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Functional circuitry of the goldfish cerebellum

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Summary

  1. 1.

    The basic circuitry of the cerebellum of goldfish is similar to that in other vertebrates but with several special features. Deep nuclei are lacking and the axons of approximately 80% of Purkinje cells leave the cerebellum.

  2. 2.

    Responses of granule cells indicate much convergence of mossy fiber inputs. Some Purkinje cells give single simple spikes, others trains of spikes in response to mossy fiber or parallel fiber stimulation.

  3. 3.

    Inhibitory interneurons—stellate and Golgi cells—are characterized by high-frequency, ongoing spikes. Parallel fibers activate interneurons which inhibit granule cell responses to mossy input and which also inhibit Purkinje cells as indicated by IPSP's, interruption of spontaneity and of responses via mossy fiber-granule cell input.

  4. 4.

    Peduncle stimulation in deafferented preparations revealed Purkinje cell collateral inhibition of other Purkinje cells and of Golgi cells.

  5. 5.

    Climbing fiber stimulation elicits complex responses in Purkinje cells, often followed by inhibition and, in some cells, a late second excitatory response.

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Author notes

  1. Naiphinich Kotchabhakdi

    Present address: Laboratory of Neuroscience, Mahidol University, Bangkok, Thailand

Authors and Affiliations

  1. Department of Physiology and Biophysics, University of Illinois, 61801, Urbana, Illinois, USA

    Naiphinich Kotchabhakdi

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  1. Naiphinich Kotchabhakdi
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Fellow of Rockefeller Foundation

This research was part of a Ph.D. thesis in Neural and Behavioral Biology, University of Illinois, 1975. Advice from Professor C. Ladd Prosser is acknowledged. Support was from Rockefeller Foundation and from NSF grant BMS-01587 to C.L. Prosser.

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Kotchabhakdi, N. Functional circuitry of the goldfish cerebellum. J. Comp. Physiol. 112, 47–73 (1976). https://doi.org/10.1007/BF00612675

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  • DOI: https://doi.org/10.1007/BF00612675

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