Skip to main content

Advertisement

SpringerLink
Log in

Development of a new calcium phosphate powder-binder system for the 3D printing of patient specific implants

  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

A key requirement for three-dimensional printing (3-DP) of medical implants is the availability of printable and biocompatible powder-binder systems. In this study we developed a powder mixture comprising tetracalcium phosphate (TTCP) as reactive component and β-tricalcium phosphate (β-TCP) or calcium sulfate as biodegradable fillers, which can be printed with an aqueous citric acid solution. The potential of this material combination was demonstrated printing various devices with intersecting channels and filigree structures. Two post-processing procedures, a sintering and a polymer infiltration process were established to substantially improve the mechanical properties of the printed devices. Preliminary examinations on relevant application properties including in vitro cytocompatibility testing indicate that the new powder-binder system represents an efficient approach to patient specific ceramic bone substitutes and scaffolds for bone tissue engineering.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. S. V. DOROZHKIN and M. EPPLE, Angew. Chem. Intern. Ed. 17 (2002) 3130

    Google Scholar 

  2. W. G. Billotte, in “Biomaterials: Principles and Applications” edited by J. B. Park and J. D. Bronzino (CRC Press, Boca Raton, 2003) p. 21

  3. A. Krajewski A. and RAVAGLIOLI in “Integrated Biomaterials Science” edited by R. Barbucci (Kluwer Academic/Plenum Publishers, New York, 2002) p. 189

  4. J. O. HOLLINGER, J. BREKKE, E. GRUSKIN and D. LEE, Clin. Orthop. Relat. Res. 324 (1996) 55

    Article  Google Scholar 

  5. M. Wang in “Biomaterials and tissue engineering”, edited by D. Shi (Springer, Berlin, 2004) p. 1

  6. W. SUN and P. LAL, Comput. Methods Program Biomed. 67 (2002) 85

    Article  Google Scholar 

  7. K. F. LEONG, C. M. CHEAH and C. K. CHUA, Biomaterials 24 (2003) 2363

    Article  CAS  Google Scholar 

  8. E. SACHLOS and J. T. CZERNUSZKA, Eur. Cells Mater. 5 (2003) 29

    CAS  Google Scholar 

  9. V. L. TSANG and S. N. BHATIA, Adv. Drug Deliv. Rev. 56 (2004) 1635

    Article  Google Scholar 

  10. D. W. HUTMACHER, M. SITTINGER and M. V. RISBUD, Trends Biotechnol. 22 (2004) 354

    Article  Google Scholar 

  11. V. K. POPOV, A. V. EVSEEV, A. L. IVANOV, V. V. ROGINSKI, A. I. VOLOZHIN and S. M. HOWDLE, J. Mater. Sci.: Mater Med. 15 (2004) 123

    Article  CAS  Google Scholar 

  12. K. H. TAN, C. K. CHUA, K. F. LEONG, C. M. CHEAH, P. CHEANG, M. S. ABU BAKAR and S. W. CHA, Biomaterials 24 (2003) 3115

    Article  CAS  Google Scholar 

  13. J. K. SHERWOOD, S. L. RILEY, R. PALAZZOLO, S. C. BROWN, D. C. MONKHOUSE, M. COATES, L. G. GRIFFITH, L. K. LANDEEN and A. RATCLIFFE, Biomaterials 23 (2002) 4739

    Article  CAS  Google Scholar 

  14. T. DUTTA ROY, J. L. SIMON, J. L. RICCI, E. D. REKOW, V. P. THOMPSON and J. R. PARSONS, J. Biomed. Mater. Res. 66A (2003) 283

    Article  Google Scholar 

  15. T. H. ANG, F. S. A. SULTANA, D. W. HUTMACHER, Y. S. WONG, J. Y. H. FUH, X. M. MO, H. A. T. LOH, E. BURDET and S. H. TEOH, Mater. Sci. Eng. C20 (2002) 35

    CAS  Google Scholar 

  16. E. SACHS, J. S. HAGGERTY, M. J. CIMA and P. A. WILLIAMS, 5. US Patent No. 5204055, 1993

  17. T. DUTTA ROY, J. L. SIMON, J. L. RICCI, E. D. REKOW, V. P. THOMPSON and J. R. PARSONS, J. Biomed. Mater. Res. 67A (2003) 1228

    Article  Google Scholar 

  18. K. CIESLA and R. RUDNICKI, Pol. J. Chem. 61 (1987) 719

    CAS  Google Scholar 

  19. S. VOGT, Y. LARCHER, B. BEER, I. WILKE and M. SCHNABELRAUCH, Eur. Cells Mater. 4 (2002) 30

    CAS  Google Scholar 

  20. C. X. F. LAM, X. M. MO, S. H. TEOH and D. W. HUTMACHER, Mater. Sci. Eng. C20 (2002) 49

    CAS  Google Scholar 

  21. A. WINTER, S. BREIT, D. PARSCH, K. BENZ, E. STECK, H. HAUNER, R. M. WEBER, V. EWERBECK and W. RICHTER, Arthritis Rheum. 48 (2003) 418

    Article  Google Scholar 

  22. R. I. MARTIN and P. W. BROWN, Adv. Cement Res. 5 (1993) 119

    CAS  Google Scholar 

  23. L. C. CHOW, M. MARKOVIC, S. A. FRUKHTBEYN and S. TAKAGI, Biomaterials 26 (2005) 393

    Article  CAS  Google Scholar 

Download references

Acknowledgment

This work was supported by the German Ministry of Economics and Labour (grant no. 134/03).

Author information

Authors and Affiliations

  1. Beckmann-Institut für Technologieentwicklung e. V., Turleyring 15, 09376, Oelsnitz, Germany

    Alaadien Khalyfa & Wolfgang Meyer

  2. Biomaterials Department, INNOVENT e. V., Pruessingstrasse 27B, 07745, Jena, Germany

    Sebastian Vogt, Jürgen Weisser, Gabriele Grimm & Matthias Schnabelrauch

  3. SciTec Department, University of Applied Sciences Jena, Carl-Zeiss-Promenade 2, 07745, Jena, Germany

    Annett Rechtenbach

Authors
  1. Alaadien Khalyfa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sebastian Vogt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jürgen Weisser
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gabriele Grimm
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Annett Rechtenbach
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Wolfgang Meyer
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Matthias Schnabelrauch
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Matthias Schnabelrauch.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Khalyfa, A., Vogt, S., Weisser, J. et al. Development of a new calcium phosphate powder-binder system for the 3D printing of patient specific implants. J Mater Sci: Mater Med 18, 909–916 (2007). https://doi.org/10.1007/s10856-006-0073-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10856-006-0073-2

Keywords

Search

Navigation