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Hybridoma Technology in the Biosciences and Medicine

  • Timothy A. Springer
Book

Table of contents

  1. Front Matter
    Pages i-xxv
    PDF

  2. The Production and Improvement through Genetic Engineering of Monoclonal Antibodies

    1. Front Matter
      Pages 1-1
      PDF
    2. Monoclonal Antibody Strategy and Techniques
      Zelig Eshhar
      Pages 3-41
    3. Strategies for Production of Human Monoclonal Antibodies
      Susan P. C. Cole, Danuta Kozbor, John C. C. Roder
      Pages 43-55
    4. The Antibody Combining Site
      Edgar Haber, Jiří Novotný
      Pages 57-76
    5. The Generation of Better Monoclonal Antibodies through Somatic Mutation
      Gad Spira, Antonio Bargellesi, Roberta R. Pollock, Hector L. Aguila, Matthew D. Scharff
      Pages 77-88
    6. Switching the Isotype of Monoclonal Antibodies
      Thomas J. Kipps
      Pages 89-101
    7. The Analysis of Structural Diversity in the Antibody Response
      Gillian M. Griffiths, Cesar Milstein
      Pages 103-115
    8. Expression of Cloned Immunoglobulin Genes
      Frederick W. Alt
      Pages 117-134

  3. Monoclonal Antibodies in Biomedical Research: Principles and Applications

    1. Front Matter
      Pages 135-135
      PDF
    2. The Immunochemistry of Monoclonal Antibodies: Studies on One Immunologic Supergene (HLA) with the Products of Another
      Peter Parham
      Pages 137-161
    3. Purification of Membrane Glycoproteins with Monoclonal Antibody Affinity Columns
      Pauline Johnson, Alan F. Williams, Gillian R. Woollett
      Pages 163-175
    4. Transferrin Receptor
      Ian S. Trowbridge
      Pages 177-189
    5. Functional and Structural Interrelationships among the Mac-1, LFA-1 Family of Leukocyte Adhesion Glycoproteins, and their Deficiency in a Novel Heritable Disease
      Timothy A. Springer, Donald C. Anderson
      Pages 191-206
    6. Demonstration of Receptor Function of Membrane Proteins by Selection and Immobilization with Monoclonal Antibodies
      Janis Jacks Weis, Douglas T. Fearon
      Pages 207-221
    7. Production of Rat × Mouse Hybridomas for the Study of the Nicotinic Acetylcholine Receptor
      Susan M. Hochschwender, Lorene K. Langeberg, Douglas W. Schneider, Jon M. Lindstrom
      Pages 223-228
    8. Sperm Surface Domains
      Diana G. Myles, Paul Primakoff
      Pages 239-250
    9. The Cytoskeleton
      Lan Bo Chen, Sharon Rosenberg, Karen K. Nadakavukaren, Elizabeth S. Walker, Elizabeth L. Shepherd, Glenn D. Steele Jr.
      Pages 251-268
    10. Monoclonal Antibodies as Molecular Probes of the Nervous System
      Colin J. Barnstable
      Pages 269-289
    11. Application of Monoclonal Antibodies to Issues of Plasma Lipoprotein Structure and Function
      Linda K. Curtiss
      Pages 291-308
    12. Enzyme Active Sites
      Sandra J. Smith-Gill
      Pages 309-325
    13. Studies of the Hong Kong Influenza Hemagglutinin
      John J. Skehel, Donald C. Wiley
      Pages 327-340
    14. Virus Receptors on Somatic and Immune Cells
      Man Sung Co, Glen N. Gaulton, Noboru Matsuzaki, Mark I. Greene
      Pages 341-351

  4. Uses of Antibodies in Recombinant DNA Technology

    1. Front Matter
      Pages 353-353
      PDF
    2. Designing and Using Site-Specific Antibodies to Synthetic Peptides
      Brian S. Schaffhausen
      Pages 355-373
    3. Gene Transfer as a General Approach to Facilitate the Recombinant DNA Cloning of Surface Antigen Genes
      Frank H. Ruddle
      Pages 375-381
    4. Amplification and Molecular Cloning of Transfected Genes
      Paula Kavathas
      Pages 383-395
    5. Screening λgt11 Expression Libraries with Antibody Probes
      Michael Snyder, Ronald W. Davis
      Pages 397-406
    6. Purification of Low-Abundance Messenger RNAs by Polysome Isolation with Polyclonal Antibodies
      Jan P. Kraus
      Pages 407-417
    7. Purification of Messenger RNA by Polysome Isolation with Monoclonal Antibodies
      Joseph P. Brown, Timothy M. Rose, Gregory D. Plowman
      Pages 419-426
    8. Expression of Foreign Proteins on the Surface of Xenopus laevis Oocytes
      Jay C. Unkeless, Daniel A. Portnoy, Andrew D. Luster, Ellen Pure
      Pages 427-438

  5. Monoclonal Antibodies in Diagnosis and Therapy

    1. Front Matter
      Pages 439-439
      PDF
    2. Antibodies in Vivo
      Edgar Haber
      Pages 441-452
    3. Human Complement-Fixing Antibodies in Transplantation
      G. Hale, H. Waldmann
      Pages 453-471
    4. Manipulation of T-Cell Populations to Abrogate Allograft Rejection
      Charles B. Carpenter
      Pages 473-492
    5. Serotherapy and Bone Marrow Transplantation
      Jerome Ritz, Stephen E. Sallan, Robert C. Bast Jr., Tak Takvorian, Stuart F. Schlossman
      Pages 493-504

  6. T-Cell Clones and Their Products

    1. Front Matter
      Pages 505-505
      PDF
    2. The Murine T-Cell Antigen: Ia Receptor: Functional and Structural Analysis with a Monoclonal Antireceptor Antibody
      Jonathan Kaye
      Pages 507-526
    3. Functional T-Cell Hybridomas
      Kenneth L. Rock
      Pages 527-544
    4. The Mechanisms That Control the Proliferation and Activity of Cytolytic T Lymphocytes
      Markus Nabholz
      Pages 545-557
    5. Human Cytolytic T-Lymphocyte Clones and Their Function-Associated Cell Surface Molecules
      Alan M. Krensky, Steven J. Mentzer, Julia L. Greenstein, Mary Crimmins, Carol Clayberger, Timothy A. Springer et al.
      Pages 559-573
    6. The Use of Mouse Lymphocyte Clones to Define T-Cell Gene Products and Analyze Lymphocyte Gene Activation
      Gary J. Nabel
      Pages 575-586
    7. Interleukin 1, Interferon Gamma, and the Modulation of Macrophage-T-Cell Interactions
      David I. Beller
      Pages 587-596
  7. Back Matter
    Pages 597-602
    PDF

About this book

Keywords

antibody antigen antigen presentation genetics immunoglobulin immunotherapy interferon lymphocytes proteins transplantation virus

Editors and affiliations

  • Timothy A. Springer
    • 1
  1. 1.Dana-Farber Cancer InstituteHarvard Medical SchoolBostonUSA

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