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Lactone Formation in Yeast and Fungi

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Fungal Metabolites

Part of the book series: Reference Series in Phytochemistry ((RSP))

Abstract

Lactones are important secondary metabolites for fungi. In this chapter are presented some lactones that are important in biotechnology such as flavoring lactones or fragrance macrocyclic musk compounds, whereas others are important for quorum sensing and health (mycotoxins). Different pathways or enzymes can give rise to lactones, and the pathways going through β-oxidation and ω-oxidation and the fungal polyketide pathway (relatively similar to the fatty acid synthesis pathway) are presented as well as the activity of Baeyer–Villiger monooxygenases and lactonases and their potential use in biotechnology.

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Abbreviations

6MSA:

6-Methylsalicylic acid

AHL:

Acyl-homoserine lactone

AF:

Aflatoxin

AFL:

Aflatoxicol

ATP:

Adenosine triphosphate

BVMO:

Baeyer–Villiger monooxygenase

CDK:

Cyclin-dependent kinase

DALs:

Dihydroxyphenylacetic acid lactones

DNA:

Deoxyribonucleic acid

ERK:

Extracellular signal-regulated kinase

FAS:

Synthesis of fatty acids

HSP:

Heat shock protein 7

IC50 :

Half maximal inhibitory concentration

MAP, MAPK, MAPKKK:

Mitogen-activated protein kinase (MAP), kinase (K)

mRNA:

Messenger ribonucleic acid

PKS:

Polyketide synthase

QS:

Quorum sensing

RALs:

Resorcylic acid lactones

TAK:

Transforming growth factor-activated kinase

ZAL:

Zearalanol

ZAN:

Zearalanone

ZEN:

Zearalenone

ZEL:

Zearalenol

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    Authors and Affiliations

    1. Department of Chemistry, Faculty of Food Sciences, Warsaw University of Life Sciences – SGGW, Warsaw, Poland

      Jolanta Krzyczkowska

    2. Laboratory PAM, Joint Research Unit AgroSup Dijon-University of Bourgogne-Franche Comté, Dijon, France

      Hanh Phan-Thi & Yves Waché

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    1. Jolanta Krzyczkowska
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    2. Hanh Phan-Thi
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    3. Yves Waché
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    Correspondence to Jolanta Krzyczkowska .

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    1. Faculty of Pharmaceutical Sciences, University of Bordeaux, Bordeaux, France

      Jean-Michel Mérillon

    2. Botany Department, M.L.Sukhadia University, Udaipur, Rajasthan, India

      Kishan Gopal Ramawat

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    Krzyczkowska, J., Phan-Thi, H., Waché, Y. (2017). Lactone Formation in Yeast and Fungi. In: Mérillon, JM., Ramawat, K. (eds) Fungal Metabolites. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-25001-4_13

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