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Monoclonal Antibody Strategy and Techniques

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Hybridoma Technology in the Biosciences and Medicine

Abstract

The novel approach of immortalizing specific antibody-forming cells by their fusion with myeloma cells was first introduced by Köhler and Milstein1 in 1975. Since then it has been widely adopted as the method of choice for the preparation of monoclonal antibodies (MAbs) to a large spectrum of antigens, and today MAbs find application in almost all facets of the life sciences. The thousands of research articles published every year that report the use of MAb as the key reagent and the tens of biotechnology companies that are involved in MAb production exemplify only part of the revolutionary impact of monoclonal antibodies.

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  1. Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel

    Zelig Eshhar

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  1. Zelig Eshhar
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  1. Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

    Timothy A. Springer

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© 1985 Plenum Press, New York

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Eshhar, Z. (1985). Monoclonal Antibody Strategy and Techniques. In: Springer, T.A. (eds) Hybridoma Technology in the Biosciences and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4964-8_1

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  • DOI: https://doi.org/10.1007/978-1-4684-4964-8_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4966-2

  • Online ISBN: 978-1-4684-4964-8

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