Abstract
In the last two decades, additive manufacturing (AM) has made significant progress towards the fabrication of biomaterials and tissue-engineering constructs. One direction of research is focused on the development of mechanically stable implants with patient-specific sizes/shapes and another direction has been to fabricate tissue-engineered scaffolds with designed porous architecture to facilitate vascularization. Among AM techniques, three dimensional powder printing (3DPP) is suitable for the fabrication of bone related prosthetic devices, while three dimensional plotting (3DPL) is based on the extrusion of biopolymers to create artificial tissues. The central theme of this chapter is to discuss the critical roles played by the binder and powder properties together with the interplay among processing parameters in the context of the physics of binder-material interaction for the fabrication of implants with predefined architecture and structural complexity. Summarising, this chapter encompasses the process and the underlying governing parameters of low temperature additive manufacturing methods.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Vasireddi, R., Basu, B.: Conceptual design of three-dimensional scaffolds for bone tissue engineering. Rapid Prototyping J. 21 (2015)
Schubert, C., van Langeveld, M.C., Donoso, L.A.: Innovations in 3D printing: a 3D overview from optics to organs. Br. J. Ophthalmol. (2013): bjophthalmol-2013
Vaezi, M., Seitz, H., Yang, S.: A review on 3D micro-additive manufacturing technologies. Int. J. Adv. Manuf. Technol. 67(5–8), 1721–1754 (2013)
PWC. 3D printing and the new shape of industrial manufacturing. In: PWC, editor (2014)
Berger, R.: Additive manufacturing: a game changer for the manufacturing industry. In: Berger, R., (ed.). Munich (2013)
Lantada, A.D., Morgado, P.L.: Rapid prototyping for biomedical engineering: current capabilities and challenges. Annu. Rev. Biomed. Eng. 14, 73–96 (2012)
Yeong, W.-Y., Chua, C.-K., Leong, K.-F., Chandrasekaran, M.: Rapid prototyping in tissue engineering: challenges and potential. Trends Biotechnol. 22(12), 643–652 (2004)
Kalejs, M., von Segesser, L.K.: Rapid prototyping of compliant human aortic roots for assessment of valved stents. Interact. Cardiovasc. Thorac. Surg. 8(2), 182–186 (2009)
FDA.: Paving the Way for Personalized Medicine. In: Hamburg, M.A. (ed.) FDA, USA (2013)
Zhao, S., Zhu, M., Zhang, J., Zhang, Y., Liu, Z., Zhu, Y., Zhang, C.: Three dimensionally printed mesoporous bioactive glass and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) composite scaffolds for bone regeneration. J. Materials Chemistry B 2(36), 6106–6118 (2014)
Klammert, U., Gbureck, U., Vorndran, E., Rödiger, J., Meyer-Marcotty, P., Kübler, A.C.: 3D powder printed calcium phosphate implants for reconstruction of cranial and maxillofacial defects. J. Cranio-Maxillofacial Surg. 38, 565–570 (2010)
Wang, J., Yang, M., Zhu, Y., Wang, L., Tomsia, A.P., Mao, C.: Phage nanofibers induce vascularized osteogenesis in 3D printed bone scaffolds. Adv. Mater. (2014)
Shim, J.-H., Kim, S.E., Park, J.Y., Kundu, J., Kim, S.W., Kang, S.S., Cho, D.-W.: Three-dimensional printing of rhBMP-2-loaded scaffolds with long-term delivery for enhanced bone regeneration in a rabbit diaphyseal defect. Tissue Eng. Part A (2014)
Kloxin, A.M., Kasko, A.M., Salinas, C.N., Anseth, K.S.: Photodegradable hydrogels for dynamic tuning of physical and chemical properties. Science 324(5923), 59–63 (2009)
Markets, M.A.: Additive Manufacturing Market, by Application (…), forecast 2012–2017. In: Markets, M.A. (2013)
Angrish, A.: 3D printing in biomedical applications: overview and opportunities. MED DEVICE ONLINE (2013)
Peltola, S.M., Melchels, F.P.W., Grijpma, D.W., Kellomäki, M.: A review of rapid prototyping techniques for tissue engineering purposes. Ann. Med. 40(4), 268–280 (2008)
Webb, P.A.: A review of rapid prototyping (RP) techniques in the medical and biomedical sector. J. Med. Eng. Technol. 24(4), 149–153 (2000)
Kolesky, D.B., Truby, R.L., Gladman, A.S., Busbee, T.A., Homan, K.A., Lewis, J.A.: 3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs. Adv. Mater. 26(19), 3124–3130 (2014)
Liu, F.-H.: Fabrication of bioceramic bone scaffolds for tissue engineering. J. Mater. Eng. Perform. 23(10), 3762–3769 (2014)
Liu, F.-H.: Synthesis of biomedical composite scaffolds by laser sintering: mechanical properties and in vitro bioactivity evaluation. Appl. Surf. Sci. 297, 1–8 (2014)
Landers, R., Pfister, A., Hübner, U., John, H., Schmelzeisen, R., Mülhaupt, R.: Fabrication of soft tissue engineering scaffolds by means of rapid prototyping techniques. J. Mater. Sci. 37(15), 3107–3116 (2002)
Huang, T., Qu, X., Liu, J., Chen, S.: 3D printing of biomimetic microstructures for cancer cell migration. Biomed. Microdevices 16(1), 127–132 (2014)
Rankin, T.M., Giovinco, N.A., Cucher, D.J., Watts, G., Hurwitz, B., Armstrong, D.G.: Three-dimensional printing surgical instruments: are we there yet? J. Surg. Res. 189(2), 193–197 (2014)
Chantarapanich, N., Puttawibul, P., Sucharitpwatskul, S., Jeamwatthanachai, P., Inglam, S., Sitthiseripratip, K.: Scaffold library for tissue engineering: a geometric evaluation. Comput. Math. Methods Med. 2012, 1–14 (2012)
El-Ayoubi, R., Eliopoulos, N., Diraddo, R., Galipeau, J., Yousefi, A.-M.: Design and fabrication of 3D porous scaffolds to facilitate cell-based gene therapy. Tissue Eng. Part A 14, 1037–1048 (2004)
Tripathi, G., Basu, B.: A porous hydroxyapatite scaffold for bone tissue engineering: physico-mechanical and biological evaluations. Ceram. Int. 38(1), 341–349 (2012)
Holmes, R.: Bone regeneration within a coralline hydroxyapatite implant. Plast. Reconstr. Surg. 63, 626–633 (1979)
Ravaglioli, A., Krajewski, A.: Implantable porous bioceramics. Mater. Sci. Forum 250, 221–230 (1997)
Hollister, S.: Engineering craniofacial scaffolds. Orthod. Craniofac. Res. 8(3), 162–173 (2005)
Damien, E., Hing, K., Saeed, S., Revell, P.: A preliminary study on the enhancement of the osteointegration of a novel synthetic hydroxyapatite scaffold in vivo. J. Biomed. Mater. Res. A 66, 241–246 (2003)
Zhang, C., Wang, J., Feng, H., Lu, B., Song, Z., Zhang, X.: Replacement of segmental bone defects using porous bioceramic cylinders: a biomechanical and X-ray diffraction study. J. Biomed. Mater. Res. 54, 407–411 (2001)
ElGhannam, A.: Advanced bioceramic composite for bone tissue engineering: design principles and structure-bioactivity relationship. J. Biomed. Mater. Res. A 69, 490–501 (2004)
Hing, K., SB, S.M., Bonfield, W.: Characterization of porous hydroxyapatite. J. Mater. Sci. Mater. Med. 10, 135–145 (1999)
Basu, B., Swain, S.K., Sarkar, D.: Cryogenically cured hydroxyapatite-gelatin nanobiocomposite with interconnected porosity as a suitable scaffold for adsorption/delivery of BSA protein of up to 60 %. RSC Adv. R. Soc. Chem. 3, 14622–14633 (2013)
Toibah, A., Iis, S.: Recent progress on the development of porous bioactive calcium phosphate for biomedical applications. Recent Pat. Biomed. Eng. 1, 213–229 (2008)
Lee, Y., Seol, Y., Lim, Y., Kim, S., Han, S., Rhyu, I., Baek, S., Heo, S., Choi, J., Klokkevold, P., et al.: Tissue-engineered growth of bone by marrow cell transplantation using porous calcium metaphosphate matrices. J. Biomed. Mater. Res. 54, 216–223 (2001)
Kyriakidou, K., Lucarini, G., Zizzi, A., Salvolini, E., Mattioli Belmonte, M., Mollica, F., Gloria, A., Ambrosio, L.: Dynamic co-seeding of osteoblast and endothelial cells on 3D polycaprolactone scaffolds for enhanced bone tissue engineering. J. Bioact. Compatible Polym. 23(3), 227–243 (2008)
Chen, Y., Ng, C., Wang, Y.: Generation of an STL file from 3D measurement data with user-controlled data reduction. Int. J. Adv. Manuf. Technol. 15(2), 127–131 (1999)
Hutmacher, D.: Scaffolds in tissue engineering bone and cartilage. Biomaterials 21, 2529 (2000)
Sachlos, E., Czernuszka, J.: Making tissue engineering scaffolds work. Review on the application of solid freeform fabrication technology to the production of tissue engineering scaffolds. Eur. Cells Mater. 5, 29–39 (2003)
Abdullah, J.: Hassan A, pp. 547–561. Principles and Applications. Bone Grafts and Bone Substitutes, Rapid Prototyping in Orthopaedics (2005)
Garrett, B.: 3D printing: new economic paradigms and strategic shifts. Global Policy 5(1), 70–75 (2014)
Mironov, V., Boland, T., Trusk, T., Forgacs, G., Markwald, R.: Organ printing: computer-aided jet-based 3D tissue engineering. Trends in Biotechnol. 21, 157–161 (2003)
Melchels, F.P.W., Feijen, J., Grijpma, D.W.: A review on stereolithography and its applications in biomedical engineering. Biomaterials 31(24), 6121–6130 (2010)
Hoque, M.E., Chuan, Y.L., Pashby, I.: Extrusion based rapid prototyping technique: an advanced platform for tissue engineering scaffold fabrication. Biopolymers 97(2), 83–93 (2012)
Giannitelli, S.M., Accoto, D., Trombetta, M., Rainer, A.: Current trends in the design of scaffolds for computer-aided tissue engineering. Acta Biomater. 10(2), 580–594 (2014)
Giannatsis, J., Dedoussis, V.: Additive fabrication technologies applied to medicine and health care: a review. Int. J. Adv. Manuf. Technol. 40(1–2), 116–127 (2009)
Ad, L., Pl, M.: Rapid prototyping for biomedical engineering: current capabilities and challenges. Annu. Rev. Biomed. Eng. 14, 73–96 (2012)
Forgacs, G., Biofabrication, S.W.: Micro- and Nano-fabrication, Printing, Patterning and Assemblies (Micro and Nano Technologies): Elsevier Amsterdam (2013)
Gaytan, S.M., Murr, L.E., Martinez, E., Martinez, J.L., Machado, B.I., Ramirez, D.A., Medina, F., Collins, S., Wicker, R.B.: Comparison of microstructures and mechanical properties for solid and mesh cobalt-base alloy prototypes fabricated by electron beam melting. Metallurgical and materials transactions A 41(12), 3216–3227 (2010)
Murr, L.E., Quinones, S.A., Gaytan, S.M., Lopez, M.I., Rodela, A., Martinez, E.Y., Hernandez, D.H., Martinez, E., Medina, F., Wicker, R.B.: Microstructure and mechanical behavior of Ti6Al4V produced by rapid-layer manufacturing, for biomedical applications. J. Mech. Behav. Biomed. Mater. 2(1), 20–32 (2009)
Palmquist, A., Snis, A., Emanuelsson, L., Browne, M., Thomsen, P.: Long-term biocompatibility and osseointegration of electron beam melted, free-form–fabricated solid and porous titanium alloy: experimental studies in sheep. J. Biomaterials Appl. (2011)
Le Guéhennec, L., Soueidan, A., Layrolle, P., Amouriq, Y.: Surface treatments of titanium dental implants for rapid osseointegration. Dent. Mater. 23(7), 844–854 (2007)
Hernandez, J., Li, S.J., Martinez, E., Murr, L.E., Pan, X.M., Amato, K.N., Cheng, X.Y., Yang, F., Terrazas, C.A., Gaytan, S.M.: Microstructures and hardness properties for β-Phase Ti–24Nb–4Zr–7.9 Sn alloy fabricated by electron beam melting. J. Mater. Sci. Technol. 29(11), 1011–1017 (2013)
Luca, F., Emanuele, M., Pierfrancesco, R., Alberto, M., Simon, H., Konrad, W.: Ductility of a Ti6Al4V alloy produced by selective laser melting of prealloyed powders. Rapid Prototyping J. 16(6), 450–459 (2010)
Thijs, L., Verhaeghe, F., Craeghs, T., Humbeeck, J.V., Kruth, J.-P.: A study of the microstructural evolution during selective laser melting of Ti6Al4V. Acta Mater. 58(9), 3303–3312 (2010)
Calvert, P.: Inkjet printing for materials and devices. Chem. Mater. 13(10), 3299–3305 (2001)
Butscher, A., Bohner, M., Roth, C., Ernstberger, A., Heuberger, R., Doebelin, N., Rudolf von Rohr, P., Müller, R.: Printability of calcium phosphate powders for three-dimensional printing of tissue engineering scaffolds. Acta Biomater. 8(1), 373–385 (2012)
Derby, B.: Inkjet printing of functional and structural materials: fluid property requirements, feature stability, and resolution. Annu. Rev. Mater. Res. 40(1), 395–414 (2010)
Lanzetta, M., Sachs, E.: Improved surface finish in 3D printing using bimodal powder distribution. Rapid Prototyping J. 9(3), 157–166 (2003)
Butscher, A., Bohner, M., Hofmann, S., Gauckler, L., Müller, R.: Structural and material approaches to bone tissue engineering in powder-based three-dimensional printing. Acta Biomater. 7(3), 907–920 (2011)
Lam, C.X.F., Mo, X., Teoh, S.-H., Hutmacher, D.: Scaffold development using 3D printing with a starch-based polymer. Mater. Sci. Eng., C 20(1), 49–56 (2002)
Khalyfa, A., Vogt, S., Weisser, J., Grimm, G., Rechtenbach, A., Meyer, W., Schnabelrauch, M.: Development of a new calcium phosphate powder-binder system for the 3D printing of patient specific implants. J. Mater. Sci. Mater. Med. 18(5), 909–916 (2007)
Landers, R., Mülhaupt, R.: Desktop manufacturing of complex objects, prototypes and biomedical scaffolds by means of computer-assisted design combined with computer-guided 3D plotting of polymers and reactive oligomers. Macromol. Mater. Eng. 282(1), 17–21 (2000)
Butscher, A., Bohner, M., Doebelin, N., Hofmann, S., Müller, R.: New depowdering-friendly designs for three-dimensional printing of calcium phosphate bone substitutes. Acta Biomater. 9(11), 9149–9158 (2013)
Xiong, Y., Qian, C., Sun, J.: Fabrication of porous titanium implants by three-dimensional printing and sintering at different temperatures. Dent. Mater. J. 31(5), 815–820 (2012)
Suwanprateeb, J., Chumnanklang, R.: Three-dimensional printing of porous polyethylene structure using water-based binders. J. Biomed. Mater. Res. B Appl. Biomater. 78B(1), 138–145 (2006)
Stringer, J., Derby, B.: Limits to feature size and resolution in ink jet printing. J. Eur. Ceram. Soc. 29, 913–918 (2009)
Derby, B.: J. Mater. Chem. 18(47), 5717–5721 (2008)
Setti, L., Fraleoni-Morgera, A., Ballarin, B., Filippini, A., Frascaro, D., Piana, C.: Biosens. Bioelectron. 20(10), 2019–2026 (2005)
Setti, L., Piana, C., Bonazzi, S., Ballarin, B., Frascaro, D., Fraleoni-Morgera, A., Giuliani, S.: Anal. Lett. 37(8), 1559–1570 (2004)
Sen, A.K., Darabi, J.: Droplet ejection performance of a monolithic thermal inkjet print head. J. Micromech. Microeng. 17(8), 1420–1427 (2007)
Saunders, R.E., Derby, B.: Inkjet printing biomaterials for tissue engineering: bioprinting. Int. Mater. Rev. 59(8), 430–448 (2014)
Zhou, Z., Buchanan, F., Mitchell, C., Dunne, N.: Printability of calcium phosphate: calcium sulfate powders for the application of tissue engineered bone scaffolds using the 3D printing technique. Mater. Sci. Eng., C 38, 1–10 (2014)
Peters, F., Haenel, T., Bernhardt, A., Lode, A., Gelinsky, M., Duerr, H.: In vitro examination of 3D printed vs. milled scaffolds from beta-tricalcium phosphate (beta-TCP) for patient individual bone regeneration (2008)
Bredt, J.: Binder Composition for use in Three Dimensional Printing (1998)
Gbureck, U., Holzel, T., Biermann, I., Barralet, J.E., Grover, L.M.: Preparation of tricalcium phosphate/calcium pyrophosphate structures via rapid prototyping. J. Mater. Sci. Mater. Med. 19(4), 1559–1563 (2008)
Klammert, U., Gbureck, U., Vorndran, E., Rödiger, J., Meyer-Marcotty, P., Kübler, A.C.: 3D powder printed calcium phosphate implants for reconstruction of cranial and maxillofacial defects. J. Cranio-Maxillofacial Surg. 38(8), 565–570 (2010)
Moseke, C., Gbureck, U.: Tetracalcium phosphate: synthesis, properties and biomedical applications. Acta Biomater. 6(10), 3815–3823 (2010)
Moseke, C., Gelinsky, M., Groll, J., Gbureck, U.: Chemical characterization of hydroxyapatite obtained by wet chemistry in the presence of V Co, and Cu ions. Mater. Sci. Eng., C 33(3), 1654–1661 (2013)
Vorndran, E., Klammert, U., Klarner, M., Grover, L.M., Barralet, J.E., Gbureck, U.: 3D printing of β-tricalcium phosphate ceramics. Dent. Mater. 25(5), e18–e19 (2009)
Lowmunkong, R., Sohmura, T., Suzuki, Y., Matsuya, S., Ishikawa, K.: Fabrication of freeform bone-filling calcium phosphate ceramics by gypsum 3D printing method. J. Biomed. Mater. Res. B Appl. Biomater. 90B(2), 531–539 (2009)
Suwanprateeb, J., Thammarakcharoen, F., Wasoontararat, K., Suvannapruk, W.: Influence of printing parameters on the transformation efficiency of 3D-printed plaster of paris to hydroxyapatite and its properties. Rapid Prototyping Journal 18(6), 490–499 (2012)
Utela, B.R., Storti, D., Anderson, R.L., Ganter, M.: Development process for custom three-dimensional printing (3DP) material systems. J. Manuf. Sci. Eng. 132(1), 011008 (2010)
Saunders, R.E., Derby, B.: Inkjet printing biomaterials for tissue engineering-Bioprinting. Int. Mater. Rev. (2014)
Reis, N., Derby, B.: Ink jet deposition of ceramic suspensions: modelling and experiments of droplet formation. MRS Symp. Proc. 624, 65–70 (2000)
Deegan, R.D., Bakajin, O., Dupont, T.F., Huber, G., Nagel, S.R., Witten, T.A.: Contact line deposits in an evaporating drop. Phys. Rev. E 62, 756–765 (2000)
Bose, S., Vahabzadeh, S., Bandyopadhyay, A.: Bone tissue engineering using 3D printing. Mater. Today 16(12), 496–504 (2013)
Kreke, M., Huckle, W., Goldstein, A.: Fluid flow stimulates expression of osteopontin and bone sialoprotein by bone marrow stromal cells in a temporally dependent manner. Bone 36, 1047–1055 (2005)
Schulze, D., Wittmaier, A.: Flow properties of highly dispersed powders at very small consolidation stresses. Chem. Eng. Technol. 26, 133–1337 (2003)
Schulze, D., Wittmaier, A.: Flow properties of highly dispersed powders at very small consolidation stresses. Chem. Eng. Technol. 26, 133–1337 (2003)
Bergmann, C., Lindner, M., Zhang, W., Koczur, K., Kirsten, A., Telle, R., Fischer, H.: 3D printing of bone substitute implants using calcium phosphate and bioactive glasses. J. Eur. Ceram. Soc. 30(12), 2563–2567 (2010)
Castilho, M., Moseke, C., Ewald, A., Gbureck, U., Groll, J., Pires, I., Teßmar, J., Vorndran, E.: Direct 3D powder printing of biphasic calcium phosphate scaffolds for substitution of complex bone defects. Biofabrication 6, 015006–015017 (2014)
Hogekamp, S., Pohl, M.: Methods for characterizing wetting and dispersing of powder. ChemIng Tech 76, 385–390 (2004)
Balakrishnan, A., Pizette, P., Martin, C.L., Joshi, S.V., Saha, B.P.: Effect of particle size in aggregated and agglomerated ceramic powders. Acta Mater. 58, 802–812 (2010)
Sachs, E., Cima, M., Bredt, J.: Massachusetts institute of technology, assignee. In: Process for Removing Loose Powder Particles from Interior Passages of a Body. United States (1996)
Pfister, A., Landers, R., Laib, A., Huebner, U., Schmelzeisen, R., Muelhaupt, R.: Biofunctional rapid prototyping for tissue-engineering applications: 3D bioplotting versus 3D printing. J. Polym. Sci. Part A: Polym. Chem. 42, 624–638 (2004)
Christ, S., Schnabel, M., Vorndran, E., Groll, J., Gbureck, U.: Fiber reinforcement during 3D printing. Mater. Lett. 139, 165–168 (2015)
Ramay, H., Zhang, M.: Biphasic calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering. Biomaterials 25, 5171–5180 (2004)
Tarafder, S., Davies, N.M., Bandyopadhyay, A., Bose, S.: 3D printed tricalcium phosphate bone tissue engineering scaffolds: effect of SrO and MgO doping on in vivo osteogenesis in a rat distal femoral defect model. Biomater. Sci. 1, 1250–1260 (2013)
Tarafder, S., Balla, V.K., Davies, N.M., Bandyopadhyay, A., Bose, S.: Microwave-sintered 3D printed tricalcium phosphate scaffolds for bone tissue engineering. J. Tissue Eng. Regenerative Med. 7(8), 631–641 (2013)
Fielding, G.A., Bandyopadhyay, A., Bose, S.: Effects of silica and zinc oxide doping on mechanical and biological properties of 3D printed tricalcium phosphate tissue engineering scaffolds. Dent. Mater. 28(2), 113–122 (2012)
Vorndran, E., Moseke, C., Gbureck, U.: 3D printing of ceramic implants. MRS Bull. 40(02), 127–136 (2015)
Alaadien, K., Sebastian, V., Jurgen, W., Gabriele, G., Annett, R., Wolfgang, M., Matthias, S.: Development of a new calcium phosphate powder-binder system for the 3D printing of patient specific implants. J. Mater. Sci. Mater. Med. 18, 909–916 (2007)
LeGeros, R., Lin, S., Rohanizadeh, R., Mijares, D., LeGeros, J.: Biphasic calcium phosphate bioceramics: preparation, properties and applications. J. Mater. Sci. Mater. Med. 14, 201–209 (2003)
Paulo, J., Bopaya, B:. Bio-Materials and Prototyping Applications in Medicine. Springer (2007)
Leukers, B., Gulkan, H., Irsen, S., Milz, S., Tille, C., Schieker, M., Seitz, H.: Hydroxyapatite scaffolds for bone tissue engineering made by 3D printing. J. Mater. Sci. Mater. Med. 16, 1121–1124 (2005)
Pilliar, R., Filiaggi, M., Wells, J., Grynpas, M., Kandel, R.: Porous calcium polyphosphate scaffolds for bone substitute applications in vitro characterization. Biomaterials 22, 963–972 (2001)
Hutmacher, D.W., Kirsch, A., Ackermann, K.L., Hürzeler, M.B.: A tissue engineered cell-occlusive device for hard tissue regeneration—a preliminary report. Int. J. Periodontics Restorative Dent. 21(1), 49–59 (2001)
Shikinami, Y., Okuno, M.: Bioresorbable devices made of forged composites of hydroxyapatite (HA) particles and poly-L-lactide (PLLA): Part I. Basic characteristics. Biomaterials 20(9), 859–877 (1999)
Agrawal, C.M., Athanasiou, K.A.: Technique to control pH in vicinity of biodegrading PLA-PGA implants. J. Biomed. Mater. Res. 38(2), 105–114 (1997)
Kim, S., Utsunomiya, H., Koski, J., Wu, B., Cima, M., Sohn, J., Mukai, K., Griffith, L., Vacanti, J.: Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels. Ann. Surg. 228, 8–13 (1998)
Vance, R., Miller, D., Thapa, A., Haberstroh, K., Webster, T.: Decreased fibroblast cell density on chemically degraded poly-lactic-co-glycolic acid, polyurethane, and polycaprolactone. Biomaterials 25, 2095–3103 (2004)
Giordano, R., Wu, B., Borland, S., Cima, L., Sachs, E., Cima, M.: Mechanical properties of dense polylactic acid structures fabricated by three dimensional printing. J. Biomat. Sci. Polym. 8, 63–75 (1997)
Tripathi, G., Basu, B.: In vitro osteogenic cell proliferation, mineralization, and in vivo osseointegration of injection molded high-density polyethylene-based hybrid composites in rabbit animal model. J. Biomater. Appl. (2014)
Tripathi, G., Basu, B.: Injection-molded high-density polyethylene–hydroxyapatite–aluminum oxide hybrid composites for hard-tissue replacement: mechanical, biological, and protein adsorption behavior. J. Appl. Polym. Sci. 124(3), 2133–2143 (2012)
Bodhak, S., Nath, S., Basu, B.: Friction and wear properties of novel HDPE–HAp–Al2O3 biocomposites against alumina counterface. J. Biomater. Appl. 23(5), 407–433 (2008)
Lu, K., Reynolds, W.T.: 3DP process for fine mesh structure printing. Powder Technol. 187, 11–18 (2008)
Ltd. MU. d-Shape, the mega scale free-form printer of buildings
Wu, W., Zheng, Q., Guo, X., Sun, J., 4:065005 YLBM. A programmed release multi drug implant fabricated by three dimensional printing technology for bone tuberculosis therapy. Biomed. Mater. 4, 65005–65015 (2009)
Zawacki, S.J., Koutsoukos, P., Salimi, N., Nancollas, G.: The growth of calcium phosphates. In: Davis, J.A., Hayes, K.F, (eds.) Geochemical Processes at Mineral Surfaces. American Chemical Society Symposium Series, vol. 323, pp. 650–662 (1996)
Suwanprateeb, J., Suvannapruk, W., Wasoontararat, K.: Low temperature preparation of calcium phosphate structure via phosphorization of 3D-printed calcium sulfate hemihydrate based material. J. Mater. Sci. Mater. Med. 21, 419–429 (2010)
Kanter, B., Geffers, M., Ignatius, A., Gbureck, U.: Control of in vivo mineral bone cement degradation. Acta Biomater. 10, 3279–3287 (2014)
Monkhouse, D.C., Kumar, S., Rowe, C.W.: Rapid prototyping and manufacturing process (2003)
Hassan, K.A.R.: MS thesis. Suny B. The Microelectrophoretic Behaviour of Sparingly Soluble Salts. State University of New York (1984)
Vorndran, E.: University of Würzburg (2012)
Klammert, U., Vorndran, E., Reuther, T., Müller, F., Zorn, K., Gbureck, U.: Low temperature fabrication of magnesium phosphate cement scaffolds by 3D powder printing. J. Mater. Sci. Mater. Med. 21, 2947–2953 (2010)
Gbureck, U., Hoelzel, T., Biermann, I., Barralet, J.E., Grover, L.M.: Preparation of tricalcium phosphate/calcium pyrophosphate structures via rapid prototyping. J. Mater. Sci. Mater. Med. 19, 1559–1563 (2008)
Barralet, J., Gbureck, U., Habibovic, P., Vorndran, E., Gerard, C., Doillon, C.: Angiogenesis in calcium phosphate scaffolds by inorganic copper ion release. Tissue Eng. Part A 15, 1601–1609 (2009)
Sodo, A., Hasegawa, M., Fukuda, A., Uchida, A.: Treatment of infected hip arthroplasty with antibiotic-impregnated calcium hydroxide. J. Arthroplasty 23, 145–150 (2008)
Uchida, A., Shinto, Y., Araki, N., Ono, K.: Slow release of anticancer drugs from porous calcium hydroxide ceramic. J. Orthop. Res. 10, 440–445 (1992)
Gbureck, U., Vorndran, E., Müller, F., Barralet, J.: Low temperature direct 3D printed bioceramics and biocomposites as drug release matrix. J. Controlled Release 122, 173–180 (2007)
Cornelsen, M., Petersen, S., Dietsch, K., Rudolph, A., Schmitz, K., Sternberg, K., Seitz, H.: Infiltration of 3D printed tricalciumphosphate scaffolds with biodegradable polymers and biomolecules for local drug delivery. Biomed. Technol. 58, 4090–4091 (2013)
Becker, S., Bolte, H., Schünemann, K., Seitz, H., Bara, J., Beck-Broichsitter, B., Russo, P., Wiltfang, J., Warnke, P.: Endocultivation: the influence of delayed vs. simultaneous application of BMP-2 onto individually formed hydroxyapatite matrices for heterotopic bone induction. Int. J. Oral Maxillofac. Surg. 41, 1153–1160 (2012)
Klammert, U., Bohm, H., Schweitzer, T., Wurzler, K., Gbureck, U., Reuther, J.: Multi-directional Le Fort III midfacial distraction using an individual prefabricated device. J. Cranio-Maxillofacial Surg. 37, 210–215 (2009)
Torres, J., Tamimi, F., Alkhraisat, M.H., Prados-Frutos, J.C., Rastikerdar, E., Gbureck, U., Barralet, J.E., Lopez-Cabarcos, E.: Vertical bone augmentation with 3D-synthetic monetite blocks in the rabbit calvaria. J. Clin. Periodontol. 38, 1147–1153 (2011)
Sandler, N., Määttänen, A., Ihalainen, P., Kronberg, L., Meierjohann, A., Viitala, T., Peltonen, J.: Inkjet printing of drugs substances and use of porous substrated-towards individualized dosing. J. Pharm. Sci. 100, 3386–3395 (2011)
Wu, B.M., Boland, S.W., Giordano, R.A., Coma, L.G., Sachs, E.M., Cima, M.J.: Solid free-form fabrication of drug delivery device. J. Controlled Release 40, 77–87 (1996)
Katstra, W.E., Palazzolo, R.D., Rowe, C.W., Giritlioglu, B., Teung, P., Cima, M.J.: Oral dosage forms fabricated by Three Dimensional Printing. J. Control Release 66, 1–9 (2000)
Wu, W.G., Zheng, Q.X.: The controlled-releasing drug implant based on the three dimensional printing technology: fabrication and properties of drug releasing in vivo. J. Wuhan Univ. Technol. Mater. Sci. Ed. 24, 977–981 (2009)
Yu, D.G., Zhu, L.M., Branford-White, C.J., Yang, X.L.: Three-dimensional printing in pharmaceutics: promises and problems. J. Pharm. Sci. 97, 3666–3690 (2007)
Yu, D.G., XL, D.G., Yang, X.L., Huang, W.D., Liu, J., Wang, Y.G., Xu, H.: Tablets with material gradients fabricated by three-dimensional printing. J. Pharm. Sci. 96, 2446–2456 (2007)
Vorndran, E., Klammert, U., Ewald, A., Barralet, J.E., Gbureck, U.: Similtaneous bioactive immobilisation during 3D powder printing of bioceramic drug release matrices. Adv. Funct. Mater. 20, 1585–1591
Luo, Y., Lode, A., Sonntag, F., Nies, B., Gelinsky, M.: Well-ordered biphasic calcium phosphate-alginate scaffolds fabricated by multi-channel 3D plotting under mild conditions. J. Mater. Chem. B 1(33), 4088–4098 (2013)
Landers, R., Hübner, U., Schmelzeisen, R., Mülhaupt, R.: Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering. Biomaterials 23(23), 4437–4447 (2002)
Luo, Y., Lode, A., Wu, C., Gelinsky, M.: 3D-plotting of bioceramic scaffolds under physiological conditions for bone tissue engineering. CRC Press, Florida (2013)
Guo, B., Lei, B., Li, P., Ma, P.X.: Functionalized scaffolds to enhance tissue regeneration. Regenerative Biomaterials 2, 47–57 (2015)
Franco, J., Hunger, P., Launey, M., Tomsia, A., Saiz, E.: Direct write assembly of calcium phosphate scaffolds using a water-based hydrogel. Acta Biomater. 6, 218–228 (2010)
De Clerck, J.P.: Microwave polymerization of acrylic resins used in dental prostheses. J. Prosthet. Dent. 57(5), 650–658 (1987)
Butscher, A., Bohner, M., Doebelin, N., Hofmann, S., Muller, R.: New depowdering-friendly designs for three-dimensional printing of calcium phosphate bone substitutes. Acta Biomater. 9, 9149–9158 (2013)
Kang, S.-J.L.: Sintering: densification, grain growth and microstructure: Butterworth-Heinemann (2004)
Basu, B., Katti, D.S., Kumar, A.: Advanced Biomaterials: Fundamentals, Processing, and Applications. Wiley, September 2009, 776 p
Suk, M., Choi, S., Kim, J., Kim, Y., YK, Y.S.: Fabrication of a porous material with a porosity gradient by a pulsed electric current sintering process. Met. Mater. Int. 9, 599–603 (2003)
Warnke, P.H., Seitz, H., Warnke, F., Becker, S.T., Sivananthan, S., Sherry, E., Liu, Q., Wiltfang Jr, Douglas T. Ceramic scaffolds produced by computer-assisted 3D printing and sintering: characterization and biocompatibility investigations. 2009
Tarafder, S., Balla, V.K., Davies, N.M., Bandyopadhyay, A., Bose, S.: Microwave-sintered 3D printed tricalcium phosphate scaffolds for bone tissue engineering. J. Tissue. Eng. Regen. Med. 7(8), 631–641 (2013)
Yadoji, P., Peelamedu, R., Agrawal, D., Roy, R.: Microwave sintering of Ni–Zn ferrites: comparison with conventional sintering. Mater. Sci. Eng., B 98(3), 269–278 (2003)
Brooke, L.F., Toby, D.B., Zee, U., Dietmar, W.H., Paul, D.D., Tim, R.D.: Dermal fibroblast infiltration of poly(ε-caprolactone) scaffolds fabricated by melt electrospinning in a direct writing mode. Biofabrication 5(2), 025001 (2013)
Gbureck, U., Grolms, O., Barralet, J.E., Grover, L.M., Thull, R.: Mechanical activation and cement formation of β-tricalcium phosphate. Biomaterials 24(23), 4123–4131 (2003)
Gbureck, U., Hozel, T., Klammert, U., Wurzler, K., Muller, F.A., Barralet, J.E.: Resorbable dicalcium phosphate bone substitutes prepared by 3D powder printing. Adv. Funct. Mater. 17, 3940–3945 (2007)
Gbureck, U., Hölzel, T., Klammert, U., Würzler, K., Müller, F.A., Barralet, J.E.: Resorbable dicalcium phosphate bone substitutes prepared by 3D powder printing. Adv. Funct. Mater. 17(18), 3940–3945 (2007)
Meininger, S., Mandal, S., Kumar, A., Groll, J., Basu, B., Gbureck, U.: Strength reliability and in vitro degradation of three-dimensional powder printed strontium-substituted magnesium phosphate scaffolds. Acta Biomaterialia (2015); Provisionally accepted
Hutchings, I.M., Martin, G.D.: Inkjet technology for digital fabrication. Wiley (2012)
Wu, B.: Microstructural control during three dimensional printing of polymeric medical devices, PhD thesis, document no 39110863, Page no. 246, Massachusetts Institute of Technology (1998)
Vorndran, E., Klammert, U., Ewald, A., Barralet, J.E., Gbureck, U.: Simultaneous immobilization of bioactives during 3D powder printing of bioceramic drug-release matrices. Adv. Funct. Mater. 20(10), 1585–1591 (2010)
Steven, M., Emanuel, M., Michael, C.: Metal parts generation by three dimensional printing. Massach. Inst. Technol. 28, 144–150 (1992)
Chandrasekaran, M., Lim, K., Lee, M., Cheang, P.: Effect of process parameter on properties of titanium alloy fabricated using three-dimensional printing. In: Proceedings of the 3rd International Conference, vol. 8, pp. 1–4, 2007
St-Pierre, J., Gauthier, M., Lefebvre, L., Tabrizian, M.: Three-dimensional growth of differentiating MC3T3-E1 pre-osteoblasts on porous titanium scaffolds. Biomaterials 26, 7319–7328 (2005)
Wu, C., Fan, W., Zhou, Y., Luo, Y., Gelinsky, M., Chang, J., Xiao, Y.: 3D-printing of highly uniform CaSiO3 ceramic scaffolds: preparation, characterization and in vivo osteogenesis. J. Mater. Chem. 22(24), 12288–12295 (2012)
Chumnanklang, R., Panyathanmaporn, T., Sitthiseripratip, K., Suwanprateeb, J.: 3D printing of hydroxyapatite: effect of binder concentration in pre-coated particle on part strength. Mater. Sci. Eng. C 27, 914–921 (2007)
Leukers, B., Gulkan, H., Irsen, S., Milz, S., Tille, C., Seitz, H., Schieker, M.: Biocompatibility of ceramic scaffolds for bone replacement made by 3D printing. Mat wiss u Werkstofftech 36, 781–787 (2005)
Seitz, H., Rieder, W., Irsen, S., Leukers, B., Tille, C.: Three-dimensional printing of porous ceramic scaffolds for bone tissue engineering. J. Biomed. Mater. Res. B Appl. Biomater. 74, 782–788 (2005)
Muller, B., Deyhle, H., F, F.: Bio-mimetic hollow scaffolds for long bone replacement. Proc. SPIE 7401, 1–13 (2009)
Schumacher, M., Deisinger, U., Detsch, R., Ziegler, G.: Indirect rapid prototyping of biphasic calcium phosphate scaffolds as bone substitutes: influence of phase composition, macroporosity and pore geometry on mechanical properties. J. Mater. Sci. Mater. Med. 21, 3119–3127 (2010)
Becker, S., Bolte, H., Krapf, O., Seitz, H., Douglas, T., Sivananthan, S., Wiltfang, J., Sherry, E., Warnke, P.: Endocultivation: 3D printed customized porous scaffolds for heterotopic bone induction. Oral Oncol. 45, 181–188 (2009)
Fierz, F., Beckmann, F., Huser, M., Irsen, S., Leukers, B., Witte, F., Degistirici, O., Andronache, A., Thie, M., Müller, B.: The morphology of anisotropic 3D-printed hydroxyapatite scaffolds. Biomaterials 29, 3799–3806 (2008)
Suwanprateeb, J., Suvannapruk, W., Sanngam, R.: Self-reinforcement of three dimensionally printed polymethyl Methacrylate. Polym. Testing 27, 711–716 (2008)
Suwanprateeb, J., Chumnanklang, R.: Three-dimensional printing of porous polyethylene structure using water-based binders. J. Biomed. Mater. Res. Part B Appl. Biomater. 78, 138–145 (2006)
Gbureck, U., Holzel, T., Thull, R., Muller, F.A., Barralet, J.E.: Preparation of nanocrystalline hydroxyapatite scaffolds by 3D powder printing. Cytotherapy 8, 14 (2006)
Inzana, J.A., Olvera, D., Fuller, S.M., Kelly, J.P., Graeve, O.A., Schwarz, E.M., Kates, S.L., Awad, H.A.: 3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration. Biomaterials 35(13), 4026–4034 (2014)
Bergmann, C., Lindner, M., Zhang, W., Koczur, K., Kirsten, A., Telle, R., Fischer, H.: 3D printing of bone substitute implants using calcium phosphate and bioactive glasses. J. Eur. Ceram. Soc. 30, 2563–2567 (2010)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2017 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Basu, B. (2017). Fundamentals of Scaffolds Fabrication Using Low Temperature Additive Manufacturing. In: Biomaterials for Musculoskeletal Regeneration. Indian Institute of Metals Series. Springer, Singapore. https://doi.org/10.1007/978-981-10-3059-8_5
Download citation
DOI: https://doi.org/10.1007/978-981-10-3059-8_5
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-3058-1
Online ISBN: 978-981-10-3059-8
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)