Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity

  • Franck Mauvais-Jarvis

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1043)

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Sex Differences in Diabetes and Obesity

    1. Front Matter
      Pages 1-1
    2. Miriam A. Bredella
      Pages 9-27
    3. Mita Varghese, Cameron Griffin, Kanakadurga Singer
      Pages 65-86
    4. Sara Della Torre, Federica Lolli, Paolo Ciana, Adriana Maggi
      Pages 141-151
    5. Lindsey J. Anderson, Haiming Liu, Jose M. Garcia
      Pages 153-197
  3. Role of Estrogens in Metabolic Homeostasis

    1. Front Matter
      Pages 215-215
    2. Franck Mauvais-Jarvis
      Pages 217-225
    3. Brian T. Palmisano, Lin Zhu, John M. Stafford
      Pages 227-256
    4. Andrea L. Hevener, Zhenqi Zhou, Brian G. Drew, Vicent Ribas
      Pages 257-284
    5. Katya B. Rubinow
      Pages 285-313
    6. Ismael González-García, Manuel Tena-Sempere, Miguel López
      Pages 315-335
    7. Yong Xu
      Pages 337-357
    8. Karen P. Briski, Hussain N. Alhamami, Ayed Alshamrani, Santosh K. Mandal, Manita Shakya, Mostafa H. H. Ibrahim
      Pages 359-383

About this book


The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases.

There are fundamental aspects of metabolic homeostasis that are regulated differently in males
and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men. 


sex differences metabolism adipose tissue estrogen androgen gender medicine

Editors and affiliations

  • Franck Mauvais-Jarvis
    • 1
  1. 1.Department of Medicine, Section of Endocrinology and MetabolismTulane University Health Sciences Center, School of MedicineNew OrleansUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-70177-6
  • Online ISBN 978-3-319-70178-3
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • About this book