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Mechanisms of Luteal Cell Regulation by Prolactin

  • Chapter
Prolactin

Part of the book series: Endocrine Updates ((ENDO,volume 12))

Abstract

The corpus luteum is an endocrine gland of limited lifespan formed from the remaining granulosa and theca cells of the follicle following ovulation. The main function of this gland is the synthesis and secretion of progesterone. Progesterone is a steroid hormone required for preparing the endometrium for implantation, regulating pituitary gonadotropin secretion and, importantly, maintaining a quiescent uterus by inhibiting the contractile activity of the myometrium, thus preventing the onset of parturition. In some species, such as the rat and mouse, the corpus luteum is responsible for the secretion of progesterone throughout pregnancy and is necessary for the entire length of gestation. In other species, such as human, the placenta assumes the majority of progesterone secretion at some point in gestation. In all mammals, however, progesterone is required for pregnancy and during a portion of gestation it must come from the corpus luteum.

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  1. University of Illinois at Chicago College of Medicine, Chicago, IL, USA

    Michael Risk & Geula Gibori

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    Nelson D. Horseman

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Risk, M., Gibori, G. (2001). Mechanisms of Luteal Cell Regulation by Prolactin. In: Horseman, N.D. (eds) Prolactin. Endocrine Updates, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1683-5_14

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