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Tumour Microenvironment in Skin Carcinogenesis

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Tumor Microenvironments in Organs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1226))

Abstract

Tumour microenvironment is a complex system comprising cells and molecules that will provide the necessary conditions for tumour development and progression. Cells residing in the tumour microenvironment gain specific phenotypes and specific functions that are pro-tumorigenic. Tumour progression is in fact a combination between tumour cell characteristics and its interplay with tumour microenvironment. This dynamic network will allow tumour cells to grow, migrate and invade tissues. In the present chapter, we are highlighting some traits that characterise tumour microenvironment in basal cell carcinoma, squamous cell carcinoma and cutaneous melanoma. In skin cancers, there are some common tumour microenvironment characteristics such as the presence of tumour-associated macrophages and regulatory T lymphocytes that are non-tumour cells promoting tumorigenesis. There are also skin cancer type differences in terms of tumour microenvironment characteristics. Thus, markers such as macrophage migration inhibitory factor in melanoma or the extraordinary diverse genetic make-up in the cancer-associated fibroblasts associated to squamous cell carcinoma are just a few of specific traits in skin cancer types. New technological advances for evaluation of tumour environment are presented. Thus, non-invasive skin imaging techniques such as reflectance confocal microscopy can evaluate skin tumour inflammatory infiltrates for density and cellular populations. Analysing tumour micromedium in depth may offer new insights into cancer therapy and identify new therapy targets.

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Acknowledgment

Authors were partially financed through Grants PN 19.29.01.01 and PN-III-P1-1.2-PCCDI-2017-0341/2018

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Authors and Affiliations

  1. “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

    Simona Roxana Georgescu, Mircea Tampa, Cristina Iulia Mitran, Madalina Irina Mitran, Constantin Caruntu & Clara Matei

  2. “Victor Babes” Clinical Hospital for Infectious Diseases, Bucharest, Romania

    Simona Roxana Georgescu & Mircea Tampa

  3. “Cantacuzino” National Medico-Military Institute for Research and Development, Bucharest, Romania

    Cristina Iulia Mitran & Madalina Irina Mitran

  4. Department of Dermatology, “Prof. N. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest, Romania

    Constantin Caruntu

  5. Department of Oral and Maxillofacial Surgery, “Carol Davila” Central Military Emergency Hospital, Bucharest, Romania

    Ana Caruntu

  6. Faculty of Medicine, Department of Preclinical Sciences, “Titu Maiorescu” University, Bucharest, Romania

    Ana Caruntu

  7. Department of Dermatology, MEDAS Medical Center, Bucharest, Romania

    Mihai Lupu

  8. Immunology Department, “Victor Babes” National Institute of Pathology, Bucharest, Romania

    Carolina Constantin & Monica Neagu

  9. Colentina Clinical Hospital, Bucharest, Romania

    Carolina Constantin & Monica Neagu

  10. Faculty of Biology, University of Bucharest, Bucharest, Romania

    Monica Neagu

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  1. Simona Roxana Georgescu
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  2. Mircea Tampa
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  3. Cristina Iulia Mitran
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  4. Madalina Irina Mitran
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  5. Constantin Caruntu
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  6. Ana Caruntu
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  7. Mihai Lupu
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  8. Clara Matei
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  9. Carolina Constantin
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  10. Monica Neagu
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Editors and Affiliations

  1. Columbia University Medical Center, Department of Radiology, New York, NY, USA, Federal University of Minas Gerais, Department of Pathology, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Georgescu, S.R. et al. (2020). Tumour Microenvironment in Skin Carcinogenesis. In: Birbrair, A. (eds) Tumor Microenvironments in Organs. Advances in Experimental Medicine and Biology, vol 1226. Springer, Cham. https://doi.org/10.1007/978-3-030-36214-0_10

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