The aim of the present work was to study the frequency and intranuclear locations of Marinesco bodies in neurons in the substantia nigra of the human brain. Marinesco bodies were detected on substantia nigra sections in five males aged 28–58 years. Nissl staining and a immunohistochemical reaction for ubiquitin – a characteristic protein for these intranuclear inclusions – were used. Marinesco bodies were seen in 1–2% of substantia nigra neurons but not in neighboring areas of the brain. One neuron could contain 1–4 Marinesco bodies of size up to 6.7 × 5.1 μm; bodies were positioned both close to and distant from the nucleolus. Ubiquitin was found in most Marinesco bodies. There was a tendency to an increase in Marinesco bodies in human substantia nigra neurons with age.
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E. G. Sukhorukova, O. S. Alekseeva, and D. E. Korzhevskii, “Catecholaminergic neurons in the mammalian brain and neuromelanin,” Zh. Evolyuts. Biol., 50, No. 5, 336–342 (2014).
P. A. Alladi, A. Mahadevan, K. Vijayalakshmi, et al., “Ageing enhances alpha-synuclein, ubiquitin and endoplasmic reticular stress protein expression in the nigral neurons of Asian Indians,” Neurochem. Int., 57, No. 5, 530–539 (2010).
D. W. Dickson, A. Wertkin, Y. Kress, et al., “Ubiquitin immunoreactive structures in normal human brains. Distribution and developmental aspects,” Lab. Invest., 63, 87–99 (1990).
S. Kumada, Y. Uchihara, M. Hayashi, et al., “Promyelocytic leukemia protein is redistributed during the formation of intranuclear inclusions independent of polyglutamine expansion: an immunohistochemical study on Marinesco bodies,” J. Neuropathol. Exp. Neurol., 61, 984–991 (2002).
G. Marinesco, “Sur la presence des corpuscles acidophiles paranucleolaires dans les cellules du locus niger et du locus ceruleus,” C. R. Acad. Sci., 135, 1000–1002 (1902).
G. E. Morris, “The Cajal body,” Biochim. Biophys. Acta, 1783, 2108–2115 (2008).
S. Odagiri, K. Tanji, F. Mori, et al., “Immunohistochemical analysis of Marinesco bodies, using antibodies against proteins implicated in the ubiquitin-proteasome system, autophagy and aggresome formation,” Neuropathology, 32, 261–266 (2012).
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Translated from Morfologiya, Vol. 148, No. 5, pp. 28–31, September–October, 2015.
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Grigor’ev, I.P., Gusel’nikova, V.V., Sukhorukova, E.G. et al. Distribution of Marinesco Bodies in Human Substantia Nigra Neurons. Neurosci Behav Physi 46, 839–842 (2016). https://doi.org/10.1007/s11055-016-0319-5
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DOI: https://doi.org/10.1007/s11055-016-0319-5