Skip to main content
SpringerLink
Log in

Neuropeptide Y, somatostatin, and cholecystokinin neurone preservation in anaplastic astrocytomas

  • Regular Papers
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Summary

Using immunohistochemistry, well-preserved neuronal cell bodies and fibres containing neuropeptide Y, somatostatin, and cholecystokinin immunoreactivity have been identified in all seven supratentorial anaplastic astrocytomas studied. These neurones have been shown not only on the edge but also in the depth of the neoplastic tissue. These neuropeptides were not present in 18 other intracranial tumours (3 astrocytomas, 1 subependymoma, 8 glioblastoma multiformes, 1 meningioma, and 5 metastases). In all 25 intracranial tumours studied, no immunoreactivity was found for vasoactive intestinal polypeptide, substance P, methionine-enkephalin, leucine-enkephalin, synenkephalin, neurophysin I-II, and corticotropin releasing factor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Adrian TE, Allen JM, Bloom SR, Ghatei MA, Rossor MN, Roberts GW, Crow TJ, Tatemoto K, Polak JM (1983) Neuropeptide Y distribution in human brain. Nature 306:584–586

    Google Scholar 

  2. Allen JM, Hoyle NR, Yeasts JC, Ghatei MA, Thomas DG, Bloom SR (1985) Neuropeptides in neurological tumours. J Neurooncol 3:197–202

    Google Scholar 

  3. Bateman DE, McDermott JR, Perry RH, Dimaline R, Biggins JA, Edwardson JA (1986) Neuropeptides in gliomas: identification of somatostatin 14 in a medulloblastoma. J Neurol Neurosurg Psychiat 49:1074–1076

    Google Scholar 

  4. Cox LB (1933) The cytology of the glioma group; with special reference to the inclusion of cells derived from the invaded tissue. Am J Pathol 9:839–898

    Google Scholar 

  5. Dahl D, Bignami A (1976) Immunogenic properties of the glial fibrillary acidic protein. Brain Res 116:150–157

    Google Scholar 

  6. Deschepper C, Lotstra F, Vanderhaeghen JJ (1983) Cholecystokinin varies in the posterior pituitary and external median eminence of the rat according to factors affecting vasopressin and oxytocin. Life Sci 32:2571–2577

    Google Scholar 

  7. Geola FL, Yamada T, Warwick RJ, Tourtelotte WW, Hershman JM (1981) Regional distribution of somatostatinlike immunoreactivity in the human brain. Brain Res 229:35–42

    Google Scholar 

  8. Goldman S, Van Reeth O, Schiffmann S, Lotstra F, Vanderhaeghen JJ (1984) Changes in neurohypophysial cholecystokinin content during oestrous cycle in the rat. Neurochem Int 6:779–782

    Google Scholar 

  9. Leboulenger F, Leroux P, Delarue C, Tonon MC, Charnay Y, Dubois PM, Coy DH, Vaudry H (1983) Co-localization of vasoactive intestinal peptide (VIP) and enkephalins in chromaffin cells of the adrenal gland of amphibia. Stimulation of corticosteroid production by VIP. Life Sci 32:375–383

    Google Scholar 

  10. Normand E, Popovici T, Onteniente B, Fellmann D, Piatier-Tonneau D, Auffray C, Bloch B (1988) Dopaminergic neurons of the substantia nigra modulate preproenkephalin A gene expression in rat striatal neurons. Brain Res 439:39–46

    Google Scholar 

  11. Pelletier G, Desy L, Kerkerian L, Cote J (1984) Immunocytochemical localization of neuropeptide Y (NPY) in the human hypothalamus. Cell Tissue Res 238:203–205

    Google Scholar 

  12. Reubi JC (1987) Somatostatin receptors in neuropathological diseases: physiological and therapeutical implications. In: Central neuropeptides: from gene to behaviour. Neuroscience Symposium organized by the European Neuroscience Association and Rhône-Poulenc Santé, Paris, pp 37–38

  13. Rougon G, Noble M, Mudge AW (1983) Neuropeptides modulate the β-adrenergic response of purified astrocytes in vitro. Nature 305:715–717

    Google Scholar 

  14. Russel DS, Rubinstein LJ (1977) Pathology of tumours of the nervous system, 4th edn. Edward Arnold, Edinburgh, pp 331–347

    Google Scholar 

  15. Scherer HJ (1940) The forms of growth in gliomas and their practical significance. Brain 63:1–35

    Google Scholar 

  16. Schoenen J, Lotstra F, Vierendeels G, Reznik M, Vanderhaeghen JJ (1985) Substance P, enkephalins, somatostatin, cholecystokinin, oxytocin, and vasopressin in human spinal cord. Neurology 35:881–890

    Google Scholar 

  17. Schulzeberg M, Foster GA, Gage FH, Björklund A, Hökfelt T (1986) Coexistence during ontogeny and transplantation. In: Hökfelt T, Fuxe K, Pernow B (eds) Coexistence of neuronal messengers: a new principle in chemical transmission. Progress in brain research, vol 68. Elsevier, Amsterdam, pp 129–145

    Google Scholar 

  18. Sofroniew MV, Weindl A, Schinko I, Wetzstein R (1979) The distribution of vasopressin-, oxytocin-, and neurophysin-producing neurons in the guinea pig brain. Cell Tissue Res 196:367–384

    Google Scholar 

  19. Sternberger LA (1979) Immunocytochemistry, 2nd edn. Wiley, New York, pp 104–169

    Google Scholar 

  20. Van Calker D, Müller M, Hamprecht B (1980) Regulation by secretin, vasoactive intestinal peptide, and somatostatin of cyclic AMP accumulation in cultured brain cells. Proc Natl Acad Sci USA 77:6907–6911

    Google Scholar 

  21. Vanderhaeghen JJ (1985) Neuronal cholecystokinin. In: Björklund A, Hökfelt T (eds) Handbook of chemical neuroanatomy, vol 4. GABA and neuropeptides in the CNS, part 1. Elsevier, Amsterdam, pp 406–435

    Google Scholar 

  22. Vanderhaeghen JJ, Lotstra F, De Mey J, Gilles C (1980) Immunohistochemical localization of cholecystokinin- and gastrin-like peptides in the brain and hypophysis of the rat. Proc Natl Acad Sci USA 77:1190–1194

    Google Scholar 

  23. Vanderhaeghen JJ, Lotstra F, Liston DR, Rossier J (1983) Proenkephalin, [Met]enkephalin, and oxitocin immunoreactivities are colocalized in bovine hypothalamic magnocellular neurons. Proc Natl Acad Sci USA 80:5139–5143

    Google Scholar 

  24. Verhaert P, Marivoet S, Vandesande F, De Loof A (1984) Localization of CRF immunoreactivity in the central nervous system of three vertebrate and one insect species. Cell Tissue Res 238:49–53

    Google Scholar 

  25. Verstappen A, Toussaint D, Lotstra F, Vanderhaeghen JJ (1986) Club endings containing substance P-like immunoreactivity in human retinal vessels: whole mount preparation. Neurochem Int 8:377–380

    Google Scholar 

  26. Zülch KJ (1986) Brain tumors. Their biology and pathology, 3rd edn. Springer, Berlin Heidelberg New York, pp 118–134

    Google Scholar 

Download references

Author information

Author notes

  1. J. J. Vanderhaeghen

    Present address: Laboratory of Neuropathology and Neuropeptide Research Erasme and Brugmann Hospitals, Université Libre de Bruxelles, Campus Anderlecht-Erasme, CP 601, 808 Route de Lennik, B-1070, Brussels, Belgium

Authors and Affiliations

  1. Laboratory of Neuropathology and Neuropeptide Research Erasme and Brugmann Hospitals, Université Libre de Bruxelles, Campus Anderlecht-Erasme, CP 601, 808 Route de Lennik, B-1070, Brussels, Belgium

    S. Przedborski (Research Assistants of the Belgian National Fund for Scientific Research), S. Goldman, S. N. Schiffmann (Research Assistants of the Belgian National Fund for Scientific Research), G. Vierendeels, M. Depierreux, M. Levivier & J. Hildebrand

Authors
  1. S. Przedborski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Goldman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. N. Schiffmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Vierendeels
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Depierreux
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. Levivier
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. Hildebrand
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. J. J. Vanderhaeghen
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported in part by the Belgian Fund for Medical Scientific Research (FRSM 3.4523.86), the Queen Elisabeth Medical Fundation (FMRE-Neurobiology 1986–87) and the Belgian National Lotery (1986).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Przedborski, S., Goldman, S., Schiffmann, S.N. et al. Neuropeptide Y, somatostatin, and cholecystokinin neurone preservation in anaplastic astrocytomas. Acta Neuropathol 76, 507–510 (1988). https://doi.org/10.1007/BF00686391

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00686391

Key words

Search

Navigation