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Adrenergic and Non-adrenergic Neural Control of the Arterial Wall

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Diseases of the Arterial Wall

Abstract

The availability of new and improved techniques in fluorescence histochemistry (particularly immunohistochemistry), electron microscopy, electrophysiology and pharmacology since the 1960s has led to a wealth of discoveries that have profoundly reshaped our understanding of the autonomic nervous system. There has also been a dramatic rise in the number of putative neurotransmitter substances, which show a marked overlap in their localization and function. These findings add new concepts and further complexity to autonomic neuroeffector mechanisms and demand a reappraisal of our definitions for subclassing these neurohumoral agents into neurotransmitters; neuromodulators and trophic factors.

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References

  1. Abráhám A (1981) Microscopic innervation of the heart and blood vessels in vertebrates including man. Pergamon Press, Oxford

    Google Scholar 

  2. Abrahams VC, Hilton SM (1958) Active muscle vasodilatation and its relation to the “fight and flight” reactions in the conscious animal. J Physiol (Lond) 140:16P

    Google Scholar 

  3. Adrian TE, Gu J, Allen JM et al. (1984) Neuropeptide Y in the male genital tract. Life Sci 35:2643–2648

    Article  PubMed  CAS  Google Scholar 

  4. Ahlqvist RP (1948) A study of the adrenotropic receptors. Am J Physiol 153:586–600

    Google Scholar 

  5. Ajelis V, Björklund B, Falk B et al. (1979) Application of the aluminium formaldehyde (ALFA) histo- fluorescence method for demonstration of peripheral stores of catecholamines and indoleamines in freeze- dried paraffin embedded tissue, cryostat sections and whole mounts. Histochemistry 65:1–15

    Article  PubMed  CAS  Google Scholar 

  6. Alafaci C, Cowen T, Crockard HA et al. (1985) The original distribution of noradrenergic and NPY-con- taining nerves in the cerebral blood vessels of the gerbil. J Cereb Blood Flow Metab 5 [Suppl 1]:S543-S544

    Google Scholar 

  7. Alafaci C, Cowen T, Crockard HA et al. (1986) Cerebral perivascular serotonergic fibres have a peripheral origin in the gerbil. Brain Res Bull 16:303–304

    Article  PubMed  CAS  Google Scholar 

  8. Alafaci C, Cowen T, Crockard HA et al. (1986) Perivascular nerve types supplying cerebral blood vessels of the gerbil. Acta Physiol Scand 127 (Suppl 552):9–12

    Google Scholar 

  9. Allan G, Brook CD, Cambridge D et al. (1983) Enhanced responsiveness of vascular smooth muscle to vasoconstrictor agents after removal of endothelial cells. Br J Pharmacol 79:334P

    Google Scholar 

  10. Allen JM, Schon F, Todd N et al. (1984) Presence of neuropeptide Y in human circle of Willis and its possible role in cerebral vasospasm. Lancet II:550–552

    Article  PubMed  CAS  Google Scholar 

  11. Allen JM, Gu J, Adrian TE et al. (1984) Neuropeptide Y in the guinea-pig biliary tract. Experientia 40:765–767

    Article  PubMed  CAS  Google Scholar 

  12. Alm P, Alumets J, Brodin E et al. (1978) Peptidergic (substance P) nerves in the genitourinary tract. Neuroscience 3:419–425

    Article  PubMed  CAS  Google Scholar 

  13. Alm P, Alumets R, Hakanson R et al. (1980) Origin and distribution of VIP (vasoactive intestinal polypeptide) nerves in the genito-urinary tract. Cell Tissue Res 205:337–347

    Article  PubMed  CAS  Google Scholar 

  14. Altura BM (1981) Pharmacology of venules: some current concepts and clinical potential. J Cardiovasc Pharmacol 3:1413–1428

    Article  PubMed  CAS  Google Scholar 

  15. Altura BM, Malaviy D, Reich CF et al. (1972) Effects of vasoactive agents on isolated human umbilical arteries and veins. Am J Physiol 222: 345–355

    PubMed  CAS  Google Scholar 

  16. Amara SG, Jonas V, Rosenfeld MG et al. (1982) Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 298:240–244

    Article  PubMed  CAS  Google Scholar 

  17. Amenta F, Cavallotti C, Collier WL (1985) The adrenergic innervation of rat uterine tubes in old age: a fluorescence histochemical study. Arch Gerontol Geriatr 4:37–42

    Article  PubMed  CAS  Google Scholar 

  18. Amenta F, De Rossi M, Mione MC et al. (1985) Characterization of [3H] 5-hydroxytryptamine uptake within rat cerebrovascular tree. Eur J Pharmacol 112:181–186

    Article  PubMed  CAS  Google Scholar 

  19. Angus JA, Brazenor RM, Le Duc MA (1982) Verapil-A selective antagonist of constrictor substance in dog coronary artery: implications for variant angina. Clin Exp Pharmacol Physiol [Suppl 6]: 15–28

    Google Scholar 

  20. Appenzeller O, Dhital KK, Cowen T et al. (1984) The nerves to blood vessels supplying blood to nerves: the innervation of vasa nervorum. Brain Res 304:383–386

    Article  PubMed  CAS  Google Scholar 

  21. Apperley E, Humphrey PPA, Levy GP (1976) Receptors for 5-hydroxytryptamine and noradrenaline in rabbit isolated ear artery and aorta. Br J Pharmacol 58:211–221

    PubMed  CAS  Google Scholar 

  22. Armati-Gulson P, Burnstock G (1983) The development of adrenergic innervation in some human foetal blood vessels. J Auton Nerv Syst 7(2): 111–118

    Article  PubMed  CAS  Google Scholar 

  23. Arneklo-Nobin B, Owman C (1985) Adrenergic and serotoninergic mechanisms in human hand arteries and veins studied by fluorescence histochemistry and in vitro pharmacology. Blood Vessels 22:1–12

    PubMed  CAS  Google Scholar 

  24. Azanza MJ, Garin P (1986) The autonomic innervation of the rat diaphragm. Gen Pharmacol 17(1): 109–112

    Article  PubMed  CAS  Google Scholar 

  25. Bannister R, Crowe R, Burnstock G (1981) Adrenergic innervation in autonomic failure. Neurology 31:1501–1506

    PubMed  CAS  Google Scholar 

  26. Barajas L, Wang P (1975) Demonstration of acetylcholinesterase in the adrenergic nerves of the renal glomerular arterioles. J Ultrastruct Res 53:244–253

    Article  PubMed  CAS  Google Scholar 

  27. Barja F, Mathison R (1982) Adrenergic and peptidergic (substance P and vasoactive intestinal polypeptide) innervation of the rat portal vein. Blood Vessels 19:263–272

    PubMed  CAS  Google Scholar 

  28. Barja F, Huggel H, Mathison R (1982) Substance P nerve fibres in peripheral blood vessels. Neuroscience 7:S18

    Google Scholar 

  29. Barja F, Mathison R, Huggel H (1983) Substance P- containing nerve fibres in large peripheral blood vessels of the rat. Cell Tissue Res 229:411–422

    Article  PubMed  CAS  Google Scholar 

  30. Barja F, Mathison R (1984) Sensory innervation of the rat portal vein and the hepatic artery. J Auton Nerv Sys 10:117–125

    Article  CAS  Google Scholar 

  31. Barnes PJ, Carstairs JR (1985) Autoradiographic localization of VIP receptors in guinea pig and human lung. Proc Br Pharmacol Soc 18–20 December, 128

    Google Scholar 

  32. Baumgarten HG (1972) Biogenic amines in the cyclo- stome and lower vertebrate brain. Prog Histochem Cytochem 4:1–90

    PubMed  CAS  Google Scholar 

  33. Bell C (1974) Selective cholinergic denervation of the uterine artery in the guinea-pig. Experimentia 30:257258

    Google Scholar 

  34. Bérubé A, Marceau F, Drouin JN et al. (1978) The rabbit mesenteric vein: a specific bioassay for substance P. Can J Physiol Pharmacol 56:603–609

    Article  PubMed  Google Scholar 

  35. Bevan JA, Su C (1973) Sympathetic mechanisms in blood vessels: nerve and muscle relationships. In: Elliot HW, George R, Okon R (eds) Annual review of pharmacology. 13:269–285

    Google Scholar 

  36. Bevan JA, Ljung B (1974) Longitudinal propagation of myogenic activity in rabbit arteries and in the rat portal vein. Acta Physiol Scand 90:703–751

    Article  PubMed  CAS  Google Scholar 

  37. Bissette G, Manberg JW, Nemeroff CB et al. (1978) Neurotensin, a biologically active peptide. Life Sci 23(22):2173–2182

    Article  PubMed  CAS  Google Scholar 

  38. Black JL, French RJ, Mylecharane EJ (1981) Receptor mechanisms for 5-hydroxytryptamine in rabbit arteries. Br J Pharmacol 74:619–626

    PubMed  CAS  Google Scholar 

  39. Blackshear JL, Orlandi C, Garnic JD et al. (1985) Differential large and small vessel responses to serotonin in the dog hindlimb in vivo: role of the 5HT2 receptor. J Cardiovasc Pharmacol 7:42–49

    Article  PubMed  CAS  Google Scholar 

  40. Blair DA, Glover WE, Roddie IC (1961) Vasomotor responses in the human arm during leg exercise. Circ Res 9:264–74

    Google Scholar 

  41. Bloom SR, Bryant MG, Polak JM et al. (1979) Vasoactive intestinal peptide-like immunoreactivity in salivary glands of the rat. J Physiol (Lond) 289:23P

    CAS  Google Scholar 

  42. Bloom SR, Edwards AV (1980) Vasoactive intestinal peptide in relation to atropine resistant vasodilatation in the submaxillary gland of the cat. J Physiol (Lond) 300:41–53

    CAS  Google Scholar 

  43. Boatman DL, Shaffer RA, Dixon RL (1965) Function of vascular smooth muscle and its sympathetic innervation in the newborn dog. J Clin Invest 44:241–246

    Article  PubMed  CAS  Google Scholar 

  44. Boe J, Boe A-M, Simonsson B et al. (1980) In vitro affects on parasympathetic agonists and atropine on human segmental pulmonary arteries. Lung 157:65–70

    Article  PubMed  CAS  Google Scholar 

  45. Borodulya AV, Pletchkova EC (1976) Cholinergic innervation of vessels of the base of the brain. Acta Anat (Basel) 96:135–147

    Article  CAS  Google Scholar 

  46. Brain SD, Williams TJ, Tippins JR et al. (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 313:54–56

    Article  PubMed  CAS  Google Scholar 

  47. Brain SD, Girgis S, MacIntyre I et al. (1985) Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability. Br J Pharmacol 86:855–860

    PubMed  CAS  Google Scholar 

  48. Brayden JE, Bevan JA (1985) Inhibition of cerebral neurovasodilatation by VIP-specific antiserum. J Cereb Blood Flow Metab 5 [Suppl 1]:S509

    Google Scholar 

  49. Brodin E, Alumets J, Hakanson R et al. (1981) Immu- noreactive substance P in the chicken gut: distribution, development and possible functional significance. Cell Tissue Res 216:455–469

    Article  PubMed  CAS  Google Scholar 

  50. Brody MJ, Shaffer RA (1970) Distribution of vasodilator nerves in the canine hindlimb. Am J Physiol 218:470–474

    PubMed  CAS  Google Scholar 

  51. Brownstein MJ, Saavedra JM, Axelrod J (1974) Coexistence of several putative neurotransmitters in single identified neurons of aplysia. Proc Natl Acad Sci USA 71:4662–4665

    Article  PubMed  CAS  Google Scholar 

  52. Buchan AMJ, Polak JM, Pearse AGE (1980) Gut hormones in Salamandra salamandra. Cell Tissue Res 211:331–343

    Article  PubMed  CAS  Google Scholar 

  53. Buchan AMJ, Polak JM, Bryant MG et al. (1981) Vasoactive intestinal polypeptide (VIP)-like immunoreactivity in anuran intestine. Cell Tissue Res 216:413–422

    Article  PubMed  CAS  Google Scholar 

  54. Bucsics A, Saria A, Lembeck F (1961) Substance P in the adrenal gland: origin and species distribution. Neuropeptides 1:329

    Article  Google Scholar 

  55. Bülbring E, Burn JH (1935) The sympathetic dilator fibres in the muscles of the cat and dog. J Physiol (Lond) 83:483–501

    Google Scholar 

  56. Burcher E, Atterhög J-H, Pernow B et al. (1977) Cardiovascular effects of substance P: effects on the heart and regional blood flow in the dog. In: Von Euler US, Pernow B (eds) Substance P. Raven Press, New York, pp 261–268

    Google Scholar 

  57. Burnstock, G (1969) Evolution of the autonomic innervation of visceral and cardiovascular systems in vertebrates. Pharmacol Rev 21:247–324

    PubMed  CAS  Google Scholar 

  58. Burnstock G (1970) Structure of smooth muscle and its innervation. In: Bülbring E, Brading A, Jones A, Tomita T (eds) Smooth muscle. Edward Arnold, London, pp 1–69

    Google Scholar 

  59. Burnstock G (1972) Purinergic nerves. Pharmacol Rev 24:509–581

    PubMed  CAS  Google Scholar 

  60. Burnstock G (1975) Innervation of vascular smooth muscle: histochemistry and electron microscopy. In: Physiological and pharmacological control of blood pressure. Clin Exp Pharmacol Physiol [Suppl 2]:7–20

    Google Scholar 

  61. Burnstock G (1976) Do some nerve cells release more than one transmitter? Neuroscience 1:239–248

    Article  PubMed  CAS  Google Scholar 

  62. Burnstock G (1977) Autonomic neuroeffector junctions - reflex vasodilatation of the skin. J Invest Dermatol 69:47–57

    Article  PubMed  CAS  Google Scholar 

  63. Burnstock G (1978) A basis for distinguishing two types of purinergic receptors. In: Straub RW, Bolis L (eds) Cell membrane receptors for drugs and hormones: a multidisciplinary approach. Raven Press, New York, pp 107–118

    Google Scholar 

  64. Burnstock G (1979) The ultrastructure of autonomic cholinergic nerves and junctions. Prog Brain Res 49:3–21

    Article  PubMed  CAS  Google Scholar 

  65. Burnstock G (1980) Cholinergic and purinergic regulation of blood vessels. In: Bohr DF, Somylo AP, Sparks HV (eds) Handbook of physiology, section 2: the cardiovascular system, vol II: vascular smooth muscle. American Physiological Society, Bethesda, pp 567–612

    Google Scholar 

  66. Burnstock G (1980) Neurotransmitters, cotransmitters, neuromodulators and trophic factors in the autonomic nervous system. In: Levi-Montalcini R (ed) Nerve cells, transmitters and behaviour. Elsevier, Amsterdam, pp 253–286

    Google Scholar 

  67. Burnstock G (1982) The co-transmitter hypothesis, with special reference to the storage and release of ATP with noradrenaline and acetylcholine. In: Cuello AC (ed) Cotransmission. Macmillan, London, pp 151–163

    Google Scholar 

  68. Burnstock G (1982) Neuropeptides as trophic factors. In: Bloom SR, Polak JM, Lindenlaub EFK (eds) Systemic role of regulatory peptides. Schattauer Verlag, Stuttgart, pp 423–441

    Google Scholar 

  69. Burnstock G (1983) Recent concepts of chemical communication between excitable cells. In: Osborne NN (ed) Dale’s principle and communication between neurones. Pergamon Press, Oxford, pp 7–35

    Google Scholar 

  70. Burnstock G (1985) Purinergic mechanisms broaden their sphere of influence. TINS 8(l):5–6

    CAS  Google Scholar 

  71. Burnstock G (1985) Neurohumoral control of blood vessels; some future directions. J Cardiovasc Pharmacol 7 [Suppl 3]:S137-S146

    Article  PubMed  CAS  Google Scholar 

  72. Burnstock G (1985) Neurogenic control of cerebral circulation. Cephalagia [Suppl 2]:25–33

    Google Scholar 

  73. Burnstock G (1985) Nervous control of smooth muscle by transmitters, cotransmitters and modulators. Experimentia 41:869–874

    Article  CAS  Google Scholar 

  74. Burnstock G (1986) Purines as cotransmitters in adrenergic and cholinergic neurones. In: Hökfelt T et al. (eds) Coexistence of neuronal messengers: a new principle in chemical transmission. (Progress in brain research 68). Elsevier, Amsterdam, pp 193–203

    Google Scholar 

  75. Burnstock G, Prosser CL (1960) Conduction in smooth muscles: comparative electrical properties. Br J Pharmacol 43:180–189

    Google Scholar 

  76. Burnstock G, Robinson PM (1967) Localization of catecholamines and acetylcholinesterase in autonomic nerves. Circ Res 21 [Suppl 3]:43–55

    CAS  Google Scholar 

  77. Burnstock G, Iwayama T (1971) Fine structural identification of autonomic nerves and their relation to smooth muscle. Prog Brain Res 34:389–404

    Article  Google Scholar 

  78. Burnstock G, Costa M (1975) Adrenergic neurons. Chapman and Hall, London

    Google Scholar 

  79. Burnstock G, Crowe R, Wong HK (1979) Comparative pharmacological and histochemical evidence for purinergic inhibitory innervation of the portal vein of the rabbit, but not guinea-pig. Br J Pharmacol 65:377–388

    PubMed  CAS  Google Scholar 

  80. Burnstock G, Chamley JM, Campbell GR (1980) The innervation of arteries. In: Schwartz CJ, Wethessen NT, Wolf S (eds) Structure and function of the circulation, vol. 1. Plenum Press, New York, pp 729–767

    Google Scholar 

  81. Burnstock G, Brown CM (1981) An introduction to purinergic receptors. In: Burnstock G (ed) Purinergic receptors. Chapman and Hall, London, pp 1–45

    Chapter  Google Scholar 

  82. Burnstock G, Griffith SG (1983) Neurohumoral control of the vasculature. In: Woolf N (eds) Biology and pathology of the vessel wall. Praeger, New York, pp 15–40

    Google Scholar 

  83. Burnstock G, Griffith SG (1983) Innervation of microvascular smooth muscle. Prog Appl Microcirc 3:19–39

    Google Scholar 

  84. Burnstock G, Griffith SG, Sneddon P (1984) Autonomic nerves in the precapillary vessel wall. J Cardiovass Pharmacol 6:S344-S353

    Article  Google Scholar 

  85. Burnstock G. Kennedy C (1985) Is there a basis for distinguishing two types of P2-purinoceptors? Gen Pharmacol 16(5):433–440

    Article  PubMed  CAS  Google Scholar 

  86. Burnstock G, Kennedy C (1986) A dual function for ATP in the regulation of vascular tone: excitatory cotransmitter with noradrenaline from perivascular nerves and locally released inhibitory intravascular agent. Circ Res 58:319–330

    PubMed  CAS  Google Scholar 

  87. Carpenter MB (1976) Human neuroanatomy, 7th edn. Williams and Wilkins, Baltimore, p 198

    Google Scholar 

  88. Carraway R, Leeman SE (1973) The isolation of a new hypotensive peptide, neurotensin from bovine hypothalami. J Biol Chem 248:6854–6861

    PubMed  CAS  Google Scholar 

  89. Chan-Palay V (1976) Serotonin axons in the supra- and subependymal plexuses and in the leptomeninges; their roles in local alterations of cerebrospinal fluid and vasomotor activity. Brain Res 102:103–130

    Article  PubMed  CAS  Google Scholar 

  90. Chan-Palay V (1977) Innervation of cerebral blood vessels by norepinephrine, indoleamine, substance P and neurotensin fibers and the leptominengeal indoleamine axons: their roles in vasomotor activity and local alterations of brain blood composition. In: Owman C, Edvinsson L (eds) Neurogenic control of brain circulation. Pergamon Press, Oxford, pp 39–53

    Google Scholar 

  91. Chang MM, Leeman SE, Niall HD (1971) Amino acid sequence of substance P. Nature New Biol 232:86

    Article  PubMed  CAS  Google Scholar 

  92. Cherry PD, Furchgott RF, Zawadzki JV et al. (1982) Role of endothelial cells in relaxation of isolated arteries by bradykinin. Proc Natl Acad Sci USA 79:2106–10

    Article  PubMed  CAS  Google Scholar 

  93. Chubb IW, Hodgson AJ, White GH (1980) Acetylcholinesterase hydrolyses substance P. Neuroscience 5:2065–2072

    Article  PubMed  CAS  Google Scholar 

  94. Clague JR, Sternini C, Brecha NC (1985) Localization of calcitonon gene-related peptide-like immuno- reactivity in neurons of the rat gastrointestinal tract. Neurosci Lett 56:63–68

    Article  PubMed  CAS  Google Scholar 

  95. Cocks TM, Angus JA (1983) Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin. Nature 305:627–630

    Article  PubMed  CAS  Google Scholar 

  96. Cohen ML, Fuller RW, Wiley KS (1981) Evidence for 5-HT2 receptors mediating contraction in vascular smooth muscle. J Pharmacol Exp Therap 218:421–425

    CAS  Google Scholar 

  97. Cohen RA, Shepherd JT, Vanhoutte PM (1983) Prejunctional and postjunctional actions of endogenous norepinephrine at the sympathetic neuroeffector junction in canine coronary arteries. Circ Res 52:16–25

    PubMed  CAS  Google Scholar 

  98. Corder R, Lowry PJ, Ramage AG et al. (1986) Comparison of the haemodynamic actions of neuropeptide Y, angiotensin II and noradrenaline, in anaesthetized cats. Eur J Pharmacol 121:25–30

    Article  PubMed  CAS  Google Scholar 

  99. Costa M, Cuello AC, Furness JB et al. (1980) Distribution of enteric neurons showing immunoreactivity for substance P in the guinea-pig ileum. Neuroscience 5:323–331

    Article  PubMed  CAS  Google Scholar 

  100. Costa M, Furness JB, Llewellyn-Smith IJ et al. (1981) Prejections of substance P-containing neurons within guinea-pig small intestine. Neuroscience 6:411–424

    Article  PubMed  CAS  Google Scholar 

  101. Cottrell GA (1976) Does the giant cerebral neurone of Helix release two transmitters: ACh and serotonin? J Physiol (Lond) 259:44–45

    Google Scholar 

  102. Coughlin SR, Moskowitz MA, Antoniades HN et al. (1981) Serotonin receptor-mediated stimulation of bovine smooth muscle cell prostacyclin synthesis and its modulation by platelet-derived growth factor. Proc Natl Acad Sci USA 78:713–7138

    Article  Google Scholar 

  103. Cowen T, MacCormick DEM, Toff WD et al. (1982) The effect of surgical procedures on blood vessel innervation. A fluorescence histochemical study of degeneration and regrowth of perivascular adrenergic nerves. Blood Vessels 19:65–78

    PubMed  CAS  Google Scholar 

  104. Cowen T, Haven AJ, Wen-Qin C et al. (1982) Development and ageing of perivascular adrenergic nerves in the rabbit. A quantitative fluorescence histochemical study using image analysis. J Auton Nerv Syst 5:317–336

    Article  PubMed  CAS  Google Scholar 

  105. Cowen T, Haven AJ, Burnstock G (1985) Pontamine sky blue: a counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry. Histochemistry 82:205–208

    Article  PubMed  CAS  Google Scholar 

  106. Cowen T, Alafaci C, Crockard HA et al. (1986) 5-HT- containing nerves to major cerebral arteries of the gerbil originate in the superior cervical ganglia. Brain Res 384:51–59

    Article  PubMed  CAS  Google Scholar 

  107. Crowe R, Lincoln J, Blacklay PF et al. (1983) Vasoactive intestinal polypeptide-like immunoreactive nerves in diabetic penis. A comparison between strep- tozotocin-treated rats and man. Diabetes 32:1075–1077

    Article  PubMed  CAS  Google Scholar 

  108. Cuello AC, Gamse R, Holzer P et al. (1981) Substance P-immunoreactive neurons following neonatal administration of capsaicin. Naunyn-Schmiedeberg’s Arch Pharmacol 315:185–194

    Article  CAS  Google Scholar 

  109. Cummings JP, Felten DL (1979) A raphe dendrite bundle in the rabbit medulla. J Comp Neurol 183:1–24

    Article  PubMed  CAS  Google Scholar 

  110. Dahlof C, Dahlof P, Lundberg JM (1985) Neuropeptide Y (NPY): enhancement of blood pressure increase upon α-adrenoceptor activation and direct pressor effects in pithed rats. Eur J Pharmacol 109:289–292

    Article  PubMed  CAS  Google Scholar 

  111. Dahlström A, Bööj S, Carlsson SS et al. (1981) Rapid accumulation and axonal transport of “cholinergic vesicles” in rat sciatic nerve, studied by immunohistochemistry. Acta Physiol Scand 111:217–219

    Article  PubMed  Google Scholar 

  112. Dalsgaard C-J, Jonsson C-E, Hökfelt T et al. (1983) Localization of SP-immunoreactive fibres in the human digital skin. Experientia 39:1018–1020

    Article  PubMed  CAS  Google Scholar 

  113. Daly I, De Burgh I, Hebb C (1966) Pulmonary and bronchial vascular systems. Edward Arnold, London

    Google Scholar 

  114. Da Prada M, Richards JG, Lorez HP (1978) Blood platelets and biogenic monoamines: biochemical, pharmacological and morphological studies. In: de Gaetano G, Garattini S (eds) Platelets: a multi-disciplinary approach. Raven Press, New York, pp 331–353

    Google Scholar 

  115. Dashwood M, Bagnall J (1982) An autoradiographic demonstration of prazosin binding to arterial vessels in the rat. Eur J Pharmacol 78:121–123

    Article  PubMed  CAS  Google Scholar 

  116. Davies B (1983) Adrenergic receptors in autonomic failure. In: Bannister R (ed) Autonomic failure. A textbook of clinical disorders of the autonomic nervous system. Oxford University Press, Oxford, pp 174–200

    Google Scholar 

  117. De La Torre JC, Surgeon JW (1976) A methodological approach to rapid and sensitive monoamine histo- fluorescence using a modified glyoxylic acid technique: the SPG method. Histochemistry 49:81–93

    Article  PubMed  CAS  Google Scholar 

  118. Delgado TJ, Brismar J, Svendgaard NA (1985) Subarachnoid haemorrhage in the rat: angiography and fluorescence microscopy of the major cerebral arteries. Stroke 16: 595–601

    Article  PubMed  CAS  Google Scholar 

  119. Dey RD, Shannon WA, Said SI (1981) Localization of VIP-immunoreactive nerves in airways and pulmonary vessels of dogs, cats and human subjects. Cell Tissue Res 220:231–238

    PubMed  CAS  Google Scholar 

  120. DeMey J, Burnstock G, Vanhoutte PM (1979) Modulation of the evoked release of noradrenaline in canine saphenous vein via presynaptic receptors for adenosine but not ATP. Eur J Pharmacol 55:401–405

    Article  CAS  Google Scholar 

  121. DeMey JG, Vanhoutte PM (1981) Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries. J Physiol (Lond) 316:347–355

    CAS  Google Scholar 

  122. Dhall U, Cowen T, Haven AJ et al. (1986) Perivascular noradrenergic and peptidergic nerves show different patterns of changes during development and ageing in the guinea-pig. J Auton Nerv Syst 16:109–126

    Article  PubMed  CAS  Google Scholar 

  123. Dhital KK, Lincoln J, Appenzeller O et al. (1986) Adrenergic innervation of vasa and nervi nervorum of optic, sciatic, vagus and sympathetic nerve trunks in normal and streptozotocin-diabetic rats. Brain Res 367:39–44

    Article  PubMed  CAS  Google Scholar 

  124. Diani AR, Peterson T, Sawada GA et al. (1985) Elevated level of vasoactive intestinal peptide in the eye and urinary bladder of diabetic and prediabetic clinical hamsters. Diabetologia 28:302–307

    Article  PubMed  CAS  Google Scholar 

  125. Di Carlo V (1977) Histochemical evidence for a serotonergic innervation of the microcirculation in the brain stem. In: Owman C, Edvinsson L (eds) Neurogenic control of the brain circulation. Pergamon Press, Oxford, pp 55–58

    Google Scholar 

  126. Di Carlo V (1981) Serotoninergic innervation of extrinsic brain stem blood vessels. Neurology 31:104

    Google Scholar 

  127. Di Carlo V (1984) Perivascular serotonergic neurons: somatodendritic contacts and axonic innervation of blood vessels. Neurosci Lett 51:295–302

    Article  PubMed  Google Scholar 

  128. Di Carlo V (1984) Segmental serotoninergic innervation of spinal cord arterial circulation. Neurosci Lett 49:225–231

    Article  PubMed  Google Scholar 

  129. Dolezel S, Gerova M, Gero J (1973) Sympathetic construction and monoaminergic innervation of large arteries. Folia Morphol (Praha) 21:364–366

    CAS  Google Scholar 

  130. Dolezel S, Gerova M, Gero J. (1974) Postnatal development of the sympathetic innervation in skeletal muscles of the dog. Physiol Bohemoslov 23:138–139

    Google Scholar 

  131. Drolet G, Gauthier P (1985) Peripheral and central mechanisms of the pressor response elicited by stimulation of the locus coeruleus in the rat. Can J Physiol Pharmacol 63:599–605

    Article  PubMed  CAS  Google Scholar 

  132. Drury AN, Szent-Györgyi A (1929) The physiological activity of adenine compounds with special reference to their action upon the mammalian heart. J Physiol (Lond) 68:213–237

    CAS  Google Scholar 

  133. Duckies SP (1983) Age-related changes in adrenergic neuronal function of rabbit vascular smooth muscle. Neurobiol Aging 4:151–156

    Article  Google Scholar 

  134. Duckies SP. Said SI (1982) Vasoactive intestinal peptide as a neurotransmitter in the cerebral circulation. Eur J Pharmacol 78:371–374

    Article  Google Scholar 

  135. Duckies SP, Buck SM (1982) Substance P in the cerebral vasculature: depletion by capsaicin suggests a sensory role. Brain Res 245:171–174

    Article  Google Scholar 

  136. Duckies SP, Carter BJ, Williams CL (1985) Vascular adrenergic neuroeffector function does not decline in aged rats. Circ Res 56:109–116

    Google Scholar 

  137. Eckenstein F, Thoenen H (1982) Production of specific antisera and monoclonal antibodies to choline ace- tyltransferase: characterization and use for identification of cholinergic neurons. EMBO 1:363–368

    CAS  Google Scholar 

  138. Edvinsson L (1985) Characterization of the contractile effect of neuropeptide Y in feline cerebral arteries. Acta Physiol Scand 125:33–41

    Article  PubMed  CAS  Google Scholar 

  139. Edvinsson L (1985) Functional role of perivascular peptides in the control of cerebral circulation. TINS 8(3): 126–131

    CAS  Google Scholar 

  140. Edvinsson L, Nielsen KC, Owman C et al. Sympathetic adrenergic influence on brain vessels as studied by changes in cerebral blood volume of mice. Eur Neurol 6:193–202

    Google Scholar 

  141. Edvinsson L, Nielsen KC, Owman C et al. (1972) Cholinergic mechanism in pial vessels. Histochemistry, electron microscopy and pharmacology. Z Zellforsch Mikrosk Anat 134:311–325

    Article  PubMed  CAS  Google Scholar 

  142. Edvinsson L, Hardebo JC, Owman C (1978) Pharmacological analysis of 5-hydroxytryptamine receptors in isolated intracranial and extracranial vessels of cat and man. Circ Res 42:143–151

    PubMed  CAS  Google Scholar 

  143. Edvinsson L, Fahrenkrug J, Hako J et al. (1980) VIP (vasoactive intestinal polypeptide)-containing nerves of intracranial arteries in mammals. Cell Tissue Res 208:135–142

    Article  PubMed  CAS  Google Scholar 

  144. Edvinsson L, Uddman R (1981) Adrenergic, cholinergic and peptidergic nerve fibres in dura mater - involvement in headache? Cephalagia 1:175–179

    Article  CAS  Google Scholar 

  145. Edvinsson L, McCulloch J, Uddman R (1981) Substance P: immunohistochemical localization and effect upon cat pial arteries in vitro and in situ. J Physiol (Lond) 318:251–258

    CAS  Google Scholar 

  146. Edvinsson L, McCulloch J, Uddman R (1982) Feline cerebral veins and arteries: composition of autonomic innervation and vasomotor responses. J Physiol (Lond) 325:161–173

    CAS  Google Scholar 

  147. Edvinsson L, Uddman R (1982) Immunohistochemical localization and dilatory effect of substance P on human cerebral vessels. Brain Res 232:466–471

    Article  PubMed  CAS  Google Scholar 

  148. Edvinsson L, Egund N, Owman CH et al. (1982) Reduced noradrenaline uptake and retention in cerebrovascular nerves associated with angiographically visible vasoconstriction following experimental subarachnoid hemorrhage in rabbits. Brain Res Bull 9:799–805

    Article  PubMed  CAS  Google Scholar 

  149. Edvinsson L, Rosendal-Hegesen S, Uddman R (1983) Substance P: localization, concentration and release in cerebral arteries, choroid plexus and dura mater. Cell Tissue Res 234:1–7

    Article  PubMed  CAS  Google Scholar 

  150. Edvinsson L, Degueurce A, Duverger D et al. (1983) Central serotonergic nerves project to the pial vessels of the brain. Nature 306:55–57

    Article  PubMed  CAS  Google Scholar 

  151. Edvinsson L, Emson P, McCulloch J et al. (1983) Neuropeptide Y: cerebrovascular innervation and vasomotor effects in the cat. Neurosci Lett 43:79–84

    Article  PubMed  CAS  Google Scholar 

  152. Edvinsson L, Emson P, McCulloch J et al. (1984) Neuropeptide Y: immunocytochemical localization to and effect upon feline pial arteries and veins in vitro and in situ. Acta Physiol Scand 122:155–163

    Article  PubMed  CAS  Google Scholar 

  153. Edvinsson L, Ekblad E, Hakanson R et al. (1984) NPY- potentiates the effect of various vasoconstrictor agents on rabbit blood vessels. Br J Pharmacol 83:519–525

    PubMed  CAS  Google Scholar 

  154. Edvinsson L, Edman R, Ottoson A et al. (1985) Distribution, concentration and effects of neuropeptide-Y (NPY), substance P (SP) and vasoactive intestinal polypeptide (VIP) in human cerebral blood vessels. J Cereb Blood Flow Metab 5 [Suppl 1]:S545

    Google Scholar 

  155. Edvinsson L, McCulloch J, Sharkey J (1985) Vasomotor responses of cerebral arterioles in situ to putative dopamine receptor agonists. Br J Pharmacol 85:403–410

    PubMed  CAS  Google Scholar 

  156. Edvinsson L, McCulloch J (1985) Distribution and vasomotor effects of peptide HI (PMI) in feline cerebral blood vessels in vitro and in situ. Regul Pept 10:345–356

    Article  PubMed  CAS  Google Scholar 

  157. Ekblad E, Edvinsson L, Wahlestedt C et al. (1984) Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibres. Regul Pept 8:225–235

    Article  PubMed  CAS  Google Scholar 

  158. Ekblad E, Rökaeus A, Hakanson R et al. (1985) Galanin nerve fibres in the rat gut: distribution, origin and projections. Neuroscience 16:355–363

    Article  PubMed  CAS  Google Scholar 

  159. Eklund S, Fahrenkrug J, Jodal M et al. (1980) Vasoactive intestinal polypeptide, 5-hydroxytryptamine and reflex hyperaemia in the small intestine of the cat. J Physiol (London) 302:549–557

    CAS  Google Scholar 

  160. Eränko O, Eränko L (1971) Loss of histochemically demonstrable catecholamines and acetylcholinesterase from sympathetic nerve fibres of the pineal body of the rat after chemical sympathectomy with 6-hydroxy- dopamine. Histochem J 3:357–363

    Article  PubMed  Google Scholar 

  161. Erspamer V, Melchiorri P, Sopranzi N (1972) The action of bombesin on the systemic arterial blood pressure of some experimental animals. Br J Pharmacol 45:442–450

    PubMed  CAS  Google Scholar 

  162. Euler US von, Gaddum JH (1931) An unidentified depressor substance in certain tissue extracts. J Physiol (Lond) 72:74

    Google Scholar 

  163. Falck B, Hillarp NA, Thieme G et al. (1962) Fluorescence of catecholamines and related compounds condensed with formaldehyde. J Histochem Cytochem 10:348–354

    Article  CAS  Google Scholar 

  164. Falck B, Owman Ch (1965) A detailed methodological description of the fluorescence method for the cellular demonstration of biogenic monoamines. Acta Univ Lund Sect 27:1–23

    Google Scholar 

  165. Felten DL, Crutcher KA (1979) Neuronal-vascular relationships in the raphe nuclei, locus coeruleus, and substantia nigra in primates. Am J Anat 155:467–482

    Article  PubMed  CAS  Google Scholar 

  166. Ferguson M, Bell C (1985) Substance P-immu- noreactive nerves in the rat kidney. Neurosci Lett 60:183–188

    Article  PubMed  CAS  Google Scholar 

  167. Fisher LA, Kikkawa DO, Rivier JE et al. (1983) Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide. Nature 305:534–536

    Article  PubMed  CAS  Google Scholar 

  168. Forssman BB, Hock D, Metz J (1982) Peptidergic innervation of the kidney. Neurosci Lett [Suppl] 10:S183

    Google Scholar 

  169. Forster C, Drew GM, Hilditch A et al. (1983) Dopamine receptors in human basilar arteries. Eur J Pharmacol 87:227–235

    Article  PubMed  CAS  Google Scholar 

  170. Franco-Cereceda A, Dahlöf C, Lundberg JM (1985) Role of neuropeptide Y and calcitonin-gene related peptide (CGRP) in cardiac sympathetic and sensory control. Acta Physiol Scand [Suppl] 124:136

    Article  Google Scholar 

  171. Fraser RAR, Stein BM, Barrett RE et al. (1970) Noradrenergic mediation of experimental cerebrovascular spasm. Stroke 1:356–362

    Article  PubMed  CAS  Google Scholar 

  172. Freund H, Ebeid AM, Fischer JE (1981) An increase in vasoactive intestinal peptide levels in canine endotoxin shock. Surg Gynecol Obstet 152:604–606

    PubMed  CAS  Google Scholar 

  173. Fukuda M, Hosoki E, Ishida Y et al. (1985) Opioid receptor types on adrenergic nerve terminals of rabbit ear artery. Br J Pharmacol 86:539–545

    PubMed  CAS  Google Scholar 

  174. Furchgott RF (1981) The requirement for endothelial cells in the relaxation of arteries by acetylcholine and some other vasodilators. Trends Pharmacol Sci 2:173–176

    Article  CAS  Google Scholar 

  175. Furchgott RF (1983) Role of endothelium in responses of vascular smooth muscle. Circ Res 53:557–573

    PubMed  CAS  Google Scholar 

  176. Furness JB (1973) Arrangement of blood vessels and their relation with adrenergic nerves in the rat mesentery. J Anat 115:346–364

    Google Scholar 

  177. Furness JB, Costa M, Wilson AJ (1977) Water-stable fluorophores produced by reaction with aldehyde solution, for the histochemical localization of catecholand indole thylamine. Histochemistry 52:159–170

    Article  PubMed  CAS  Google Scholar 

  178. Furness JB, Papka RE, Della NG et al. (1982) Substance P-like immunoreactivity in nerves associated with the vascular system of guinea-pigs. Neuroscience 7:447–459

    Article  PubMed  CAS  Google Scholar 

  179. Furness JB, Costa M, Eckenstein F (1983) Neurones localized with antibodies against choline ace- tyltransferase in the enteric nervous system. Neurosci Lett 40:105–109

    Article  PubMed  CAS  Google Scholar 

  180. Furness JB, Costa M, Keast JR (1984) Choline ace- tyltransferase and peptide immunoreactivity of sub- mucous neurons in the small intestine of the guinea- pig. Cell Tissue Res 237:329–336

    Article  PubMed  CAS  Google Scholar 

  181. Furness JB, Costa M, Papka RE et al. (1984) Neuropeptides contained in peripheral cardiovascular nerves. Clin Exp Hypertens [A] 6 (12):91–106

    Article  CAS  Google Scholar 

  182. Furness JB, Costa M, Gibbins IL et al. (1985) Neuro- chemically similar myenteric and submucous neurons directly traced to the mucosa of the small intestine. Cell Tissue Res 241:155–163

    Article  PubMed  CAS  Google Scholar 

  183. Gabella G (1976) Structure of the autonomic nervous system. Chapman and Hall, London

    Book  Google Scholar 

  184. Gaddum JH, Picarelli ZP (1957) Two kinds of tryp- tamine receptor. Br J Pharmacol 12:323–328

    CAS  Google Scholar 

  185. Gamse R, Leeman SE, Holzer P et al. (1981) Differential aspects of capsaicin on the content of somatostatin, substance P and neurotensin in the nervous system of the rat. Naunyn Schmiedebergs Arch Pharmacol 317:140

    Article  PubMed  CAS  Google Scholar 

  186. Gaudin-Chazel G, Portalier P, Barrit MC et al. (1982) Serotonin-like immunoreactivity in paraffin sections of the nodose ganglia of the cat. Neurosci Lett 33:169–172

    Article  Google Scholar 

  187. Gautret B, Schmidt H (1985) Central and peripheral sites for cardiovascular actions of Dynorphin- (1–13) in rats. Eur J Pharmacol 111:263–266

    Article  PubMed  CAS  Google Scholar 

  188. Gazelius B, Olgart L (1980) Vasodilatation in the dental pulp produced by electrical stimulation of the inferior olveolar nerve in the cat. Acta Physiol Scand 108:181–186

    Article  PubMed  CAS  Google Scholar 

  189. Gazelius B, Edwall B, Lundberg J et al. (1985) Calcitonin gene-related peptide (CGRP), a potent vasodilator related to sensory nerves in the cat. Acta Physiol Scand [Suppl] 124:134

    Google Scholar 

  190. Geffen LB, Livett DB, Rush RA (1969) Immunohistochemical localization of protein components of catecholamine storage vesicles. J Physiol (Lond) 204:593–605

    CAS  Google Scholar 

  191. Geller RG, Govier WC, Pisano JJ et al. (1970) The action of ranatensin, a new polypeptide from amphibian skin, on the blood pressure of experimental animals. Br J Pharmacol 40:605–616

    PubMed  CAS  Google Scholar 

  192. Gibbins IL, Brayden JE, Bevan JA (1984) Perivascular nerves with immunoreactivity to vasoactive intestinal polypeptide in cephalic arteries of the cat: distribution, possible origins and functional implications. Neuroscience 13:1327–1346

    Article  PubMed  CAS  Google Scholar 

  193. Gibbins IL, Morris J-L, Furness JB et al. (1985) Neuropeptide Y and dynorphin in noradrenergic neurons and substance P in presumptive cholinergic neurons innervating the guinea-pig iris. Proc Aust Physiol Pharmacol Soc 16(2):91P

    Google Scholar 

  194. Gibbins IL, Furness JB, Costa M et al. (1985) Colocalization of calcitonin gene-related peptide-like immunoreactivity with substance P in cutaneous vascular and visceral sensory neurons of guinea-pigs. Neurosci Lett 57:125–130

    Article  PubMed  CAS  Google Scholar 

  195. Gibson SJ, Polak JM, Bloom SR et al. (1984) Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species. J Neurosci 4:3101–3111

    PubMed  CAS  Google Scholar 

  196. Glover WE (1985) Increased sensitivity of rabbit ear artery to noradrenaline following perivascular nerve stimulation may be a response to neuropeptide Y released as cotransmitter. Clin Exp Pharmacol Physiol 12:227–230

    Article  PubMed  CAS  Google Scholar 

  197. Gokhale SD, Gulati OD, Kelkar LV et al. (1966) Effects of some drugs on human umbilical artery in vitro. Br J Pharmacol 27:332–346

    CAS  Google Scholar 

  198. Goldberg LI, Kohli JD (1981) Specific dopamine receptors in vascular smooth muscle. In: Vanhoutte PM, Leussen I (eds) Vasodilatation. Raven Press, New York, pp 131–140

    Google Scholar 

  199. Gräb W, Jenssen S, Rein N (1929) Die leberals Blutdepot. Klin Wochschr 8:1539–1548

    Article  Google Scholar 

  200. Greenwald SE, Lever MJ, MacIntyre I et al. (1985) Human calcitonin gene-related peptide is a potent vasodilator in the pig coronary circulation. Proc Br Pharmacol Soc (Abstracts) 1985, 18–20

    Google Scholar 

  201. Greenway CV, Lawson AE (1966) The effects of adrenaline and noradrenaline on venous return and regional blood flow in the anaesthetised cat with special reference to intestinal blood flow. J Physiol (Lond) 186:579–595

    CAS  Google Scholar 

  202. Griffith SG, Lincoln J, Burnstock G (1982) Serotonin as a neurotransmitter in cerebral arteries. Brain Res 247:388–392

    Article  PubMed  CAS  Google Scholar 

  203. Griffith SG, Burnstock G (1983) Serotoninergic neurons in human fetal intestine: an immu- nohistochemical study. Gastroenterology 85:929–937

    PubMed  CAS  Google Scholar 

  204. Griffith SG, Burnstock G (1983) Immunohistochemical demonstration of serotonin in nerves supplying human cerebral and mesenteric blood-vessels: some speculations about their involvement in vascular disorders. Lancet I:561–562

    Article  PubMed  CAS  Google Scholar 

  205. Grigor’eva TA (1962) The innervation of blood vessels. Pergamon Press, New York

    Google Scholar 

  206. Gu J, Huang WM, Blank M et al. (1983) Measurement of VIP and origin of its innervation in the rat urinary bladder. Regul Pept 6(3):305

    Article  Google Scholar 

  207. Gu J, Polak JM, Allen JM, et al. (1984) High concentrations of a novel peptide, Neuropeptide Y, in the innervation of mouse and rat heart. J Histochem Cytochem 32:467–472

    Article  PubMed  CAS  Google Scholar 

  208. Hallberg D, Pernow B (1975) Effect of substance P on various vascular beds in the dog. Acta Physiol Scand 93:277–285

    Article  PubMed  CAS  Google Scholar 

  209. Hanko J, Hardebo JE, Owman Ch (1981) Effects of various neuropeptides on cerebral blood flow. J Cereb Blood Flow Metab 1:S346-S347

    Google Scholar 

  210. Hanko JH, Tornebrandt K, Hardebo JE et al. (1985) Neuropeptide Y induces and modulates vasoconstriction in intracranial and peripheral vessels of animals and man. J Cereb Blood Flow Metab 5 [Suppl 1]:S511

    Google Scholar 

  211. Hanko J, Hardebo JE, Kahrström J et al. (1985) Calcitonin gene-related peptide is present in mammalian cerebrovascular nerve fibres and dilates pial and peripheral arteries. Neurosci Lett 57:91–95

    Article  PubMed  CAS  Google Scholar 

  212. Hanko J, Sundler F, Hardebo JE et al. (1985) Dilatation of pial and peripheral arteries by calcitonin gene- related peptides. J Cereb Blood Flow Metab 5 [Suppl 1]:S507

    Google Scholar 

  213. Hanley MR, Benton HP, Lightman SL et al. (1984) A vasopressin-like peptide in the mammalian sympathetic nervous system. Nature 309:258–261

    Article  PubMed  CAS  Google Scholar 

  214. Häppölä O, Pä värinta H, Soinila S et al. (1986) Pre- and postnatal development of 5-hydroxytryptamine- immunoreactive cells in the superior cervical ganglion of the rat. J Auton Nerv Syst 15:21–31

    Article  PubMed  Google Scholar 

  215. Hara H, Hamill GS, Jacobowitz DM (1985) Origin of cholinergic nerves to the rat major cerebral arteries: coexistence with vasoactive intestinal polypeptide. Brain Res Bull 14:179–188

    Article  PubMed  CAS  Google Scholar 

  216. Hardebo JE, Hanko J, Kährström J et al. (1985) Endothelium-dependent relaxation in cerebral arteries. J Cereb Flood Flow Metab 5 [Suppl 1]:S533

    Google Scholar 

  217. Head RJ, Stitzel RE, Delaland IS et al (1977) Effect of chronic denervation on activities of monoamineoxidase and catechol-O-methyl transferase and on contents of noradrenaline and adenosine-triphosphate in rabbit ear artery. Blood Vessels 14:229–239

    PubMed  CAS  Google Scholar 

  218. Hedge GA, Huffman LF, Grunditz T et al. (1984) Immunocytochemical studies of the peptidergic innervation of the thyroid gland in the Brattleboro rat. Endocrinology 115:2071–2076

    Article  PubMed  CAS  Google Scholar 

  219. Helke CJ, O’Donohue TL, Jacobowitz DM (1980) Substance P as a baro- and chemoreceptor afferent neurotransmitter: immunocytochemical and neurochemical evidence in the rat. Peptides 1:1–9

    Article  PubMed  CAS  Google Scholar 

  220. Hellstrand P, Järhult J (1980) Effects of nine different gastrointestinal polypeptides on vascular smooth muscle in vitro. Acta Physiol Scand 110:89–94

    Article  PubMed  CAS  Google Scholar 

  221. Hellstrand P, Fahrenkrug J, Uddman R et al. (1985) Role of vasoactive intestinal polypeptide (VIP) in the neurogenic vasodilatation of the portal vein in the rabbit. Regul Pept 12:309–316

    Article  PubMed  CAS  Google Scholar 

  222. Hendry SHC, Jones EG, Beinfeld MC (1983) Chole- cystokinin-immunoreactive neurons in rat and monkey cerebral cortex make symmetric synapses and have intimate associations with blood vessels. Proc Natl Acad Sci USA 80:2400–2404

    Article  PubMed  CAS  Google Scholar 

  223. Hill CE, Hirst GDS, Van Helden DF (1983) Development of sympathetic innervation to proximal and distal arteries of the rat mesentery. J Physiol (Lond) 338:129–147

    CAS  Google Scholar 

  224. Hillarp N-A (1946) Structure of the synapse and the peripheral innervation apparatus of the autonomic nervous system. Acta Anat [Suppl 4]: 1–153

    Google Scholar 

  225. Hirst GDS, Neild TO (1980) Evidence for two populations of excitatory receptors for noradrenaline on arteriolar smooth muscle. Nature 283:767–768

    Article  PubMed  CAS  Google Scholar 

  226. Hogaboom GK, O’Donnell JP, Fedan JS (1980) Purinergic receptors: photoaffinity analog of adenosine triphosphate is a specific adenosine triphosphate antagonist. Science 208:1273–1275

    Article  PubMed  CAS  Google Scholar 

  227. Hökfelt T, Kellerth J-O, Nilsson G et al. (1975) Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons. Brain Res 100:235–252

    Article  PubMed  Google Scholar 

  228. Hökfelt T, Johansson O, Kellerth J-O (1977) Immunohistochemical distribution of substance P. In: Von Euler, US, Pernow B (eds) Substance P. Raven Press, New York, pp 117–145

    Google Scholar 

  229. Hökfelt T, Lundberg JM, Schultzberg M et al. (1981) Immunohistochemical evidence for a local VIP-ergic neuron system in the adrenal gland of the rat. Actas Physiol Scand 113:575–576

    Article  Google Scholar 

  230. Holmgren S, Vaillant C, Dimaline R (1982) VIP-, substance P-, gastrin/CCK-, bombesin-, somatostatin- and glucagon-like immunoreactivities in the gut of the rainbow trout, Salmo gairdneń. Cell Tissue Res 223:141–153

    Article  PubMed  CAS  Google Scholar 

  231. Holton P (1959) The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J Physiol (Lond) 145:494–504

    CAS  Google Scholar 

  232. Holzer P, Gamse R, Lembeck F (1980) Distribution of substance P in the rat gastrointestinal tract - lack of effect of capsaicin pretreatment. Eur J Pharmacol 61:303

    Article  PubMed  CAS  Google Scholar 

  233. Holzer P, Ducsics A, Lembeck F (1982) Distribution of capsaicin-sensitive nerve fibres containing immuno- reactive substance P in cutaneous and visceral tissues of the rat. Neurosci Lett 31:253

    Article  PubMed  CAS  Google Scholar 

  234. Honig CR, Frierson JL (1976) Neurons intrinsic to arterioles initiate postcontraction vasodilation. Am J Physiol 230:493–507

    PubMed  CAS  Google Scholar 

  235. Honma S (1970) Presence of monoaminergic neurons in the spinal cord and intestine of the Lamprey, Lampetra japonica. Arch Histol Jpn 32:383–393

    PubMed  CAS  Google Scholar 

  236. Humphrey PPA, Feniuk W, Watts AD (1983) Prejunctional effects of 5-hydroxytryptamine on noradrenergic nerves in the cardiovascular system. Fed Proc 42:218–222

    PubMed  CAS  Google Scholar 

  237. Iijima T (1977) A histochemical study of the innervation of cerebral blood vessels in the turtle. J Comp Neurol 176:307–314

    Article  PubMed  CAS  Google Scholar 

  238. Iijima T, Wasano T (1980) A histochemical and ultra- structural study of serotonin-containing nerves in cerebral blood vessels of the lamprey. Anat Rec 198:671–680

    Article  PubMed  CAS  Google Scholar 

  239. Itakura T, Okuno T, Nakakita K et al. (1984) A light and electron microscopic immunohistochemical study of vasoactive intestinal polypeptide- and substance P- containing nerve fibres along the cerebral blood vessels: Comparison with aminergic and cholinergic nerve fibres. J Cereb Blood Flow Metab 4:407–414

    Article  PubMed  CAS  Google Scholar 

  240. Itakura T, Yokote H, Kumura H et al. (1985) 5- Hydroxytryptamine innervation of vessels in the rat cerebral cortex. Immunohistochemical findings and hydrogen clearance study of CBF. J Neurosurg 62:42–47

    Article  PubMed  CAS  Google Scholar 

  241. Hakura T, Nakai K, Nakakita K et al. (1985) Autoradiographic demonstration of adrenergic receptors in cerebral blood vessels. J of Cereb Blood Flow Metab 5 [Suppl 1]:S495

    Google Scholar 

  242. Järhult J, Hellstrand P, Sundler F (1980) Immunohistochemical localization and vascular effects of vasoactive intestinal polypeptide in skeletal muscle of the cat. Cell Tissue Res 207:55–64

    Article  PubMed  Google Scholar 

  243. Järhult J, Fahrenkrug J, Hellstrand P et al. (1982) VIP (vasoactive intestinal polypeptide)-immunoreactive innervation of the portal vein. Cell Tissue Res 221:617–625

    Article  PubMed  Google Scholar 

  244. Jessen KR, Saffrey MJ, Van Noorden S et al. (1980) Immunohistochemical studies of the enteric nervous system in tissue culture and in situ: localization of vasoactive intestinal polypeptide (VIP), substance P and enkephalin immunoreactive nerves in the guinea- pig gut. Neuroscience 5:1717–1735

    Article  PubMed  CAS  Google Scholar 

  245. Jójárt I, Joó F, Siklós L, László FA (1984) Immunoelectronhistochemical evidence for innervation of brain microvessels bu vasopressin-immunoreactive neurons in the rat. Neurosci Lett 51:259–264

    Article  PubMed  Google Scholar 

  246. Kai-Kai MA, Ken P (1985) Localization of 5-hydro- zytryptamine to neurons and endoneurial mast cells in rat sensory ganglia. J Neurocytol 14:63–78

    Article  PubMed  CAS  Google Scholar 

  247. Kalkman HO, Boddeke HWGM, Doods HN et al. (1981) Hypotensive activity of serotonin receptor agonists in rats is related to their affinity for 5-HT, receptors. Eur J Pharmacol 91:155–156

    Article  Google Scholar 

  248. Kamilkawa Y, Cline JR, Su C (1980) Diminished purinergic modulation of the vascular adrenergic neu- trotransmission in spontaneously hypertensive rats. Eur J Pharmacol 66:347–353

    Article  Google Scholar 

  249. Kapadia SE, de Lanerolle NC (1984) Immunohistochemical and electron microscopic demonstration of vascular innervation in the mammalian brain stem. Brain Res 292:33–39

    Article  PubMed  CAS  Google Scholar 

  250. Karenkan K-S, Chao LP (1981) Localization of choline acetyltransferase at neuromuscular junctions. Muscle Nerve 4:91–93

    Article  Google Scholar 

  251. Karnovsky MJ, Roots L (1964) A “direct coloring” thiocholine method for Cholinesterase. J Histochem Cytochem 12:219–221

    Article  PubMed  CAS  Google Scholar 

  252. Kása P, Mann SP, Hebb C (1970) Localization of choline acetyltransferase. Nature 226:812–814

    Article  PubMed  Google Scholar 

  253. Kasakov L, Burnstock G (1983) The use of the slowly degradable analog, α-ß -methylene ATP, to produce desensitisation of the P2-purinoceptor: effect on non- adrenergic, noncholinergic responses of the guinea-pig urinary bladder. Eur J Pharmacol 86:291–294

    Article  Google Scholar 

  254. Katsuragi T, Su C (1980) Purine release from vascular adrenergic nerves by high potassium and a calcium ionophore A-23187. J Pharmacol Exp Ther 215:685–690

    PubMed  CAS  Google Scholar 

  255. Katsuragi T, SU C (1982) Augmentation by theophylline of (3H) purine release from vascular adrenergic nerves: evidence for presynaptic autoinhibition. J Pharmacol Exp Ther 220:152–156

    PubMed  CAS  Google Scholar 

  256. Katz B (1966) Nerve, muscle and synapse. McGraw- Hill, New York

    Google Scholar 

  257. Kennedy C, Burnstock G (1985) Evidence for two types of P2-purinoceptors in the longitudinal muscle of the rabbit portal vein. Eur J Pharmacol 111:49–56

    Article  PubMed  CAS  Google Scholar 

  258. Kennedy C, Delbro D, Burnstock G (1985) P2-Puri- noceptors mediate both vasodilation (via the endothelium) and vasoconstriction of the isolated rat femoral artery. Eur J Pharamcol 107:161–168

    Article  CAS  Google Scholar 

  259. Kilborn MJ, Potter EK, McCloskey DI (1985) Neuromodulation of the cardiac vagus: comparison of neuropeptide Y and related peptides. Regul Pept 12:155–161

    Article  PubMed  CAS  Google Scholar 

  260. Kobayashi S, Tsukahara S, Sugita K et al. (1981) Adrenergic and cholinergic innervation of rat cerebral arteries. Histochem 70:129–138

    Article  CAS  Google Scholar 

  261. Kobayashi S, Kyoshima K, Olschowka JA et al. (1983) Vasoactive intestinal polypeptide immunoreactive and cholinergic nerves in the whole mount preparation of the major cerebral arteries of the rat. Histochemistry 79:377–381

    Article  PubMed  CAS  Google Scholar 

  262. Kobayashi H, Wada A, Izumi F et al. (1985) Alpha- adrenergic receptors in cerebral microvessels of nor- motensive and hypertensive rats. Circ Res 56:402–409

    PubMed  CAS  Google Scholar 

  263. Koelle GB, Friedenwald JS (1949) A histochemical method for localizing Cholinesterase activity. Proc Soc Exp Biol Med 70:617–622

    PubMed  CAS  Google Scholar 

  264. Kubo T, Su C (1983) Effects of adenosine on [3H] norepinephrine release from perfused mesenteric arteries of SHR and renal hypertensive rats. Eur J Pharmacol 87:349–352

    Article  PubMed  CAS  Google Scholar 

  265. Kügelen IV, Starke K (1985) Noradrenaline and adenosine triphosphate as co-transmitters of neurogenic vasoconstriction in rabbit mesenteric artery. J Physiol (Lond) 367:435–455

    Google Scholar 

  266. Lagnado MLJ, Crowe R, Lincoln J et al. (1988) A reduction of nerves containing vasoactive intestinal polypeptide and serotonin, but not neuropeptide Y and noradrenaline in cerebral blood vessel of the 8 week streptozotocin-induced diabetic rat. Blood Vessels (in press)

    Google Scholar 

  267. Lamotte CC, Johns DR, de Lanerolle NC (1982) Immunohistochemical evidence of indolamine neurons in Monkey spinal cord. J Comp Neurol 206:359–370

    Article  PubMed  CAS  Google Scholar 

  268. Lands AM, Arnold A, McAuliff JP et al. (1967) Differentiation of receptor systems activated by sympathomimetic amines. Nature 214:597–598

    Article  PubMed  CAS  Google Scholar 

  269. Langer SZ (1974) Presynaptic regulation of the release of catecholamines. Pharmacol Rev 23:1793–1800

    CAS  Google Scholar 

  270. Larsson L-I, Fahrenkrug J, Schaffalitzky de Muckadell O et al. (1976) Localization of vasoactive intestinal polypeptide (VIP) to central and peripheral neurons. Proc Natl Acad Sci USA 73:3197–3200

    Article  PubMed  CAS  Google Scholar 

  271. Larsson L-I, Edvinsson L, Fahrenkrug J et al. (1976) Immunohistochemical localization of a vasoactive polypeptide (VIP) in cerebrovascular nerves. Brain Res 113:400–404

    Article  PubMed  CAS  Google Scholar 

  272. Larsson L-I, Fahrenkrug J, Schaffalitzky de Muckadell O (1977) Occurrence of nerves containing vasoactive intestinal polypeptide immunoreactivity in the male genital tract. Life Sci 21:503–508

    Article  PubMed  CAS  Google Scholar 

  273. Larsson L-I, Fahrenkrug J, Schaffalitzky de Muckadell O (1977) Vasoactive intestinal polypeptide occurs in nerves of the female genitourinary tract. Science 197:1374–1375

    Article  PubMed  CAS  Google Scholar 

  274. Lechin F, Van der Dijs B, Lechin E et al. (1978) The dopaminergic and noradrenergic blockades: a new treatment for headache. Headache 18: 69–74

    Article  PubMed  CAS  Google Scholar 

  275. Lee TJ-F, Saito A (1984) Altered cerebral vessel innervation in the spontaneously hypertensive rat. Circ Res 55:393–403

    Google Scholar 

  276. Lee TJ-F, Saito A, Berezin I (1984) Vasoactive intestinal polypeptide-like substance: the potential transmitter for cerebral circulation. Science 224:898–901

    Article  PubMed  CAS  Google Scholar 

  277. Lee Y, Takami K, Kawai Y et al. (1985) Distribution of calcitonin gene-related peptide in the rat peripheral nervous system with reference to its coexistence with substance P. Neuroscience 15:1227–1237

    Article  PubMed  CAS  Google Scholar 

  278. Lembeck F, Holzer P (1979) Substance P as neurogenic mediator of antidromic vasocilation and neurogenic plasma extravasation. Naunyn Schmiedebergs Arch Pharmacol 310:175

    Article  PubMed  CAS  Google Scholar 

  279. Lembeck F, Donnerer J, Bartho L (1982) Inhibition of neurogenic vasodilatation and plasma extravasation by substance P antagonists, somatostatin and (D-METZ, PRO5) enkephalinamide. Eur J Pharmacol 85:171–176

    Article  PubMed  CAS  Google Scholar 

  280. Levitt B, Westfall DP (1982) Factors influencing the release of purines and norepinephrine in the rabbit portal vein. Blood Vessels 19:30–40

    PubMed  CAS  Google Scholar 

  281. Liang CC (1975) A possible sympathetic cholinergic mechanism in the renal reflex elicited by stimulation of abdominal viscera in the dog. Clin Exp Pharmacol Physiol 2:103–117

    Article  PubMed  CAS  Google Scholar 

  282. Lindvall O, Björklund A (1974) The glyoxylic acid fluorescence histochemical method: a detailed account of the methodology for the visualization of central catecholamine neurons. Histochemistry 39:97–127

    Article  PubMed  CAS  Google Scholar 

  283. Lindvall M, Alumets J, Edvinsson L et al. (1978) Peptidergic (VIP) nerves in the mammalian choroid plexus. Neurosci Lett 9:77–82

    Article  PubMed  CAS  Google Scholar 

  284. Liu-Chen LY, Mayberg M, Moskowitz MA (1983) Immunohistochemical evidence for a substance P-con- taining trigemino-vascular pathway to pial arteries in cats. Brain Res 268:162–166

    Article  PubMed  CAS  Google Scholar 

  285. Liu-Chen LY, Gillespie SA, Norregaard TV et al. (1984) Cholecystokinin-8 (CCK8) immunoreactivity in cerebral arteries and pia arachnoid and the effect of unilateral trigeminal ganglionectomy. Fed Proc 43:304

    Google Scholar 

  286. Lobato RD, Marin J, Salaices M et al. (1980) Effect of experimental subarachnoid hemorrhage on the adrenergic innervation of cerebral arteries. J Neurosurg 53:477–479

    Article  PubMed  CAS  Google Scholar 

  287. Londos C, Cooper DMF, Wolff J (1980) Subclasses of external adenosine receptors. Proc Natl Acad Sci USA 77:2551–2554

    Article  PubMed  CAS  Google Scholar 

  288. Low PA, Walsh JC, Huang CY et al. (1975) The sympathetic nervous system in alcoholic neuropathy. A clinical and pathological study. Brain 98:357–364

    Article  PubMed  CAS  Google Scholar 

  289. Lundberg JM (1981) Evidence for coexistence of vasoactive intestinal polypeptide (VIP) and acetylcholine in neurons of cat exocrine glands: morphological, biochemical and functional studies. Acta Physiol Scand [Suppl 496]: 1–57

    Google Scholar 

  290. Lundberg J, Ljung B, Stage D et al. (1976) Postnatal autogenic development of the adrenergic innervation pattern in rat portal vein: a histochemical study. Cell Tissue Res 172:15–27

    Article  PubMed  CAS  Google Scholar 

  291. Lundberg JM, Hökfelt T, Schultzberg M et al. (1979) Occurrence of vasoactive intestinal polypeptide (VIP)- like immunoreactivity in certain cholinergic neurons of the cat: evidence from combined immunohistochem- istry and acetylcholinesterase staining. Neuroscience. 4:1539–1559

    Article  PubMed  CAS  Google Scholar 

  292. Lundberg JM, Hökfelt T, Fahrenkrug J et al. (1979) Peptides in the cat carotid body (glomus caroticum): VIP-, enkephalin-, and substance P-like immunoreactivity. Acta Physiol Scand 107:279–281

    Article  PubMed  CAS  Google Scholar 

  293. Lundberg JM, Hökfelt T, Änggärd et al. (1980) Peripheral peptide neurons: distribution, axonal transport, and some aspects on possible function. In: Costa E, Trabucchi M (eds) Advances in biochemical psychopharmacology, vol 22. Neural peptides and neuronal communication. Raven Press, New York, pp 25–36

    Google Scholar 

  294. Lundberg JM, Änggärd A, Fahrenkrug J et al. (1980) Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: functional significance of coexisting transmitters for vasodilation and secretion. Proc Natl Acad Sci USA 77:1651–1655

    Article  PubMed  CAS  Google Scholar 

  295. Lundberg JM, Hökfelt T, Änggärd A et al. (1980) Peripheral peptide neurons: distribution, axonal transport, and some aspects on possible function. In: Costa E, Trabucchi M (eds) Advances in biochemical psychopharmacology, vol 22. Neural peptides and neuronal communication. Raven Press, New York, pp 25–36

    Google Scholar 

  296. Lundberg JM, Hökfelt T, Änggärd A et al. (1980) Coexistence of an avian pancreatic polypeptide (APP) immunoreactive substance and catecholamines in some peripheral and central neurons. Acta Physiol Scand 110:107–109

    Article  PubMed  CAS  Google Scholar 

  297. Lundberg JM, Änggärd A, Emson P et al. (1981) Vasoactive intestinal polypeptide and cholinergic mechanisms in cat nasal mucosa: studies on choline acetyltransferase and release of vasoactive intestinal polypeptide. Proc Natl Acad Sci USA 78:5255–5259

    Article  PubMed  CAS  Google Scholar 

  298. Lundberg JM, Terenius L, Hökfelt T et al. (1982) Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function. Acta Physiol Scand 116:477–480

    Article  PubMed  CAS  Google Scholar 

  299. Lundberg JM, Änggärd A, Fahrenkrug J (1982) VIP as a mediator of hexamethonium-sensitive, atropine- resistant vasodilation in the cat tongue. Acta Physiol Scand 116:387–392

    Article  PubMed  CAS  Google Scholar 

  300. Lundberg JM, Tatemoto K (1982) Pancreatic polypeptide family (APP, BPP, NPY and NPY) in relation to sympathetic vasoconstriction resistant to α-adreno- ceptor blockade. Acta Physiol Scand 116:393–402

    Article  PubMed  CAS  Google Scholar 

  301. Lundberg JM, Saria A (1982) Vagal substance P nerves involved in control of vascular permeability and smooth muscle tone in trachea and bronchi. Br J Pharmacol 77:441P

    Google Scholar 

  302. Lundberg JM, Terenius L, Hökfelt T et al. (1983) High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man. Neurosci Lett 42:167–172

    Article  PubMed  CAS  Google Scholar 

  303. Lundberg JM, Fahrenkrug J, Larsson O et al. (1984) Corelease of vasoactive intestinal polypeptide and peptide histidine isolencine in relation to atropine- resistant vasodilatation in cat submandibular salivary gland. Neurosci Lett 52:37–42

    Article  PubMed  CAS  Google Scholar 

  304. Lundberg JM, Änggärd A, Pernow J et al. (1985) Neuropeptide Y-, substance P- and VIP-immunoreactive nerves in cat spleen in relation to autonomic vascular and volume control. Cell Tissue Res 239:9–18

    Article  PubMed  CAS  Google Scholar 

  305. Lundberg JM, Saria A, Franco-Cerceda A et al. (1985) Differential effects of reserpine and 6-hydroxydopa- mine on neuropeptide Y (NPY) and noradrenaline in peripheral neurons. Naunyn Schmiedebergs Arch Pharmacol 328:331–340

    Article  PubMed  CAS  Google Scholar 

  306. Lundberg JM, Franco-Cereceda A, Hua X et al. (1985) Coexistence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin. Eur J Pharmacol 108:315–319

    Article  PubMed  CAS  Google Scholar 

  307. Lundvall J, Järhult J (1976) Beta-adrenergic dilator component of the sympathetic vascular response in skeletal muscle. Acta Physiol Scand 96:180–192

    Article  PubMed  CAS  Google Scholar 

  308. Mabe Y, Tatemoto K, Huidobro-Turo JP (1985) Neuropeptide Y- induced pressor responses: Activation of a non-adrenergic mechanism, potentiation by reserpine and blockade by nifedipine. Eur J Pharmacol 116:33–39

    Article  PubMed  CAS  Google Scholar 

  309. Malm L, Sundler F, Uddman R (1980) Effects of vasoactive intestinal polypeptide on resistance and capacitance vessels in the nasal mucosa. Acta Otolaryngol (Stockh) 90:304–308

    Article  CAS  Google Scholar 

  310. Matsuyama T, Shiosaka S, Matsumoto M et al. (1983) Overall distribution of vasoactive intestinal polypeptide-containing nerves on the wall of cerebral arteries: an immunohistochemical study using whole- mounts. Neuroscience 10:89–96

    Article  PubMed  CAS  Google Scholar 

  311. Matsuyama T, Matsumoto M, Shiosaka S et al. (1984) dual innervation of substance P-containing neuron system in the wall of the cerebral arteries. Brain Res 322:144–147

    Article  PubMed  CAS  Google Scholar 

  312. Matsuyama T, Matsumoto M, Shiosaka S et al. (1984) Serotonergic and peptidergic innervation of the cerebral arteries: an immunohistochemical and electron microscopic study. Neurosci Lett [Suppl 17]:S118

    Google Scholar 

  313. Mattiason A, Ekblad E, Sundler F et al. (1985) Origin and distribution of neuropeptide Y-, vasoactive intestinal polypeptide- and substance P- containing nerve fibres in the urinary bladder of the rat. Cell Tissue Res 239:141–146

    Article  Google Scholar 

  314. McCulloch J (1983) Peptides and the microregulation of blood flow in the brain. Nature 304:120

    Article  PubMed  CAS  Google Scholar 

  315. McCulloch J (1984) Role of dopamine in interactions among cerebral function, metabolism and blood flow. In: MacKenzie ET et al. (eds) Neurotransmitters and the cerebral circulation. (LERS Monograph, vol 2) Raven Press, New York, pp 137–155

    Google Scholar 

  316. McCulloch J (1984) Perivascular nerve fibres and the cerebral circulation. TINS 7(5): 135–138

    Google Scholar 

  317. McCulloch J, Edvinsson L (1980) The effects of vasoactive intestinal polypeptide upon pial arteriolar calibre, cerebral blood flow, cerebral oxygen consumption and the electroencephalogram. Am J Physiol 238:H449–456

    PubMed  CAS  Google Scholar 

  318. McGrath JC (1982) Evidence for more than one type of postjunctional α-adrenoceptor. Biochem Pharmacol 31:467–484

    Article  PubMed  CAS  Google Scholar 

  319. McGrath JC (1983) The variety of vascular α-adre- noceptors. TIPS 4:14–18

    CAS  Google Scholar 

  320. McKenna OC, Angelakos ET (1968) Acetylcholinesterase-containing nerve fibres in the canine kidney. Circ Res 23:645–651

    PubMed  CAS  Google Scholar 

  321. Melander T, Hökfelt T, Rökaeus A et al. (1985) Distribution of galanin-like immunoreactivity in the gastro-intestinal tract of several mammalian species; Cell Tissue Res 239:253–270

    Article  PubMed  CAS  Google Scholar 

  322. Meldrum LA, Burnstock G (1983) Evidence that ATP acts as a cotransmitter with noradrenaline in sympathetic nerves supplying the guinea-pig vas deferens. Eur J Pharmacol 92:161–163

    Article  PubMed  CAS  Google Scholar 

  323. Mellander S, Johansson B (1968) Control of resistance, exchange and capacitance junctions in the peripheral circulation. Pharmacol Rev 20:117–196

    PubMed  CAS  Google Scholar 

  324. Mellander S, Andersson P-O, Afzelius L-E et al. (1981) Neural beta-adrenergic dilation of the facial vein in man. Possible mechanism in emotional blushing. Acta Physiol Scand 114:393–399

    Article  Google Scholar 

  325. Morris JL, Gibbins IL, Furness JB et al. (1985) Colocalization of neuropeptide Y, vasoactive intestinal polypeptide and dynorphin in non-noradrenergic axons of the guinea-pigs uterine artery. Neurosci Lett 62:31–37

    Article  PubMed  CAS  Google Scholar 

  326. Moritoki H, Su I (1981) Potentiating effects of 5- hydroxytryptamine and histamine on nerve stimulation induced contractions of the rabbit mesenteric artery. Arch Int Pharmacodyn Ther 252(2): 186–195

    PubMed  CAS  Google Scholar 

  327. Moskowitz MA (1984) The neurobiology of vascular head pain. Ann Neurol 16:157–168

    Article  PubMed  CAS  Google Scholar 

  328. Moskowitz MA, Liebmann JE, Reinhard JF et al. (1979) Raphe origin of serotonin-containing neurons within choroid plexus of the cat. Brain Res 169:590–594

    Article  PubMed  CAS  Google Scholar 

  329. Moskowitz MA, Norregaard TV, Liu-Chen L-Y et al. (1984) VIP, CCK, and met-enkephalin in pia arachnoid and cerebral arteries after unilateral lesion of cat trigeminal ganglia. Abstr Soc Neurosci 13:576

    Google Scholar 

  330. Mott JC (1961) The stability of the cardiovascular system. In: Wolstenholme GEW, O’Connor M (eds): Somatic stability in the newly born. A Ciba Foundation symposium. Little Brown, Boston, pp 192–214

    Google Scholar 

  331. Mulderry PK, Ghatei MA, Rodrigo J et al. (1985) Calcitronin gene-related peptide in cardiovascular tissues of the rat. Neuroscience 14:947–954

    Article  PubMed  CAS  Google Scholar 

  332. Muramatsu I, Fujiwara M, Mivra A et al. (1981) Possible involvement of adenine nucleotides in sympathetic neuroeffector mechanisms of dog basilar artery. J Pharmacol Exp Ther 216:401–409

    PubMed  CAS  Google Scholar 

  333. Myers HZ, Axhwnk EA, Honig CR (1975) Ganglion cells in arterioles of skeletal muscles role in sympathetic vasodilation. Am J Physiol 229:126–138

    PubMed  CAS  Google Scholar 

  334. Nagy JI, LaBella LA, Buss M (1984) Immuno- histochemistry of adenosine deaminase: implications for adenosine neurotransmission. Science 224:166–168

    Article  PubMed  CAS  Google Scholar 

  335. Nagy JI, Buss M, LaBella LA, Daddona PE (1984) Immunohistochemical localization of adenosine deaminase in primary afferent neurons of the rat. Neurosci Lett 48:133–138

    Article  PubMed  CAS  Google Scholar 

  336. Napoleone P, Sancesario G, Amenta F (1982) 5- Hydroxytryptophan uptake in the indoleaminergic nerve fibres within rat cerebrovascular tree. Neurosci Lett 28:57–60

    Article  PubMed  CAS  Google Scholar 

  337. Napoleone P, Sancesario G, Amenta F (1982) Indoleaminergic innervation of rat choroid plexus: a fluorescence histochemical study. Neurosci Lett 34:143–147

    Article  PubMed  CAS  Google Scholar 

  338. Nilsson SFE, Bill A (1985) Effects of facial nerve stimulation, VIP and PHI on ocular blood flow. Acta Physiol Scand 124 [Suppl 542]: 132

    Google Scholar 

  339. Norregaard TV, Moskowitz MA (1985) Substance P and the sensory innervation of intracranial and extracranial feline cephalic arteries. Implications for vascular pain mechanisms in man. Brain 108:517–533

    Article  PubMed  Google Scholar 

  340. Oleson S-P (1985) A calcium-dependent reversible permeability increase in microvessels in frog brain, induced by serotonin. J Physiol (Lond) 361:103–113

    Google Scholar 

  341. Olgart L, Hökfelt T, Nillson G et al. (1977) Localization of substance P-like immunoreactivity in nerves in the tooth pulp. Pain 4:153–159

    Article  PubMed  CAS  Google Scholar 

  342. Osias MB, Siegel NJ, Chaudry IH et al. (1977) Post- ischemic renal failure: accelerated recovery with adenosine triphosphate magnesium chloride infusion. Arch Surg 112:729–731

    PubMed  CAS  Google Scholar 

  343. Olson L, Alund M, Norberg K-A (1976) Fluorescence microscopical demonstration of a population of gastrointestinal nerve fibres with a selective affinity for quina- crine. Cell Tissue Res 171:407–423

    Article  PubMed  CAS  Google Scholar 

  344. Osborne LW, Silva DG (1970) Histological, acetylcholinesterase and fluorescence histochemical studies on the atrial ganglia of the monkey heart. Exp Neurol 27:497–511

    Article  PubMed  CAS  Google Scholar 

  345. Owman C, Edvinsson L, Hardebo JE et al. (1977) Immunohistochemical demonstration of actin and myosin in brain capillaries. Acta Neurol Scand 56 [Suppl 64]:384–385

    Google Scholar 

  346. Page IH (1954) Serotonin (5-hydroxytryptamine) Physiol Rev 34:563–588

    PubMed  CAS  Google Scholar 

  347. Papka RE, Furness JB, Della NG et al. (1981) Depletion by capsaicin of substance P-immu- noreactivity and acetylcholinesterase activity from nerve fibres in the guinea pig heart. Neurosci Lett 27:47–54

    Article  PubMed  CAS  Google Scholar 

  348. Papka RE, Cotton JP, Traurig HH (1985) Comparative distribution of neuropeptide tyrosine-vasoactive intestinal polypeptide-, substance P- immunoreactive, acetylcholinesterase-positive and noradrenergic nerves in the reproductive tract of the female rat. Cell Tissue Res 242:475–490

    Article  PubMed  CAS  Google Scholar 

  349. Parnavelas JG, Kelly W, Burnstock G (1985) Ultra- structural localization of choline acetyltransferase in vascular endothelial cells in rat brain. Nature 316:724–725

    Article  PubMed  CAS  Google Scholar 

  350. Paton DM (1981) Presynaptic neuromodulation mediated by purinergic receptors. In: Burnstock G (ed) Purinergic receptors. Chapman and Hall, London, pp 199–219 (Receptors and recognition, series B, vol 12)

    Chapter  Google Scholar 

  351. Paton WDM, Vizi ES (1969) The inhibitory action of noradrenaline and adrenaline on acetylcholine output by guinea-pig ileum longitudinal muscle strip. Br J Pharmacol 35:10–18

    PubMed  CAS  Google Scholar 

  352. Pegram BL, Bevan RD, Bevan JA (1976) Facial vein of the rabbit: neurogenic vasodilation mediated by ß- adrenergic receptors. Circ Res 39:854–860

    PubMed  CAS  Google Scholar 

  353. Peng JH, Kimura H, McGreer PL et al. (1981) Anticholine acetyltransferase fragments antigen binding (Fab) for immunohistochemistry. Neurosci Lett 21:281–285

    Article  PubMed  CAS  Google Scholar 

  354. Peroutka SJ, Snyder SH (1979) Multiple serotonin receptors: differential binding of [3H]5-hydroxy- tryptamine, [3H]lysergic acid diethylamide and [3H]spir- peridol. Mol Pharmacol 16:687–699

    PubMed  CAS  Google Scholar 

  355. Polak JM, Bloom SR (1980) Peripheral localization of regulatory peptides as a clue to their function. J Histochem Cytochem 28:918–924

    Article  PubMed  CAS  Google Scholar 

  356. Puroy RE, Huributt DE, Rains LA (1981) Receptors for 5-hydroxytryptamine in rabbit isolated ear artery and aorta. Blood Vessels 18:16–27

    Google Scholar 

  357. Quirion R, Rioux F, St Pierre S et al. (1979) Increased sensitivity to neurotensin in fasted rats. Life Sci 25:1969–1973

    Article  PubMed  CAS  Google Scholar 

  358. Rapport MM, Green AA, Page I (1948) Serum vasoconstrictor (serotonin). IV. Isolation and characterization. J Biol Chem 176:1243–1251

    PubMed  CAS  Google Scholar 

  359. Reinecke M, Weihe E, Forsmann WG (1980) Substance P- immunoreactive nerve fibres in the heart. Neurosci Letts 20:265–269

    Article  CAS  Google Scholar 

  360. Reinecke M, Schlüter P, Yanaihara N et al. (1981) VIP immunoreactivity in enteric nerves and endocrine cells of the vertebrate gut. Peptides 2 (Suppl. 2): 149–156

    Article  PubMed  CAS  Google Scholar 

  361. Reinecke M, Weihe E, Carraway RE et al. (1982) Localization of neurotensin immunoreactive nerve fibres in the guinea-pig heart: evidence derived by immunohistochemistry, radioimmunoassay and chromatography. Neuroscience 7:1785–1795

    Article  PubMed  CAS  Google Scholar 

  362. Reinecke M, Vallance C, Weihe E et al. (1982) Neuropeptide (substance P, neurotensin) immunoreactive nerve fibres in the heart of higher vertebrates. Neurosci Lett [Suppl] 10:S403

    Google Scholar 

  363. Reinhard JF, Koskowitz MA, Elspas S et al. (1978) Serotoninergic innervation of rat and bovine parenchymal brain blood vessels: biochemical and pharmacological studies. Neurosci Abstr 4:451

    Google Scholar 

  364. Reinhard JF, Liebmann JE, Schlosberg AJ et al. (1979) Serotonin neurons project to small blood vessels in the brain. Science 206:85–87

    Article  PubMed  CAS  Google Scholar 

  365. Rennels ML, Nelson E (1975) Capillary innervation in the mammalian central nervous system: an electron microscopic demonstration. Am J Anat 144:233–241

    Article  PubMed  CAS  Google Scholar 

  366. Rennels ML, Fujimoto K, Nelson E (1979) Capillary innervation in the hypothalamus: a fluorescence histochemical and electron microscopic study. Acta Neurol Scand 60 [Suppl 72]:92–93

    Google Scholar 

  367. Rennels ML, Gregory TF, Fujimoto K (1983) Innervation of capillaries by local neurons in the cat hypothalamus: a light microscopic study with horseradish peroxidase. J Cereb Blood Flow Metab 3:535–542

    Article  PubMed  CAS  Google Scholar 

  368. Riphagen CL, Pittman Q (1985) Cardiovascular responses to intrathecal administration of arginine vasopression in rats. Regul Pept 10:293–298

    Article  PubMed  CAS  Google Scholar 

  369. Richardson BP, Engels G, Donatsch P et al. (1985) Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs. Nature 316:126–131

    Article  PubMed  CAS  Google Scholar 

  370. Roddie IC, Shepherd JT, Whelan RF (1957) Contribution of constrictor and dilator nerves to skin vasodilatation during body heating. J Physiol (Lond) 136:489

    CAS  Google Scholar 

  371. Rodrigo J, Polak JM, Terenghi G et al. (1985) Calcitonin gene-related peptide (CGRP)-immunoreactive sensory and motor nerves of the mammalian palate. Histochemistry 82:67–74

    Article  PubMed  CAS  Google Scholar 

  372. Rose GA, Moulds RFW (1979) Pharmacological comparison of isolated human cerebral and digital arteries. Stroke 10:736–741

    Article  PubMed  CAS  Google Scholar 

  373. Rosenfeld MG, Mermod J-J, Amara SG et al. (1983) Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 304:129–135

    Article  PubMed  CAS  Google Scholar 

  374. Rossel S, Olgart L, Gazelius B (1981) Inhibition of antidromic and substance P-induced vasodilation by a substance P-antagonist. Acta Physiol Scand 111:381–382

    Article  Google Scholar 

  375. Rowan RA, Bevan JA (1982) Distribution of adrenergic synaptic cleft width in vascular and non-vascular smooth muscle. In: Bevan JA (ed) Vascular neuroeffector mechanisms IV. Proceedings of the 4th international symposium on vascular neuroeffector mechanisms, Kyoto, Japan. Raven Press, New York

    Google Scholar 

  376. Rubenstein AE, Rudansky MC, Yahr MD (1983) Autonomic failure due to amyloid. In: Bannister R (ed) Autonomic failure. A textbook of clinical disorders of the autonomic nervous system. Oxford University Press, Oxford, pp 574–595

    Google Scholar 

  377. Ryan ML, Clark KE, Brody MJ (1974) Neurogenic and mechanical control of canine uterine vascular resistance. Am J Physiol 227:547–555

    PubMed  CAS  Google Scholar 

  378. Saba H, Cowen T, Haven AJ et al. (1984) Reduction in noradrenergic perivascular nerve density in the left and right cerebral arteries of old rabbits. J Cereb Blood Flow Metab 4:284–289

    Article  PubMed  CAS  Google Scholar 

  379. Saffrey MJ, Polak JM, Burnstock G (1982) Distribution of vasoactive intestinal polypeptide-, substance P, enkephalin- and neurotensin-like immunoreactive nerves in the chicken gut during development. Neuroscience 7:279–293

    Article  PubMed  CAS  Google Scholar 

  380. Said SI, Mutt V (1970) Polypeptide with broad biological activity: isolation from small intestines. Science 169:1217–1218

    Article  PubMed  CAS  Google Scholar 

  381. Santer RM (1982) Fluorescence histochemical observations on the adrenergic innervation of the cardiovascular system in the aged rat. Brain Res Bull 9:667–672

    Article  PubMed  CAS  Google Scholar 

  382. Saria A, Martling C-R, Dalsgaard C-J et al. (1985) Evidence for substance P-immunoreactive spinal affer- ents that mediate bronchoconstriction. Acta Physiol Scand 125:407–414

    Article  PubMed  CAS  Google Scholar 

  383. Scatton B, Duverger D, L’Heureux R et al. (1985) Neurochemical studies on the nature of the serotoninergic innervation of the cerebral circulation of the cerebral circulation. J Cereb Blood Flow Metab 5 [Suppl 1]:S527

    Google Scholar 

  384. Schmidt M, Imbs J-L, Schwartz J (1981) The vascular dopamine receptor: a review. J Pharmacol 12:355–382

    PubMed  CAS  Google Scholar 

  385. Schon F, Ghatei MA, Allen JM et al. (1985) The effect of sympathectomy on calcitonin gene related peptide levels in the rat trigeminovascular system. Brain Res 348:197–200

    Article  PubMed  CAS  Google Scholar 

  386. Schon F, Allen JM, Yeats JC et al. (1985) Neuropeptide Y innervation of the rodent pineal gland and cerebral blood vessels. Neurosci Lett 57:65–71

    Article  PubMed  CAS  Google Scholar 

  387. Schultzberg M, Hökfelt T, Nilsson G et al. (1980) Distribution of peptide- and catecholamine-containing neurons in the gastro-intestinal tract of rat and guinea- pig: immunohistochemical studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin/cholecystokinin, neurotensin and dopamine β-hydroxylase, Neuroscience 5:689–744

    Article  PubMed  CAS  Google Scholar 

  388. Scott TM, Foote J, Galway G (1984) Changes in the catecholaminergic innervation of jejunal arteries following induction of diabetes with streptozotocin. J Anat 139:738

    Google Scholar 

  389. Shibata S, Hattori K, Sakurai I, Mori I et al. (1971) Adrenergic innervation and cocaine-induced potentiation of adrenergic responses of aortic strips from young and old rabbits. J Pharmacol Exp Ther 177:621–632

    PubMed  CAS  Google Scholar 

  390. Sikri KL, Hoyes AD, Barber P et al. (1981) Substance P-like immunoreactivity in the intramural nerve plexuses of the guinea-pig ureter: a light and electron microscopical study. J Anat 133:425–442

    PubMed  CAS  Google Scholar 

  391. Skok VI (1973) Physiology of autonomic ganglia. Igaku Shoin, Tokyo

    Google Scholar 

  392. Sneddon P, Burnstock G (1984) Inhibition of excitatory junction potentials in guinea-pig vas deferens by α, ß- methylene-ATP: further evidence for ATP and noradrenaline as cotransmitters. Eur J Pharmacol 100:85–90

    Article  PubMed  CAS  Google Scholar 

  393. Sneddon P, Burnstock G (1984) Do we need γ-receptors? TIPS 5:264–265

    CAS  Google Scholar 

  394. Sneddon P, Burnstock G (1984) ATP as a co-transmitter in rat tail artery. Eur J Pharmacol 106:149–152

    Article  PubMed  CAS  Google Scholar 

  395. Sternini C, Brecha N (1985) Distribution and colocalization of neuropeptide Y- and tyrosine hydroxylaselike immunoreactivity in the guinea-pig heart. Cell Tissue Res 241:93–102

    Article  PubMed  CAS  Google Scholar 

  396. Stjernquist M, Hakanson R, Leander S et al. (1983) Immunohistochemical localization of substance P, vasoactive intestinal polypeptide and gastrin-releasing peptide in vas deferens and seminal vesicle, and the effect of these and eight other neuropeptides on resting tension and neurally evoked contractile activity. Regul Pept 7:67–86

    Article  PubMed  CAS  Google Scholar 

  397. Stone RA, Laties AM, Brecha NC (1982) Substance P- like immunoreactive nerves in the anterior segment of the rabbit, cat and monkey eye. Neuroscience 7:2459–2468

    Article  PubMed  CAS  Google Scholar 

  398. Story DF, Allen GS, Glover AB et al. (1975) Modulation of adrenergic transmission by acetylcholine. Clin Exp Pharmacol Physiol [Suppl 2]:27–33

    Google Scholar 

  399. Ström C, Lundberg J, Ahlman H et al. (1981) On the VIP-ergic innervation of the uterotubal junction. Acta Physiol Scand 11:213–215

    Article  Google Scholar 

  400. Su C (1975) Neurogenic release of purine compounds in blood vessels. J Pharmacol Exp Ther 195:159–166

    PubMed  CAS  Google Scholar 

  401. Su C (1978) Modes of vasoconstrictor and vasodilator neurotransmission. Blood Vessels 15:183–189

    PubMed  CAS  Google Scholar 

  402. Su C (1981) Purinergic receptors in blood vessels. In: Burnstock G (ed) Purinergic receptors. Chapman and Hall, London, pp 93–117 (Receptors and recognition, series B, vol 12)

    Chapter  Google Scholar 

  403. Su C, Duckies SP, Florence V (1977) Uptake of 3H- norepinephrine in rabbit mesenteric blood vessels. Blood Vessels 14:65–76

    PubMed  CAS  Google Scholar 

  404. Su C, Bevan JA, Assali NS et al. (1977) Development of neuroeffector mechanisms in the carotid artery of the fetal lamb. Blood Vessels 14:12–24

    PubMed  CAS  Google Scholar 

  405. Sundler F, Alumets J, Brodin E (1977) Perivascular substance P-immunoreactive nerves in tracheobronchial tissue. In: Von Euler US, Pernow B (eds) Substance P. Raven Press, New York, pp 271–273

    Google Scholar 

  406. Sundler F, Alumets J, Hakanson R et al. (1977) VIP innervation of the gallbladder. Gastroenterology 72:1375–1377

    PubMed  CAS  Google Scholar 

  407. Sundler F, Moghimzadeh E, Hakanson R et al. (1983) Nerve fibres in the gut and pancreas of the rat displaying neuropeptide-Y immunoreactivity. Intrinsic and extrinsic origin. Cel Tissue Res 230:487–193

    Article  CAS  Google Scholar 

  408. Svendgaard N-A, Edvinsson L, Olin T et al. (1977) On the pathophysiology of cerebral vasospasm: transmitter changes in perivascular sympathetic nerves, and increased pial artery sensitivity to norepinephrine and serotonin. In: Owman C, Edvinsson (eds) Neurogenic control of brain circulation. Proceedings of international symposium, Wenner-Gren. Pergamon Press, Oxford, pp 143–152

    Google Scholar 

  409. Taché Y, Gonion M, Lauffenberger M et al. (1984) Inhibition of gastric acid secretion by intrathecal injection of calcitonin gene-related peptide in rats. Life Sci 35:871–878

    Article  PubMed  Google Scholar 

  410. Tagawa T, Ando K, Wasano T et al. (1979) A histochemical study of the innervation of cerebral blood vessels in the bullfrog. J Comp Neurol 183:25–32

    Article  PubMed  CAS  Google Scholar 

  411. Takami K, Kawai Y, Shiosaka S et al. (1985) Immunohistochemical evidence for the coexistence of calcitonin gene-related peptide and choline acetyltransferase-like immunoreactivity in neurons of the rat hypoglossal facial and ambiguous nuclei. Brain Res 328:386–389

    Article  PubMed  CAS  Google Scholar 

  412. Tatemoto K, Carlquist M, Mutt V (1982) Neuropeptide Y - a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 296:659–660

    Article  PubMed  CAS  Google Scholar 

  413. Terenghi G, Polak JM, Proberg L et al. (1982) Mapping, quantitative distribution and origin of substance P- and VIP-containing nerves in the uvea of guinea-pig eye. Histochemistry 75:399–417

    Article  PubMed  CAS  Google Scholar 

  414. Terenghi G, Polak JM, Ghatei MA et al. (1985) Distribution and origin of calcitonin gene-related peptide (CGRP) immunoreactivity in the sensory innervation of the mammalian eye. J Comp Neurol 233:506–516

    Article  PubMed  CAS  Google Scholar 

  415. Terenghi G, Polak JM, Rodrigo J et al. (1986) Calcitonin gene-related peptide-immunoreactive nerves in the tongue, epiglottis and pharynx of the rat: occurrence, distribution and origin. Brain Res 365:1–14

    Article  PubMed  CAS  Google Scholar 

  416. Toda N, Fujita Y (1973) Responsiveness of isolated cerebral and peripheral arteries to serotonin, norepinephrine and transmural electrical stimulation. Circ Res 33:98–104

    PubMed  CAS  Google Scholar 

  417. Toda N (1976) Influence of dopamine and noradrenaline on isolated cerebral arteries of the dog. Br J Pharmacol 58:121

    PubMed  CAS  Google Scholar 

  418. Tonoue T, Hata H, Ohnishi T et al. (1985) Somatostatin and GABA correlate with cervical autonomic nerve activity. Regul Pept 10:299–307

    Article  PubMed  CAS  Google Scholar 

  419. Tuor UI, Kelly P, Edvinsson L et al. (1985) Neuro peptide Y and the regulation of local cerebral blood flow. A quantitative autoradiographic study. J Cereb Blood Flow Metab 5 [Suppl 1]:S513

    Google Scholar 

  420. Uddman R, Alumets J, Densert O et al. (1978) Occurrence and distribution of VIP nerves in the nasal mucosa and tracheobronchial wall. Acta Otolaryngol (Stockh) 86:443–448

    CAS  Google Scholar 

  421. Uddman R, Alumets J, Edvinsson L et al. (1978) Peptidergic (VIP) innervation of the oesophagus. Gastroenterology 75:5–8

    PubMed  CAS  Google Scholar 

  422. Uddman R, Sundler F (1979) Vasoactive intestinal polypeptide nerves in human upper respiratory tract. Otol Rhinol Laryngol 41:221–226

    CAS  Google Scholar 

  423. Uddman R, Alumets J, Densert O et al. (1979) Innervation of the feline eustachian tube. Ann Otol Rhinol Laryngol 88:557–561

    PubMed  CAS  Google Scholar 

  424. Uddman R, Malm L, Sundler F (1980) The origin of vasoactive intestinal polypeptide (VIP) nerves in the feline nasal mucosa. Acta Otolaryngol (Stockh) 89:152–156

    Article  CAS  Google Scholar 

  425. Uddman R, Björlin G, Möller B et al. (1980) Occurrence of VIP nerves in mammalian dental pulps. Acta Odontol Scand 38:325–328

    Article  PubMed  CAS  Google Scholar 

  426. Uddman R, Fahrenkrug J, Malm L et al. (1980) Neuronal VIP in salivary glands: distribution and release. Acta Physiol Scand 110:31–38

    Article  PubMed  CAS  Google Scholar 

  427. Uddman R, Alumets J, Ehinger B et al. (1980) Vasoactive intestinal peptide nerves in ocular and orbital structures of the cat. Invest Ophthalmol Vis Sei 19:878–885

    CAS  Google Scholar 

  428. Uddman R, Alumets J, Hakanson R et al. (1980) Vasoactive intestinal peptide (VIP) occurs in nerves of the pineal gland. Experientia 36:1119–1120

    Article  PubMed  CAS  Google Scholar 

  429. Uddman R, Edvinsson L, Sundler F (1981) Perivascular substance P: occurrence and distribution in mammalian pial vessels. J Cereb Blood Flow Metab 1:227–232

    Article  PubMed  CAS  Google Scholar 

  430. Uddman R, Alumets J, Edvinsson L et al. (1981) VIP nerve fibres around peripheral blood vessels. Acta Physiol Scand 112:65–70

    Article  PubMed  CAS  Google Scholar 

  431. Uddman R, Edvinsson L, Hakanson R et al. (1982) Immunohistochemical demonstration of APP (avian pancreatic polypeptide) - immunoreactive nerve fibres around cerebral blood vessels. Brain Res Bull 9:715–718

    Article  PubMed  CAS  Google Scholar 

  432. Uddman R, Edvinsson L, Malm L (1982) Perivascular nerves in the feline carotid rete. Cell Tissue Res 226:301–308

    Article  PubMed  CAS  Google Scholar 

  433. Uddman R, Ninoyu O, Sundler F (1982) Adrenergic and peptidergic innervation of cochlear blood vessels. Arch Otol Rhinol Laryngol 236:7–14

    Article  CAS  Google Scholar 

  434. Uddman R, Edvinsson L, Owman C et al. (1983) Nerve fibres containing gastrin-releasing peptide around pial vessels. J Cereb Blood Flow Metab 3:386–390

    Article  PubMed  CAS  Google Scholar 

  435. Uddman R, Sundler F, Emson P (1984) Occurrence and distribution of neuropeptide-Y-immunoreactive nerves in the respiratory tract and middle ear. Cell Tissue Res 237:321–327

    Article  PubMed  CAS  Google Scholar 

  436. Uddman R, Edvinsson L, Ekman R et al. (1985) Innervation of the feline cerebral vasculature by nerve fibres containing calcitonin gene-related peptide: trigeminal origin and co-existence with substance P. Neurosci Lett 62:131–136

    Article  PubMed  CAS  Google Scholar 

  437. Uddman R, Ekblad E, Edvinsson L et al. (1985) Neuropeptide Y-like immunoreactivity in perivascular nerve fibres of the guinea-pig. Regul Pept 10:243–257

    Article  PubMed  CAS  Google Scholar 

  438. Uvnäs B (1966) Cholinergic vasodilator nerves. Fed Proc 25:1613–1622

    Google Scholar 

  439. Vaalasti A, Linnoila I, Hervonen A (1980) Immunohistochemical demonstration of VIP, [Met5]- and [Leu5]-enkephalin immunoreactive nerve fibres in the human prostate and vesicles. Histochemistry 66:89–98

    Article  PubMed  CAS  Google Scholar 

  440. Van Calker D, Muller M, Hamprecht B (1979) Adenosine regulates via two different types of receptors, the accumulation of cyclic AMP in cultured brain cells. J Neurochem 33:999–1005

    Article  PubMed  Google Scholar 

  441. Vanhoutte PM (1974) Inhibition of acetylcholine of adrenergic neurotransmission in vascular smooth muscle. Circ Res 34:317–326

    PubMed  CAS  Google Scholar 

  442. Vanhoutte PM, Cohen RA, Van Nueten JM (1984) Serotonin and arterial vessels. J Cardiovasc Pharmacol 6:S421-S428

    Article  PubMed  Google Scholar 

  443. Van Neuten JM, Janssen PAJ, De Ridder W et al. (1982) Interaction between 5-hydroxytryptamine and other vasoconstrictor substances in the isolated femoral artery of the rabbit: effect of ketanserin (R41468). Eur J Pharmacol 77:281–287

    Article  Google Scholar 

  444. Verrecchia C, Hamel E, Sercombe R et al. (1985) Constriction of cerebral arteries to noradrenaline is modulated by the endothelium. J Cereb Blood Flow Metab 5 [Suppl 1]:S549

    Google Scholar 

  445. Vizi ES (1979) Presynaptic modulation of neurochemical transmission. Prog Neurobiol 12:181–290

    Article  PubMed  CAS  Google Scholar 

  446. Wall PD, Fitzgerald M (1982) If substance P fails to fulfill the criteria as a neurotransmitter in somatosensory efferents, what might be its function? In: Ciba Found Symp 91:249–266

    PubMed  CAS  Google Scholar 

  447. Wharton J, Polak JM, Bryant MG et al. (1979) Vasoactive intestinal polypeptide (VIP)-like immunoreactivity in salivary glands. Life Sci 25:273–280

    Article  PubMed  CAS  Google Scholar 

  448. Wharton J, Polak JM, Bloom SR et al. (1979) Substance P-like immunoreactive nerves in mammalian lung. Invest Cell Pathol 2:3

    PubMed  CAS  Google Scholar 

  449. Wharton J, Polak JM, Pearse AGE et al. (1980) Enkephalin-, VIP- and substance P-like immunoreactivity in the carotid body. Nature 284:269–271

    Article  PubMed  CAS  Google Scholar 

  450. Wharton J, Polak JM, Probert L et al. (1981) Peptide containing nerves in the ureter of the guinea-pig and cat. Neuroscience 6:969–982

    Article  PubMed  CAS  Google Scholar 

  451. Wharton J, Polak JM, McGregor GP et al. (1981) The distribution of substance P-like immunoreactive nerves in the guinea-pig heart. Neuroscience 6:2193–2204

    Article  PubMed  CAS  Google Scholar 

  452. Willis E, Ottesen B, Wagner G et al. (1981) Vasoactive intestinal polypeptide (VIP) as a possible neurotransmitter involved in penile erection. Acta Physiol Scand 113:545–547

    Article  PubMed  CAS  Google Scholar 

  453. Winquist RJ, Bevan JA (1981) Relation location of alpha- and beta-adrenoceptors to site of release of sympathetic transmitter in rabbit facial vein. Circ Res 49:486–491

    PubMed  CAS  Google Scholar 

  454. Woods JR, Dandavino A, Murayama K et al. (1977) Autonomic control of cardiovascular functions during neonatal development and in adult sheep. Circ Res 40:401–407

    PubMed  CAS  Google Scholar 

  455. Yamamoto K, Matsuyama T, Shiosaka S et al. (1983) Overall distribution of substance P-containing nerves in the wall of cerebral arteries of the guinea pig and its origins. J Comp Neurol 215:421–426

    Article  PubMed  CAS  Google Scholar 

  456. Zaidi M, Bevis PJR, Girgis SI et al. (1985) Circulating CGRP comes from the perivascular nerves. Eur J Pharmacol 117:283–284

    Article  PubMed  CAS  Google Scholar 

  457. Zawadzki JV, Furchgott RF, Cherry P (1981) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by substance P. Fed Proc 40:689

    Google Scholar 

  458. Zerbe RL, Feverstein G (1985) Cardiovascular effects of centrally administered vasopressin in conscious and anaesthetised rats. Neuropeptides 6:471–484

    Article  PubMed  CAS  Google Scholar 

  459. Zhang SQ, Terenghi G, Unger WG et al. (1984) Changes in substance P- and neuropeptide Y-immu- noreactive fibres in rat and guinea-pig irides following unilateral sympathectomy. Exp Eye Res 39:365–372

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. K. K. Dhital
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  2. G. Burnstock
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Editors and Affiliations

  1. Service d’Anatomie Pathologique et Unité de Recherche sur la Pathologie Rénale et Vasculaire, INSERM U28, Paris, France

    Jean-Pierre Camilleri (Professeur) (Professeur)

  2. Department of Morbid Anatomy, Institute of Pathology, The London Hospital, Whitechapel, London, E1 1BB, UK

    Colin L. Berry (Professor) (Professor)

  3. Service de Médecine Interne et de Pathologie Vasculaire, Hôpital Broussais, Paris, France

    Jean-Noël Fiessinger (Professeur) (Professeur)

  4. Service de Néphrologie et Unité de Recherche sur la Pathologie Rénale et Vasculaire, INSERM U28, Hôpital Broussais, Paris, France

    Jean Bariéty (Professeur) (Professeur)

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Dhital, K.K., Burnstock, G. (1989). Adrenergic and Non-adrenergic Neural Control of the Arterial Wall. In: Camilleri, JP., Berry, C.L., Fiessinger, JN., Bariéty, J. (eds) Diseases of the Arterial Wall. Springer, London. https://doi.org/10.1007/978-1-4471-1464-2_7

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  • DOI: https://doi.org/10.1007/978-1-4471-1464-2_7

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