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Carcinogenicity of nitrosothiomorpholine and 1-nitrosopiperazine in rats

Carcinogene Wirkung von Nitrosothiomorpholine und 1-Nitrosopiperazine bei Ratten

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Zusammenfassung

Zwei cyclische Nitrosamine, nitroso-thiomorpholine und 1-Nitrosopiperazine, wurden Ratten in Langzeit-Versuchen im Trinkwasser appliziert (50 mg/l bzw. 200 mg/l). Nitroso-thiomorpholine führte zu benignen und malignen Tumoren des Oesophagus und der Zunge. Nitroso-pieerazine zeigte ebenfalls tumorigene Wirkung für eine große Zahl von Organen und Geweben, allerdings keine Organ-Spezifität. Nitroso-piperazine erwies sich als von sehr viel geringerer akuter Toxicität als Dinitroso-piperazin.

Summary

Two cyclic nitrosamines, nitrosothiomorpholine and 1-nitrosopiperazine, have been tested by long term feeding to rats in drinking water, at 50 mg/l and 200 mg/l. Nitrosothiomorpholine produced tumors, both benign and malignant, of the esophagus and tongue. Nitrosopiperazine appeared to be definitely tumorigenic, although it showed no selectivity of site for tumor induction and induced tumors in a wide range of organs and tissues. Nitrosopiperazine was very much less acutely toxic than dinitrosopiperazine.

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References

  • Banasch, P., Müller, H.-A.: Lichtmikroskopische Untersuchungen über die Wirkung von N-Nitrosomorpholin auf die Leber von Ratte und Maus. Arzneimittel-Forsch. 14, 805 (1964).

    Google Scholar 

  • Berg, R. G.: N-Nitrosopiperazine. U.S. Patent # 2907767 (1959); Chem. Abs. 54, 7744 (1960).

  • Druckrey, H., Preussmann, R., Ivankovic, S., Schmähl, D.: Organotrope carcinogene Wirkungen an BD-Ratten. Z. Krebsforsch. 69 103 (1967).

    Google Scholar 

  • Goodall, C. M., Lijinsky, W., Tomatis, L.: Tumorigenicity of N-nitrosohexamethyleneimine. Cancer Res. 28, 1217 (1968).

    Google Scholar 

  • Sommers, A. H., Horrom, B. W.: New synthesis of thiamorpholine. The reduction of monoand dioxothiazines by lithium aluminum hydride. J. Amer. chem. Soc. 76, 1187 (1954).

    Google Scholar 

  • Thomas, C.: Zur Morphologie der Nasenhöhlentumoren bei der Ratte. Z. Krebsforsch. 67, 1 (1965).

    Google Scholar 

  • Weil, C. S.: Tables for convenient calculations of median-effective dose (LD50 or ED50) and instructions in their use. Biometrics 8, 249 (1952).

    Google Scholar 

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Authors and Affiliations

  1. Eppley Institute for Research in Cancer, University of Nebraska College of Medicine, Omaha, Nebraska, USA

    Humberto Garcia, Larry Keefer, William Lijinsky & Charles E. M. Wenyon

Authors
  1. Humberto Garcia
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  2. Larry Keefer
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  3. William Lijinsky
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  4. Charles E. M. Wenyon
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Additional information

This investigation was supported by Contract # 43-68-959 from the National Cancer Institute, U.S.P.H.S.

We wish to thank Miss P. Johns, Mrs. J. Stroud for skilled technical assistance.

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Garcia, H., Keefer, L., Lijinsky, W. et al. Carcinogenicity of nitrosothiomorpholine and 1-nitrosopiperazine in rats. Z Krebs-forsch 74, 179–184 (1970). https://doi.org/10.1007/BF00525883

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  • DOI: https://doi.org/10.1007/BF00525883

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