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Phosphorylation of Elongation Factor 2

A Mechanism to Shut Off Protein Synthesis for Reprogramming Gene Expression

  • Chapter
Translational Regulation of Gene Expression 2

Abstract

In 1987 the phosphorylation of elongation factor 2 (eEF-2) was discovered.1 At that time it seemed as though this was merely a demonstration that one more translation factor could be phosphorylated. It now appears, however, that eEF-2 phosphorylation is involved in the regulation of the cell cycle, cell differentiation, and many other processes. Here we summarize what is currently known about eEF-2 phosphorylation and its physiological role.

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Authors and Affiliations

  1. Institute of Protein Research, Academy of Sciences of Russia, 142292, Pushchino, Moscow Region, Russia

    Alexey G. Ryazanov & Alexander S. Spirin

  2. Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey, 08854, USA

    Alexey G. Ryazanov

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  1. Alexey G. Ryazanov
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  2. Alexander S. Spirin
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  1. Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106, USA

    Joseph Ilan

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Ryazanov, A.G., Spirin, A.S. (1993). Phosphorylation of Elongation Factor 2. In: Ilan, J. (eds) Translational Regulation of Gene Expression 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2894-4_21

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  • DOI: https://doi.org/10.1007/978-1-4615-2894-4_21

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