Summary
Immunohistochemical and radioimmunochemical investigations have shown, in various species, the occurrence of numerous nerve fibres containing vasoactive intestinal polypeptide (VIP) in connection with blood vessels of the central nervous system. Pial arteries from pig, cat, and rat have the richest supply of VIP nerve fibres; those of cow, dog, guinea pig and hamster have an intermediary number of nerves, while only few are found in pial arteries from the monkey, rabbit, gerbil, and mouse. The regional variation in VIP-nerve density follows the order: cerebral arteries > cerebellar arteries > basilar > vertebral > spinal cord arteries. Unilateral extirpation of either the pterygopalatine or the superior cervical ganglia does not affect the amount or distribution of VIP fibres in the wall of brain vessels of the ipsilateral side.
Measurement of the VIP content by radioimmunoassay shows mean concentrations in the pial arteries varying between 19 and 82 pmol/g tissue wet weight. Regional and species variations in measured VIP levels are similar to the variations in distribution of immunoreactive nerve fibres.
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References
Alm P, Alumets J, Håkanson R, Sundler F (1977) Peptidergic (VIP) nerves in the genito-urinary tract. Neuroscience 2:751–754
Bryant MG, Bloom SR, Polak JM, Albuquerque RH, Modlin J, Pearse AGE (1976) Possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance. Lancet 1:991–993
Burnstock G (1972) Purinergic nerves. Pharmacol Rev 24:509–581
Coons AH, Leduc EH, Connolly JM (1955) Studies on antibody production. I. A method for histochemical demonstration of specific antibody and its application to a study of the hyperimmune rabbit. J Exp Med 102:49–60
Edvinsson L, Owman C (1977) Sympathetic innervation and adrenergic receptors in intraparenchymal cerebral arterioles of baboon. Acta Physiol Scand Suppl 452:57–59
Edvinsson L, Owman Ch (1980) Adrenergic innervation of spinal cord blood vessels. (in preparation)
Edvinsson L, MacKenzie ET (1977) Amine mechanisms in the cerebral circulation. Pharmacol Rev 28:275–348
Edvinsson L, McCulloch J (1979) Cerebral circulatory and metabolic effects of vasoactive intestinal polypeptide. J Physiol 291:42–43P
Edvinsson L, Nielsen KC, Owman C, Sporrong B (1972) Cholinergic mechanisms in pial vessels. Histochemistry, electron microscopy and pharmacology. Z Zellforsch 134:311–325
Emson PC, Fahrenkrug J, Schaffalitzky de Muckadell OB, Jessel TM, Iversen (1977) Vasoactive intestinal polypeptide (VIP): Vesicular localization and potassium-evoked release from rat hypothalamus. Brain Res 143:174–178
Fahrenkrug J (1979) Vasoactive intestinal polypeptide: Measurement, distribution and putative neurotransmitter function. Digestion 19:149–169
Fahrenkrug J, Schaffalitzky de Muckadell OB (1977) Radioimmunoassay of vasoactive intestinal polypeptide (VIP) in plasma. J Lab Clin Med 89:1379–1388
Fahrenkrug J, Schaffalitzky de Muckadell OB, Fahrenkrug A (1977) Vasoactive intestinal polypeptide (VIP) in human cerebrospinal fluid. Brain Res. 124:581–584
Fahrenkrug J, Schaffalitzky de Muckadell OB (1978) Distribution of vasoactive intestinal polypeptide (VIP) in the porcine central nervous system. J Neurochem 31:1445–1451
Fahrenkrug J, Galbo H, Holst JJ, Schaffalitzky de Muckadell OB (1978a) Influence of the autonomic nervous system on the release of vasoactive intestinal polypeptide from the porcine gastrointestinal tract. J Physiol 280:405–422
Fahrenkrug J, Haglund U, Jodal M, Lundgren O, Olbe L, Schaffalitzky de Muckadell OB (1978b) Nervous release of vasoactive intestinal polypeptide in the gastrointestinal tract of cats: Possible physiological implications. J Physiol 284:291–305
Fuxe K, Hökfelt T, Said SI, Mutt V (1977) Vasoactive intestinal polypeptide and the nervous system: Immunohistochemical evidence for localization in central and peripheral neurons, particularly intracortical neurons of the cerebral cortex. Neurosci Lett 5:241–246
Giachetti A, Said SI, Reynolds RC, Koniges FC (1977) Vasoactive intestinal polypeptide in brain: Localization in and release from isolated nerve terminals. Proc Natl Acad Sci USA 74:3424–3428
Larsson LI, Edvinsson L, Fahrenkrug J, Håkanson R, Owman C, Schaffalitzky de Muckadell O, Sundler F (1976a) Immunohistochemical localization of a vasodilatory polypeptide (VIP) in cerebrovascular nerves. Brain Res 113:400–404
Larsson LI, Fahrenkrug J, Schaffalitzky de Muckadell O, Sundler F, Håkanson R, Rehfield JF (1976b) Localisation of vasoactive intestinal polypeptide (VIP) to central and peripheral neurons. Proc Natl Acad Sci USA 73:3197–3200
Larsson LI, Fahrenkrug J, Schaffalitzky de Muckadell OB (1977a) Occurrence of nerves containing vasoactive intestinal polypeptide immunoreactivity in the male genital tract. Life Sci 21:503–508
Larsson LI, Fahrenkrug J, Schaffalitzky de Muckadell OB (1977b) Vasoactive intestinal polypeptide occurs in nerves of the female genitourinary tract. Science 197:1374–1375
Lindvall M, Alumets J, Edvinsson L, Fahrenkrug J, Håkanson R, Hanko J, Owman C, Schaffalitzky de Muckadell OB, Sundler F (1978) Peptidergic (VIP) nerves in the mammalian choroid plexus. Neurosci Lett 9:77–82
Malm L, Sundler F, Uddman R (1980) Effects of vasoactive intestinal polypeptide (VIP) on resistance and capacitance vessels in the nasal mucosa. Acta Otolaryngol 00:000–000
Morgan KG, Schmalz PF, Szurszewski JH (1978) The inhibitory effects of vasoactive intestinal polypeptide on the mechanical and electrical activity of canine antral smooth muscle. J Physiol 282:437–450
Owman C, Edvinsson L (eds) (1977) Neurogenic Control of Brain Circulation, Pergamon Press, Oxford New York
Pearse AGE, Polak JM, Adams C, Kendall PA (1974) Diethylpyrocarbonate, a vapour-phase fixative for immunofluorescence studies on polypeptide hormones. Histochem J 6:347–352
Rennels ML, Nelson E (1975) Capillary innervation in the mammalian central nervous system: An electron microscopic demonstration. Am J Anat 144:233
Said SI, Mutt V (1972) Isolation from porcine intestinal wall of a vasoactive actacosa-peptide related to secretion and to glucagon. Europ J Biochem 28:199–204
Said SI, Rosenberg RN (1976) Vasoactive intestinal polypeptide: Abundant immunoreactivity in neural cell lines and normal tissue. Science 192:907–908
Sousa Pereira de JMM (1974) Circulacáo Colateral do Cérebro, Inova-Artes Gráficas, Porto, Portugal
Sundler F, Alumets J, Håkanson R, Ingemansson S, Fahrenkrug J, Schaffalitzky de Muckadell O (1977) VIP innervation of the gallbladder. Gastroenterology 72:1375–1378
Swanson LW, Connelly MA, Hartman BK (1977) Ultrastructural evidence for central monoaminergic innervation of blood vessels in the paraventricular nucleus of the hypothalamus. Brain Res 136:166–173
Uddman R, Alumets J, Densert O, Håkanson R, Sundler F (1978a) Occurrence and distribution of VIP nerves in the nasal mucosa and tracheobronchial wall. Acta Otolaryngol 86:443–448
Uddman R, Alumets J, Edvinsson L, Håkanson R, Sundler F (1978b) Peptidergic (VIP) innervation of the esophagus. Gastroenterology 75:5–8
Uddman R, Malm L, Sundler F (1980) The origin of vasoactive intestinal polypeptide (VIP) nerves in the feline nasal mucosa. Acta Otolaryngol 89:152–156
Uddman R, Alumets J, Edvinsson L, Håkanson R, Sundler F (1980) Distribution and possible significance of vasoactive intestinal polypeptide (VIP) in peripheral blood vessels. In preparation
Vasques J, Purves M (1977) Studies on the dilator pathway to cerebral blood vessels. In: Owman C, Edvinsson L (eds) Neurogenic Control of Brain Circulation. Pergamon Press, Oxford New York, pp 59–73
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Edvinsson, L., Fahrenkrug, J., Hanko, J. et al. VIP (vasoactive intestinal polypeptide)-containing nerves of intracranial arteries in mammals. Cell Tissue Res. 208, 135–142 (1980). https://doi.org/10.1007/BF00234179
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DOI: https://doi.org/10.1007/BF00234179