Abstract
The article presents the results of an experiment to determine the protective activity of hepavitol on a model of acute fatty liver degeneration in laboratory rats. Acute fatty hepatosis in animals was caused by a single intragastric administration of an aqueous solution of hydrazine at a dose of 200 mg / kg (40–50 mg / animal), and then the animals were injected with hepavitol for 28 days. The total weight gain of the rats by groups relative to the initial indicators by the end of the experiment was: experimental group “ +” 1.6%, control group “−” 3.7%, intact group “ +” 6.1%. There were also significant changes in the level of LPO products between the experimental and control groups. The level of diene conjugates in the blood of control rats exceeded those of experimental animals in 1.88 times, ketodienes exceeded in 1.75 times, malondialdehyde exceeded by 30.2%, respectively. Experimental animals showed stabilization of hepatoindicator enzymes, total protein and bilirubin almost to the level of healthy animals. The liver histostructure of the rats of the control group was distinguished by extensive areas of granular, fatty degeneration and necrosis of hepatocytes. On the significant part of the liver tissue of the experimental rats, the integrity of hepatocytes and the beam structure of the organ parenchyma were preserved. Thus, from the results obtained in the model experiment, it can be concluded that hepavitol has a pronounced protective activity.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Alyokhin, Y., Zhukov, M.S., Kalyuzhny, I.I., Papunidi, K., Aslanov, R.M., Smolentsev, S.: Rheological properties of nasal mucus of calves during periods of development of bronchopneumonia. Indian Vet. J. 96(07), 36–39 (2019)
Egorov, V.I., et al.: Toxicity indices of uracil derivatives on lung epithelial cells. Indian Vet. J. 95(6), 33–36 (2018)
Galyautdinova, G.G., et al.: Detection of tetracycline antibiotics in honey using high-performance liquid hromatography. Int. J. Res. Pharm. Sci. 11(1), 313–314 (2020)
Gracheva, O.A., et al.: Study of the effect of different levels of arginine in feed on broiler chickens. Int. J. Res. Pharm. Sci. 11(1), 908–912 (2020)
Hairullin, D.D., et al.: Section original articles study of scar content in cows when using carbohydrate-vitamin-mineral concentrate «LS». Int. J. Res. Pharm. Sci. 11(2), 2241–2243 (2020)
Ilyasovich, S.E., et al.: Efficiency of application of a polysaccharide enterosorbent of “Fitosorb” for prevention of the combined mycotoxicosis. Res. J. Pharm. Biol. Chem. Sci. 7(4), 2229–2237 (2016)
Popov, S.V., et al.: Acid-base homeostasis indices upon electric neurostimulation therapy of calves with acute pulmonary pathologies. Res. J. Pharm. Biol. Chem. Sci. 9(3), 553–556 (2018)
Kalyuzhny, I.I., et al.: Peculiarities of respiratory pathology of young cattle in the lower Volga region Russian Federation. Int. J. Res. Pharm. Sci. 11(2), 2360–2364 (2020)
Melnik, N.V., et al.: Efficiency of probiotics use in treatment of calves. Int. J. Res. Pharm. Sci. 11(2), 1674–1678 (2020)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Semenenko, M.P. et al. (2023). Experimental Evaluation of the Protective Activity of Hepavitol on the Model of Acute Fatty Hepatosis in Rats. In: Beskopylny, A., Shamtsyan, M., Artiukh, V. (eds) XV International Scientific Conference “INTERAGROMASH 2022”. INTERAGROMASH 2022. Lecture Notes in Networks and Systems, vol 574. Springer, Cham. https://doi.org/10.1007/978-3-031-21432-5_201
Download citation
DOI: https://doi.org/10.1007/978-3-031-21432-5_201
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-21431-8
Online ISBN: 978-3-031-21432-5
eBook Packages: EngineeringEngineering (R0)