Abstract
The physical nature of lipids has always provided a limitation to metabolic studies in that the surrounding aqueous medium provides an environment that is attractive for neither many of the precursors nor most of the products. Thus, the various hydrophobic regions of cellular membranes are sites of lipid metabolism at which substrate accessibility, critical micelle concentrations, and microenvironmental factors all play significant roles. In fact, as the integrated metabolism of other biological materials is elaborated, their intracellular compartmentation also becomes apparent, and much of the restrictive nature of the barriers to metabolite movement is attributed to the lipid components that are either deliberately or inadvertently located in the intracellular membranes. We still have too few guidelines to help us select the useful facts from the artifacts, and this chapter is designed to help the readers understand the multiple variables that influence our current understanding of the control of membrane phospholipids.
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References
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© 1976 Plenum Press, New York
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Lands, W.E.M., Crawford, C.G. (1976). Enzymes of Membrane Phospholipid Metabolism in Animals. In: Martonosi, A. (eds) The Enzymes of Bioligical Membranes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2655-7_1
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