol. Neurosurg. Psychiatry23, 283–290 (1960)
Holland, J. M., Davis, W. C., Prieur, D. J., Collins, G. H.: Lafora's disease in the dog. A comparative study. Am. J. Pathol.58, 509–530 (1970)
Hoof, F. van, Hageman-Bal, M.: Progressive familial myoclonic epilepsy with Lafora bodies. Cerebral biopsy. Acta Neuropathol. (Berl.)7, 315–326 (1976)
Kobayashi, M., Iijima, M., Hatano, M., Akai, K., Yoshikura, N.: An autopsy case of progressive supranuclear palsy (The Steele-Richardson-Olszewski syndrome) with Lafora-like intraneuronal inclusions. Advances in Neurological sciences19, 384–395 (1975)
Krieg, K.: Das Vorkommen unspezifischer Einschlußkörperchen in den Zellen des ZNS der Katze und ihrer Bedeutung für die Tollwutdiagnose. Arch. Exp. Veterinaermed.17, 391–401 (1963)
Lafora, G. R., Glück, B.: Beitrag zur Histopathologie der myoklonischen Epilepsie. Z. ges. Neurol. Psychiat.6, 1–14 (1911)
León, G. A. de: Bielschowsky bodies: Lafora-like inclusions associated with atrophy of the lateral pallidum. Acta Neuropathol. (Berl.)30, 183–188 (1974)
Lipkin, L. E.: Cytoplasmic inclusions in ganglion cells associated with parkinsonian states. A neurocellular change studied in 53 cases and 206 controls. Am. J. Pathol.35, 1117–1133 (1959)
Loewenthal, W.: Eine Fehldiagnose auf Wut? Zbl. Bakt. (I. Orig.).101, 393–396 (1927)
Morales, R., Duncan, D., Rehmet, R.: A distinctive laminated cytoplasmic body in the lateral geniculate body neurons of the cat. J. Ultrastruct. Res.10, 116–123 (1964)
Namba, M.: Grundlage der charakteristischen Verteilung des Myoklonus-Körperchens im Zentralnervensystem. Bull. Yamaguchi Med. Sch.13, 251–264 (1966)
Orthner, H., Becker, P. E., Müller, D.: Reccesiv erbliche amyotrophische Lateralsklerose mit “Lafora-Körpern”. Arch. Psychiatr. Nervenkr.217, 387–412 (1973)
Padgett, G. A., Hegreberg, G. A.: Myoclonic epilepsy (Lafora's disease) in man and dog. JAVMA165, 745 (1974)
Petito, C. K., Hart, M. N., Porro, R. S., Earle, K. M.: Ultrastructural studies of olivopontocerebellar atrophy. J. Neuropathol. Exp. Neurol.31, 503–522 (1973)
Ramsey, H. J.: Ultrastructure of corpora amylacea. J. Neuropathol. Exp. Neurol.24, 29–39 (1965)
Schochet, S. S., Jr.: Neuronal inclusions. In: The structure and function of nervous tissue, IV (ed. G. H. Bourne), pp. 129–177. New York-London: Academic Press 1972
Seitelberger, F., Jacob, H., Peiffer, J., Colmant, H. J.: Die Myoklonus-Körperkrankheit. Eine angeborene Störung des Kohlenhydratstoffwechsels. Klinisch-pathologische Studie an fünf Fällen. Fortschr. Neurol. Psychiatr.32, 305–354 (1964)
Singer, M.: The brain of the dog in section. pp. 6–54. Philadelphia-London: Saunders 1962
Suzuki, K., David, E., Kutschman, B.: Presenile dementia with “Lafora-like” intraneuronal inclusions. Arch. Neurol.25, 69–80 (1971)
Szlachta, H. L., Habel, R. E.: Inclusions resembling negri bodies in the brains of nonrabid cats. Cornell Vet.43, 207–212 (1953)
Takahashi, K., Agari, M., Nakamura, H.: Intra-axonal corpora amylacea in ventral and lateral horns of the spinal cord. Acta Neuropathol. (Berl.)21, 151–158 (1975)
Tomchick, T. L.: Familial Lafora's disease in the beagle dog. Fed. Proc.32, 821 (1973)
Von Mickwitz, C.-U.: Einschlußkörperchen in den Ganglienzellen des Ammonshornes und des Thalamus von Haus-und Zookatzen. Path. Vet.3, 569–587 (1966)
Yoshimura, T.: Beiträge zu den klinisch- und histopathologischen Untersuchungen über die Fälle der Lafora-ähnlichen Einschlußkörperchen. Folia Psychiatr. Neurol. Jpn31, 89–102 (1977)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Suzuki, Y., Akiyama, K. & Suu, S. Lafora-like inclusion bodies in the CNS of aged dogs. Acta Neuropathol 44, 217–222 (1978). https://doi.org/10.1007/BF00691070
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00691070