Skip to main content
SpringerLink
Log in

Effect of Phosphatidylcholine Nanosomes on Phospholipid Composition of the Plasma Membranes in Liver Cells and Blood Serum in Experimental Atherosclerosis

  • GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Alimentary atherosclerosis is associated with a significant decrease in the content of phosphatidylcholine, the phospholipid that provides antioxidant protection, in the plasma membrane of liver cells, while the level of phosphatidic acid that initiates generation of superoxides, on the contrary, increases. The level of membrane phosphatidylserine, a target of the scavenger receptors, which initiates removal of damaged cells and modified lipoproteins from the circulation was also elevated. In the blood serum of rabbits receiving an atherogenic diet, the content of cardiolipin involved in the immune mechanisms of atherosclerosis development and a risk factor for thrombosis, sharply increased. The level of lysophosphatidylcholine that mediates initiation and progression of atherosclerosis increased. The content of phosphatidylinositol that is involved in the mechanisms protecting from exposure to excess cholesterol was significantly reduced. Treatment of alimentary atherosclerosis with “empty” phosphatidylcholine nanosomes eliminates the key factors initiating atherosclerosis development.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Karagodin VP, Bobryshev YV, Orekhov AN. Inflammation, immune cells, cytokines - role in atherogenesis. Patogenez. 2014;12(1):21-35. Russian.

    Google Scholar 

  2. Kargapolov AV, Kartsova SV. A method of simultaneous fractionation of the main fractions of lysophospholipids and their diacyl derivatives. Vopr. Med. Khimii. 1975;21(3):325-327. Russian.

    CAS  PubMed  Google Scholar 

  3. Pospelova AV. Modern Methods in Biochemistry. Moscow, 1977. P. 326-329. Russian.

  4. Baccante G, Mincione G, Di Febbo C, Coppa A, Angelucci D, Lapenna D, Cuccurullo F, Colletta G, Porreca E. Increased type II transforming growth factor-beta receptor expression in liver cells during cholesterol challenge. Atherosclerosis. 2000;152(1):51-57.

    Article  CAS  Google Scholar 

  5. Banoth B, Cassel SL. Mitochondria in innate immune signaling. Transl. Res. 2018;202:52-68.

    Article  CAS  Google Scholar 

  6. Bedadun S, Subratty AH. Plasma cardiolipin in postmenopausal women in mauritius. Afr. J. Reprod. Health. 2001;5(2):135- 138.

    Article  CAS  Google Scholar 

  7. Burgess JW, Boucher J, Neville TA, Rouillard P, Stamler C, Zachariah S, Sparks DL. Phosphatidylinositol promotes cholesterol transport and excretion. J. Lipid Res. 2003;44(7):1355- 1363.

    Article  CAS  Google Scholar 

  8. English D. Phosphatidic acid: a lipid messenger involved in intracellular and extracellular signalling. Cell Signal. 1996;8(5):341-347.

    Article  CAS  Google Scholar 

  9. Fruhwürth S, Kovacs WJ, Bittman R, Messner S, Röhrl C, Stangl H. Differential basolateral-apical distribution of scavenger receptor, class B, type I in cultured cells and the liver. Histochem. Cell Biol. 2014;142(6):645-655.

    Article  Google Scholar 

  10. Hoekstra M. SR-BI as target in atherosclerosis and cardiovascular disease - A comprehensive appraisal of the cellular functions of SR-BI in physiology and disease. Atherosclerosis. 2017;258:153-161.

    Article  CAS  Google Scholar 

  11. Iseme RA, McEvoy M, Kelly B, Agnew L, Walker FR, Handley T, Oldmeadow C, Attia J, Boyle M. A role for autoantibodies in atherogenesis. Cardiovasc. Res. 2017;113(10):1102- 1112.

    Article  CAS  Google Scholar 

  12. Qiao J, Huang F, Naikawadi RP, Kim KS, Said T, Lum H. Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4. Am. J. Physiol. Lung Cell Mol. Physiol. 2006;291(1):L91-101.

    Article  CAS  Google Scholar 

  13. Terpstra V, van Berkel TJ. Scavenger receptors on liver Kupffer cells mediate the in vivo uptake of oxidatively damaged red blood cells in mice. Blood. 2000;95(6):2157-2163.

    Article  CAS  Google Scholar 

  14. Zeisel SH. Choline: critical role during fetal development and dietary requirements in adults. Annu. Rev. Nutr. 2006;26:229- 250.

    Article  CAS  Google Scholar 

  15. Zhao Z, Wang M, Tian Y, Hilton T, Salsbery B, Zhou E.Z, Wu X, Thiagarajan P, Boilard E, Li M, Zhang J, Dong JF. Cardiolipin-mediated procoagulant activity of mitochondria contributes to traumatic brain injury-associated coagulopathy in mice. Blood. 2016;127(22):2763-2772.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Institute of General Pathology and Pathophysiology, Moscow, Russia

    G. F. Leskova

  2. M. V. Lomonosov Institute of Fine Chemical Technology, MIREA — Russian University of Technology, Moscow, Russia

    A. P. Kaplun, D. A. Bezrukov & A. I. Lvovsky

Authors
  1. G. F. Leskova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. P. Kaplun
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. A. Bezrukov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. I. Lvovsky
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. F. Leskova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 8, pp. 143-147, August, 2020

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Leskova, G.F., Kaplun, A.P., Bezrukov, D.A. et al. Effect of Phosphatidylcholine Nanosomes on Phospholipid Composition of the Plasma Membranes in Liver Cells and Blood Serum in Experimental Atherosclerosis. Bull Exp Biol Med 170, 181–184 (2020). https://doi.org/10.1007/s10517-020-05028-9

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-020-05028-9

Key Words

Search

Navigation