Summary
A quantitative study of the myelination and axonal growth in the corpus callosum and posterior columns of the spinal cord in the Jimpy mouse gave the following results: The reduction in the number of myelinated fibers is much more important in regions with late myelination, e.g. corpus callosum and pyramidal tracts than in the previously myelinated fascicles of Goll and Burdach. There is an important delay in the increase in volume of axons particularly within the structures of late myelination. The importance of the lacking axonal growth in relation to myelination is discussed.
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Bernstein, J. J.: Relationship of corticospinal tract growth to age and body weight in the rat. J. comp. Neurol.127, 207–218 (1966)
Dunkerley, G. B., Duncan, D.: A light and electron microscopic study of the normal and degenerating corticospinal tract in the rat. J. comp. Neurol.137, 155–184 (1969)
Edström, A., Sjöstrand, J.: Protein synthesis in the isolated Mauthner nerve fibre of goldfish. J. Neurochem.16, 67–82 (1969)
Elam, J. S., Agranoff, B. W.: Rapid transport of protein in the optic system of the goldfish. J. Neurochem.8, 357–387 (1971)
Farkas-Bargeton, E., Robain, O., Mandel, P.: Abnormal glial maturation in the white matter in Jimpy mice. Acta neuropath. (Berl.)21, 272–281 (1972)
Fleischhauer, K., Wartenberg, H.: Elektronenmikroskopische Untersuchungen über das Wachstum der Nervenfasern und über das Auftreten von Markscheiden im Corpus callosum der Katze. Z. Zellforsch.83, 568–581 (1967)
Friede, R. C.: Control of myelin formation by axon caliber (with a model of the control mechanism). J. comp. Neurol.144, 233–252 (1972)
Giorgi, Karlsoen, Sjöstrand, Field: Possible synthesis by neurones and dependence on axonal flow. Nature (Lond.) (New Biol.)244, 121–123 (1973)
Golgi, Hortega, Cajal, S., de Castro F.: Elementos de tecnica micrografica del sistema nervioso. Madrid: Tipografica Artistica 1933
Hirano, A., Sax, D. S., Zimmerman, H. M.: The fine structure of the cerebella of Jimpy mice and their normal litter mates. J. Neuropath. exp. Neurol.28, 388–400 (1969)
Kohlschütter, A., Herschkovitz, N.: Sulfatide synthesis in neurons: a defect in mice with a hereditary myelination disorder. Brain Res.50, 379–385 (1973)
Kraus-Ruppert, R., Herschkowitz, N., Furst, S.: Morphological studies on neuroglial cells in the corpus callosum of the Jimpy mutant mouse. J. Neuropath. exp. Neurol.32, 197–202 (1973)
Luse, S. A.: Formation of myelin in the central nervous systems of mice and rats, as studied with the electron microscope. J. biophys. biochem. Cytol.2, 777–784 (1956)
Martinez, A. J., Friede, R. C.: Changes in nerve cell bodies during the myelination of their axons. J. comp. Neurol.138, 329–338 (1970)
Matthews, M. A., Duncan, D.: A quantitative study of morphological changes accompanying the initiation and progress of myelin production in the dorsal funiculus of the rat spinal cord. J. comp. Neurol.142, 1–22 (1971)
Neskovic, N., Sarlieve, L., Mandel, P.: Biosynthesis of glycolipids in myelin deficient mutants: Brain glycosyltransferase in Jimpy and Quaking mice. Brain Res.42, 147 (1972)
Nussbaum, J. L., Neskovic, N., Mandel, P.: A study of lipid composents in brain of the Jimpy mouse, a mutant with myelin deficiency. J. Neurochem.16, 927–934 (1969)
Philipps, R. J. S.: Jimpy a new totally sex-linked gene in the house mouse. Z. Vererbungslehre86, 322 (1954)
Privat, A., Robain, O., Mandel, P.: Aspects ultrastructuraux du corps calleux chez la souris Jimpy. Acta neuropath. (Berl.)21, 282–295 (1972)
Sarlieve, L., Neskovic, N., Rebel, G., Mandel, P.: Some properties of brain PAPS cerebroside sulphotransferase in Jimpy and Quaking mice. Neurobiology2, 70–82 (1972)
Schonbach, J., Schonbach, Ch., Cuenod, M.: Distribution of transported proteins in the slow phase of axoplasmic flow. An electron microscopical autoradiography study. J. comp. Neurol.152, 1–16 (1973)
Sidman, R. L.: Mutant mice (quaking and Jimpy) with deficient myelination in the central nervous system. Science144, 309–311 (1964)
Stensaas, L. J.: The development of hippocampal and dorso-lateral pallial regions of the cerebral hemisphere in fetal rabbits. J. comp. Neurol.129, 59–70 (1967)
Torii, J., Adachi, M., Volk, B. W.: Histochemical and ultrastructural studies of experimental leucodystrophy in mice. J. Neuropath. exp. Neurol.30, 278–289 (1971)
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Robain, O., Mandel, P. Etude quantitative de la myélinisation et de la croissance axonale dans le corps calleux et le cordon postérieur de la moëlle chez la souris Jimpy. Acta Neuropathol 29, 293–309 (1974). https://doi.org/10.1007/BF00685483
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DOI: https://doi.org/10.1007/BF00685483