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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 77))

Abstract

As noted in the different chapters of this volume, most infections due to worms living in the gastrointestinal tract can now be cured by anthelmintics. In general these drugs can be divided into four classes: herbal preparations, inorganic and metallorganic compounds, “antibiotics,” and synthetic organic compounds.

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References

  • Actor P, Anderson EL, Dicuollo CJ, Ferlanto RJ, Hoover JRE, Pagano JF, Ravin LR, Scheidy SF, Stedman RJ, Theodorides VJ (1967) New broad spectrum anthelmintic, methyl 5(6)-butyl-2-benzimidazolecarbamate. Nature 215:321–322

    Article  PubMed  CAS  Google Scholar 

  • Aldridge WN, Holmstedt B (1981) History and scope of the conference. Acta Pharmacol Toxicol [Suppl V] 49:3–6

    Article  Google Scholar 

  • Andrews P (1981) A summary of the efficacy of praziquantel against schistosomes in animal experiments and notes on its mode of action. Arzneimittelforsch 31:538–541

    PubMed  CAS  Google Scholar 

  • Andrews P, Thomas H (1983) Praziquantel. Medical Research Reviews 3:147–200

    Article  CAS  Google Scholar 

  • Andrews P, Dycka J, Frank G (1980) Effect of praziquantel on clinical-chemical parameters in healthy and schistosome-infected mice. Ann Trop Med Parasitol 74:167–177

    PubMed  CAS  Google Scholar 

  • Aronson CE, Serlick ER (1977) Effects of disophenol on the isolated perfused rat heart. Biochem Pharmacol 26:2297–2305

    Article  PubMed  CAS  Google Scholar 

  • Aubry ML, Cowell P, Davey MJ, Shevde S (1970) Aspects of the pharmacology of a new anthelmintic: pyrantel. Br J Pharmacol 38:332–344

    PubMed  CAS  Google Scholar 

  • Austin WC, Courtney W, Danilewicz JC, Margan DH, Conover LH, Howes HL, Lynch JE, McFarland JW, Cornwell RL, Theodorides VJ (1966) Pyrantel tartrate, a new anthelmintic effective against infections of domestic animals. Nature 212:1273–1274

    Article  PubMed  CAS  Google Scholar 

  • Averkin EA, Beard CC, Dvorak CA, Edwards JA, Fried JH, Kilan JG, Schiltz RA, Kistner TP, Drudge JH, Lyons ET, Sharp NL, Corwin RM (1975) Methyl 5(6)-phenylsulfinyl- 2-benzimidazole carbamate. A new potent anthelmintic. J Med Chem 11:1164—1166

    Google Scholar 

  • Barett J (1981) Biochemistry of parasitic helminths. Macmillan, London

    Google Scholar 

  • Behm CA, Bryant C (1979) Anthelmintic action. A metabolic approach. Vet Parasitol 5:39–49

    Article  CAS  Google Scholar 

  • Bellander BTD, Hagmar LE, Osterdahl BG (1981) Nitrosation of piperazine in the stomach. Lancet 2:372

    Article  PubMed  CAS  Google Scholar 

  • Borgers M, Nollin S de (1975) Ultrastruetural changes in Ascaris suum intestine after mebendazole treatment in vivo. J Parasitol 61:110–122

    Article  PubMed  CAS  Google Scholar 

  • Borgers M, Thone F (1976) Further characterization of phosphatase activities using nonspecific substrates. Histochem J 8:301–317

    Article  PubMed  CAS  Google Scholar 

  • Borgers M, Nollin S de, Verheyen A, Brabander M de, Thienpont D (1975 a) Effects of new anthelmintics on the microtubular system of parasites. In: Borgers M, Brabander M de (eds) Microtubules and microtubule inhibitors. Elsevier, Amsterdam, pp 497–508

    Google Scholar 

  • Borgers M, Nollin S de, Verheyen A, Vanparys O, Thienpont D (1975 b) Morphological changes in cysticerci of Taenia taeniaeformis after mebendazole treatment. J Parasitol 61:830–843

    Article  PubMed  CAS  Google Scholar 

  • Borgers M, Nollins S de, Brabander M de, Thienpont D (1975 c) Influence of the anthelmintic mebendazole on microtubules and intracellular organelle movement in nematode intestinal cells. Am J Vet Res 36:1153–1166

    PubMed  CAS  Google Scholar 

  • Botero DR (1978) Chemotherapy of human intestinal parasitic diseases. Ann Rev Pharmacol Toxicol 18:1–15

    Article  CAS  Google Scholar 

  • Boyd JE, Bullock NW, Champagne DA, Gotterdam PE, Morici IJ, Plaisted PH, Spicer LD, Wayne RS, Zulalian J (1969) Metabolism of L-tetramisole in rats. In: 158th National meeting of the American Chemical Society, New York, 7–12 September

    Google Scholar 

  • Brodie RR, Mayo BC, Chasseaud LF, Hawkings DR (1977) The disposition of radioactivity after administration of the anthelmintic methyl- 14C-5-cyclopropylcarbonyl-2-benz- imidazole carbamate (ciclobendazole) to rats and dogs. Arzneimittelforsch 27:593–598

    PubMed  CAS  Google Scholar 

  • Broome AWJ (1962) Mechanisms of anthelmintic action with particular reference to drugs affecting neuromuscular activity. In: Goodwin LG, Nimmo-Smith RM (eds) Drugs, parasites and hosts. Churchill, London, pp 43–61

    Google Scholar 

  • Bryant C, Cornish RA, Rahman MS (1976) Adenine nucleotides as indicators of anthelmintic efficacy. In: Bossche H vanden (ed) Biochemistry of parasites and host- parasite relationships, Elsevier, Amsterdam, pp 599–604

    Google Scholar 

  • Bryceson ADM, Woestenborghs R, Michiels M, Bossche H vanden (1982) Bioavailability and tolerability of mebendazole in patients with inoperable hydatid disease. Trans R Soc Trop Med Hyg 16:563–564

    Article  Google Scholar 

  • Buchanan RA, Barrow WB, Heffelfinger JC, Kinkel AW, Smith TC, Turner JC (1974) Pyr- vinium pamoate. Clin Pharmacol Ther 16:716–719

    PubMed  CAS  Google Scholar 

  • Bueding E (1969) Some biochemical effects of anthelmintic drugs. Biochem Pharmacol 18:1541–1547

    Article  PubMed  CAS  Google Scholar 

  • Bueding E, Liu CL, Rogers SH (1972) Inhibition by metrifonate and dichlorvos of cho- linesterases in schistosomes. Br J Pharmacol 46:480–487

    PubMed  CAS  Google Scholar 

  • Bueding E, Batzinger R, Petterson G (1976) Antischistosomal and some toxicological properties of a nitrodiphenylaminoisothiocyanate (C 9330-G0/CGP 4540). Experi- entia 32:604–606

    CAS  Google Scholar 

  • Bühring KU, Diekmann HW, Müller H, Garbe A, Nowak H (1978) Metabolism of praziquantel in man. Eur J Drug Metab Pharmacokinet 3:179–190

    Article  Google Scholar 

  • Burg RW, Miller BM, Baker EE, Birnbaum J, Currie SA, Hartman R, Kong YL, Mo- naghan RL, Olson G, Putter I, Tunac JB, Wallick H, Stapley EO, Oiwa R, Omura S (1979) Avermectins, new family of potent anthelmintic agents: producing organism and fermentation. Antimicrob Agents Chemother 15:361–367

    PubMed  CAS  Google Scholar 

  • Campbell A J, Montague PE (1981) A comparison of the activity of uncouplers of oxidative phosphorylation against the common liver fluke Fasciola hepatica. Mol Biochem Parasitol 4:139–147

    Article  PubMed  CAS  Google Scholar 

  • Campbell WC (1981) An introduction to the avermectins. NZ Vet J 29:174–178

    Article  CAS  Google Scholar 

  • Castaner J (1978) Febantel - veterinary anthelmintic. Drugs of the future 3:377–378

    Google Scholar 

  • Cavier R (1973) Chemotherapy of intestinal nematodes. In: Cavier R, Hawking F (eds) Chemotherapy of helminthiasis, vol 1. Pergamon, Oxford, pp 215–436

    Google Scholar 

  • Cavier R. Hawking F (eds) (1973) Chemotherapy of helminthiasis. Pergamon, Oxford

    Google Scholar 

  • Christ O, Kellner H-M, Klöpffer G (1974) Studies on pharmacokinetics and metabolism with fenbendazole - a new anthelmintic. In: Proceedings 3rd international congress of parasitology, vol 3. Facta Publication, Vienna, pp 1448–1449

    Google Scholar 

  • Chubb JM, Bennett JL, Akera T, Brody TM (1978) Effects of praziquantel, a new anthelmintic, on electromechanical properties of isolated rat atria. J Pharmacol Exp Ther 207:284–293

    PubMed  CAS  Google Scholar 

  • Coles GC (1977) The biochemical mode of action of some modern anthelmintics. Pestic Sci 8:536—543

    Article  Google Scholar 

  • Coles GC (1979) The effect of praziquantel on Schistosoma manson. J Helminthol 53:31–33

    Article  PubMed  CAS  Google Scholar 

  • Coles GC, East JM, Jenkins SN (1975) The mechanism of action of the anthelmintic leva- misole. Gen Pharmacol 6:309–313

    Article  CAS  Google Scholar 

  • Comley JCW (1980) Ultrastructure of the intestinal cells ofAspiculuris tetraptera after in vivo treatment of mice with mebendazole and thiabendazole. Int J Parasitol 10:143–150

    Article  PubMed  CAS  Google Scholar 

  • Cornish RA, Bryant C (1976) Changes in energy metabolism due to anthelmintics in Fasciola hepatica maintained in vitro. Int J Parasitol 6:393–398

    Article  PubMed  CAS  Google Scholar 

  • Cornish RA, Behm CA, Butler RW, Bryant C (1977) The in vivo effects of rafoxanide on the energy metabolism of Fasciola hepatica. Int J Parasitol 7:217–220

    Article  PubMed  CAS  Google Scholar 

  • Cornwell RL (1966) Controlled laboratory trials in sheep with the anthelmintic pyrantel startrate. Vet Ree 79:590–595

    Article  CAS  Google Scholar 

  • Cross BG, David A, Vallance DK (1954) Piperazine adipate: a new anthelmintic agent. J Pharm Pharmacol 6:711–717

    Article  CAS  Google Scholar 

  • Davidse LC (1976) The antimitotic properties of the benzimidazole fungicide carbendazim and a mechanism of resistance to this compound in Aspergillus nidulans. Thesis, Land- bouwhogeschool, Binnenhaven 9, Wageningen

    Google Scholar 

  • Davidse LC, Flach W (1978) Interaction of thiabendazole with fungal tubulin. Biochim BiophysActa 543:82–90

    CAS  Google Scholar 

  • Davis A (1973) Drug treatment in intestinal helminthiases. World Health Organization, Geneva

    Google Scholar 

  • Davis A (1975) Clinical available antischistosomal drugs. J Toxicol Environ Health 1:191- 201

    Google Scholar 

  • Davis A, Biles JE, Ulrich AM, Dixon H (1981) Tolerance and efficacy of praziquantel in phase IIA and II B therapeutic trials in Zambian patients. Arzneimittelforsch 31:568- 574

    Google Scholar 

  • Degremont A, Stahel E (1978) Klinische Bewertung von Ciclobendazol (C-C 2481) bei der Behandlung von Wurmkrankungen des Darmes. Schweiz Med Wochenschr 108:1430— 1433

    Google Scholar 

  • Delatour P, Burgat-Sacaze V (1981) Vers une procedure alternative d’évaluation toxicolo- gique des résidus? Application aux anthelminthiques dérivés du benzimidazole. Reel Med Vet 157:213–218

    CAS  Google Scholar 

  • Delatour P, Lorgue G, Lapras M, Deschanel J-P (1974) Propriétés embryotoxiques (rat) et résidus (ovins, bovins) de trois anthelmintiques dérivés du benzimidazole. Bull Soc Sci Vét Méd Comp 76:147–154

    CAS  Google Scholar 

  • Delatour P, Lorgue G, Lapras M, Richard Y (1976 a) Propriétés embryotoxiques et antimitotiques du parbendazole, mebendazole et du cambendazole. CR Séances Acad Sci 282:517–518

    CAS  Google Scholar 

  • Delatour P, Lorgue G, Courtot D, Lapras M (1976 b) Tolerance embryonaire de Foxiben- dazole chez le rat et le mouton. Reel Med Vet 152:467–470

    CAS  Google Scholar 

  • Delatour P, Debroye J, Lorgue G, Courtot D (1977) Embryotoxicité experimentale de l’ox- fendazole chez le rat et le mouton. Reel Med Vet 153:639–645

    CAS  Google Scholar 

  • Del Castillo J (1969) Pharmacology of nematoda. In: Florkin M, Scheer BT (eds) Chemical

    Google Scholar 

  • zoology, vol 3. Academic, New York, pp 521–554

    Google Scholar 

  • Demoen P, Aelst C van, Loomans J, Verhaegen H, Cree J de, Verbruggen F, Ringoir S (1973) The absorption and urinary excretion of mebendazole after oral administration. In: Clin Res Report, R 17 635/36 Janssen Pharmaceutica, Beerse

    Google Scholar 

  • De Nollin S, Bossche H vanden (1973) Biochemical effects of mebendazole on Trichinella spiralis larvae. J Parasitol 59:970–976

    Article  PubMed  Google Scholar 

  • Dicuollo CJ, Miller JA, Coiman WF, Kraeer PM, Wong MY (1977) Albendazole metabolic and tissue residue studies in sheep and cattle. In: Proceeding of the 8th international conference of WAAVP, Sydney Juli (Abstract)

    Google Scholar 

  • Diekmann HW, Bühring KU (1976) The fate of praziquantel in the organism III. Metabolism in rat, beagle dog and rhesus monkey. Eur J Drug Metab Pharmacokinet 2:107- 112

    Article  Google Scholar 

  • Druckrey M, Preussman R, Ivankovic S, Schmähl D (1967) Organotrope carcinogene Wirkungen bei 65 verschiedenen TV-Nitroso-Verbindungen an BD-Ratten. Z Krebsforsch 69:103–201

    Article  PubMed  CAS  Google Scholar 

  • Drugs of Today vol 17 (1981) Oxantel pamoate/pyrantel pamoate. In: Leeson PA, Mealy NE (eds) JR Prous, SA, Barcelona, pp 41–12

    Google Scholar 

  • Düwel D (1977) Fenbendazole. Biological properties and activity. Pest Sei 8:550–555

    Article  Google Scholar 

  • Düwel D (1979) Summary and evaluation of the worldwide published investigations. Hoechst, Frankfurt

    Google Scholar 

  • Düwel D, Schleich H (1978) In vivo investigations on the mode of action of fenbendazole. Zentralbl Veterinaermed [B] 25:800–805

    Article  Google Scholar 

  • Düwel D, Hajdu P, Damm D (1975) Zur Pharmakokinetic von Fenbendazol. Berl Munch Tierärztl Wochenschr 88:131–134

    PubMed  Google Scholar 

  • Düwel D, Aguilar FJ, Batte EG, Bürger HJ, Thomas RJ, Zahner H (1981) Therapy in nematode and acanthocephalan infections. In: Slusarski W (ed) Review of advances in parasitology. PWN, Warszawa, pp 507–524

    Google Scholar 

  • Dunn GL, Gallagher G, Davis LD, Hoover JRE, Stedman RJ (1973) Metabolites of methyl 5(6)-butyl-2-benzimidazole carbamate (parbendazole) structure and synthesis. J Med Chem 16:996–1002

    Article  PubMed  CAS  Google Scholar 

  • Egerton JR, Campbell WC (1970) The efficacy of 5-isopropoxy-carbonylamino-2-(4-thiazolyl) benzimidazole against helminths of sheep. Res Vet Sei 11:193–195

    CAS  Google Scholar 

  • Egerton JR, Ostlind DA, Blair LS, Eary CH, Suhoyda D, Cifelli S, Riek RF, Campbell WC (1979) Avermectins, new family of potent anthelmintic agents: efficacy of the Bla component. Antimicrob Agents Chemother 15:372–378

    PubMed  CAS  Google Scholar 

  • Eichler DA (1973) The anthelmintic activity of thiophanate in sheep and cattle. Br Vet J 129:533–543

    PubMed  CAS  Google Scholar 

  • Eichler DA (1974) The toxicity of thiophanate (“Nemafax”) in sheep and cattle. Br Vet J 130:570–576

    PubMed  CAS  Google Scholar 

  • Eyre P (1970) Some pharmacodynamic effects of the nematodes: methyridine, tetramisole and pyrantel. J Pharm Pharmacol 22:26–36

    Article  PubMed  CAS  Google Scholar 

  • Fetterer RH, Pax RA, Thompson D, Bricker C, Bennett JL (1980 a) Praziquantel: mode of its antischistosomal action. In: Bossche H vanden (ed) The host invader interplay. Elsevier, Amsterdam, pp 695–698

    Google Scholar 

  • Fetterer RH, Pax RA, Bennett JL (1980 b) Praziquantel, potassium and 2,4-dinitrophenol: analysis of their action on the musculature of Schistosoma mansoni. Eur J Pharmacol 64:31–38

    Article  PubMed  CAS  Google Scholar 

  • Friedman PA, Platzer EG (1978) Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin. Biochim Biophys Acta 544:605–614

    Article  PubMed  CAS  Google Scholar 

  • Friedman PA, Platzer EG (1980 a) The molecular mechanism of action of benzimidazoles in embryos of Ascaris suum. In: Bossche H vanden (ed) The host invader interplay. Elsevier, Amsterdam, pp 595–604

    Google Scholar 

  • Friedman PA, Platzer EG (1980 b) Interaction of anthelmintic benzimidazoles with Ascaris suum embryonic tubulin. Biochim Biophys Acta 630:271–278

    Article  PubMed  CAS  Google Scholar 

  • Fritz LC, Wang CC, Gorio A (1979) Avermectin Bla irreversibly blocks postsynaptic potentials at the bolster neuromuscular junction by reducing muscle membrane resistance. Proc Natl Acad Sei USA 76:2062–2066

    Article  CAS  Google Scholar 

  • Frohberg H, Schencking MS (1981) Toxicological profile of praziquantel, a new drug against cestode and schistosome infections, as compared to some other schistosomicides. Arzneimittelforsch 31:555–565

    PubMed  CAS  Google Scholar 

  • Garcia EG (1976) Treatment for trichuriasis with oxantel. Am J Trop Med Hyg 25:914–915

    PubMed  CAS  Google Scholar 

  • Garcia H, Keefer L, Lyinsky W, Wenyon CEM (1970) Carcinogenicity of nitrosothiomor- pholine and 1 nitrosopiperazine in rats. Z Krebsforsch 74:179–184

    Article  PubMed  CAS  Google Scholar 

  • Garin JP, Kalb JC, Despeignes J, Vincent G (1970) Action des antibiotiques oligosaccharides sur Taenia saginata. J Parasitol 56:112 (No 4, section II, part 1)

    Google Scholar 

  • Gönnert R, Andrews P (1977) Praziquantel, a new broad-spectrum antischistostomal agent. Z Parasitenkd 52:129–150

    Article  PubMed  Google Scholar 

  • Gönnert R, Johannis J, Schraufstätter E, Strufe R (1963) Konstitution und Cestocide Wirkung in der Yomesan-Reiche. In: Medizin und Chemie. Bayer, Leverkusen, pp 540–567

    Google Scholar 

  • Goodwin LG (1980) New drugs for old diseases. Trans R Soc Trop Med Hyg 74:1–7

    Article  PubMed  CAS  Google Scholar 

  • Graziani G, Martin GL de (1977 a) Pharmacokinetic studies on levamisole. Drugs Exp Clin Res 2:221–223

    CAS  Google Scholar 

  • Graziani G, Martin GL de (1977 b) Pharmacokinetic studies on levamisole: on the pharmacokinetics and relative bioavailability of levamisole in man. Drugs Exp Clin Res 2:235- 240

    CAS  Google Scholar 

  • Hall CA, Kelly JD, Campbell NJ, Whitlock HV, Martin ICA (1978) The dose response of several benzimidazole anthelmintics against resistant strains of Haemonchus contortus andTrichostrongylus colubriformis selected with thiabendazole. Res Vet Sei 25:364–367

    CAS  Google Scholar 

  • Hamajima F (1973) Studies on metabolism of lung fluke genus Paragonimus. VII. Action of bithionol on glycolytic and oxidative metabolism of adult worms. Exp Parasitol 34:1–11

    Article  PubMed  CAS  Google Scholar 

  • Hashimoto Y, Makita T, Ohnuma N, Noguchi T (1972) Acute toxicity on dimethyl 4,4’-0 phenylene bis (3-thioallophanate), thiophanate-methyl fungicide. Toxicol Appl Pharmacol 23:606–615

    Article  PubMed  CAS  Google Scholar 

  • Hecht G, Gloxhuber Chr (1960) Experimentelle Untersuchungen mit N-(2’-Chlor-4’-Nitro- phenyl)-5-Chlorsalicylamid, einem neuen Bandwurmmittel: toxicologische Untersuchungen. Arzneimittelforsch 10:884–885

    PubMed  CAS  Google Scholar 

  • Hefferren JJ, Schrotenboer G, Wolman W (1955) Preparation and properties of citric acid and tartaric acid and salts of piperazine. J Am Pharmacol Assoc 44:678–682

    Article  CAS  Google Scholar 

  • Heykants J (1972) The excretion and metabolism of mebendazole (R 17 635) in the dog. In: Biol Res Report, serial no R 17 635/3. Janssen Pharmaceutica, Beerse

    Google Scholar 

  • Hoebeke J, Neyen G van, Brabander M de (1976) Interaction of oncodazole (R17 934) a new anti-tumoral drug, with rat brain tubulin. Biochem Biophys Res Commun 69:319- 324

    Google Scholar 

  • Hoff DR, Fisher MH, Bochis RJ, Lusi A, Waksmunski F, Egerton JR, Yakstis JJ, Cuckler AC, Campbell WC (1970) A new broad-spectrum anthelmintic: 2-(4-thiazolyl)-5 iso- propoxycarbonylamino-benzimidazole. Experientia 26:550–551

    Article  PubMed  CAS  Google Scholar 

  • Hogg RA (1978) Death after cambendazole dosing. Vet Ree (Nov 18):477–478

    Article  Google Scholar 

  • Ireland M, Gull K, Gutteridge WE, Pogson CI (1979) The interaction of benzimidazole carbamates with mammalian microtubule protein. Biochem Pharmacol 28:2680–2682

    Article  PubMed  CAS  Google Scholar 

  • Janssen PAJ (1976) The levamisole story. In: Jucker E (ed) Progress research, vol 20. Birkhäuser, Basel, pp 347–383

    Google Scholar 

  • Janssen Pharmaceutica (1972) Mebendazole synopsis. Beerse

    Google Scholar 

  • Johns DJ, Philip JR (1977) Albendazole: safety in sheep. Abstr Pap 8th Int Conf For Adv of Vet Par, Sydney

    Google Scholar 

  • Junod Ch (1965) Essai de traitement de la trichocephalose par la diphetarsone. Bull Soc Pathol Exot Filiales 58:653–660

    PubMed  CAS  Google Scholar 

  • Kaiser JA (1964) Studies on the toxicity of disophenol (2,6-diiodo-4-nitrophenol) to dogs and rodents plus some comparisons with 2,4-dinitrophenol. Toxicol Appl Pharmacol 6:232–244

    Article  CAS  Google Scholar 

  • Kane HJ, Behm CA, Bryant C (1980) Metabolic studies on the new fasciolicidal drug, closantel. Mol Biochem Parasitol 1:347–355

    Article  CAS  Google Scholar 

  • Kass IS, Wang CC, Walrond JP, Stretton AOW (1980) Avermectin Bla, a paralyzing anthelmintic that affects interneurons and inhibitory motoneurons in Ascaris. Proc Natl Acad Sei USA 77:6211–6215

    Article  CAS  Google Scholar 

  • Kaushik RK, Katiyar JC, Sen AB (1974) Studies on the mode of action of anthelmintics with Ascaridia galli as the test parasite. Indian J Med Res 62:1367–1375

    PubMed  CAS  Google Scholar 

  • Köhler P, Bachmann R (1980) The possible mode of action of mebendazole in Ascaris suum. In: Bossche H vanden (ed) The host invader interplay. Elsevier, Amsterdam, pp 727–730

    Google Scholar 

  • Köhler P, Bachmann R (1981) Intestinal tubulin as possible target for the chemotherapeutic action of mebendazole in parasitic nematodes. Mol Biochem Parasitol 4:325–336

    Article  PubMed  Google Scholar 

  • Lapras M, Deshanel JP, Delatour R, Gastellu J, Lombard M (1973) Accidents tératologi- ques chez le mouton après administration de parbendazole. Bull Soc Sci Vét Méd Comp 75:53–61

    Google Scholar 

  • Machemer L (1981) Chronic toxicity of metrifonate. Acta Pharmacol Toxicol [Suppl V] 43:15–28

    Google Scholar 

  • Malkin MF, Camacho RM (1977) The effect of thiabendazole on fumarate reductase from thiabendazole-sensitive and resistant Haemonchus conturtus. J Parasitol 58:845–846

    Article  Google Scholar 

  • Marriner SE, Bogan J A (1980) Pharmacokinetics of albendazole in sheep. Am J Vet Res 41:1126–1129

    PubMed  CAS  Google Scholar 

  • Marriner SE, Bogan JA (1981) Pharmacokinetics of oxfendazole in sheep. Am J Vet Res 42:1143–1145

    PubMed  CAS  Google Scholar 

  • Marsboom R (1973) Toxicological studies on mebendazole. Toxicol Appl Pharmacol 24:371–377

    Article  PubMed  CAS  Google Scholar 

  • McCracken RO, Stillwell WH, Hudson HM (1982) A possible biochemical mode of action of benzimidazole anthelmintics. Mol Biochem Parasitol [Suppl] 726

    Google Scholar 

  • Mehlhorn H, Becker B, Andrews P, Thomas H, Frenkel JK (1981) In vivo and in vitro experiments on the effects of praziquantel on Schistosoma mansoni. A light and electron microscopic study. Arzneimittelforsch 31:544–554

    PubMed  CAS  Google Scholar 

  • Mehlhorn H, Kojima S, Rim HJ, Ruenwongsa P, Andrews P, Thomas H, Bunnag B (1983) Ultrastructural investigations on the effects of praziquantel on human trematodes from Asia: Clonorchis sinensis, Metagonimus Yokogawai, Opisthorchis viverrini, Paragonimus westermani andSchistosoma japonicum. Arzneimittelforsch 33:91–98

    PubMed  CAS  Google Scholar 

  • Merck (1981) Ivermectin, annotated bibliography, June. Darmstadt

    Google Scholar 

  • Metcalf RL, Fukuto RB, March RB (1959) Toxic action of Dipterex® and DDVP to the house fly. J Econ Entomol 52:44–49

    CAS  Google Scholar 

  • Metzger H, Duwel D (1974) The development of anthelmintics, based on investigation of metabolism of the liver fluke (Fasciola hepatica). Proceedings of the third international congress of parasitology, vol 3, pp 1444–1449. Abstract No. E8(4). Facta publication, Vienna

    Google Scholar 

  • Meuldermans WEG, Hurkmans RM A, Lauwers WFJ, Heykants JJP (1976) The in vitro metabolism of mebendazole in pig, rat, and dog liver fractions. Eur J Drug Metab Pharmacokinet 1:35–40

    Article  CAS  Google Scholar 

  • Meuldermans W, Hurkmans R, Swijsen E, Heykants J (1977) A comparative study on the excretion and metabolism of flubendazole (R 17 889) and mebendazole (R 17 635) in the rat. In: Preclin Res Report, R17 889/5. Janssen Pharmaceutica Beerse

    Google Scholar 

  • Michiels M, Woestenborghs R, Heykants J (1977 a) On the absorption and distribution of closantel (R 31 520) in sheep after oral and intramuscular administration. Janssen Research Products Information Service, Beerse

    Google Scholar 

  • Michiels M, Heykants J, Sneyers R, Wynants J, Marsboom R (1977 b) Residual tissue levels of flubendazole in the pig after a single oral administration. In: Preclin Res Report, R 17 889/6. Janssen Pharmaceutica Beerse

    Google Scholar 

  • Michiels M, Woestenborghs R, Heykants J (1978) Plasma concentrations of closantel in cattle after a single intramuscular or subcutaneous administration. Janssen Research Products Information Service, Beerse

    Google Scholar 

  • Michiels M, Hendriks R, Heykants J, Bossche H vanden (1982) The pharmacokinetics of mebendazole and flubendazole in animals and man. Arch Int Pharmacodyn Ther 256:180–191

    PubMed  CAS  Google Scholar 

  • Mirvish SS (1975) Formation of N-nitroso compounds: chemistry, kinetics, and in vivo occurrence. Toxicol Appl Pharmacol 31:325—351

    Article  PubMed  Google Scholar 

  • Miko M, Chance B (1975) Isothiocyanates, a new class of uncouplers. Biochim Biophys Acta 396:165–174

    Article  PubMed  CAS  Google Scholar 

  • Moreno MS, Barrett J (1979) Monoamine oxidase in adult Hymenolepis diminuta (Cesto-da). Parasitology 78:1–5

    Google Scholar 

  • Mrozik H, Jones H, Friedman J, Schwartzkopf G, Schardt RA, Patchett AA, Hoff DR, Yakstis JJ, Riek RF, Ostlind DA, Plishker GA, Butler RW, Cuckler AC, Campbell WC (1969) A new agent for the treatment of liver fluke infection (fascioliasis). Experientia 25:883

    Article  PubMed  CAS  Google Scholar 

  • Miinst GJ, Kalaganis G, Bircher J (1980) Plasma concentrations of mebendazole during treatment of echinococcosis. Preliminary results. Eur J Clin Pharmacol 17:375–378

    Article  Google Scholar 

  • Niemegeers CJE (1976) Acute intramuscular and oral toxicity of R 31 520 in mice and rats. Janssen Research Products Information Service

    Google Scholar 

  • Nordgren I, Bengtsson E, Holmstedt B, Pettersson B-M (1981) Levels of metrifonate and dichlorvos in plasma and erythrocytes during treatment of schistosomiasis with Bilar- cil®. Acta Pharmacol Toxicol [Suppl V] 49:79–86

    Article  CAS  Google Scholar 

  • Norton S, Beer EJ de (1957) Investigations on the action of piperazine on Ascaris lumbricoides. Am J Trop Med Hyg 6:898–905

    PubMed  CAS  Google Scholar 

  • O’Brien JJ (1970) Toxicological aspects of some modern anthelmintics. Aust Vet J 46:297- 300

    Article  PubMed  Google Scholar 

  • Oelkers H-A (1959) Die Chemotherapie der Wurmkrankheiten. In: Jucker E (ed) Progress in drug research, vol 1. Birkhâuser, Basel, pp 159–242

    Google Scholar 

  • Osteux R, Guerrin F, Lesieur-Demarquilly I (1971) Mode d’action de la pipérazine sur Ascaris lumbricoides var. suum. II. Etude des contractions musculaires deY Ascaris en présence de pipérazine, de coenzyme A et de l’adénosine-triphosphate. Ann Pharm Fr 29:173–178

    PubMed  CAS  Google Scholar 

  • Pax RA, Bennett JL, Fetterer RH (1978) A benzodiazepine derivative and praziquantel: effects on musculature of Schistosoma mansoni and Schistosoma japonicum. Naunyn Schmiedebergs Arch Pharmacol 304:309–315

    Article  PubMed  CAS  Google Scholar 

  • Phillips JL, Sturman G, West GB (1976) The interaction between anthelmintic drugs and histamine in Ascaris suum. Br J Pharmacol 57:417–420

    PubMed  CAS  Google Scholar 

  • Pong S-S, Wang CC (1979) Specific binding of avermectin Bla to brain synaptosomes. In:Abstract 11th international congress of biochemistry, Toronto, July.

    Google Scholar 

  • Pong S-S, Wang CC (1980) The specificity of high-affinity binding of avermectin Bla to mammalian brain. Neuropharmacology 19:311–317

    Article  PubMed  CAS  Google Scholar 

  • Pong S-S, Wang CC, Fritz LC (1980) Studies on the mechanism of action of avermectin Bla: stimulation of release of y-aminobutyric acid from brain synaptosomes. J Neuro- chem 34:351–358

    CAS  Google Scholar 

  • Pouplard L (1976) Les anthelmintiques en médicine vétérinaire 9. Les Nématodes. Ann MédVét 120:515–529

    CAS  Google Scholar 

  • Prichard RK (1970) Mode of action of the anthelmintic thiabendazole in Haemonchus con- tortus. Nature 228:684–685

    Article  PubMed  CAS  Google Scholar 

  • Prichard RK (1973) The fumarate reductase reaction of Haemonchus contortus and the mode of action of some anthelmintics. Int J Parasitol 3:409–417

    Article  PubMed  CAS  Google Scholar 

  • Prichard RK (1974) Exploitation of the comparative biochemistry of the host/parasite system with thiabendazole and related anthelmintics. In: Proceedings 3rd international congress of parasitology, vol 3. Facta Publications, Vienna, pp 1446–1447

    Google Scholar 

  • Prichard RK (1978) The metabolic profile of adult Fasciola hepatica obtained from rafox-anide-treated sheep. Parasitology 76:277–288

    Article  PubMed  CAS  Google Scholar 

  • Prichard RK, Hennessy DR (1981) Effect of oesophogeal groove closure on the pharmacokinetic behaviour and efficacy of oxfendazole in sheep. Res Vet Sci 30:22–27

    PubMed  CAS  Google Scholar 

  • Prichard RK, Hennessy DR, Steel JW (1978 a) Prolonged administration: a new concept of increasing the spectrum and effectiveness of anthelmintics. Vet Parasitol 4:309–315

    Google Scholar 

  • Prichard RK, Kelly JD, Thompson HG (1978 b) The effects of benzimidazole resistance and route of administration on the uptake of fenbendazole and thiabendazole by Haemonchus contortus and Trichostrongylus colubriformis in sheep. Vet Parasitol 4:243–255

    Article  CAS  Google Scholar 

  • Prichard RK, Kelly JD, Bolin TD, Duncombe VM, Fagan MR (1981 a) The effect of iron and protein deficiency on plasma levels and parasite uptake of [14C]fenbendazole in rats infected with Nippostrongylus brasiliensis. AJEBAK 59:567–573

    PubMed  CAS  Google Scholar 

  • Prichard RK, Steel JW, Hennessy DR (1981 b) Fenbendazole and thiabendazole in cattle: partition of gastrointestinal absorption and pharmacokinetic behaviour. J Vet Pharmacol Ther 4:295–304

    Article  PubMed  CAS  Google Scholar 

  • Prous JR, Mealy NE, Serradell MN, Blancafort P (1982) Annual drug data report, vol 4. Prous JR, SA, Barcelona, p 30

    Google Scholar 

  • Raeymaekers AHM, Roevens LFC, Janssen PAJ (1967) The absolute configuration of the optical isomers of the broad spectrum anthelmintic tetramisole. Tetrahedron Lett 1467–1470

    Google Scholar 

  • Rahman MS, Bryant C (1977) Studies of regulatory metabolism in Moniezia expansa: effects of cambendazole and mebendazole. Int J Parasitol 7:403–409

    Article  CAS  Google Scholar 

  • Rahman MS, Cornish RA, Chevis RF, Bryant C (1977) Studies of the metabolic changes in parasitic helminths from sheep treated with mebendazole. NZ Vet J 25:79–83

    Article  CAS  Google Scholar 

  • Reiner E (1981) Esterases on schistosomes: reaction with substrates and inhibitors. Acta Pharmacol Toxicol [Suppl V] 49:72–78

    Article  CAS  Google Scholar 

  • Rew RS, Smith C, Conglazier ML (1982) Glucose metabolism of Haemonchus contortus adults: effects of thiabendazole on susceptible versus resistant strains. J Parasitol 68:845–850

    Article  PubMed  CAS  Google Scholar 

  • Robinson HJ, Stoerk HC, Graessle OE (1965) Studies on the toxicologic and pharmacologic properties of thiabendazole. Toxicol Appl Pharmacol 7:53–63

    Article  PubMed  CAS  Google Scholar 

  • Rogers EW (1958) Excretion of bephenium salts in urine of human volunteers. Br Med J (2): 1576–1577

    Article  PubMed  CAS  Google Scholar 

  • Romanowski RD, Rhoads ML, Colglazier ML, Kates KC (1975) Effect of cambendazole, thiabendazole and levamisole on fumarate reductase in cambendazole-resistant and -sensitive strains ofHaemonchus contortus. J Parasitol 61:777—778

    Article  PubMed  Google Scholar 

  • Roseby FB, Boray JC (1970) The anthelmintic efficiency against Fasciola hepatica and the toxicity of BAY 4059 in sheep. Aust Vet J 46:308–310

    Article  PubMed  CAS  Google Scholar 

  • Rousseau F, Haguenoer J-M, Lesieur D, Gamot AP (1981) Gas-chromatographic determination of levamisole in human plasma. Normalization and reliability of the method. Eur J Drug Metab Pharmacokinet 6:281–288

    Article  PubMed  CAS  Google Scholar 

  • Sander J, Labar J, Ladenstein M, Schweinsberg F (1975) Quantitative measurement of in vivo nitrosamine formation. I ARC Sci Publ 9:123–131

    CAS  Google Scholar 

  • Sano M, Terada M, Ishii AI, Kino H (1981) Effects of avermectin Bla on the motility of various parasitic helminths. Experientia 37:844–846

    Article  PubMed  CAS  Google Scholar 

  • Sano M, Terada M, Ishii AI, Kino H, Anantaphruti M (1982) Studies on chemotherapy of parasitic helminths (V). Effects of niclosamide on the motility of various parasitic helminths. Experientia 38:547–559

    Article  PubMed  CAS  Google Scholar 

  • Sasi PK, Raj RK (1975) Effect of piperazine on the level of phospholipid and on the activities of certain enzymes of phospholipid metabolism in human Ascaris lumbricoides. Experientia 31:1261–1262

    Article  PubMed  CAS  Google Scholar 

  • Savin YI, Singin AS, Korolev GK (1977) Synthesis of 14C-piperazine and features of its distribution in animals. Khim Farm Zh 11:26–30

    CAS  Google Scholar 

  • Saz DK, Bonner TP, Karlin M, Saz HJ (1971) Biochemical observations on adult Nippo- strongylus brasiliensis. J Parasitol 57:1159–1162

    Article  PubMed  CAS  Google Scholar 

  • Saz HJ (1972 a) Comparative biochemistry of carbohydrates in nematodes and cestodes. In: Bossche H vanden (ed) Comparative biochemistry of parasites. Academic, New York, pp 33–47

    Google Scholar 

  • Saz HJ (1972 b) Effects of anthelmintics on 32P-esterification in helminth metabolism. In: Bossche H vanden (ed) Comparative biochemistry of parasites. Academic, New York, pp 445–454

    Google Scholar 

  • Saz HJ, Lescure OL (1968) Effects of anticestodal agents on mitochondria from the nematode, Ascaris lumbricoides. Mol Pharmacol 4:407–410

    PubMed  CAS  Google Scholar 

  • Schantz PM, Bossche H vanden, Eckert J (1982) Chemotherapy for larval echinococcosis in animals and humans: report of a workshop. Z Parasitenkd 67:5–26

    Article  PubMed  CAS  Google Scholar 

  • Scheibel LW, Saz HJ, Bueding E (1968) The anaerobic incorporation of 32P into adenosine triphosphate byHymenolepis diminuta. J Biol Chem 243:2229–2235

    PubMed  CAS  Google Scholar 

  • Selling HA, Vonk JW, Kaars-Sypestyn A (1970) Transformation of the systemic fungicide methyl thiophanate into 2-benzimidazole carbonic acid methyl ester. Chem Ind: 1625- 1626

    Google Scholar 

  • Seubert J, Pohlke R, Loebich F (1977) Synthesis and properties of praziquantel, a novel broad spectrum anthelmintic with excellent activity against schistosomes and cestodes. Experientia 33:1036–1037

    Article  PubMed  CAS  Google Scholar 

  • Smith TC, Kinkel AW, Gryczko CM, Goulet JR (1976) Absorption of pyrvinium pamoate. Clin Pharmacol Ther 19:802–806

    PubMed  CAS  Google Scholar 

  • Spaldonovä R (1981) Efficacy of febantel onTrichinella spiralis larvae in white mice. In: Kim CW Ruitenberg EJ, Teppema JS (eds) Trichinellosis. Proceedings of the 5th international conference on trichinellosis. Reedbooks, Surrey, pp 323–325

    Google Scholar 

  • Steiner K, Garbe A, Diekman HW, Nowak H (1976) The fate of praziquantel in the organism. I. Pharmacokinetics in animals. Eur J Drug Metab Pharmacokinet 2:85–95

    Article  Google Scholar 

  • Striebel HP (1976) 4-Isothiocyanato-4’-nitrodiphenylamine (C 9333 - GO/CGP 4540), an anthelmintic with an unusual spectrum of activity against intestinal nematodes, filariae and schistosomes. Experientia 32:457–458

    Article  PubMed  CAS  Google Scholar 

  • Strufe R, Gönnert R (1960) Experimentelle Untersuchungen mit Af-(2’-chlor-4’-nitrophe- nyl)-5-chlorsalicylamid, einem neuen Bandwurmmittel. Arzneimittelforsch 10:886–890

    CAS  Google Scholar 

  • Strufe R, Gönnert R (1967) Über die Beeinflussung der Bandwurmstoffwechsel durch Arzneimittel. Z Tropenmed Parasitol 18:193–202

    PubMed  CAS  Google Scholar 

  • Symoens J, Cree J de, Bever WFM van, Janssen PAJ (1979) Levamisole In: Goldberg ME (ed) Pharmacological and biochemical properties of drug substances, vol 2. American Pharmaceutical Association Academy of Pharmaceutical Sciences, Washington DC, pp 407–464

    Google Scholar 

  • Terada M, Ishii AI, Kino H, Sano M (1982 a) Studies on chemotherapy of parasitic helminths (VII). Effects of various cholinergic agents on the motility ofAngiostrongylus cantonensis. Jpn J Pharmacol 32:633–642

    Article  PubMed  CAS  Google Scholar 

  • Terada M, Ishii AI, Kino H, Sano M (1982 b) Studies on chemotherapy of parasitic helminths (VIII). Effects of some possible neurotransmitters on the motility of Angiostrongylus cantonensis. Jpn J Pharmacol 32:643–653

    Article  PubMed  CAS  Google Scholar 

  • Terada M, Ishii AI, Kino H, Sano M (1982 c) Studies on chemotherapy of parasitic helminths VI. Effects of various neuropharmacological agents on the motility of Dipy- lidium caninum. Jpn J Pharmacol 32:479–488

    Article  PubMed  CAS  Google Scholar 

  • Terada M, Ishii AI, Kino H, Fujiu Y, Sano M (1982 d) Studies on chemotherapy of parasitic helminths (IX). Effects of praziquantel on the motility of various parasitic helminths and isolated host tissues. Experientia 38:549–553

    Article  PubMed  CAS  Google Scholar 

  • The Merck Index, 9th edn (1976) Rahwag ND (ed) Merck, Darmstadt

    Google Scholar 

  • The Merck Index (1983) An encyclopedia of chemicals, drugs and biologicals. 10th edition. Merck & Co Inc. Rahways

    Google Scholar 

  • Theodorides VJ, Chang J, Dicuollo CJ, Grass GM, Parish RC, Scott GC (1973) Oxi- bendazole, a new broad spectrum anthelmintic effective against gastrointestinal nematodes of domestic animals. Br Vet J 129:97–98

    Google Scholar 

  • Theodorides VJ, Parish RC, Fuchsman CH, Lee RM (1974) Bromoxanide, a new anthelmintic. Vet Ree (July 27th):84–85

    Google Scholar 

  • Theodorides VJ, Gyurik RJ, Kingsbury WC, Parish RC (1976) Anthelmintic activity of albendazole against liver flukes, tapeworms, lung- and gastrointestinal roundworms. Experientia 32:702–703

    Article  PubMed  CAS  Google Scholar 

  • Thienpont D, Vanparijs O, Niemegeers C, Marsboom R (1978) Biological and pharmacological properties of flubendazole. Arzneimittelforsch 28:605–612

    PubMed  CAS  Google Scholar 

  • Thomas H (1979) The efficacy of amidantel, a new anthelmintic, on hookworms and ascarids in dogs. Tropenmed Parasitol 30:404–408

    PubMed  CAS  Google Scholar 

  • Tocco DJ, Buhs RP, Brown MD, Matzuk AR, Mertel HE, Harman RE, Trenner NR (1964) The metabolic fate of thiabendazole in sheep. J Med Chem 7:399–405

    Article  PubMed  CAS  Google Scholar 

  • Tocco DJ, Egerton JR, Bowers W, Christensen VW, Rosenblum C (1965) Absorption, metabolism and elimination of thiabendazole in farm animals and a method for its estimation in biological materials. J Pharmacol Exp Ther 149:263–270

    PubMed  CAS  Google Scholar 

  • Tollenaere JP, Moereels H, Bossche H vanden (1976) Comparison of the structure-activity relationships of substituted phenols as uncouplers of oxidative phosphorylation in rat liver and Ascaris muscle mitochondria. In: Bossche H vanden (ed) Biochemistry of parasites and host-parasite relationships. Elsevier, Amsterdam, pp 629–636

    Google Scholar 

  • Tollenaere JP, Moereels H, Raymaekers LA (1979) Atlas of the three-dimensional structure of drugs. Elsevier, Amsterdam

    Google Scholar 

  • Ueno H, Watanabe S, Fujita A (1959) Studies on anthelmintics of common liver fluke. J Jpn Vet Med Assoc 12:301

    Google Scholar 

  • Ueno H, Watanabe S, Fujita A (I960) Studies on anthelmintics against the common liver- fluke II. Action of bithionol in cattle. J Jpn Vet Med Assoc 13:151–155

    Google Scholar 

  • Vakil BJ, Dalai NJ, Shah PN, Koti ST, Mankodi NA, Sen HG, Vaidya AB (1977) Clinical evaluation of a new anthelmintic - C 9330 GO/CGP 4540 in human hookworm infection. Trans R Trop Med Hyg 71:247–250

    Article  CAS  Google Scholar 

  • Van Belle H (1972) Kinetics and inhibition of alkaline phosphatases from canine tissues. Biochim Biophys Acta 289:158–168

    PubMed  Google Scholar 

  • Van Belle H (1976) Kinetics and inhibition of rat and avian alkaline phosphatases. Gen Pharmacol 7:53–58

    Article  PubMed  Google Scholar 

  • Van Belle H, Janssen PAJ (1979) a-Ketoaldehydes, specific catalysts for thiol formation from levamisole. Biochem Pharmacol 28:1313–1318

    Google Scholar 

  • Vanden Bossche H (1972a) Biochemical effects of the anthelmintic drug, mebendazole. In: Bossche H vanden (ed) Comparative biochemistry of parasites. Academic, New York, pp 139–157

    Google Scholar 

  • Vanden Bossche H (1972) Studies on the phosphorylation in Ascaris mitochondria. In: Bossche H vanden (ed) Comparative biochemistry of parasites. Academic, New York, pp 455–468

    Google Scholar 

  • Vanden Bossche H (1976a) The molecular basis of anthelmintic action. In: Bossche H vanden (ed) Elsevier, Amsterdam, pp 533–572

    Google Scholar 

  • Vanden Bossche H (1976b) Effects of levamisole and tetramisole on the acetylcholinesterase activity. Janssen Research Products Information Service. Serial number: R 8299/4, R 12 564/3, Beerse

    Google Scholar 

  • Vanden Bossche H (1978) Chemotherapy of parasitic infections. Nature 273:626–630

    Article  PubMed  Google Scholar 

  • Vanden Bossche H (1980 a) Chemotherapy of hymenolepiasis. In: Arai HP (ed) Biology of the tapeworm Hymenolepis diminuta. Academic, New York, pp 639–693

    Google Scholar 

  • Vanden Bossche H (1980 b) Peculiar targets in anthelmintic chemotherapy. Biochem Pharmacol 29:1981–1990

    Article  PubMed  Google Scholar 

  • Vanden Bossche H, Nollin S de (1973) Effects of mebendazole on the absorption of low molecular weight nutrients by Ascaris suum. Int J Parasitol 3:401–407

    Article  PubMed  Google Scholar 

  • Vanden Bossche H, Janssen PAJ (1983) Mode of action of known and experimental anti- filarial compounds. In: Anand N, Sen AB (eds) Proceedings symposium on “chemotherapy & immunology in the control of malaria, filaria and leishmaniasis”, February 17–21,1981, Lucknow, India. Tata McGraw-Hill, New Dehli, pp 187–201

    Google Scholar 

  • Vanden Bossche H, Verhoeven H (1982) Biochemical effects of the antiparasitic drug closantel. Proceedings of the British Society for Parasitology. Joint spring meeting 1981. Parasitology 84: (Li) (abstract)

    Google Scholar 

  • Vanden Bossche H, Claes J, Verhoeven H (1975) The uptake and distribution of mebendazole in Ascaris suum. In: Biol Res Report R 17 635, LVD, 2183, Section 11. Jans- sen Pharmaceutica, Beerse

    Google Scholar 

  • Vanden Bossche H. Verhoeven H, Vanparijs O, Lauwers H, Thienpont D (1979) Closantel, a new antiparasitic hydrogen ionophore. Arch Int Physiol Biochim 87:851–852

    Google Scholar 

  • Vanden Bossche H, Verhoeven H, Lauwers H (1980) Uncoupling of liver mitochondria associated with fasciolasis in rats - normalization by closantel. In: Bossche H vanden (ed) The host invader interplay. Elsevier, Amsterdam, pp 699–704

    Google Scholar 

  • Vanden Bossche H, Senft AW, Steck EA (1981) Antiparasitic agents: mode of action, drug resistance. In: Slusarski W (ed) Review of advances in parasitology. Proceedings of ICOPAIV. Polish Scientific Warszawa, pp 461–480

    Google Scholar 

  • Vanden Bossche H, Rochette F, Hörig C (1982) Mebendazole and related anthelmintics. In: Garattini S, Goldin A, Hawking F, Kopin IJ (eds) Advances in pharmacology and chemotherapy, vol 19. Academic Press, New York, pp 67–128

    Google Scholar 

  • Vanhoutte PM, Nueten JM van, Verbeuzen TJ, Laduron PM (1977) Differential effects of the isomers of tetramisole on adrenergic neurotransmission in cutaneous veins of dogs. J Pharmacol Exp Ther 200:127–140

    PubMed  CAS  Google Scholar 

  • Van Nueten JM (1972) Pharmacological aspects of tetramisole. In: Bossche H vanden (ed) Comparative biochemistry of parasites. Academic, New York, pp 101–115

    Google Scholar 

  • Verheyen A, Borgers M, Vanparijs O, Thienpont D (1976) The effects of mebendazole on the ultrastructure of cestodes. In: Bossche H vanden (ed) Biochemistry of parasite? and host-parasite relationships. Elsevier, Amsterdam, pp 605–618

    Google Scholar 

  • Verheyen A, Borgers M, Bossche H vanden, Vanparijs O, Lauwers H, Thienpont D (1979) The localization of mitochondrial ATPase in the different tissues of the mature liver fluke Fasciola hepatica L. The influence of in vivo administration of closantel, a new antiparasitic hydrogen-ionophore. Biol Cell 35:36 a

    Google Scholar 

  • Verheyen A, Vanparijs O, Lauwers H, Thienpont D (1980) The influence of closantel administration to sheep on the ultrastructure of the adult liver fluke, Fasciola hepatica L. In: Bossche H vanden (ed) The host invader interplay. Elsevier, Amsterdam, pp 705–708

    Google Scholar 

  • Verhoeven HLE, Willemsens G, Bossche H vanden (1976) Uptake and distribution of leva- misole in Ascaris suum. In: Bossche H vanden (ed) Biochemistry of parasites and host- parasite relationships. Elsevier, Amsterdam, pp 573–579

    Google Scholar 

  • WHO (1974) Technical report serial number 542, Geneva

    Google Scholar 

  • Williamson RL, Metcalf RL (1967) Salicylanilides: a new group of active uncouplers of oxidative phosphorylation. Science 158:1694–1695

    Article  PubMed  CAS  Google Scholar 

  • Wilson CG, Parke DV, Cawthorne MA (1973) Investigations of the 5-hydroxylation of thiabendazole in rat liver microsomal preparations. Biochem Soc Trans 1:195–196

    CAS  Google Scholar 

  • Wollweber H, Rolling H, Widdig A, Thomas H, Schulz H-P, Murmann P (1978) Febantel, a new broad-spectrum anthelminthic. Arzneimittelforsch 28:2193–2195

    PubMed  CAS  Google Scholar 

  • Wollweber H, Niemers E, Flucke W, Andrews P, Schulz H-P, Thomas H (1979) Amidantel, a potent anthelmintic from a new chemical class. Arzneimittelforsch 29:31–32

    PubMed  CAS  Google Scholar 

  • Yorke RE, Turton J A (1974) The influence of a range of anthelmintic drugs on the respiration of isolatedHymenolepis diminuta mitochondria. Z Parasitenkd 45:1–10

    Article  PubMed  CAS  Google Scholar 

  • Zintz K, Frank W (1982) Ultrastructural modifications in Heterakis spumosa after treatment with febantel or mebendazole. Vet Parasitol 10:47–56

    Article  PubMed  CAS  Google Scholar 

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Bossche, H.V. (1985). Pharmacology of Anthelmintics. In: Bossche, H.V., Thienpont, D., Janssens, P.G. (eds) Chemotherapy of Gastrointestinal Helminths. Handbook of Experimental Pharmacology, vol 77. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69527-8_4

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