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Increase of serum very low density lipoproteins in rats after administration of α-hexachlorocyclohexane

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Summary

After enteral administration of 200 mg/kg α-hexachlorocyclohexane (α-HCH) female Wistar rats develop a hyperlipemia. 48 h after administration of α-HCH, serum triglycerides are increased by 300%, whereas both serum cholesterol and serum total phospholipids only increase by about 45%. Serum free fatty acids are not significantly altered. Fractionation of the serum lipoproteins by ultracentrifugation shows that the hyperlipemia is due to a fivefold increase in serum very low density lipoproteins.

Hepatic triglyceride secretion, calculated after i.v. injection of Triton WR 1339, is increased in animals pretreated with α-HCH. Corresponding to this observation, drugs known to diminish the triglyceride secretion of the liver, such as actinomycin D, cycloheximide; glucagon, orotic acid, CFT 1201, and CFT 1042 reduce the α-HCH-induced hyperlipemia.

We concluded from the results that hyperlipoproteinemia after α-HCH is due to an increased hepatic very low density lipoprotein secretion.

At the same time, the blood sugar level was decreased in fasting animals after treatment with α-HCH. Earlier experiments suggest that this effect is due to a decreased gluconeogenesis in the liver.

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  1. Pharmakologisches Institut der Freien Universität Berlin, Thielallee 69/73, D-1000, Berlin 33

    O. Grajewski & E. Oberdisse

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  1. O. Grajewski
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  2. E. Oberdisse
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Grajewski, O., Oberdisse, E. Increase of serum very low density lipoproteins in rats after administration of α-hexachlorocyclohexane. Naunyn-Schmiedeberg's Arch. Pharmacol. 298, 129–135 (1977). https://doi.org/10.1007/BF00508619

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  • DOI: https://doi.org/10.1007/BF00508619

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