Abstract
With aging and other muscle wasting diseases, men and women undergo similar pathological changes in skeletal muscle: increased inflammation, enhanced oxidative stress, mitochondrial dysfunction, satellite cell senescence, elevated apoptosis and proteasome activity, and suppressed protein synthesis and myocyte regeneration. Decreased food intake and physical activity also indirectly contribute to muscle wasting. Sex hormones also play important roles in maintaining skeletal muscle homeostasis. Testosterone is a potent anabolic factor promoting muscle protein synthesis and muscular regeneration. Estrogens have a protective effect on skeletal muscle by attenuating inflammation; however, the mechanisms of estrogen action in skeletal muscle are less well characterized than those of testosterone. Age- and/or disease-induced alterations in sex hormones are major contributors to muscle wasting. Hence, men and women may respond differently to catabolic conditions because of their hormonal profiles. Here we review the similarities and differences between men and women with common wasting conditions including sarcopenia and cachexia due to cancer, end-stage renal disease/chronic kidney disease, liver disease, chronic heart failure, and chronic obstructive pulmonary disease based on the literature in clinical studies. In addition, the responses in men and women to the commonly used therapeutic agents and their efficacy to improve muscle mass and function are also reviewed.
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References
Abs, R., Bengtsson, B. A., Hernberg-Stahl, E., Monson, J. P., Tauber, J. P., Wilton, P., & Wuster, C. (1999). GH replacement in 1034 growth hormone deficient hypopituitary adults: Demographic and clinical characteristics, dosing and safety. Clinical Endocrinology, 50, 703–713.
Adams, V., Jiang, H., Yu, J. T., Mobius-Winkler, S., Fiehn, E., Linke, A., Weigl, C., Schuler, G., & Hambrecht, R. (1999). Apoptosis in skeletal myocytes of patients with chronic heart failure is associated with exercise intolerance. Journal of the American College of Cardiology, 33, 959–965.
Adunsky, A., Chandler, J., Heyden, N., Lutkiewicz, J., Scott, B. B., Berd, Y., Liu, N., & Papanicolaou, D. A. (2011). MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: A multicenter, randomized, placebo-controlled phase IIb study. Archives of Gerontology and Geriatrics, 53, 183–189.
Ali, S., & Garcia, J. M. (2014). Sarcopenia, cachexia and aging: Diagnosis, mechanisms and therapeutic options – a mini-review. Gerontology, 60, 294–305.
Ali, S., Chen, J. A., & Garcia, J. M. (2013). Clinical development of ghrelin axis-derived molecules for cancer cachexia treatment. Current Opinion in Supportive and Palliative Care, 7, 368–375.
Allan, G. F., Tannenbaum, P., Sbriscia, T., Linton, O., Lai, M. T., Haynes-Johnson, D., Bhattacharjee, S., Zhang, X., Sui, Z., & Lundeen, S. G. (2007). A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats. Endocrine, 32, 41–51.
Amirouche, A., Durieux, A. C., Banzet, S., Koulmann, N., Bonnefoy, R., Mouret, C., Bigard, X., Peinnequin, A., & Freyssenet, D. (2009). Down-regulation of Akt/mammalian target of rapamycin signaling pathway in response to myostatin overexpression in skeletal muscle. Endocrinology, 150, 286–294.
Anderson, L. J., Albrecht, E. D., & Garcia, J. M. (2017). Update on management of cancer-related cachexia. Current Oncology Reports, 19, 3.
Anker, S. D. (1997). Wasting as an independent risk factor for mortality in chronic heart failure (vol 349, pg 1052, 1997). Lancet, 349, 1258–1258.
Anker, S. D., Ponikowski, P. P., Clark, A. L., Leyva, F., Rauchhaus, M., Kemp, M., Teixeira, M. M., Hellewell, P. G., Hooper, J., Poole-Wilson, P. A., & Coats, A. J. S. (1999). Cytokines and neurohormones relating to body composition alterations in the wasting syndrome of chronic heart failure. European Heart Journal, 20, 683–693.
Anker, S. D., Volterrani, M., Pflaum, C. D., Strasburger, C. J., Osterziel, K. J., Doehner, W., Ranke, M. B., Poole-Wilson, P. A., Giustina, A., Dietz, R., & Coats, A. J. S. (2001). Acquired growth hormone resistance in patients with chronic heart failure: Implications for therapy with growth hormone. Journal of the American College of Cardiology, 38, 443–452.
Anker, S. D., Negassa, A., Coats, A. J. S., Afzal, R., Poole-Wilson, P. A., Cohn, J. N., & Yusuf, S. (2003). Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: An observational study. Lancet, 361, 1077–1083.
Aquilani, R., Opasich, C., Guagco, A., Verri, M., Testa, A., Pasini, E., Viglio, S., Iadarola, P., Pastoris, O., Dossena, M., & Boschi, F. (2008). Adequate energy-protein intake is not enough to improve nutritional and metabolic status in muscle-depleted patients with chronic heart failure. European Journal of Heart Failure, 10, 1127–1135.
Araujo, J. P., Lourenco, P., Rocha-Goncalves, F., Ferreira, A., & Bettencourt, P. (2009). Adiponectin is increased in cardiac cachexia irrespective of body mass index. European Journal of Heart Failure, 11, 567–572.
Arthur, S. T., Noone, J. M., Van Doren, B. A., Roy, D., & Blanchette, C. M. (2014). One-year prevalence, comorbidities and cost of cachexia-related inpatient admissions in the USA. Drugs Context, 3, 212265.
Bach, M. A., Rockwood, K., Zetterberg, C., Thamsborg, G., Hebert, R., Devogelaer, J. P., Christiansen, J. S., Rizzoli, R., Ochsner, J. L., Beisaw, N., Gluck, O., Yu, L., Schwab, T., Farrington, J., Taylor, A. M., Ng, J., Fuh, V., & Group, M. K. H. F. S. (2004). The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture. Journal of the American Geriatrics Society, 52, 516–523.
Backer, J. M. (2008). The regulation and function of Class III PI3Ks: Novel roles for Vps34. The Biochemical Journal, 410, 1–17.
Baracos, V. E., Reiman, T., Mourtzakis, M., Gioulbasanis, I., & Antoun, S. (2010). Body composition in patients with non-small cell lung cancer: A contemporary view of cancer cachexia with the use of computed tomography image analysis. American Journal of Clinical Nutrition, 91, 1133s–1137s.
Basaria, S., Coviello, A. D., Travison, T. G., Storer, T. W., Farwell, W. R., Jette, A. M., Eder, R., Tennstedt, S., Ulloor, J., Zhang, A., Choong, K., lakshman, K. M., Mazer, N. A., Miciek, R., Krasnoff, J., Elmi, A., Knapp, P. E., Brooks, B., Appleman, E., Aggarwal, S., Bhasin, G., Hede-Brierley, L., Bhatia, A., Collins, L., Lebrasseur, N., Fiore, L. D., & Bhasin, S. (2010). Adverse events associated with testosterone administration. The New England Journal of Medicine, 363, 109–122.
Basualto-Alarcon, C., Varela, D., Duran, J., Maass, R., & Estrada, M. (2014). Sarcopenia and androgens: A link between pathology and treatment. Frontier Endocrinology (Lausanne), 5, 217.
Batista, M. L., Peres, S. B., McDonald, M. E., Alcantara, P. S. M., Olivan, M., Otoch, J. P., Farmer, S. R., & Seelaender, M. (2012). Adipose tissue inflammation and cancer cachexia: Possible role of nuclear transcription factors. Cytokine, 57, 9–16.
Baumann, C. W., Kwak, D., Liu, H. M., & Thompson, L. V. (2016). Age-induced oxidative stress: How does it influence skeletal muscle quantity and quality? Journal Applied Physiology (1985), 121, 1047–1052.
Baumgartner, R. N., Waters, D. L., Gallagher, D., Morley, J. E., & Garry, P. J. (1999). Predictors of skeletal muscle mass in elderly men and women. Mechanisms of Ageing and Development, 107, 123–136.
Bea, J. W., Zhao, Q., Cauley, J. A., Lacroix, A. Z., Bassford, T., Lewis, C. E., Jackson, R. D., Tylavsky, F. A., & Chen, Z. (2011). Effect of hormone therapy on lean body mass, falls, and fractures: 6-year results from the Women’s Health Initiative hormone trials. Menopause, 18, 44–52.
Beaudart, C., Buckinx, F., Rabenda, V., Gillain, S., Cavalier, E., Slomian, J., Petermans, J., Reginster, J. Y., & Bruyere, O. (2014). The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: A systematic review and meta-analysis of randomized controlled trials. The Journal of Clinical Endocrinology and Metabolism, 99, 4336–4345.
Bekfani, T., Pellicori, P., Morris, D. A., Ebner, N., Valentova, M., Steinbeck, L., Wachter, R., Elsner, S., Sliziuk, V., Schefold, J. C., Sandek, A., Doehner, W., Cleland, J. G., Lainscak, M., Anker, S. D., & Von Haehling, S. (2016). Sarcopenia in patients with heart failure with preserved ejection fraction: Impact on muscle strength, exercise capacity and quality of life. International Journal of Cardiology, 222, 41–46.
Bhasin, S., & Jasuja, R. (2009). Selective androgen receptor modulators as function promoting therapies. Current Opinion in Clinical Nutrition and Metabolic Care, 12, 232–240.
Bhasin, S., Calof, O. M., Storer, T. W., Lee, M. L., Mazer, N. A., Jasuja, R., Montori, V. M., Gao, W., & Dalton, J. T. (2006a). Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging. Nature Clinical Practice. Endocrinology & Metabolism, 2, 146–159.
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2006b). Testosterone therapy in adult men with androgen deficiency syndromes: An endocrine society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism, 91, 1995–2010.
Biesemann, N., Mendler, L., Wietelmann, A., Hermann, S., Schafers, M., Kruger, M., Boettger, T., Borchardt, T., & Braun, T. (2014). Myostatin regulates energy homeostasis in the heart and prevents heart failure. Circulation Research, 115, 296–310.
Blackman, M. R., Sorkin, J. D., Munzer, T., Bellantoni, M. F., Busby-Whitehead, J., Stevens, T. E., Jayme, J., O’Connor, K. G., Christmas, C., Tobin, J. D., Stewart, K. J., Cottrell, E., St Clair, C., Pabst, K. M., & Harman, S. M. (2002). Growth hormone and sex steroid administration in healthy aged women and men: A randomized controlled trial. JAMA, 288, 2282–2292.
Boland, R., Vasconsuelo, A., Milanesi, L., Ronda, A. C., & De Boland, A. R. (2008). 17beta-estradiol signaling in skeletal muscle cells and its relationship to apoptosis. Steroids, 73, 859–863.
Bonkovsky, H. L., Fiellin, D. A., Smith, G. S., Slaker, D. P., Simon, D., & Galambos, J. T. (1991). A randomized, controlled trial of treatment of alcoholic hepatitis with parenteral-nutrition and oxandrolone. 1. Short-term effects on liver-function. American Journal of Gastroenterology, 86, 1200–1208.
Budoff, M. J., Ellenberg, S. S., Lewis, C. E., Mohler, E. R., 3rd, Wenger, N. K., Bhasin, S., Barrett-Connor, E., Swerdloff, R. S., Stephens-Shields, A., Cauley, J. A., Crandall, J. P., Cunningham, G. R., Ensrud, K. E., Gill, T. M., Matsumoto, A. M., Molitch, M. E., Nakanishi, R., Nezarat, N., Matsumoto, S., Hou, X., Basaria, S., Diem, S. J., Wang, C., Cifelli, D., & Snyder, P. J. (2017). Testosterone treatment and coronary artery plaque volume in older men with low testosterone. JAMA, 317, 708–716.
Cabello-Verrugio, C., Cordova, G., & Salas, J. D. (2012). Angiotensin II: Role in skeletal muscle atrophy. Current Protein & Peptide Science, 13, 560–569.
Calnan, D. R., & Brunet, A. (2008). The FoxO code. Oncogene, 27, 2276–2288.
Caminiti, G., Volterrani, M., Iellamo, F., Marazzi, G., Massaro, R., Miceli, M., Mammi, C., Piepoli, M., Fini, M., & Rosano, G. M. C. (2009). Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study. Journal of the American College of Cardiology, 54, 919–927.
Campbell, M. J., Mccomas, A. J., & Petito, F. (1973). Physiological changes in ageing muscles. Journal of Neurology, Neurosurgery, and Psychiatry, 36, 174–182.
Cappola, A. R., Ratcliffe, S. J., Bhasin, S., Blackman, M. R., Cauley, J., Robbins, J., Zmuda, J. M., Harris, T., & Fried, L. P. (2007). Determinants of serum total and free testosterone levels in women over the age of 65 years. The Journal of Clinical Endocrinology and Metabolism, 92, 509–516.
Carrero, J. J., Chmielewski, M., Axelsson, J., Snaedal, S., Heimburger, O., Barany, P., Suliman, M. E., Lindholm, B., Stenvinkel, P., & Qureshi, A. R. (2008). Muscle atrophy, inflammation and clinical outcome in incident and prevalent dialysis patients. Clinical Nutrition, 27, 557–564.
Carrero, J. J., Stenvinkel, P., Cuppari, L., Ikizler, T. A., Kalantar-Zadeh, K., Kaysen, G., Mitch, W. E., Price, S. R., Wanner, C., Wang, A. Y., Ter Wee, P., & Franch, H. A. (2013). Etiology of the protein-energy wasting syndrome in chronic kidney disease: A consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM). Journal of Renal Nutrition, 23, 77–90.
Carson, J. A., & Manolagas, S. C. (2015). Effects of sex steroids on bones and muscles: Similarities, parallels, and putative interactions in health and disease. Bone, 80, 67–78.
Carter, A., Dobridge, J., & Hackney, A. C. (2001). Influence of estrogen on markers of muscle tissue damage following eccentric exercise. Fiziologiia Cheloveka, 27, 133–137.
Casaburi, R., Bhasin, S., Cosentino, L., Porszasz, J., Somfay, A., Lewis, M. I., Fournier, M., & Storer, T. W. (2004). Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 170, 870–878.
Cheema, B., Abas, H., Smith, B., O’Sullivan, A., Chan, M., Patwardhan, A., Kelly, J., Gillin, A., Pang, G., Lloyd, B., & Singh, M. F. (2007a). Progressive exercise for anabolism in kidney disease (PEAK): A randomized, controlled trial of resistance training during hemodialysis. Journal of the American Society of Nephrology, 18, 1594–1601.
Cheema, B., Abas, H., Smith, B., O’Sullivan, A., Chan, M., Patwardhan, A., Kelly, J., Gillin, A., Pang, G., Lloyd, B., & Singh, M. F. (2007b). Randomized controlled trial of intradialytic resistance training to target muscle wasting in ESRD: The progressive exercise for anabolism in kidney disease (PEAK) study. American Journal of Kidney Diseases, 50, 574–584.
Chen, J., Kim, J., & Dalton, J. T. (2005). Discovery and therapeutic promise of selective androgen receptor modulators. Molecular Interventions, 5, 173–188.
Christensen, H. M., Kistorp, C., Schou, M., Keller, N., Zerahn, B., Frystyk, J., Schwarz, P., & Faber, J. (2013). Prevalence of cachexia in chronic heart failure and characteristics of body composition and metabolic status. Endocrine, 43, 626–634.
Churchward-Venne, T. A., Breen, L., & Phillips, S. M. (2014). Alterations in human muscle protein metabolism with aging: Protein and exercise as countermeasures to offset sarcopenia. BioFactors, 40, 199–205.
Cianciaruso, B., Brunori, G., Kopple, J. D., Traverso, G., Panarello, G., Enia, G., Strippoli, P., Devecchi, A., Querques, M., Viglino, G., Vonesh, E., & Maiorca, R. (1995). Cross-sectional comparison of malnutrition in continuous ambulatory peritoneal-dialysis and hemodialysis-patients. American Journal of Kidney Diseases, 26, 475–486.
Cicoira, M., Kalra, P. R., & Anker, S. D. (2003). Growth hormone resistance in chronic heart failure and its therapeutic implications. Journal of Cardiac Failure, 9, 219–226.
Clarke, B. A., Drujan, D., Willis, M. S., Murphy, L. O., Corpina, R. A., Burova, E., Rakhilin, S. V., Stitt, T. N., Patterson, C., Latres, E., & Glass, D. J. (2007). The E3 ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle. Cell Metabolism, 6, 376–385.
Coats, A. J. S., Ho, G. F., Prabhash, K., Von Haehling, S., Tilson, J., Brown, R., Beadle, J., Anker, S. D., & GRP, A.-O. S. (2016). Espindolol for the treatment and prevention of cachexia in patients with stage III/IV non-small cell lung cancer or colorectal cancer: A randomized, double-blind, placebo-controlled, international multicentre phase II study (the ACT-ONE trial). Journal of Cachexia, Sarcopenia and Muscle, 7, 355–365.
Codes, L., Asselah, T., Cazals-Hatem, D., Tubach, F., Vidaud, D., Parana, R., Bedossa, P., Valla, D., & Marcellin, P. (2007). Liver fibrosis in women with chronic hepatitis C: Evidence for the negative role of the menopause and steatosis and the potential benefit of hormone replacement therapy. Gut, 56, 390–395.
Cohen, S., Brault, J. J., Gygi, S. P., Glass, D. J., Valenzuela, D. M., Gartner, C., Latres, E., & Goldberg, A. L. (2009). During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. The Journal of Cell Biology, 185, 1083–1095.
Cohn, L., Feller, A. G., Draper, M. W., Rudman, I. W., & Rudman, D. (1993). Carpal tunnel syndrome and gynaecomastia during growth hormone treatment of elderly men with low circulating IGF-I concentrations. Clinical Endocrinology, 39, 417–425.
Constantin, D., Menon, M. K., Houchen-Wolloff, L., Morgan, M. D., Singh, S. J., Greenhaff, P., & Steiner, M. C. (2013). Skeletal muscle molecular responses to resistance training and dietary supplementation in COPD. Thorax, 68, 625–633.
Crawford, J., Johnston, M. A., Taylor, R. P., Dalton, J. T., & Steiner, M. S. (2014). Enobosarm and lean body mass in patients with non-small cell lung cancer. Journal of Clinical Oncology, 32, 9618–9618.
Creutzberg, E. C., Wouters, E. F., Mostert, R., Pluymers, R. J., & Schols, A. M. (2003). A role for anabolic steroids in the rehabilitation of patients with COPD? A double-blind, placebo-controlled, randomized trial. Chest, 124, 1733–1742.
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J. P., Rolland, Y., Schneider, S. M., Topinkova, E., Vandewoude, M., Zamboni, M., & European Working Group on Sarcopenia in Older, P. (2010). Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age and Ageing, 39, 412–423.
Cunha, T. F., Bacurau, A. V. N., Moreira, J. B. N., Paixao, N. A., Campos, J. C., Ferreira, J. C. B., Leal, M. L., Negrao, C. E., Moriscot, A. S., Wisloff, U., & Brum, P. C. (2012). Exercise training prevents oxidative stress and ubiquitin-proteasome system overactivity and reverse skeletal muscle atrophy in heart failure. Plos One, 7, e41701.
Dalton, J. T., Barnette, K. G., Bohl, C. E., Hancock, M. L., Rodriguez, D., Dodson, S. T., Morton, R. A., & Steiner, M. S. (2011). The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: Results of a double-blind, placebo-controlled phase II trial. Journal of Cachexia, Sarcopenia and Muscle, 2, 153–161.
Dasarathy, S., & Merli, M. (2016). Sarcopenia from mechanism to diagnosis and treatment in liver disease. Journal of Hepatology, 65, 1232–1244.
De Brito-Ashurst, I., Varagunam, M., Raftery, M. J., & Yaqoob, M. M. (2009). Bicarbonate supplementation slows progression of CKD and improves nutritional status. Journal of the American Society of Nephrology, 20, 2075–2084.
Del Fabbro, E., Hui, D., Nooruddin, Z. I., Dalal, S., Dev, R., Freer, G., Roberts, L., Palmer, J. L., & Bruera, E. (2010). Associations among hypogonadism, C-reactive protein, symptom burden, and survival in male cancer patients with cachexia: A preliminary report. Journal of Pain and Symptom Management, 39, 1016–1024.
Del Fabbro, E., Garcia, J. M., Dev, R., Hui, D., Williams, J., Engineer, D., Palmer, J. L., Schover, L., & Bruera, E. (2013). Testosterone replacement for fatigue in hypogonadal ambulatory males with advanced cancer: A preliminary double-blind placebo-controlled trial. Support Care Cancer, 21, 2599–2607.
Dennison, E. M., Sayer, A. A., & Cooper, C. (2017). Epidemiology of sarcopenia and insight into possible therapeutic targets. Nature Reviews Rheumatology, 13, 340–347.
Dieli-Conwright, C. M., Spektor, T. M., Rice, J. C., Sattler, F. R., & Schroeder, E. T. (2009). Hormone therapy attenuates exercise-induced skeletal muscle damage in postmenopausal women. Journal Applied Physiology (1985), 107, 853–858.
Dieli-Conwright, C. M., Spektor, T. M., Rice, J. C., Sattler, F. R., & Schroeder, E. T. (2012). Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women. Journal of Strength and Conditioning Research, 26, 1374–1382.
Dobs, A. S., Nguyen, T., Pace, C., & Roberts, C. P. (2002). Differential effects of oral estrogen versus oral estrogen-androgen replacement therapy on body composition in postmenopausal women. The Journal of Clinical Endocrinology and Metabolism, 87, 1509–1516.
Dobs, A. S., Boccia, R. V., Croot, C. C., Gabrail, N. Y., Dalton, J. T., Hancock, M. L., Johnston, M. A., & Steiner, M. S. (2013). Effects of enobosarm on muscle wasting and physical function in patients with cancer: A double-blind, randomised controlled phase 2 trial. Lancet Oncology, 14, 335–345.
Dong, J., Sundell, M. B., Pupim, L. B., Wu, P. S., Shintani, A., & Ikizler, T. A. (2011). The effect of resistance exercise to augment long-term benefits of intradialytic oral nutritional supplementation in chronic hemodialysis patients. Journal of Renal Nutrition, 21, 149–159.
Dos Santos, M. R., Sayegh, A. L. C., Bacurau, A. V. N., Arap, M. A., Brum, P. C., Pereira, R. M. R., Takayama, L., Barretto, A. C. P., Negrao, C. E., & Alves, M. J. D. N. (2016). Effect of exercise training and testosterone replacement on skeletal muscle wasting in patients with heart failure with testosterone deficiency. Mayo Clinic Proceedings, 91, 575–586.
Dubois, V., Laurent, M., Boonen, S., Vanderschueren, D., & Claessens, F. (2012). Androgens and skeletal muscle: Cellular and molecular action mechanisms underlying the anabolic actions. Cellular and Molecular Life Sciences, 69, 1651–1667.
Ebner, N., Elsner, S., Springer, J., & Von Haehling, S. (2014). Molecular mechanisms and treatment targets of muscle wasting and cachexia in heart failure: An overview. Current Opinion in Supportive and Palliative Care, 8, 15–24.
Evans, W. J. (2010). Skeletal muscle loss: Cachexia, sarcopenia, and inactivity. The American Journal of Clinical Nutrition, 91, 1123S–1127S.
Fazio, S., Sabatini, D., Capaldo, B., Vigorito, C., Giordano, A., Guida, R., Pardo, F., Biondi, B., & Sacca, L. (1996). A preliminary study of growth hormone in the treatment of dilated cardiomyopathy. New England Journal of Medicine, 334, 809–814.
Fearon, K. C. H., Barber, M. D., Moses, A. G., Ahmedzai, S. H., Taylor, G. S., Tisdale, M. J., & Murray, G. D. (2006). Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia. Journal of Clinical Oncology, 24, 3401–3407.
Fearon, K., Strasser, F., Anker, S. D., Bosaeus, I., Bruera, E., Fainsinger, R. L., Jatoi, A., Loprinzi, C., MacDonald, N., Mantovani, G., Davis, M., Muscaritoli, M., Ottery, F., Radbruch, L., Ravasco, P., Walsh, D., Wilcock, A., Kaasa, S., & Baracos, V. E. (2011). Definition and classification of cancer cachexia: An international consensus. Lancet Oncology, 12, 489–495.
Fenster, L. F. (1966). Nonefficacy of short-term anabolic steroid therapy in alcoholic liver disease. Annals of Internal Medicine, 65, 738.
Ferrando, A. A., Sheffield-Moore, M., Paddon-Jones, D., Wolfe, R. R., & Urban, R. J. (2003). Differential anabolic effects of testosterone and amino acid feeding in older men. The Journal of Clinical Endocrinology and Metabolism, 88, 358–362.
Ferreira, I. M., Verreschi, I. T., Nery, L. E., Goldstein, R. S., Zamel, N., Brooks, D., & Jardim, J. R. (1998). The influence of 6 months of oral anabolic steroids on body mass and respiratory muscles in undernourished COPD patients. Chest, 114, 19–28.
Ferry, Noirez, Page, C. L., Salah, I. B., Daegelen, & Rieu. (1999). Effects of anabolic/androgenic steroids on regenerating skeletal muscles in the rat. Acta Physiologica Scandinavica, 166, 105–110.
Flynn, M. A., Weaver-Osterholtz, D., Sharpe-Timms, K. L., Allen, S., & Krause, G. (1999). Dehydroepiandrosterone replacement in aging humans. The Journal of Clinical Endocrinology and Metabolism, 84, 1527–1533.
Fouque, D., Kalantar-Zadeh, K., Kopple, J., Cano, N., Chauveau, P., Cuppari, L., Franch, H., Ghuarnieri, G., Ikizler, T. A., Kaysen, G., Lindholm, B., Massy, Z., Mitch, W., Pineda, E., Stenvinkel, P., Trevinho-Becerra, A., & Wanner, C. (2008). A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney International, 73, 391–398.
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., McBurnie, M. A., & Cardiovascular Health Study Collaborative Research, G. (2001). Frailty in older adults: Evidence for a phenotype. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 56, M146–M156.
Fulster, S., Tacke, M., Sandek, A., Ebner, N., Tschope, C., Doehner, W., Anker, S. D., & Von Haehling, S. (2013). Muscle wasting in patients with chronic heart failure: Results from the studies investigating co-morbidities aggravating heart failure (SICA-HF). European Heart Journal, 34, 512–519.
Gallagher, D., Visser, M., De Meersman, R. E., Sepulveda, D., Baumgartner, R. N., Pierson, R. N., Harris, T., & Heymsfield, S. B. (1997). Appendicular skeletal muscle mass: Effects of age, gender, and ethnicity. Journal Applied Physiology (1985), 83, 229–239.
Gallagher, D., Ruts, E., Visser, M., Heshka, S., Baumgartner, R. N., Wang, J., Pierson, R. N., Pi-Sunyer, F. X., & Heymsfield, S. B. (2000). Weight stability masks sarcopenia in elderly men and women. American Journal of Physiology. Endocrinology and Metabolism, 279, E366–E375.
Garcia, J. M., Li, H., Mann, D., Epner, D., Hayes, T. G., Marcelli, M., & Cunningham, G. R. (2006). Hypogonadism in male patients with cancer. Cancer, 106, 2583–2591.
Garcia, J. M., Boccia, R. V., Graham, C. D., Yan, Y., Duus, E. M., Allen, S., & Friend, J. (2015). Anamorelin for patients with cancer cachexia: An integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials. Lancet Oncology, 16, 108–116.
Gielen, S., Adams, V., Mobius-Winkler, S., Linke, A., Erbs, S., Yu, J. T., Kempf, W., Schubert, A., Schuler, G., & Hambrecht, R. (2003). Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. Journal of the American College of Cardiology, 42, 861–868.
Glaser, R., & Dimitrakakis, C. (2013). Testosterone therapy in women: Myths and misconceptions. Maturitas, 74, 230–234.
Glass, D. J. (2005). Skeletal muscle hypertrophy and atrophy signaling pathways. The International Journal of Biochemistry & Cell Biology, 37, 1974–1984.
Gluud, C. (1986). Testosterone treatment of men with alcoholic cirrhosis – a double-blind-study. Hepatology, 6, 807–813.
Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., & Newman, A. B. (2006). The loss of skeletal muscle strength, mass, and quality in older adults: The health, aging and body composition study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 61, 1059–1064.
Gosker, H. R., Kubat, B., Schaart, G., Van Der Vusse, G. J., Wouters, E. F., & Schols, A. M. (2003). Myopathological features in skeletal muscle of patients with chronic obstructive pulmonary disease. The European Respiratory Journal, 22, 280–285.
Grinspoon, S., Corcoran, C., Lee, K., Burrows, B., Hubbard, J., Katznelson, L., Walsh, M., Guccione, A., Cannan, J., Heller, H., Basgoz, N., & Klibanski, A. (1996). Loss of lean body and muscle mass correlates with androgen levels in hypogonadal men with acquired immunodeficiency syndrome and wasting. The Journal of Clinical Endocrinology and Metabolism, 81, 4051–4058.
Grobe, Y. G., Rodriguez, G. P., Ramos, M. H., Uribe, M., & Sanchez, N. M. (2010). Prevalence of non alcoholic fatty liver disease in premenopausal, posmenopausal and polycystic ovary syndrome women. The role of estrogens. Annals of Hepatology, 9, 402–409.
Gross, D. N., Van Den Heuvel, A. P., & Birnbaum, M. J. (2008). The role of FoxO in the regulation of metabolism. Oncogene, 27, 2320–2336.
Grossmann, M., Hoermann, R., Gani, L., Chan, I., Cheung, A., Gow, P. J., Li, A., Zajac, J. D., & Angus, P. (2012). Low testosterone levels as an independent predictor of mortality in men with chronic liver disease. Clinical Endocrinology, 77, 323–328.
Grounds, M. D. (1987). Phagocytosis of necrotic muscle in muscle isografts is influenced by the strain, age, and sex of host mice. The Journal of Pathology, 153, 71–82.
Gulati, P., Gaspers, L. D., Dann, S. G., Joaquin, M., Nobukuni, T., Natt, F., Kozma, S. C., Thomas, A. P., & Thomas, G. (2008). Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. Cell Metabolism, 7, 456–465.
Gungor, O., Kircelli, F., Carrero, J. J., Asci, G., Toz, H., Tatar, E., Hur, E., Sever, M. S., Arinsoy, T., & Ok, E. (2010). Endogenous testosterone and mortality in male hemodialysis patients: Is it the result of aging? Clinical Journal of the American Society of Nephrology, 5, 2018–2023.
Haizlip, K. M., Harrison, B. C., & Leinwand, L. A. (2015). Sex-based differences in skeletal muscle kinetics and fiber-type composition. Physiology (Bethesda), 30, 30–39.
Hanai, T., Shiraki, M., Nishimura, K., Ohnishi, S., Imai, K., Suetsugu, A., Takai, K., Shimizu, M., & Moriwaki, H. (2015). Sarcopenia impairs prognosis of patients with liver cirrhosis. Nutrition, 31, 193–199.
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., blackman, M. R., & Baltimore Longitudinal Study of, A. (2001). Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. The Journal of Clinical Endocrinology and Metabolism, 86, 724–731.
Harrington, D., Chua, T. P., & Coats, A. J. S. (2000). The effect of salbutamol on skeletal muscle in chronic heart failure. International Journal of Cardiology, 73, 257–265.
Heimburger, O., Qureshi, A. R., Blaner, W. S., Berglund, L., & Stenvinkel, P. (2000). Hand-grip muscle strength, lean body mass, and plasma proteins as markers of nutritional status in patients with chronic renal failure close to start of dialysis therapy. American Journal of Kidney Diseases, 36, 1213–1225.
Herbst, K. L., & Bhasin, S. (2004). Testosterone action on skeletal muscle. Current Opinion in Clinical Nutrition and Metabolic Care, 7, 271–277.
Hetzler, K. L., Hardee, J. P., Lavoie, H. A., Murphy, E. A., & Carson, J. A. (2017). Ovarian function’s role during cancer cachexia progression in the female mouse. American Journal of Physiology. Endocrinology and Metabolism, 312, E447–E459.
Hong, D. S., Janku, F., Naing, A., Falchook, G. S., Piha-Paul, S., Wheler, J. J., Fu, S. Q., Tsimberidou, A. M., Stecher, M., Mohanty, P., Simard, J., & Kurzrock, R. (2015). Xilonix, a novel true human antibody targeting the inflammatory cytokine interleukin-1 alpha, in non-small cell lung cancer. Investigational New Drugs, 33, 621–631.
Hopkinson, N. S., Tennant, R. C., Dayer, M. J., Swallow, E. B., Hansel, T. T., Moxham, J., & Polkey, M. I. (2007). A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease. Respiratory Research, 8, 25.
Horstman, A. M., Dillon, E. L., Urban, R. J., & Sheffield-Moore, M. (2012). The role of androgens and estrogens on healthy aging and longevity. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 67, 1140–1152.
Huang, H., & Tindall, D. J. (2007). Dynamic FoxO transcription factors. Journal of Cell Science, 120, 2479–2487.
Iellamo, F., Volterrani, M., Caminiti, G., Karam, R., Massaro, R., Fini, M., Collins, P., & Rosano, G. M. C. (2010). Testosterone therapy in women with chronic heart failure a pilot double-blind, randomized, placebo-controlled study. Journal of the American College of Cardiology, 56, 1310–1316.
Iglesias, P., Diez, J. J., Fernandez-Reyes, M. J., Aguilera, A., Burgues, S., Martinez-Ara, J., Miguel, J. L., Gomez-Pan, A., & Selgas, R. (1998). Recombinant human growth hormone therapy in malnourished dialysis patients: A randomized controlled study. American Journal of Kidney Diseases, 32, 454–463.
Igwebuike, A., Irving, B. A., Bigelow, M. L., Short, K. R., McConnell, J. P., & Nair, K. S. (2008). Lack of dehydroepiandrosterone effect on a combined endurance and resistance exercise program in postmenopausal women. The Journal of Clinical Endocrinology and Metabolism, 93, 534–538.
Ikizler, T. A., Pupim, L. B., Brouillette, J. R., Levenhagen, D. K., Farmer, K., Hakim, R. M., & Flakoll, P. J. (2002). Hemodialysis stimulates muscle and whole body protein loss and alters substrate oxidation. American Journal of Physiology. Endocrinology and Metabolism, 282, E107–E116.
Isgaard, J., Bergh, C. H., Caidahl, K., Lomsky, M., Hjalmarson, A., & Bengtsson, B. A. (1998). A placebo-controlled study of growth hormone in patients with congestive heart failure. European Heart Journal, 19, 1704–1711.
Itoh, T., Nagaya, N., Yoshikawa, M., Fukuoka, A., Takenaka, H., Simizu, Y., Haruta, Y., Oya, H., Yamagishi, M., Hosoda, H., Kangawa, K., & Kimura, H. (2004). Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 170, 879–882.
Jang, S. W., Yang, S. J., Srinivasan, S., & Ye, K. (2007). Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation. The Journal of Biological Chemistry, 282, 30836–30844.
Janssen, I., Heymsfield, S. B., Wang, Z. M., & Ross, R. (2000). Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr. Journal Applied Physiology (1985), 89, 81–88.
Janssen, I., Baumgartner, R. N., Ross, R., Rosenberg, I. H., & Roubenoff, R. (2004a). Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. American Journal of Epidemiology, 159, 413–421.
Janssen, I., Shepard, D. S., Katzmarzyk, P. T., & Roubenoff, R. (2004b). The healthcare costs of sarcopenia in the United States. Journal of the American Geriatrics Society, 52, 80–85.
Jasuja, R., & Lebrasseur, N. K. (2014). Regenerating skeletal muscle in the face of aging and disease. American Journal of Physical Medicine & Rehabilitation, 93, S88–S96.
Jedrzejuk, D., Medras, M., Milewicz, A., & Demissie, M. (2003). Dehydroepiandrosterone replacement in healthy men with age-related decline of DHEA-S: Effects on fat distribution, insulin sensitivity and lipid metabolism. The Aging Male, 6, 151–156.
Johansen, K. L., Painter, P. L., Sakkas, G. K., Gordon, P., Doyle, J., & Shubert, T. (2006). Effects of resistance exercise training and nandrolone decanoate on body composition and muscle function among patients who receive hemodialysis: A randomized, controlled trial. Journal of the American Society of Nephrology, 17, 2307–2314.
Ju, C. R., & Chen, R. C. (2012). Serum myostatin levels and skeletal muscle wasting in chronic obstructive pulmonary disease. Respiratory Medicine, 106, 102–108.
Kaizu, Y., Ohkawa, S., Odamaki, M., Ikegaya, N., Hibi, I., Miyaji, K., & Kumagai, H. (2003). Association between inflammatory mediators and muscle mass in long-term hemodialysis patients. American Journal of Kidney Diseases, 42, 295–302.
Kamada, Y., Kiso, S., Yoshida, Y., Chatani, N., Kizu, T., Hamano, M., Tsubakio, M., Takemura, T., Ezaki, H., Hayashi, N., & Takehara, T. (2011). Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet. American Journal of Physiology. Gastrointestinal and Liver Physiology, 301, G1031–G1043.
Kamalakkannan, G., Petrilli, C. M., George, I., Lamanca, J., McLaughlin, B. T., Shane, E., Mancini, D. M., & Maybaum, S. (2008). Clenbuterol increases lean muscle mass but not endurance in patients with chronic heart failure. Journal of Heart and Lung Transplantation, 27, 457–461.
Kenny, A. M., Boxer, R. S., Kleppinger, A., Brindisi, J., Feinn, R., & Burleson, J. A. (2010). Dehydroepiandrosterone combined with exercise improves muscle strength and physical function in frail older women. Journal of the American Geriatrics Society, 58, 1707–1714.
Khor, S. C., Abdul Karim, N., Ngah, W. Z., Yusof, Y. A., & Makpol, S. (2014). Vitamin E in sarcopenia: Current evidences on its role in prevention and treatment. Oxidative Medicine and Cellular Longevity, 2014, 914853.
Kopple, J. D., Wang, H. Y., Casaburi, R., Fournier, M., Lewis, M. I., Taylor, W., & Storer, T. W. (2007). Exercise in maintenance hemodialysis patients induces transcriptional changes in genes favoring anabolic muscle. Journal of the American Society of Nephrology, 18, 2975–2986.
Kovacheva, E. L., Hikim, A. P., Shen, R., Sinha, I., & Sinha-Hikim, I. (2010). Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways. Endocrinology, 151, 628–638.
Krasnoff, J. B., Basaria, S., Pencina, M. J., Jasuja, G. K., Vasan, R. S., Ulloor, J., Zhang, A., Coviello, A., Kelly-Hayes, M., D’Agostino, R. B., Wolf, P. A., Bhasin, S., & Murabito, J. M. (2010). Free testosterone levels are associated with mobility limitation and physical performance in community-dwelling men: The Framingham Offspring Study. The Journal of Clinical Endocrinology and Metabolism, 95, 2790–2799.
La Colla, A., Pronsato, L., Milanesi, L., & Vasconsuelo, A. (2015). 17beta-estradiol and testosterone in sarcopenia: Role of satellite cells. Ageing Research Reviews, 24, 166–177.
Lagirand-Cantaloube, J., Offner, N., Csibi, A., Leibovitch, M. P., Batonnet-Pichon, S., Tintignac, L. A., Segura, C. T., & Leibovitch, S. A. (2008). The initiation factor eIF3-f is a major target for atrogin1/MAFbx function in skeletal muscle atrophy. The EMBO Journal, 27, 1266–1276.
Lagirand-Cantaloube, J., Cornille, K., Csibi, A., Batonnet-Pichon, S., Leibovitch, M. P., & Leibovitch, S. A. (2009). Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo. PLoS One, 4, e4973.
Laviano, A., & Meguid, M. M. (1996). Nutritional issues in cancer management. Nutrition, 12, 358–371.
Lee, S. J., & McPherron, A. C. (2001). Regulation of myostatin activity and muscle growth. Proceedings of the National Academy of Sciences of the United States of America, 98, 9306–9311.
Legrain, S., Massien, C., Lahlou, N., Roger, M., Debuire, B., Diquet, B., Chatellier, G., Azizi, M., Faucounau, V., Porchet, H., Forette, F., & Baulieu, E. E. (2000). Dehydroepiandrosterone replacement administration: Pharmacokinetic and pharmacodynamic studies in healthy elderly subjects. The Journal of Clinical Endocrinology and Metabolism, 85, 3208–3217.
Lenk, K., Erbs, S., Hollriegel, R., Beck, E., Linke, A., Gielen, S., Mobius-Winkler, S., Sandri, M., Hambrecht, R., Schuler, G., & Adams, V. (2012). Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure. European Journal of Preventive Cardiology, 19, 404–411.
Lenk, K., Palus, S., Schur, R., Datta, R., Dong, J., Culler, M. D., Anker, S., Springer, J., Schuler, G., & Adams, V. (2013). Effect of ghrelin and its analogues, BIM-28131 and BIM-28125, on the expression of myostatin in a rat heart failure model. Journal of Cachexia, Sarcopenia and Muscle, 4, 63–69.
Levine, B., Kalman, J., Mayer, L., Fillit, H. M., & Packer, M. (1990). Elevated circulating levels of tumor-necrosis-factor in severe chronic heart-failure. New England Journal of Medicine, 323, 236–241.
Levinson, B. G. J. (2012). Randomized study of the efficacy and safety of SUN11031 (synthetic human ghrelin) in cachexia associated with chronic obstructive pulmonary disease. e-SPEN Journal, 7, e171–e175.
Lindberg, S., Jensen, J. S., Bjerre, M., Pedersen, S. H., Frystyk, J., Flyvbjerg, A., & Mogelvang, R. (2014). Cardio-adipose tissue cross-talk: Relationship between adiponectin, plasma pro brain natriuretic peptide and incident heart failure. European Journal of Heart Failure, 16, 633–638.
Lindle, R. S., Metter, E. J., Lynch, N. A., Fleg, J. L., Fozard, J. L., Tobin, J., Roy, T. A., & Hurley, B. F. (1997). Age and gender comparisons of muscle strength in 654 women and men aged 20–93 yr. Journal Applied Physiology (1985), 83, 1581–1587.
Lund, L. H., Williams, J. J., Freda, P., Lamanca, J. J., Lejemtel, T. H., & Mancini, D. M. (2009). Ghrelin resistance occurs in severe heart failure and resolves after heart transplantation. European Journal of Heart Failure, 11, 789–794.
Lundholm, K., Gunnebo, L., Korner, U., Iresjo, B. M., Engstrom, C., Hyltander, A., Smedh, U., & Bosaeus, I. (2010). Effects by daily long term provision of ghrelin to unselected weight-losing cancer patients a randomized double-blind study. Cancer, 116, 2044–2052.
Luo, F. M., Liu, X. J., Li, S. Q., Wang, Z. L., Liu, C. T., & Yuan, Y. M. (2005). Circulating ghrelin in patients with chronic obstructive pulmonary disease. Nutrition, 21, 793–798.
MacLean, H. E., Chiu, W. S., Notini, A. J., Axell, A. M., Davey, R. A., McManus, J. F., Ma, C., Plant, D. R., Lynch, G. S., & Zajac, J. D. (2008). Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice. The FASEB Journal, 22, 2676–2689.
Malkin, C. J., Pugh, P. J., West, J. N., Van Beek, E., Jones, T. H., & Channer, K. S. (2006). Testosterone therapy in men with moderate severity heart failure: A double blind RCT. European Heart Journal, 27, 23–23.
Marcen, R., Teruel, J. L., Delacal, M. A., Gamez, C., Caramelo, J., Herrero, J. A., Hernandez, E., Dearribas, G., Jarillo, M. D., Montoyo, C., Revuelta, K. L., Perez, R., Martinez, J., Miguel, J. L., Naya, M., Sanz, P., Sanchez, A., Caparros, L., Chacon, J. C., Paraiso, V., Oliet, A., Vigil, A., Sanz, R., Tornero, F., Lozano, L., Diaz, R., Vazquez, I., Ruiz, Lamas, S., Naranjo, J., & Hernando, P. (1997). The impact of malnutrition in morbidity and mortality in stable haemodialysis patients. Nephrology, Dialysis, Transplantation, 12, 2324–2331.
Mauras, N., Hayes, V., Welch, S., Rini, A., Helgeson, K., Dokler, M., Veldhuis, J. D., & Urban, R. J. (1998). Testosterone deficiency in young men: Marked alterations in whole body protein kinetics, strength, and adiposity. The Journal of Clinical Endocrinology and Metabolism, 83, 1886–1892.
Mcentegart, M. B., Awede, B., Petrie, M. C., Sattar, N., Dunn, F. G., MacFarlane, N. G., & McMurray, J. J. V. (2007). Increase in serum adiponectin concentration in patients with heart failure and cachexia: Relationship with leptin, other cytokines, and B-type natriuretic peptide. European Heart Journal, 28, 829–835.
Mckenzie, J., Fisher, B. M., Jaap, A. J., Stanley, A., Paterson, K., & Sattar, N. (2006). Effects of HRT on liver enzyme levels in women with type 2 diabetes: A randomized placebo-controlled trial. Clinical Endocrinology, 65, 40–44.
Mcmahon, C. D., Chai, R., Radley-Crabb, H. G., Watson, T., Matthews, K. G., Sheard, P. W., Soffe, Z., Grounds, M. D., & Shavlakadze, T. (2014). Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice. Scandinavian Journal of Medicine & Science in Sports, 24, e423–e435.
Mehra, M. R., Lavie, C. J., Ventura, H. O., & Milani, R. V. (2006). Fish oils produce anti-inflammatory effects and improve body weight in severe heart failure. Journal of Heart and Lung Transplantation, 25, 834–838.
Mendenhall, C. L., Anderson, S., Garcia-Pont, P., Goldberg, S., Kiernan, T., Seeff, L. B., Sorrell, M., Tamburro, C., Weesner, R., Zetterman, R., et al. (1984). Short-term and long-term survival in patients with alcoholic hepatitis treated with oxandrolone and prednisolone. The New England Journal of Medicine, 311, 1464–1470.
Mendenhall, C. L., Moritz, T. E., Roselle, G. A., Morgan, T. R., Nemchausky, B. A., Tamburro, C. H., Schiff, E. R., McClain, C. J., Marsano, L. S., Allen, J. I., Samanta, A., Weesner, R. E., Henderson, W., Cartside, P., Chen, T. S., French, S. W., & Chedid, A. (1993). A study of oral nutritional support with oxandrolone in malnourished patients with alcoholic hepatitis – results of a department-of-veterans-affairs cooperative study. Hepatology, 17, 564–576.
Miki, K., Maekura, R., Nagaya, N., Nakazato, M., Kimura, H., Murakami, S., Ohnishi, S., Hiraga, T., Miki, M., Kitada, S., Yoshimura, K., Tateishi, Y., Arimura, Y., Matsumoto, N., Yoshikawa, M., Yamahara, K., & Kangawa, K. (2012). Ghrelin treatment of cachectic patients with chronic obstructive pulmonary disease: A multicenter, randomized, double-blind, placebo-controlled trial. Plos One, 7, e35708.
Milanovic, Z., Pantelic, S., Trajkovic, N., Sporis, G., Kostic, R., & James, N. (2013). Age-related decrease in physical activity and functional fitness among elderly men and women. Clinical Interventions in Aging, 8, 549–556.
Mirdamadi, A., Garakyaraghi, M., Pourmoghaddas, A., Bahmani, A., Mahmoudi, H., & Gharipour, M. (2014). Beneficial effects of testosterone therapy on functional capacity, cardiovascular parameters, and quality of life in patients with congestive heart failure. Biomed Research International, 2014, 1–7.
Mitch, W. E. (2007). Malnutrition is an unusual cause of decreased muscle mass in chronic kidney disease. Journal of Renal Nutrition, 17, 66–69.
Mitchell, W. K., Williams, J., Atherton, P., Larvin, M., Lund, J., & Narici, M. (2012). Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review. Frontiers in Physiology, 3, 260.
Miyazaki, M., & Esser, K. A. (2009). Cellular mechanisms regulating protein synthesis and skeletal muscle hypertrophy in animals. Journal Applied Physiology (1985), 106, 1367–1373.
Mondello, P., Mian, M., Aloisi, C., Fama, F., Mondello, S., & Pitini, V. (2015). Cancer cachexia syndrome: Pathogenesis, diagnosis, and new therapeutic options. Nutrition and Cancer-an International Journal, 67, 12–26.
Montano-Loza, A. J. (2014). Severe muscle depletion predicts postoperative length of stay but is not associated with survival after liver transplantation. Liver Transplantation, 20, 1424–1424.
Mooradian, A. D., Morley, J. E., & Korenman, S. G. (1987). Biological actions of androgens. Endocrine Reviews, 8, 1–28.
Morales, A. J., Haubrich, R. H., Hwang, J. Y., Asakura, H., & Yen, S. S. C. (1998). The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clinical Endocrinology, 49, 421–432.
Moran, A. L., Nelson, S. A., Landisch, R. M., Warren, G. L., & Lowe, D. A. (2007). Estradiol replacement reverses ovariectomy-induced muscle contractile and myosin dysfunction in mature female mice. Journal Applied Physiology (1985), 102, 1387–1393.
Mori, A., Nishino, T., Obata, Y., Nakazawa, M., Hirose, M., Yamashita, H., Uramatsu, T., Shinzato, K., & Kohno, S. (2013). The effect of active vitamin D administration on muscle mass in hemodialysis patients. Clinical Drug Investigation, 33, 837–846.
Morley, J. E. (2016). Pharmacologic options for the treatment of sarcopenia. Calcified Tissue International, 98, 319–333.
Morley, J. E., & Malmstrom, T. K. (2013). Frailty, sarcopenia, and hormones. Endocrinology and Metabolism Clinics of North America, 42, 391–405.
Morley, J. E., & Perry, H. M. (2003). Androgens and women at the menopause and beyond. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 58, M409–M416.
Morley, J. E., Thomas, D. R., & Wilson, M. M. G. (2006). Cachexia: Pathophysiology and clinical relevance. American Journal of Clinical Nutrition, 83, 735–743.
Murdoch, D. R., Rooney, E., Dargie, H. J., Shapiro, D., Morton, J. J., & McMurray, J. J. V. (1999). Inappropriately low plasma leptin concentration in the cachexia associated with chronic heart failure. Heart, 82, 352–356.
Nagaya, N., Moriya, J., Yasumura, Y., Uematsu, M., Ono, F., Shimizu, W., Ueno, K., Kitakaze, M., Miyatake, K., & Kangawa, K. (2004). Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation, 110, 3674–3679.
Nagaya, N., Itoh, T., Murakami, S., Oya, H., Uematsu, M., Miyatake, K., & Kangawa, K. (2005). Treatment of cachexia with ghrelin in patients with COPD. Chest, 128, 1187–1193.
Nair, K. S., Rizza, R. A., O’Brien, P., Dhatariya, K., Short, K. R., Nehra, A., Vittone, J. L., Klee, G. G., Basu, A., Basu, R., Cobelli, C., Toffolo, G., Dalla Man, C., Tindall, D. J., Melton, L. J., 3rd, Smith, G. E., Khosla, S., & Jensen, M. D. (2006). DHEA in elderly women and DHEA or testosterone in elderly men. The New England Journal of Medicine, 355, 1647–1659.
Nakae, J., Oki, M., & Cao, Y. (2008). The FoxO transcription factors and metabolic regulation. FEBS Letters, 582, 54–67.
Nakamura, N., Hara, T., Shibata, Y., Matsumoto, T., Nakamura, H., Ninomiya, S., Kito, Y., Kitagawa, J., Kanemura, N., Goto, N., Shiraki, M., Miyazaki, T., Takeuchi, T., Shimizu, M., & Tsurumi, H. (2015). Sarcopenia is an independent prognostic factor in male patients with diffuse large B-cell lymphoma. Annals of Hematology, 94, 2043–2053.
Narici, M. V., & Maffulli, N. (2010). Sarcopenia: Characteristics, mechanisms and functional significance. British Medical Bulletin, 95, 139–159.
Nass, R., Pezzoli, S. S., Oliveri, M. C., Patrie, J. T., Harrell, F. E., Jr., Clasey, J. L., Heymsfield, S. B., Bach, M. A., Vance, M. L., & Thorner, M. O. (2008). Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: A randomized trial. Annals of Internal Medicine, 149, 601–611.
Newman, A. B., & Brach, J. S. (2001). Gender gap in longevity and disability in older persons. Epidemiologic Reviews, 23, 343–350.
Orentreich, N., Brind, J. L., Vogelman, J. H., Andres, R., & Baldwin, H. (1992). Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men. The Journal of Clinical Endocrinology and Metabolism, 75, 1002–1004.
Ortega, F., Toral, J., Cejudo, P., Villagomez, R., Sanchez, H., Castillo, J., & Montemayor, T. (2002). Comparison of effects of strength and endurance training in patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 166, 669–674.
Osterziel, K. J., Strohm, O., Schuler, J., Friedrich, M., Hanlein, D., Willenbrock, R., Anker, S. D., Poole-Wilson, P. A., Ranke, M. B., & Dietz, R. (1998). Randomised, double-blind, placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy. Lancet, 351, 1233–1237.
Page, S. T., Amory, J. K., Bowman, F. D., Anawalt, B. D., Matsumoto, A. M., Bremner, W. J., & Tenover, J. L. (2005). Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. The Journal of Clinical Endocrinology and Metabolism, 90, 1502–1510.
Pahor, M., Guralnik, J. M., Ambrosius, W. T., Blair, S., Bonds, D. E., Church, T. S., Espeland, M. A., Fielding, R. A., Gill, T. M., Groessl, E. J., King, A. C., Kritchevsky, S. B., Manini, T. M., McDermott, M. M., Miller, M. E., Newman, A. B., Rejeski, W. J., Sink, K. M., Williamson, J. D., & Investigators, L. S. (2014). Effect of structured physical activity on prevention of major mobility disability in older adults: The LIFE study randomized clinical trial. JAMA, 311, 2387–2396.
Palus, S., Von Haehling, S., Doehner, W., Datta, R., Zhang, J., Dong, J. Z., Culler, M. D., Anker, S. D., & Springer, J. (2013). Effect of application route of the ghrelin analog BIM-28131 (RM-131) on body weight and body composition in a rat heart failure model. International Journal of Cardiology, 168, 2369–2374.
Papanicolaou, D. A., Ather, S. N., Zhu, H., Zhou, Y., Lutkiewicz, J., Scott, B. B., & Chandler, J. (2013). A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia. The Journal of Nutrition, Health & Aging, 17, 533–543.
Peng, S., Plank, L. D., McCall, J. L., Gillanders, L. K., McIlroy, K., & Gane, E. J. (2007). Body composition, muscle function, and energy expenditure in patients with liver cirrhosis: A comprehensive study. American Journal of Clinical Nutrition, 85, 1257–1266.
Percheron, G., Hogrel, J. Y., Denot-Ledunois, S., Fayet, G., Forette, F., Baulieu, E. E., Fardeau, M., Marini, J. F., & Double-Blind Placebo-Controlled, T. (2003). Effect of 1-year oral administration of dehydroepiandrosterone to 60- to 80-year-old individuals on muscle function and cross-sectional area: A double-blind placebo-controlled trial. Archives of Internal Medicine, 163, 720–727.
Perrini, S., Laviola, L., Carreira, M. C., Cignarelli, A., Natalicchio, A., & Giorgino, F. (2010). The GH/IGF1 axis and signaling pathways in the muscle and bone: Mechanisms underlying age-related skeletal muscle wasting and osteoporosis. The Journal of Endocrinology, 205, 201–210.
Pineda-Juarez, J. A., Sanchez-Ortiz, N. A., Castillo-Martinez, L., Orea-Tejeda, A., Cervantes-Gaytan, R., Keirns-Davis, C., Perez-Ocampo, C., Quiroz-Bautista, K., Tenorio-Dupont, M., & Ronquillo-Martinez, A. (2016). Changes in body composition in heart failure patients after a resistance exercise program and branched chain amino acid supplementation. Clinical Nutrition, 35, 41–47.
Plank, L. D., Gane, E. J., Peng, S., Muthu, C., Mathur, S., Gillanders, L., McIlroy, K., Donaghy, A. J., & McCall, J. L. (2008). Nocturnal nutritional supplementation improves total body protein status of patients with liver cirrhosis: A randomized 12-month trial. Hepatology, 48, 557–566.
Plant, P. J., Brooks, D., Faughnan, M., Bayley, T., Bain, J., Singer, L., Correa, J., Pearce, D., Binnie, M., & Batt, J. (2010). Cellular markers of muscle atrophy in chronic obstructive pulmonary disease. American Journal of Respiratory Cell and Molecular Biology, 42, 461–471.
Plata-Salaman, C. (2001). Cytokines and feeding. International Journal of Obesity, 25, S48–S52.
Pollanen, E., Ronkainen, P. H., Horttanainen, M., Takala, T., Puolakka, J., Suominen, H., Sipila, S., & Kovanen, V. (2010). Effects of combined hormone replacement therapy or its effective agents on the IGF-1 pathway in skeletal muscle. Growth Hormone & IGF Research, 20, 372–379.
Pomies, P., Rodriguez, J., Blaquiere, M., Sedraoui, S., Gouzi, F., Carnac, G., Laoudj-Chenivesse, D., Mercier, J., Prefaut, C., & Hayot, M. (2015). Reduced myotube diameter, atrophic signalling and elevated oxidative stress in cultured satellite cells from COPD patients. Journal of Cellular and Molecular Medicine, 19, 175–186.
Powers, S. K., Wiggs, M. P., Duarte, J. A., Zergeroglu, A. M., & Demirel, H. A. (2012). Mitochondrial signaling contributes to disuse muscle atrophy. American Journal of Physiology. Endocrinology and Metabolism, 303, E31–E39.
Prado, C. M. M., Baracos, V. E., McCargar, L. J., Reiman, T., Mourtzakis, M., Tonkin, K., Mackey, J. R., Koski, S., Pituskin, E., & Sawyer, M. B. (2009). Sarcopenia as a determinant of chemotherapy toxicity and time to tumor progression in metastatic breast cancer patients receiving capecitabine treatment. Clinical Cancer Research, 15, 2920–2926.
Pu, C. T., Johnson, M. T., Forman, D. E., Hausdorff, J. M., Roubenoff, R., Foldvari, M., Fielding, R. A., & Singh, M. A. F. (2001). Randomized trial of progressive resistance training to counteract the myopathy of chronic heart failure. Journal of Applied Physiology, 90, 2341–2350.
Pugh, P. J., Jones, R. D., West, J. N., Jones, T. H., & Channer, K. S. (2004). Testosterone treatment for men with chronic heart failure. Heart, 90, 446–447.
Puig-Vilanova, E., Rodriguez, D. A., Lloreta, J., Ausin, P., Pascual-Guardia, S., Broquetas, J., Roca, J., Gea, J., & Barreiro, E. (2015). Oxidative stress, redox signaling pathways, and autophagy in cachectic muscles of male patients with advanced COPD and lung cancer. Free Radical Biology & Medicine, 79, 91–108.
Puliyel, M. M., Vyas, G. P., & Mehta, G. S. (1977). Testosterone in management of cirrhosis of liver – controlled-study. Australian and New Zealand Journal of Medicine, 7, 596–599.
Quinten, C., Coens, C., Mauer, M., Comte, S., Sprangers, M. A. G., Cleeland, C., Osoba, D., Bjordal, K., Bottomley, A., & GRP, E. C. (2009). Baseline quality of life as a prognostic indicator of survival: A meta-analysis of individual patient data from EORTC clinical trials. Lancet Oncology, 10, 865–871.
Qureshi, A. R., Alvestrand, A., Danielsson, A., Divino-Filho, J. C., Gutierrez, A., Lindholm, B., & Bergstrom, J. (1998). Factors predicting malnutrition in hemodialysis patients: A cross-sectional study. Kidney International, 53, 773–782.
Raj, D. S. C., Zager, P., Shah, V. O., Dominic, E. A., Adeniyi, O., Blandon, P., Wolfe, R., & Ferrando, A. (2004). Protein turnover and amino acid transport kinetics in end-stage renal disease. American Journal of Physiology. Endocrinology and Metabolism, 286, E136–E143.
Rauchhaus, M., Doehner, W., Francis, D. P., Davos, C., Kemp, M., Liebenthal, C., Niebauer, J., Hooper, J., Volk, H. D., Coats, A. J. S., & Anker, S. D. (2000). Plasma cytokine parameters and mortality in patients with chronic heart failure. Circulation, 102, 3060–3067.
Reid, J., Noble, H., Slee, A., Davenport, A., Farrington, K., Fouque, D., Kalantar-Zadeh, K., Porter, S., Seres, D., Witham, M., & Maxwell, A. (2016). Distinguishing between cachexia, sarcopenia and protein energy wasting in end-stage renal disease patients on dialysis. Palliative Medical Hospital Care Open Journal, 2, e11–e13.
Rigas, J. R., Schuster, M., Orlov, S. V., Milovanovic, B., Prabhash, K., Smith, J. T., & GRP, A. S. (2010). Efect of ALD518, a humanized anti-IL-6 antibody, on lean body mass loss and symptoms in patients with advanced non-small cell lung cancer (NSCLC): Results of a phase II randomized double-blind safety and efficacy trial. Journal of Clinical Oncology, 28, 7622.
Ronkainen, P. H., Kovanen, V., Alen, M., Pollanen, E., Palonen, E. M., Ankarberg-Lindgren, C., Hamalainen, E., Turpeinen, U., Kujala, U. M., Puolakka, J., Kaprio, J., & Sipila, S. (2009). Postmenopausal hormone replacement therapy modifies skeletal muscle composition and function: A study with monozygotic twin pairs. Journal of Applied Physiology, 107, 25–33.
Rossignol, P., Masson, S., Barlera, S., Girerd, N., Castelnovo, A., Zannad, F., Clemenza, F., Tognoni, G., Anand, I. S., Cohn, J. N., Anker, S. D., Tavazzi, L., Latini, R., Investigator, G.-H, & Investigator, V.-H. (2015). Loss in body weight is an independent prognostic factor for mortality in chronic heart failure: Insights from the GISSI-HF and Val-HeFT trials. European Journal of Heart Failure, 17, 424–433.
Rossouw, J. E., Anderson, G. L., Prentice, R. L., Lacroix, A. Z., Kooperberg, C., Stefanick, M. L., Jackson, R. D., Beresford, S. A. A., Howard, B. V., Johnson, K. C., Kotchen, J. M., & Ockene, J. (2002). Risks and benefits of estrogen plus progestin in healthy postmenopausal women – principal results from the Women’s Health Initiative randomized controlled trial. JAMA-Journal of the American Medical Association, 288, 321–333.
Roth, S. M., Martel, G. F., Ivey, F. M., Lemmer, J. T., Metter, E. J., Hurley, B. F., & Rogers, M. A. (2000). High-volume, heavy-resistance strength training and muscle damage in young and older women. Journal Applied Physiology (1985), 88, 1112–1118.
Rozentryt, P., Von Haehling, S., Lainscak, M., Nowak, J. U., Kalantar-Zadeh, K., Polonski, L., & Anker, S. D. (2010). The effects of a high-caloric protein-rich oral nutritional supplement in patients with chronic heart failure and cachexia on quality of life, body composition, and inflammation markers: A randomized, double-blind pilot study. Journal of Cachexia, Sarcopenia and Muscle, 1, 35–42.
Rudman, D., Feller, A. G., Nagraj, H. S., Gergans, G. A., Lalitha, P. Y., Goldberg, A. F., Schlenker, R. A., Cohn, L., Rudman, I. W., & Mattson, D. E. (1990). Effects of human growth hormone in men over 60 years old. The New England Journal of Medicine, 323, 1–6.
Rutten, E. P. A., Franssen, F. M. E., Engelen, M. P. K. J., Wouters, E. F. M., Deutz, N. E. P., & Schols, A. M. W. J. (2006). Greater whole-body myofibrillar protein breakdown in cachectic patients with chronic obstructive pulmonary disease. American Journal of Clinical Nutrition, 83, 829–834.
Sacheck, J. M., Hyatt, J. P., Raffaello, A., Jagoe, R. T., Roy, R. R., Edgerton, V. R., Lecker, S. H., & Goldberg, A. L. (2007). Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases. The FASEB Journal, 21, 140–155.
Salih, D. A., & Brunet, A. (2008). FoxO transcription factors in the maintenance of cellular homeostasis during aging. Current Opinion in Cell Biology, 20, 126–136.
Samaras, N., Samaras, D., Frangos, E., Forster, A., & Philippe, J. (2013). A review of age-related dehydroepiandrosterone decline and its association with well-known geriatric syndromes: Is treatment beneficial? Rejuvenation Research, 16, 285–294.
Sanchez-Lara, K., Turcott, J. G., Juarez-Hernandez, E., Nunez-Valencia, C., Villanueva, G., Guevara, P., De La Torre-Vallejo, M., Mohar, A., & Arrieta, O. (2014). Effects of an oral nutritional supplement containing eicosapentaenoic acid on nutritional and clinical outcomes in patients with advanced non-small cell lung cancer: Randomised trial. Clinical Nutrition, 33, 1017–1023.
Sandri, M. (2008). Signaling in muscle atrophy and hypertrophy. Physiology (Bethesda), 23, 160–170.
Schols, A. M. W. J., Soeters, P. B., Mostert, R., Pluymers, R. J., & Wouters, E. F. M. (1995). Physiological-effects of nutritional support and anabolic-steroids in patients with chronic obstructive pulmonary-disease – a placebo-controlled randomized trial. American Journal of Respiratory and Critical Care Medicine, 152, 1268–1274.
Sergi, G., Coin, A., Marin, S., Vianello, A., Manzan, A., Peruzza, S., Inelmen, E. M., Busetto, L., Mulone, S., & Enzi, G. (2006). Body composition and resting energy expenditure in elderly mate patients with chronic obstructive pulmonary disease. Respiratory Medicine, 100, 1918–1924.
Serra-Prat, M., Papiol, M., Monteis, R., Palomera, E., & Cabre, M. (2015). Relationship between plasma ghrelin levels and sarcopenia in elderly subjects: A cross-sectional study. The Journal of Nutrition, Health & Aging, 19, 669–672.
Sharma, S., Arneja, A., McLean, L., Duerksen, D., Leslie, W., Sciberras, D., & Lertzman, M. (2008). Anabolic steroids in COPD: A review and preliminary results of a randomized trial. Chronic Respiratory Disease, 5, 169–176.
Simons, J. P. F. H. A., Schols, A. M. W. J., Buurman, W. A., & Wouters, E. F. M. (1999). Weight loss and low body cell mass in males with lung cancer: Relationship with systemic inflammation, acute-phase response, resting energy expenditure, and catabolic and anabolic hormones. Clinical Science, 97, 215–223.
Sinclair, M., Gow, P. J., Grossmann, M., & Angus, P. W. (2016a). Review article: Sarcopenia in cirrhosis – aetiology, implications and potential therapeutic interventions. Alimentary Pharmacology & Therapeutics, 43, 765–777.
Sinclair, M., Grossmann, M., Angus, P. W., Hoermann, R., Hey, P., Scodellaro, T., & Gow, P. J. (2016b). Low testosterone as a better predictor of mortality than sarcopenia in men with advanced liver disease. Journal of Gastroenterology and Hepatology, 31, 661–667.
Sinha-Hikim, I., Arver, S., Beall, G., Shen, R., Guerrero, M., Sattler, F., Shikuma, C., Nelson, J. C., Landgren, B. M., Mazer, N. A., & Bhasin, S. (1998). The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virus-infected women. The Journal of Clinical Endocrinology and Metabolism, 83, 1312–1318.
Sinha-Hikim, I., Taylor, W. E., Gonzalez-Cadavid, N. F., Zheng, W., & Bhasin, S. (2004). Androgen receptor in human skeletal muscle and cultured muscle satellite cells: Up-regulation by androgen treatment. The Journal of Clinical Endocrinology and Metabolism, 89, 5245–5255.
Sipila, S., Taaffe, D. R., Cheng, S., Puolakka, J., Toivanen, J., & Suominen, H. (2001). Effects of hormone replacement therapy and high-impact physical exercise on skeletal muscle in post-menopausal women: A randomized placebo-controlled study. Clinical Science (London, England), 101, 147–157.
Sipila, S., Narici, M., Kjaer, M., Pollanen, E., Atkinson, R. A., Hansen, M., & Kovanen, V. (2013). Sex hormones and skeletal muscle weakness. Biogerontology, 14, 231–245.
Snyder, P. J., Peachey, H., Hannoush, P., Berlin, J. A., Loh, L., Lenrow, D. A., Holmes, J. H., Dlewati, A., Santanna, J., Rosen, C. J., & Strom, B. L. (1999). Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. The Journal of Clinical Endocrinology and Metabolism, 84, 2647–2653.
Snyder, P. J., Bhasin, S., Cunningham, G. R., Matsumoto, A. M., Stephens-Shields, A. J., Cauley, J. A., Gill, T. M., Barrett-Connor, E., Swerdloff, R. S., Wang, C., Ensrud, K. E., Lewis, C. E., Farrar, J. T., Cella, D., Rosen, R. C., Pahor, M., Crandall, J. P., Molitch, M. E., Cifelli, D., Dougar, D., Fluharty, L., Resnick, S. M., Storer, T. W., Anton, S., Basaria, S., Diem, S. J., Hou, X., Mohler, E. R., 3rd, Parsons, J. K., Wenger, N. K., Zeldow, B., Landis, J. R., EELLENBERG, S. S., & Testosterone Trials, I. (2016). Effects of testosterone treatment in older men. The New England Journal of Medicine, 374, 611–624.
Sorensen, M. B., Rosenfalck, A. M., Hojgaard, L., & Ottesen, B. (2001). Obesity and sarcopenia after menopause are reversed by sex hormone replacement therapy. Obesity Research, 9, 622–626.
Stenvinkel, P., Barany, P., Chung, S. H., Lindholm, B., & Heimburger, O. (2002). A comparative analysis of nutritional parameters as predictors of outcome in male and female ESRD patients. Nephrology, Dialysis, Transplantation, 17, 1266–1274.
Stephens, N. A., Gray, C., MacDonald, A. J., Tan, B. H., Gallagher, I. J., Skipworth, R. J. E., Ross, J. A., Fearon, K. C. H., & Greig, C. A. (2012). Sexual dimorphism modulates the impact of cancer cachexia on lower limb muscle mass and function. Clinical Nutrition, 31, 499–505.
Stitt, T. N., Drujan, D., Clarke, B. A., Panaro, F., Timofeyva, Y., Kline, W. O., Gonzalez, M., Yancopoulos, G. D., & Glass, D. J. (2004). The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Molecular Cell, 14, 395–403.
Stout, M., Tew, G. A., Doll, H., Zwierska, I., Woodroofe, N., Channer, K. S., & Saxton, J. M. (2012). Testosterone therapy during exercise rehabilitation in male patients with chronic heart failure who have low testosterone status: A double-blind randomized controlled feasibility study. American Heart Journal, 164, 893–901.
Straight, C. R., Brady, A. O., & Evans, E. (2015). Sex-specific relationships of physical activity, body composition, and muscle quality with lower-extremity physical function in older men and women. Menopause, 22, 297–303.
Strasser, F., Palmer, J. L., Schover, L. R., Yusuf, S. W., Pisters, K., Vassilopoulou-Sellin, R., Degracia, B., Willey, J. S., & Bruera, E. (2006). The impact of hypogonadism and autonomic dysfunction on fatigue, emotional function, and sexual desire in male patients with advanced cancer: A pilot study. Cancer, 107, 2949–2957.
Stratton, R. J., Bircher, G., Fouque, D., Stenvinkel, P., De Mutsert, R., Engfer, M., & Elia, M. (2005). Multinutrient oral supplements and tube feeding in maintenance dialysis: A systematic review and meta-analysis. American Journal of Kidney Diseases, 46, 387–405.
Sun, L. J., Sun, Y. N., Chen, S. J., Liu, S., & Jiang, G. R. (2017). Resveratrol attenuates skeletal muscle atrophy induced by chronic kidney disease via MuRF1 signaling pathway. Biochemical and Biophysical Research Communications, 487, 83–89.
Supasyndh, O., Satirapoj, B., Aramwit, P., Viroonudomphol, D., Chaiprasert, A., Thanachatwej, V., Vanichakarn, S., & Kopple, J. D. (2013). Effect of oral anabolic steroid on muscle strength and muscle growth in hemodialysis patients. Clinical Journal of the American Society of Nephrology, 8, 271–279.
Svartberg, J., Aasebo, U., Hjalmarsen, A., Sundsfjord, J., & Jorde, R. (2004). Testosterone treatment improves body composition and sexual function in men with COPD, in a 6-month randomized controlled trial. Respiratory Medicine, 98, 906–913.
Szabo, T., Scherbakov, N., Sandek, A., Kung, T., Von Haehling, S., Lainscak, M., Jankowska, E. A., Rudovich, N., Anker, S. D., Frystyk, J., Flyvbjerg, A., Pfeiffer, A. F. H., & Doehner, W. (2014). Plasma adiponectin in heart failure with and without cachexia: Catabolic signal linking catabolism, symptomatic status, and prognosis. Nutrition, Metabolism, and Cardiovascular Diseases, 24, 50–56.
Taira, A. V., Merrick, G. S., Galbreath, R. W., Butler, W. M., Wallner, K. E., Allen, Z. A., Lief, J. H., & Adamovich, E. (2009). Pretreatment serum testosterone and androgen deprivation: Effect on disease recurrence and overall survival in prostate cancer patients treated with brachytherapy. International Journal of Radiation Oncology, Biology, Physics, 74, 1143–1149.
Tandon, P., Ney, M., Irwin, I., Ma, M. M., Gramlich, L., Bain, V. G., Esfandiari, N., Baracos, V., Montano-Loza, A. J., & Myers, R. P. (2012). Severe muscle depletion in patients on the liver transplant wait list: Its prevalence and independent prognostic value. Liver Transplantation, 18, 1209–1216.
Teixeira, P. J., Going, S. B., Houtkooper, L. B., Metcalfe, L. L., Blew, R. M., Flint-Wagner, H. G., Cussler, E. C., Sardinha, L. B., & Lohman, T. G. (2003). Resistance training in postmenopausal women with and without hormone therapy. Medicine and Science in Sports and Exercise, 35, 555–562.
Temel, J. S., Abernethy, A. P., Currow, D. C., Friend, J., Duus, E. M., Yan, Y., & Fearon, K. C. (2016). Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): Results from two randomised, double-blind, phase 3 trials. Lancet Oncology, 17, 519–531.
Theriault, M. E., Pare, M. E., Maltais, F., & Debigare, R. (2012). Satellite cells senescence in limb muscle of severe patients with COPD. Plos One, 7, e39124.
Thompson, L. V. (2009). Age-related muscle dysfunction. Experimental Gerontology, 44, 106–111.
Toma, M., McAlister, F. A., Coglianese, E. E., Vidi, V., Vasaiwala, S., Bakal, J. A., Armstrong, P. W., & Ezekowitz, J. A. (2012). Testosterone supplementation in heart failure a meta-analysis. Circulation. Heart Failure, 5, 315–321.
Traish, A. M., Kang, H. P., Saad, F., & Guay, A. T. (2011). Dehydroepiandrosterone (DHEA) – a precursor steroid or an active hormone in human physiology. The Journal of Sexual Medicine, 8, 2960–2982. quiz 2983.
Tseng, L. A., Delmonico, M. J., Visser, M., Boudreau, R. M., Goodpaster, B. H., Schwartz, A. V., Simonsick, E. M., Satterfield, S., Harris, T., & Newman, A. B. (2014). Body composition explains sex differential in physical performance among older adults. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 69, 93–100.
Turola, E., Petta, S., Vanni, E., Milosa, F., Valenti, L., Critelli, R., Miele, L., Maccio, L., Calvaruso, V., Fracanzani, A. L., Bianchini, M., Raos, N., Bugianesi, E., Mercorella, S., Di Giovanni, M., Craxi, A., Fargion, S., Grieco, A., Camma, C., Cotelli, F., & Villa, E. (2015). Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis. Disease Models & Mechanisms, 8, 1037–1046.
Utech, A. E., Tadros, E. M., Hayes, T. G., & Garcia, J. M. (2012). Predicting survival in cancer patients: The role of cachexia and hormonal, nutritional and inflammatory markers. Journal of Cachexia, Sarcopenia and Muscle, 3, 245–251.
Uzum, A. K., Aydin, M. M., Tutuncu, Y., Omer, B., Kiyan, E., & Alagol, F. (2014). Serum ghrelin and adiponectin levels are increased but serum leptin level is unchanged in low weight chronic obstructive pulmonary disease patients. European Journal of Internal Medicine, 25, 364–369.
Valentova, M., Von Haehling, S., Bauditz, J., Doehner, W., Ebner, N., Bekfani, T., Elsner, S., Sliziuk, V., Scherbakov, N., Murin, J., Anker, S. D., & Sandek, A. (2016). Intestinal congestion and right ventricular dysfunction: A link with appetite loss, inflammation, and cachexia in chronic heart failure. European Heart Journal, 37, 1684–1691.
Van Den Beld, A. W., De Jong, F. H., Grobbee, D. E., Pols, H. A., & Lamberts, S. W. (2000). Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. The Journal of Clinical Endocrinology and Metabolism, 85, 3276–3282.
Van Den Borst, B., Gosker, H. R., Koster, A., Yu, B., Kritchevsky, S. B., Liu, Y., Meibohm, B., Rice, T. B., Shlipak, M., Yende, S., Harris, T. B., Schols, A. M., Health, A, & Body Composition, S. (2012). The influence of abdominal visceral fat on inflammatory pathways and mortality risk in obstructive lung disease. American Journal of Clinical Nutrition, 96, 516–526.
Vasconsuelo, A., Pronsato, L., Ronda, A. C., Boland, R., & Milanesi, L. (2011). Role of 17beta-estradiol and testosterone in apoptosis. Steroids, 76, 1223–1231.
Velema, M. S., Kwa, B. H., & De Ronde, W. (2012). Should androgenic anabolic steroids be considered in the treatment regime of selected chronic obstructive pulmonary disease patients? Current Opinion in Pulmonary Medicine, 18, 118–124.
Vescovo, G., Volterrani, M., Zennaro, R., Sandri, M., Ceconi, C., Lorusso, R., Ferrari, R., Ambrosio, G. B., & Dalla Libera, L. (2000). Apoptosis in the skeletal muscle of patients with heart failure: Investigation of clinical and biochemical changes. Heart, 84, 431–437.
Vestbo, J., Prescott, E., Almdal, T., Dahl, M., Nordestgaard, B. G., Andersen, T., Sorensen, T. I. A., & Lange, P. (2006). Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample – findings from the Copenhagen City Heart Study. American Journal of Respiratory and Critical Care Medicine, 173, 79–83.
Villareal, D. T., & Holloszy, J. O. (2004). Effect of DHEA on abdominal fat and insulin action in elderly women and men: A randomized controlled trial. JAMA, 292, 2243–2248.
Vivodtzev, I., Pepin, J. L., Vottero, G., Mayer, V., Porsin, B., Levy, P., & Wuyam, B. (2006). Improvement in quadriceps strength and dyspnea in daily tasks after 1 month of electrical stimulation in severely deconditioned and malnourished COPD. Chest, 129, 1540–1548.
Vivodtzev, I., Debigare, R., Gagnon, P., Mainguy, V., Saey, D., Dube, A., Pare, M. E., Belanger, M., & Maltais, F. (2012). Functional and muscular effects of neuromuscular electrical stimulation in patients with severe COPD a randomized clinical trial. Chest, 141, 716–725.
Vogiatzis, I., Stratakos, G., Simoes, D. C., Terzis, G., Georgiadou, O., Roussos, C., & Zakynthinos, S. (2007). Effects of rehabilitative exercise on peripheral muscle TNFalpha, IL-6, IGF-I and MyoD expression in patients with COPD. Thorax, 62, 950–956.
Von Haehling, S. (2015). The wasting continuum in heart failure: From sarcopenia to cachexia. Proceedings of the Nutrition Society, 74, 367–377.
Von Haehling, S., Morley, J. E., & Anker, S. D. (2010). An overview of sarcopenia: Facts and numbers on prevalence and clinical impact. Journal of Cachexia, Sarcopenia and Muscle, 1, 129–133.
Vonbank, K., Strasser, B., Mondrzyk, J., Marzluf, B. A., Richter, B., Losch, S., Nell, H., Petkov, V., & Haber, P. (2012). Strength training increases maximum working capacity in patients with COPD – randomized clinical trial comparing three training modalities. Respiratory Medicine, 106, 557–563.
Watson, E. L., Greening, N. J., Viana, J. L., Aulakh, J., Bodicoat, D. H., Barratt, J., Feehally, J., & Smith, A. C. (2015). Progressive resistance exercise training in CKD: A feasibility study. American Journal of Kidney Diseases, 66, 249–257.
Welch, A. A. (2014). Nutritional influences on age-related skeletal muscle loss. The Proceedings of the Nutrition Society, 73, 16–33.
Wells, R. (1960). Prednisolone and testosterone propionate in cirrhosis of the liver – a controlled trial. Lancet, 2, 1416–1419.
White, H. K., Petrie, C. D., Landschulz, W., Maclean, D., Taylor, A., Lyles, K., Wei, J. Y., Hoffman, A. R., Salvatori, R., Ettinger, M. P., Morey, M. C., Blackman, M. R., Merriam, G. R., & Capromorelin Study, G. (2009). Effects of an oral growth hormone secretagogue in older adults. The Journal of Clinical Endocrinology and Metabolism, 94, 1198–1206.
White, J. P., Baynes, J. W., Welle, S. L., Kostek, M. C., Matesic, L. E., Sato, S., & Carson, J. A. (2011). The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse. PLoS One, 6, e24650.
Williamson, D. L., Raue, U., Slivka, D. R., & Trappe, S. (2010). Resistance exercise, skeletal muscle FOXO3A, and 85-year-old women. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 65, 335–343.
Wolf, I., Sadetzki, S., Kanety, H., Kundel, Y., Pariente, C., Epstein, N., Oberman, B., Catane, R., Kaufman, B., & Shimon, I. (2006). Adiponectin, ghrelin, and leptin in cancer cachexia in breast and colon cancer patients. Cancer, 106, 966–973.
Wolfe, R., Ferrando, A., Sheffield-Moore, M., & Urban, R. (2000). Testosterone and muscle protein metabolism. Mayo Clinic Proceedings, 75(Suppl), S55–S59. discussion S59–60.
Yeh, S. S., Deguzman, B., Kramer, T., & Group, M. S. (2002). Reversal of COPD-associated weight loss using the anabolic agent oxandrolone. Chest, 122, 421–428.
Yende, S., Waterer, G. W., Tolley, E. A., Newman, A. B., Bauer, D. C., Taaffe, D. R., Jensen, R., Crapo, R., Rubin, S., Nevitt, M., Simonsick, E. M., Satterfield, S., Harris, T., & Kritchevsky, S. B. (2006). Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects. Thorax, 61, 10–16.
Zambom-Ferraresi, F., Cebollero, P., Gorostiaga, E. M., Hernandez, M., Hueto, J., Cascante, J., Rezusta, L., Val, L., & Anton, M. M. (2015). Effects of combined resistance and endurance training versus resistance training alone on strength, exercise capacity, and quality of life in patients with COPD. Journal of Cardiopulmonary Rehabilitation and Prevention, 35, 446–453.
Zamboni, M., Zoico, E., Scartezzini, T., Mazzali, G., Tosoni, P., Zivelonghi, A., Gallagher, D., De Pergola, G., Di Francesco, V., & Bosello, O. (2003). Body composition changes in stable-weight elderly subjects: The effect of sex. Aging Clinical and Experimental Research, 15, 321–327.
Zanotti, E., Felicetti, G., Maini, M., & Fracchia, C. (2003). Peripheral muscle strength training in bed-bound patients with COPD receiving mechanical ventilation – effect of electrical stimulation. Chest, 124, 292–296.
Zietz, B., Lock, G., Plach, B., Drobnik, W., Grossmann, J., Scholmerich, J., & Straub, R. H. (2003). Dysfunction of the hypothalamic-pituitary-glandular axes and relation to Child-Pugh classification in male patients with alcoholic and virus-related cirrhosis. European Journal of Gastroenterology & Hepatology, 15, 495–501.
Zumoff, B., Strain, G. W., Miller, L. K., & Rosner, W. (1995). Twenty-four-hour mean plasma testosterone concentration declines with age in normal premenopausal women. The Journal of Clinical Endocrinology and Metabolism, 80, 1429–1430.
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Anderson, L.J., Liu, H., Garcia, J.M. (2017). Sex Differences in Muscle Wasting. In: Mauvais-Jarvis, F. (eds) Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity. Advances in Experimental Medicine and Biology, vol 1043. Springer, Cham. https://doi.org/10.1007/978-3-319-70178-3_9
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