Abstract
Purpose
Chronic diseases often hinder the natural healing process, making wound infections a prevalent clinical concern. In severe cases, complications can arise, potentially leading to fatal outcomes. While allopathic treatments offer numerous options for wound repair and management, the enduring popularity of herbal medications may be attributed to their perceived minimal side effects. Hence, this review aims to investigate the potential of herbal remedies in efficiently treating wounds, presenting a promising alternative for consideration.
Methods
A literature search was done including research, reviews, systematic literature review, meta-analysis, and clinical trials considered. Search engines such as Pubmed, Google Scholar, and Scopus were used while retrieving data. Keywords like Wound healing ‘Wound healing and herbal combinations’, ‘Herbal wound dressing’, Nanotechnology and Wound dressing were used.
Result
This review provides valuable insights into the role of natural products and technology-based formulations in the treatment of wound infections. It evaluates the use of herbal remedies as an effective approach. Various active principles from herbs, categorized as flavonoids, glycosides, saponins, and phenolic compounds, have shown effectiveness in promoting wound closure. A multitude of herbal remedies have demonstrated significant efficacy in wound management, offering an additional avenue for care. The review encompasses a total of 72 studies, involving 127 distinct herbs (excluding any common herbs shared between studies), primarily belonging to the families Asteraceae, Fabaceae, and Apiaceae. In research, rat models were predominantly utilized to assess wound healing activities. Furthermore, advancements in herbal-based formulations using nanotechnology-based wound dressing materials, such as nanofibers, nanoemulsions, nanofiber mats, polymeric fibers, and hydrogel-based microneedles, are underway. These innovations aim to enhance targeted drug delivery and expedite recovery. Several clinical-based experimental studies have already been documented, evaluating the efficacy of various natural products for wound care and management. This signifies a promising direction in the field of wound treatment.
Conclusion
In recent years, scientists have increasingly utilized evidence-based medicine and advanced scientific techniques to validate the efficacy of herbal medicines and delve into the underlying mechanisms of their actions. However, there remains a critical need for further research to thoroughly understand how isolated chemicals extracted from herbs contribute to the healing process of intricate wounds, which may have life-threatening consequences. This ongoing research endeavor holds great promise in not only advancing our understanding but also in the development of innovative formulations that expedite the recovery process.
Graphical abstract
Similar content being viewed by others
References
Chhabra S, Chhabra N, Kaur A, Gupta N. Wound Healing concepts in Clinical Practice of OMFS. J Maxillofac Oral Surg. 2017;16(4):403–23. https://doi.org/10.1007/s12663-016-0880-z.
Sen CK. Human wound and its Burden: updated 2020 Compendium of estimates. Adv Wound Care (New Rochelle). 2021;10(5):281–92. https://doi.org/10.1089/wound.2021.0026.
Mieczkowski M, Mrozikiewicz-Rakowska B, Kowara M, Kleibert M, Czupryniak L. The problem of wound healing in diabetes—from molecular pathways to the design of an animal model. Int J Mol Sci. 2022;23: 7930. https://doi.org/10.3390/ijms23147930.
Latalski M, Starobrat G, Fatyga M, Sowa I, Wojciak M, Wessely-Szponder J, et al. Wound-related complication in growth-friendly spinal surgeries for early-onset scoliosis—literature review. J Clin Med. 2022;11: 2669. https://doi.org/10.3390/jcm11092669.
Falanga V, Isseroff RR, Soulika AM, Romanelli M, Margolis D, Kapp S, et al. Chronic wounds. Nat Rev Dis Primers. 2022;8:50. https://doi.org/10.1038/s41572-022-00377-3.
Oliveira A, Simoes S, Ascenso A, Reis CP. Therapeutic advances in wound healing. J Dermatolog Treat. 2022;33:2–22. https://doi.org/10.1080/09546634.2020.1730296.
Brown HL, Clayton A, Stephens P. The role of bacterial extracellular vesicles in chronic wound Infections: current knowledge and future challenges. Wound Repair Regen. 2021;29:864–80. https://doi.org/10.1111/wrr.12949.
Thomas RE, Thomas BC. Reducing biofilm Infections in burn patients’ wounds and biofilms on surfaces in hospitals, Medical Facilities and Medical Equipment to improve burn care: a systematic review. Int J Environ Res Public Health. 2021;18: 13195. https://doi.org/10.3390/ijerph182413195.
Sandoz H. An overview of the prevention and management of wound Infection. Nurs Standard. 2022;37:75–82. https://doi.org/10.7748/ns.2022.e11889.
Lux CN. Wound healing in animals: a review of physiology and clinical evaluation. Vet Dermatol. 2022;33:91. https://doi.org/10.1111/vde.13032.
Hassanshahi A, Moradzad M, Ghalamkari S, Fadaei M, Cowin AJ, Hassanshahi M. Macrophage-mediated inflammation in skin Wound Healing. Cells. 2022;11: 2953. https://doi.org/10.3390/cells11192953.
Talbott HE, Mascharak S, Griffin M, Wan DC, Longaker MT. Wound healing, fibroblast heterogeneity, and fibrosis. Cell Stem Cell. 2022;29:1161–80. https://doi.org/10.1016/j.stem.2022.07.006.
Beura SK, Panigrahi AR, Yadav P, Agrawal S, Singh SK. Role of neurons and Glia Cells in Wound Healing as a Novel Perspective considering platelet as a conventional player. Mol Neurobiol. 2022;59:137–60. https://doi.org/10.1007/s12035-021-02587-4.
Wang XH, Guo W, Qiu W, Ao LQ, Yao MW, Xing W, et al. Fibroblast-like cells promote Wound Healing via PD-L1-mediated inflammation resolution. Int J Biol Sci. 2022;18:4388–99. https://doi.org/10.7150/ijbs.69890.
Mogren S, Berlin F, Ramu S, Sverrild A, Porsbjerg C, Uller L, et al. Mast cell tryptase enhances wound healing by promoting migration in human bronchial epithelial cells. Cell Adh Migr. 2021;15:202–14. https://doi.org/10.1080/19336918.2021.1950594.
Kandoi LPK, Misra S, V RS, Verma KR. The mesenchymal stem cell secretome: a new paradigm towards cell-free therapeutic mode in regenerative medicine. Cytokine Growth Factor Rev. 2019;46:1–9. https://doi.org/10.1016/j.cytogfr.2019.04.002.
Wang YX, Chen JJ, Cen Y, Li ZY, Zhang ZY. [Research advances on exosomes derived from adipose-derived mesenchymal stem cells in promoting diabetic wound healing]. Zhonghua Shao Shang Za Zhi. 2022;38:491–5. https://doi.org/10.3760/cma.j.cn501120-20210218-00057.
Gao YX, Wang LF, Ba SJ, Cao JL, Li F, Li B, et al. Research advances on thymosin β4 in promoting wound healing. Zhonghua Shao Shang Za Zhi. 2022;38:378–84. https://doi.org/10.3760/cma.j.cn501120-20210221-00059.
Derakhshanfar A, Moayedi J, Derakhshanfar G, Poostforoosh Fard A. The role of Iranian medicinal plants in experimental surgical skin wound healing: an integrative review. Iran J Basic Med Sci. 2019;22(6):590–600. https://doi.org/10.22038/ijbms.2019.32963.7873.
Thornfeldt CR. Therapeutic herbs confirmed by evidence-based medicine. Clin Dermatol. 2018;36(3):289–98. https://doi.org/10.1016/j.clindermatol.2018.03.003.
Kumar V, Nesari TM, Ghildiyal S, Sherkhane R. Pharmacodynamic appraisal of wound-healing herbs of Sushruta Samhita. Ayu. 2021;42(1):1–18. https://doi.org/10.4103/ayu.AYU_34_20.
Hosseinkhani A, Falahatzadeh M, Raoofi E, Zarshenas MM. An evidence-based review on Wound Healing Herbal remedies from reports of traditional Persian Medicine. J Evid Based Complementary Altern Med. 2017;22(2):334–43. https://doi.org/10.1177/2156587216654773.
Li Q, Niu Y, Xing P, Wang C. Bioactive polysaccharides from natural resources including Chinese medicinal herbs on tissue repair. Chin Med. 2018;13:7. https://doi.org/10.1186/s13020-018-0166-0.
Siddique Z, Shah GM, Ahmed HM, Nisa S, Khan A, Idrees M, et al. Ethnophytotherapy Practices for Wound Healing among populations of District Haripur, KPK, Pakistan. Evid Based Complement Alternat Med. 2019;2019: 4591675. https://doi.org/10.1155/2019/4591675.
Hosein Farzaei M, Abbasabadi Z, Reza Shams-Ardekani M, Abdollahi M, Rahimi R. A comprehensive review of plants and their active constituents with wound healing activity in traditional Iranian medicine. Wounds. 2014;26(7):197–206.
Ambika AP, Nair SN. Wound Healing activity of plants from the Convolvulaceae Family. Adv Wound Care (New Rochelle). 2019;8(1):28–37. https://doi.org/10.1089/wound.2017.0781.
Viaña-Mendieta P, Sánchez ML, Benavides J. Rational selection of bioactive principles for wound healing applications: growth factors and antioxidants. Int Wound J. 2022;19:100–13. https://doi.org/10.1111/iwj.13602.
Bassino E, Gasparri F, Munaron L. Natural dietary antioxidants containing flavonoids modulate keratinocytes physiology: in vitro tri-culture models. J Ethnopharmacol. 2019;238: 111844. https://doi.org/10.1016/j.jep.2019.111844.
Shirbeigi L, Mohebbi M, Karami S, Nejatbakhsh F. The Role of Nutrition and Edible Medicinal Plants in the treatment of chronic wounds based on the principles of Iranian traditional medicine. Iran J Med Sci. 2016;41(3 Suppl):72.
Nagoba B, Davane M. Studies on wound healing potential of topical herbal formulations- do we need to strengthen study protocol? J Ayurveda Integr Med. 2019;10(4):316–8. https://doi.org/10.1016/j.jaim.2019.09.002.
Sheikh M, Khan HM, Zafar Khan MU, Sharif A. Formulation, evaluation and optimization of Antimicrobial potential of herbal cream containing Allium sativum, Moringa oleifera extracts and Thymus vulgaris oil. Curr Pharm Biotechnol. 2023. https://doi.org/10.2174/1389201024666230504124838.
Dubey S, Dixit AK. Preclinical evidence of polyherbal formulations on wound healing: a systematic review on research trends and perspectives. J Ayurveda Integr Med. 2023;14(2): 100688. https://doi.org/10.1016/j.jaim.2023.100688.
Mandrika I, Kumar S, Zandersone B, Eranezhath SS, Petrovska R, Liduma I, et al. Antibacterial and anti-inflammatory potential of Polyherbal Formulation used in Chronic Wound Healing. Evid Based Complement Alternat Med. 2021;2021: 9991454. https://doi.org/10.1155/2021/9991454.
Lim KM. Skin epidermis and barrier function. Int J Mol Sci. 2021;22(6): 3035. https://doi.org/10.3390/ijms22063035.
Wong BJ, Hollowed CG. Current concepts of active vasodilation in human skin. Temp (Austin). 2016;4(1):41–59. https://doi.org/10.1080/23328940.2016.1200203.
Eming SA, Martin P, Tomic-Canic M. Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med. 2014;6(265):265sr6. https://doi.org/10.1126/scitranslmed.3009337.
Sorg H, Tilkorn DJ, Hager S, Hauser J, Mirastschijski U. Skin Wound Healing: an update on the current knowledge and concepts. Eur Surg Res. 2017;58:81–94. https://doi.org/10.1159/000454919.
Albahri G, Badran A, Hijazi A, Daou A, Baydoun E, Nasser M, et al. The therapeutic Wound Healing bioactivities of various Medicinal plants. Life (Basel). 2023;13(2): 317. https://doi.org/10.3390/life13020317.
van Koppen CJ, Hartmann RW. Advances in the treatment of chronic wounds: a patent review. Expert Opin Ther Pat. 2015;25:931–7. https://doi.org/10.1517/13543776.2015.1045879.
Rodrigues M, Kosaric N, Bonham CA, Gurtner GC. Wound healing: a cellular perspective. Physiol Rev. 2019;99(1):665–706. https://doi.org/10.1152/physrev.00067.2017.
Masson-Meyers DS, Andrade TAM, Caetano GF, Guimaraes FR, Leite MN, Leite SN, et al. Experimental models and methods for cutaneous wound healing assessment. Int J Exp Pathol. 2020;101(1–2):21–37. https://doi.org/10.1111/iep.12346.
Zeng RJ, Lin CQ, Lin ZH, Chen H, Lu WY, Lin CM, et al. Approaches to cutaneous wound healing: basics and future directions. Cell Tissue Res. 2018;374:217–32. https://doi.org/10.1007/s00441-018-2830-1.
Dehkordi AN, Babaheydari FM, Chehelgerdi M, Dehkordi SR. Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies. Stem Cell Res Ther. 2019;10:111. https://doi.org/10.1186/s13287-019-1212-2.
Vitale S, Colanero S, Placidi M, Di Emidio G, Tatone C, Amicarelli F, et al. Phytochemistry and biological activity of medicinal plants in wound healing: an overview of current research. Molecules. 2022;27(11): 3566. https://doi.org/10.3390/molecules27113566.
Wang PH, Huang BS, Horng HC, Yeh CC, Chen YJ. Wound healing. J Chin Med Assoc. 2018;81(2):94–101. https://doi.org/10.1016/j.jcma.2017.11.002.
Li S, Renick P, Senkowsky J, Nair A, Tang L. Diagnostics for wound infections. Adv Wound Care (New Rochelle). 2021;10(6):317–27. https://doi.org/10.1089/wound.2019.1103.
Smet S, Probst S, Holloway S, Fourie A, Beele H, Beeckman D. The measurement properties of assessment tools for chronic wounds: a systematic review. Int J Nurs Stud. 2021;121: 103998. https://doi.org/10.1016/j.ijnurstu.2021.103998.
Ousey K, Roberts D, Gefen A. Early identification of wound Infection: understanding wound odour. J Wound Care. 2017;26(10):577–82. https://doi.org/10.12968/jowc.2017.26.10.577.
Stallard Y. When and how to perform cultures on chronic wounds? J Wound Ostomy Continence Nurs. 2018;45(2):179–86. https://doi.org/10.1097/WON.0000000000000414.
Nuutila K, Eriksson E. Moist wound healing with commonly available dressings. Adv Wound Care (New Rochelle). 2021;10(12):685–98. https://doi.org/10.1089/wound.2020.1232.
Davini G, Dini V, Janowska A, Macchia M, Gualtieri B, Granieri G, et al. Wound dehiscence after Achilles tendon trauma and repair: treatment with ultraportable negative pressure wound therapy and compression therapy. Wounds. 2021;33(12):E93-98.
Simoes D, Miguel SP, Ribeiro MP, Coutinho P, Mendonça AG, Correia IJ. Recent advances on antimicrobial wound dressing: a review. Eur J Pharm Biopharm. 2018;127:130–41. https://doi.org/10.1016/j.ejpb.2018.02.022.
Skowronska W, Bazylko A. The potential of medicinal plants and natural products in the treatment of burns and sunburn-a review. Pharmaceutics. 2023;15(2): 633. https://doi.org/10.3390/pharmaceutics15020633.
Li Z, Yu Q, Wang S, Wang G, Li T, Tang PF, et al. Impact of negative-pressure wound therapy on bacterial behaviour and bioburden in a contaminated full-thickness wound. Int Wound J. 2019;16(5):1214–21. https://doi.org/10.1111/iwj.13197.
Tettelbach W, Arnold J, Aviles A, Barrett C, Bhatia A, Desvigne M, et al. Use of mechanically powered disposable negative pressure wound therapy: recommendations and reimbursement update. Wounds. 2019;31(2 Supp):1-S17.
Wang Z, Bai M, Zeng A, Liu Z, Zhao R, Wang X. The role of negative pressure wound therapy in managing Chinese patients with wound-derived acute severe Illness. Wounds. 2018;30(8):235–41.
Xu Q, Shen L, Yang X, Peng H, Liu M. Comparison of changes in wound healing parameters following treatment with three topical wound care products using a laser wound model. Am J Transl Res. 2021;13(4):2644–52.
Westby MJ, Dumville JC, Soares MO, Stubbs N, Norman G. Dressings and topical agents for treating pressure ulcers. Cochrane Database Syst Rev. 2017;6(6):CD011947. https://doi.org/10.1002/14651858.CD011947.pub2.
Norman G, Westby MJ, Rithalia AD, Stubbs N, Soares MO, Dumville JC. Dressings and topical agents for treating venous leg ulcers. Cochrane Database Syst Rev. 2018;6(6):CD012583. https://doi.org/10.1002/14651858.CD012583.pub2.
Jarl G, Rusaw DF, Terrill AJ, Barnett CT, Woodruff MA, Lazzarini PA. Personalized offloading treatments for Healing Plantar Diabetic Foot Ulcers. J Diabetes Sci Technol. 2023;17(1):99–106. https://doi.org/10.1177/19322968221101632.
Fernando ME, Horsley M, Jones S, Martin B, Nube VL, Charles J, et al. Australian diabetes-related Foot Disease Guidelines & Pathways Project. Australian guideline on offloading treatment for foot ulcers: part of the 2021 Australian evidence-based guidelines for diabetes-related foot Disease. J Foot Ankle Res. 2022;15(1):31. https://doi.org/10.1186/s13047-022-00538-3.
Daeschlein G. Antimicrobial and antiseptic strategies in wound management. Int Wound J. 2013;10:9–14. https://doi.org/10.1111/iwj.12175.
Gacto-Sanchez P. Surgical treatment and management of the severely burn patient: review and update. Med Intensiva. 2017;41(6):356–64. https://doi.org/10.1016/j.medin.2017.02.008.
Tyavambiza C, Dube P, Goboza M, Meyer S, Madiehe AM, Meyer M. Wound Healing activities and potential of selected African Medicinal plants and their synthesized biogenic nanoparticles. Plants (Basel). 2021;10(12): 2635. https://doi.org/10.3390/plants10122635.
Pang C, Ibrahim A, Bulstrode NW, Ferretti P. An overview of the therapeutic potential of regenerative medicine in cutaneous wound healing. Int Wound J. 2017;14(3):450–9. https://doi.org/10.1111/iwj.12735.
Shi C, Wang C, Liu H, Li Q, Li R, Zhang Y, et al. Selection of appropriate wound dressing for various wounds. Front Bioeng Biotechnol. 2020;8: 182. https://doi.org/10.3389/fbioe.2020.00182.
Khanam S. A systematic review on wound healing and its promising medicinal plants. IP Int J Compr Adv Pharmacol. 2020;5(4):170–6. https://doi.org/10.18231/j.ijcaap.2020.036.
Liu E, Gao H, Zhao Y, Pang Y, Yao Y, Yang Z, et al. Front Pharmacol. 2022;13: 900439. https://doi.org/10.3389/fphar.2022.900439.
Quave CL. Wound healing with botanicals: a review and future perspectives. Curr Dermatol Rep. 2018;7(4):287–95. https://doi.org/10.1007/s13671-018-0247-4.
Ning S, Zang J, Zhang B, Feng X, Qiu F. Botanical drugs in traditional chinese medicine with wound healing properties. Front Pharmacol. 2022;13: 885484. https://doi.org/10.3389/fphar.2022.885484.
Xu Z, Dong M, Yin S, Dong J, Zhang M, Tian R, et al. Why traditional herbal medicine promotes wound healing: research from immune response, wound microbiome to controlled delivery. Adv Drug Deliv Rev. 2023;195: 114764. https://doi.org/10.1016/j.addr.2023.114764.
Marume A, Matope G, Katsande S, Khoza S, Mutingwende I, Mduluza T, et al. Wound Healing properties of selected plants used in Ethnoveterinary Medicine. Front Pharmacol. 2017;8: 544. https://doi.org/10.3389/fphar.2017.00544.
Herman A, Herman AP. Herbal products in postsurgical wound healing - incision, excision and dead space wound models. Planta Med. 2020;86(11):732–48. https://doi.org/10.1055/a-1162-9988.
Moses RL, Prescott TAK, Mas-Claret E, Steadman R, Moseley R, et al. Evidence for natural products as alternative wound-healing therapies. Biomolecules. 2023;13(3): 444. https://doi.org/10.3390/biom13030444.
Herman A, Herman AP. Herbal products and their active constituents for diabetic wound healing-preclinical and clinical studies: a systematic review. Pharmaceutics. 2023;15(1): 281. https://doi.org/10.3390/pharmaceutics15010281.
Kotian S, Bhat K, Pai S, Nayak J, Souza A, Gourisheti K, et al. The role of natural medicines on wound healing: a biomechanical, histological, biochemical and molecular study. Ethiop J Health Sci. 2018;28(6):759–70. https://doi.org/10.4314/ejhs.v28i6.11.
Bahramsoltani R, Farzaei MH, Rahimi R. Medicinal plants and their natural components as future Drugs for the treatment of burn wounds: an integrative review. Arch Dermatol Res. 2014;306(7):601–17. https://doi.org/10.1007/s00403-014-1474-6.
El-Sherbeni SA, Negm WA. The wound healing effect of botanicals and pure natural substances used in in vivo models. Inflammopharmacology. 2023;31(2):755–72. https://doi.org/10.1007/s10787-023-01157-5.
Nomoto T, Iizaka S. Effect of an oral nutrition supplement containing collagen peptides on stratum corneum hydration and skin elasticity in hospitalized older adults: a multicenter open-label randomized controlled study. Adv Skin Wound Care. 2020;33(4):186–91. https://doi.org/10.1097/01.ASW.0000655492.40898.55.
Birkbeck R, Donaldson R, Chan DL. Nutritional management of a kitten with thermal Burns and septicaemia. JFMS Open Rep. 2020;6(1): 2055116920930486. https://doi.org/10.1177/2055116920930486.
Dorresteijn JA, Kriegsman DM, Assendelft WJ, Valk GD. Patient education for preventing diabetic foot ulceration. Cochrane Database Syst Rev. 2014;2014(12):CD001488. https://doi.org/10.1002/14651858.CD001488.pub5.
Tobiano G, Walker RM, Chaboyer W, Carlini J, Webber L, Latimer S, et al. Patient experiences of, and preferences for, surgical wound care education. Int Wound J. 2023;20(5):1687–99. https://doi.org/10.1111/iwj.14030.
Ramalingam S, Chandrasekar MJN, Nanjan MJ. Plant-based natural products for wound healing: a critical review. Curr Drug Res Rev. 2022;14:37–60. https://doi.org/10.2174/2589977513666211005095613.
Chaniad P, Tewtrakul S, Sudsai T, Langyanai S, Kaewdana K. Anti-inflammatory, wound healing and antioxidant potential of compounds from Dioscorea bulbifera L. bulbils. PLoS ONE. 2020;15: e0243632. https://doi.org/10.1371/journal.pone.0243632.
Chaniad P, Wattanapiromsakul C, Pianwanit S, Tewtrakul S. Anti-HIV-1 integrase compounds from Dioscorea bulbifera and molecular docking study. Pharm Biol. 2016;54(6):1077–85. https://doi.org/10.3109/13880209.2015.1103272.
Juneja K, Mishra R, Chauhan S, Gupta S, Roy P, Sircar D, et al. Metabolite profiling and wound-healing activity of Boerhavia diffusa leaf extracts using in vitro and in vivo models. J Tradit Complement Med. 2019;10:52–9. https://doi.org/10.1016/j.jtcme.2019.02.002.
Sinan KI, Akpulat U, Aldahish AA, Celik Altunoglu Y, Baloglu MC, Zheleva-Dimitrova D, et al. LC-MS/HRMS Analysis, Anti-Cancer, Anti-enzymatic and Anti-oxidant effects of Boerhavia diffusa extracts: a potential raw material for functional applications. Antioxid (Basel). 2021;10: 2003. https://doi.org/10.3390/antiox10122003.
Venthodika A, Chhikara N, Mann S, Garg MK, Sofi SA, Panghal A. Bioactive compounds of Aegle marmelos L., medicinal values and its food applications: a critical review. Phytother Res. 2021;35:1887–907. https://doi.org/10.1002/ptr.6934.
Azmi L, Shukla I, Goutam A, Allauddin, Rao CV, Jawaid T, et al. In vitro wound healing activity of 1-hydroxy-5,7-dimethoxy-2-naphthalene-carboxaldehyde (HDNC) and other isolates of Aegle marmelos L.: enhances keratinocytes motility via Wnt/β-catenin and RAS-ERK pathways. Saudi Pharm J. 2019;27:532–9. https://doi.org/10.1016/j.jsps.2019.01.017
Dahmani M, Laoufi R, Selama O, Arab K. Gas chromatography coupled to mass spectrometry characterization, anti-inflammatory effect, wound-healing potential, and hair growth-promoting activity of Algerian Carthamus caeruleus L (Asteraceae). Indian J Pharmacol. 2018;50:123. https://doi.org/10.4103/ijp.IJP_65_17.
Ichimaru Y, Kanaeda N, Tominaga S, Suzui M, Maeda T, Fujii H, et al. Sasa veitchii extract induces anticancer effects via inhibition of cyclin D1 expression in MCF-7 cells. Nagoya J Med Sci. 2020;82:509–18. https://doi.org/10.18999/nagjms.82.3.509.
Tan HL, Chan KG, Pusparajah P, Lee LH, Goh BH. Gynura procumbens: an overview of the Biological activities. Front Pharmacol. 2016;7: 52. https://doi.org/10.3389/fphar.2016.00052.
Sutthammikorn N, Supajatura V, Yue H, Takahashi M, Chansakaow S, Nakano N, et al. Topical Gynura procumbens as a Novel Therapeutic improves Wound Healing in Diabetic mice. Plants (Basel). 2021;10: 1122. https://doi.org/10.3390/plants10061122.
Peng W, Qin R, Li X, Zhou H. Botany, phytochemistry, pharmacology, and potential application of Polygonum cuspidatum Sieb.et Zucc.: a review. J Ethnopharmacol. 2013;148:729–45. https://doi.org/10.1016/j.jep.2013.05.007.
Nawrot-Hadzik I, Matkowski A, Pitulaj A, Sterczala B, Olchowy C, Szewczyk A, et al. In Vitro Gingival Wound Healing activity of extracts from Reynoutria japonica Houtt Rhizomes. Pharmaceutics. 2021;13: 1764. https://doi.org/10.3390/pharmaceutics13111764.
Figueiredo FF, Cechinel Filho V, Damazo AS, Arunachalam K, Colodel EM, Ribeiro M, et al. Sorocea Guilleminiana Gaudich.: Wound healing activity, action mechanisms, and chemical characterization of the leaf infusion. J Ethnopharmacol. 2020;248: 112307. https://doi.org/10.1016/j.jep.2019.112307.
Pereira LOM, Vilegas W, Tangerina MMP, Arunachalam K, Balogun SO, Orlandi-Mattos PE, et al. Lafoensia Pacari A. St.-Hil.: Wound healing activity and mechanism of action of standardized hydroethanolic leaves extract. J Ethnopharmacol. 2018;219:337–50. https://doi.org/10.1016/j.jep.2018.02.038.
Park KS, Park DH. The effect of Korean Red Ginseng on full-thickness skin wound healing in rats. J Ginseng Res. 2019;43:226–35. https://doi.org/10.1016/j.jgr.2017.12.006.
Namchaiw P, Jaisin Y, Niwaspragrit C, Malaniyom K, Auvuchanon A, Ratanachamnong P. The leaf extract of coccinia grandis (L.) Voigt Accelerated in Vitro Wound Healing by reducing oxidative stress Injury. Oxid Med Cell Longev. 2021;3963510. https://doi.org/10.1155/2021/3963510
Al-Madhagy SA, Mostafa NM, Youssef FS, Awad GEA, Eldahshan OA, Singab ANB. Metabolic profiling of a polyphenolic-rich fraction of Coccinia grandis leaves using LC-ESI-MS/MS and in vivo validation of its antimicrobial and wound healing activities. Food Funct. 2019;10(10):6267–75. https://doi.org/10.1039/c9fo01532a.
Danna C, Bazzicalupo M, Ingegneri M, Smeriglio A, Trombetta D, Burlando B, et al. Anti-inflammatory and Wound Healing properties of Leaf and Rhizome extracts from the Medicinal Plant Peucedanum ostruthium (L.) W. D. J. Koch. Molecules. 2022;27: 4271. https://doi.org/10.3390/molecules27134271.
Szopa A, Pajor J, Klin P, Rzepiela A, Elansary HO, Al-Mana FA, et al. Artemisia absinthium L.—Importance in the history of medicine, the latest advances in phytochemistry and therapeutical, cosmetological and culinary uses. Plants. 2020;9: 1063. https://doi.org/10.3390/plants9091063.
Sultan MH, Zuwaiel AA, Moni SS, Alshahrani S, Alqahtani SS, Madkhali O, et al. Bioactive principles and Potentiality of Hot Methanolic Extract of the leaves from Artemisia absinthium L in vitro cytotoxicity against human MCF-7 Breast Cancer cells, antibacterial study and wound healing activity. Curr Pharm Biotechnol. 2020;21:1711–21. https://doi.org/10.2174/1389201021666200928150519.
Zhou YX, Xin HL, Rahman K, Wang SJ, Peng C, Zhang H. Portulaca oleracea L.: a review of Phytochemistry and Pharmacological effects. Biomed Res Int. 2015;2015: 925631. https://doi.org/10.1155/2015/925631.
Guo J, Peng J, Han J, Wang K, Si R, Shan H, et al. Extracts of Portulaca oleracea promote wound healing by enhancing angiology regeneration and inhibiting iron accumulation in mice. Chin Herb Med. 2022;14:263–72. https://doi.org/10.1016/j.chmed.2021.09.014.
Alsareii SA, Alzerwi NAN, AlAsmari MY, Alamri AM, Mahnashi MH, Shaikh IA. Topical application of Premna Integrifolia Linn on skin Wound Injury in rats accelerates the Wound Healing process: evidence from in Vitro and in vivo experimental models. Evid Based Complement Alternat Med. 2022;132022:1–14. https://doi.org/10.1155/2022/6449550.
Devkota HP, Paudel KR, Khanal S, Baral A, Panth N, Adhikari-Devkota A, et al. Stinging nettle (Urtica dioica L.): nutritional composition, bioactive compounds, and food functional properties. Molecules. 2022;27: 5219. https://doi.org/10.3390/molecules27165219.
Kasouni AI, Chatzimitakos TG, Stalikas CD, Trangas T, Papoudou-Bai A, Troganis AN. The unexplored Wound Healing activity of Urtica dioica L. Extract: an in Vitro and in vivo study. Molecules. 2021;26: 6248. https://doi.org/10.3390/molecules26206248.
Zulkipli IN, Rajabalaya R, Idris A, Sulaiman NA, David SR. Clinacanthus nutans: a review on ethnomedicinal uses, chemical constituents and pharmacological properties. Pharm Biol. 2017;55:1093–113. https://doi.org/10.1080/13880209.2017.1288749.
Roeslan MO, Ayudhya TDN, Yingyongnarongkul B, Koontongkaew S. Anti-biofilm, nitric oxide inhibition and wound healing potential of purpurin-18 phytyl ester isolated from Clinacanthus nutans leaves. Biomed Pharmacother. 2019;113:108724. https://doi.org/10.1016/j.biopha.2019.108724.
Daemi A, Lotfi M, Farahpour MR, Oryan A, Ghayour SJ, Sonboli A. Topical application of Cinnamomum hydroethanolic extract improves wound healing by enhancing re-epithelialization and keratin biosynthesis in streptozotocin-induced diabetic mice. Pharm Biol. 2019;57(1):799–806. https://doi.org/10.1080/13880209.2019.1687525.
Farahpour MR, Sheikh S, Kafshdooz E, Sonboli A. Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis. Pharm Biol. 2021;59(1):1–10. https://doi.org/10.1080/13880209.2020.1861029.
Assar DH, Elhabashi N, Mokhbatly AA, Ragab AE, Elbialy ZI, Rizk SA, et al. Wound healing potential of licorice extract in rat model: antioxidants, histopathological, immunohistochemical and gene expression evidences. Biomed Pharmacother. 2021;143: 112151. https://doi.org/10.1016/j.biopha.2021.112151.
Somwong P, Kamkaen N. Wound-healing activity and quantification of bioactive compounds from Derris scandens extract. J Adv Pharm Technol Res. 2022;13(1):38–43. https://doi.org/10.4103/japtr.japtr_208_21.
Akbari F, Azadbakht M, Bagheri A, Vahedi L. Vitro and in vivo Wound Healing activity of Astragalus Floccosus Boiss. (Fabaceae). Adv Pharmacol Pharm Sci. 2022;2022:7865015. https://doi.org/10.1155/2022/7865015.
Ahmed SR, Mostafa EM, Musa A, Rateb EE, Al-Sanea MM, Abu-Baih DH, et al. Wound healing and antioxidant properties of Launaea procumbens supported by metabolomic profiling and molecular docking. Antioxid (Basel). 2022;11(11): 2258. https://doi.org/10.3390/antiox11112258.
Lulseged K, Akele MZ, Abiye AA, Abebe B, Assefa Huluka S. Wound healing and antioxidant properties of 80% methanol leaf extract of Verbascum sinaiticum (Scrophulariaceae): an Ethiopian Medicinal Plant. Evid Based Complement Alternat Med. 2022;2022: 9836773. https://doi.org/10.1155/2022/9836773.
Selseleh M, Nejad ES, Aliahmadi A, Sonboli A, Mirjalili MH. Metabolic profiling, antioxidant, and antibacterial activity of some Iranian Verbascum L. species. Ind Crops Prod. 2020;153. https://doi.org/10.1016/j.indcrop.2020.112609.112609
Zhao B, Zhang X, Han W, Cheng J, Qin Y. Wound healing effect of an Astragalus membranaceus polysaccharide and its mechanism. Mol Med Rep. 2017;15(6):4077–83. https://doi.org/10.3892/mmr.2017.6488.
Ahmad SU, Binti Aladdin NA, Jamal JA, Shuid AN, Mohamed IN. Evaluation of wound-healing and antioxidant effects of Marantodes Pumilum (Blume) Kuntze in an Excision Wound Model. Molecules. 2021;26(1): 228. https://doi.org/10.3390/molecules26010228.
Yeh CJ, Chen CC, Leu YL, Lin MW, Chiu MM, Wang SH. The effects of artocarpin on wound healing: in vitro and in vivo studies. Sci Rep. 2017;7(1):15599. https://doi.org/10.1038/s41598-017-15876-7.
Aulanniam A, Ora KM, Ariandini NA, Wuragil DK, Permata FS, Riawan W, et al. Wound healing properties of Gliricidia sepium leaves from Indonesia and the Philippines in rats (Rattus norvegicus). Vet World. 2021;14(3):820–4. https://doi.org/10.14202/vetworld.2021.820-824.
Mehraein F, Sarbishegi M, Aslani A. Evaluation of effect of oleuropein on skin wound healing in aged male BALB/c mice. Cell J. 2014;16(1):25–30.
Prakoso YA, Rini CS, Rahayu A, Sigit M, Widhowati D. Celery (Apium graveolens) as a potential antibacterial agent and its effect on cytokeratin-17 and other healing promoters in skin wounds infected with methicillin-resistant Staphylococcus aureus. Vet World. 2020;13(5):865–71. https://doi.org/10.14202/vetworld.2020.865-871.
Chattopadhyay P, Goyary D, Mazumder PM, Veer V. Euphorbia hirta accelerates fibroblast proliferation and smad-mediated collagen production in rat excision wound. Pharmacogn Mag. 2014;10(Suppl 3):534–42. https://doi.org/10.4103/0973-1296.139801.
Pang Y, Zhang Y, Huang L, Xu L, Wang K, Wang D, et al. Effects and mechanisms of total flavonoids from Blumea balsamifera (L.) DC. On skin wound in rats. Int J Mol Sci. 2017;18(12): 2766. https://doi.org/10.3390/ijms18122766.
Americo AVLDS, Nunes KM, de Assis FFV, Dias SR, Passos CTS, Morini AC, et al. Efficacy of phytopharmaceuticals from the amazonian plant libidibia ferrea for wound healing in dogs. Front Vet Sci. 2020;12: 244. https://doi.org/10.3389/fvets.2020.00244.
Lee SY, Chang WL, Li ZX, Kirkby NS, Tsai WC, Huang SF, et al. Astragaloside VI and cycloastragenol-6-O-beta-D-glucoside promote wound healing in vitro and in vivo. Phytomedicine. 2018;38:183–91. https://doi.org/10.1016/j.phymed.2017.12.003.
Abeje BA, Bekele T, Getahun KA, Asrie AB. Evaluation of Wound Healing activity of 80% hydromethanolic crude extract and solvent fractions of the leaves of Urtica simensis in mice. J Exp Pharmacol. 2022;14:221–41. https://doi.org/10.2147/JEP.S363676.
Wang CG, Lou YT, Tong MJ, Zhang LL, Zhang ZJ, Feng YZ, et al. Asperosaponin VI promotes angiogenesis and accelerates wound healing in rats via up-regulating HIF-1α/VEGF signaling. Acta Pharmacol Sin. 2018;39(3):393–404. https://doi.org/10.1038/aps.2017.161.
Agour A, Mssillou I, Es-Safi I, Conte R, Mechchate H, Slighoua M, et al. The antioxidant, Analgesic, anti-inflammatory, and Wound Healing activities of Haplophyllum tuberculatum (Forsskal) A. Juss Aqueous and Ethanolic Extract. Life (Basel). 2022;12(10): 1553. https://doi.org/10.3390/life12101553.
Abdulhafiz F, Reduan MFH, Hisam AH, Mohammad I, Abdul Wahab IR, Abdul Hamid FF, et al. LC-TOF-MS/MS and GC-MS based phytochemical profiling and evaluation of wound healing activity of Oroxylum Indicum (L.) Kurz (Beka). Front Pharmacol. 2022;13: 1050453. https://doi.org/10.3389/fphar.2022.1050453.
Ananda N, Ariawan D, Juniantito V. Effects of the hydnophytum formicarum plant extract on collagen density, angiogenesis, wound length, and re-epithelialization in wound healing: experimental study on rats. Dent Med Probl. 2022;59(1):67–73. https://doi.org/10.17219/dmp/140208.
Ren J, Yang M, Chen J, Ma S, Wang N. Anti-inflammatory and wound healing potential of kirenol in diabetic rats through the suppression of inflammatory markers and matrix metalloproteinase expressions. Biomed Pharmacother. 2020;129: 110475. https://doi.org/10.1016/j.biopha.2020.110475.
Rhimi W, Hlel R, Ben Salem I, Boulila A, Rejeb A, Saidi M. Dittrichia viscosa L. Ethanolic Extract based ointment with Antiradical, antioxidant, and Healing Wound activities. Biomed Res Int. 2019;2019: 4081253. https://doi.org/10.1155/2019/4081253.
Duymus ME, Aydin HA, Bulgurcu A, Bayramoglu Z, Durhan A, Salih S, et al. Effect of topical application and/or systemic use of red ginseng extract on wound healing in rats with experimentally induced diabetes. Wound Manag Prev. 2022;68(6):28–37.
Rahman S, Karibasappa SN, Mehta DS. Evaluation of the wound-healing potential of the kiwifruit extract by assessing its effects on human gingival fibroblasts and angiogenesis. Dent Med Probl. 2023;60(1):71–7. https://doi.org/10.17219/dmp/146635.
Rezaei M, Dadgar Z, Noori-Zadeh A, Mesbah-Namin SA, Pakzad I, Davodian E. Evaluation of the antibacterial activity of the Althaea officinalis L. leaf extract and its wound healing potency in the rat model of excision wound creation. Avicenna J Phytomed. 2015;5(2):105–12.
Hyun SW, Kim J, Jo K, Kim JS, Kim CS. Aster Koraiensis extract improves impaired skin wound healing during hyperglycemia. Integr Med Res. 2018;7(4):351–7. https://doi.org/10.1016/j.imr.2018.09.001.
Asante-Kwatia E, Adjei S, Jibira Y, Gyimah L, Adjei-Hinneh G, Amponsah IK, et al. Amphimas pterocarpoides harms.: an evaluation of flavonoid and phenolic contents, wound healing, anthelmintic and antioxidant activities of the leaves and stem bark. Heliyon. 2021;7(11): e08261. https://doi.org/10.1016/j.heliyon.2021.e08261.
Rujirachotiwat A, Suttamanatwong S. Curcumin promotes collagen Type I, Keratinocyte growth Factor-1, and epidermal growth factor receptor expressions in the In Vitro wound healing model of human gingival fibroblasts. Eur J Dent. 2021;15(1):63–70. https://doi.org/10.1055/s-0040-1715781.
Bueno FG, Moreira EA, Morais GR, Pacheco IA, Baesso ML, Leite-Mello EV, et al. Enhanced cutaneous wound healing in vivo by standardized crude extract of Poincianella Pluviosa. PLoS ONE. 2016;11(3): e0149223. https://doi.org/10.1371/journal.pone.0149223.
Parasuraman S, Thing GS, Dhanaraj SA. Polyherbal formulation: Concept of ayurveda. Pharmacogn Rev. 2014;8(16):73–80. https://doi.org/10.4103/0973-7847.134229.
Nagore SG, Kuber DH, Gupta VV, Patil PK. Design and development of a stable polyherbal formulation based on the results of compatibility studies. Pharmacognosy Res. 2011;3(2):122–9. https://doi.org/10.4103/0974-8490.81960.
Amin AH, Fatima F, Shafiq B, Rehman A, Haq NU, Gilani IU. Systematic review of polyherbal combinations used in metabolic syndrome. Front Pharmacol. 2021;12: 752926. https://doi.org/10.3389/fphar.2021.752926.
Das R, Pal P, Bhutia S. Pharmacognostical characterization and formulation of herbal-based low-cost mosquito repellents from Elettaria cardamomum (Linn.) Seed by using natural binder. Futur J Pharm Sci. 2021;7:15. https://doi.org/10.1186/s43094-020-00166-3.
Chi J, Sun L, Cai L, Fan L, Shao C, Shang L, et al. Chinese herb microneedle patch for wound healing. Bioact Mater. 2021;6:3507–14. https://doi.org/10.1016/j.bioactmat.2021.03.023.
Niknam S, Tofighi Z, Faramarzi MA, Abdollahifar MA, Sajadi E, Dinarvand R, et al. Polyherbal combination for wound healing: Matricaria chamomilla L. and Punica granatum L. Daru. 2021;29:133–45. https://doi.org/10.1007/s40199-021-00392-x.
Wu JR, Lu YC, Hung SJ, Lin JH, Chang KC, Chen JK, et al. Antimicrobial and immunomodulatory activity of Herb extracts used in burn Wound Healing: San Huang Powder. Evid Based Complement Alternat Med. 2021;2021:1–13. https://doi.org/10.1155/2021/2900060.
Zhou Z, Chen L, Su Y, Li M, Zhong L, Liao L. A New Target of the four-Herb Chinese Medicine for Wound Repair promoted by mitochondrial metabolism using protein acetylation analysis. Med Sci Monit. 2022;28: e934816. https://doi.org/10.12659/MSM.934816.
Zhou H, Fang Q, Li N, Yu M, Chen H, Guo S. ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria associated apoptosis via the Erk/p90RSK/Bad pathway. Mol Med Rep. 2021;23:390. https://doi.org/10.3892/mmr.2021.12029.
Porwal A, Kundu G, Bhagwat G, Butti R. Polyherbal formulation Anoac H suppresses the expression of RANTES and VEGF for the management of bleeding hemorrhoids and fistula. Mol Med Rep. 2021;24:736. https://doi.org/10.3892/mmr.2021.12376.
Miyano K, Eto M, Hitomi S, Matsumoto T, Hasegawa S, Hirano A, et al. The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis. Sci Rep. 2020;10:625. https://doi.org/10.1038/s41598-019-57192-2.
Her Y, Lee TK, Ahn JH, Lim SS, Kang BG, Park JS, et al. Chemical composition of a Novel Distillate from Fermented mixture of nine anti-inflammatory herbs and its UVB-Protective efficacy in mouse dorsal skin via Attenuating Collagen Disruption and Inflammation. Molecules. 2020;26: 124. https://doi.org/10.3390/molecules26010124.
Zhong L, Shi C, Hou Q, Yang R, Li M, Fu X. Promotive effects of four herbal medicine ARCC on wound healing in mice and human. Health Sci Rep. 2022;5(3): e494. https://doi.org/10.1002/hsr2.494.
Elzayat EM, Auda SH, Alanazi FK, Al-Agamy MH. Evaluation of wound healing activity of henna, pomegranate and myrrh herbal ointment blend. Saudi Pharm J. 2018;26(5):733–8. https://doi.org/10.1016/j.jsps.2018.02.016.
Mahboubi M, Taghizadeh M, Khamechian T, Tamtaji OR, Mokhtari R, Talaei SA. The Wound Healing effects of Herbal cream containing Oliveria Decumbens and Pelargonium Graveolens essential oils in Diabetic Foot Ulcer Model. World J Plast Surg. 2018;7(1):45–50.
Aslam MS, Ahmad MS, Mamat AS, Ahmad MZ, Salam F. Antioxidant and Wound Healing activity of Polyherbal fractions of Clinacanthus nutans and Elephantopus scaber. Evid Based Complement Alternat Med. 2016;2016: 4685246. https://doi.org/10.1155/2016/4685246.
Ho TJ, Jiang SJ, Lin GH, Li TS, Yiin LM, Yang JS, et al. The in vitro and in vivo wound healing properties of the Chinese Herbal Medicine Jinchuang Ointment. Evid Based Complement Alternat Med. 2016;2016: 1654056. https://doi.org/10.1155/2016/1654056.
Talekar YP, Apte KG, Paygude SV, Tondare PR, Parab PB. Studies on wound healing potential of polyherbal formulation using in vitro and in vivo assays. J Ayurveda Integr Med. 2017;8(2):73–81. https://doi.org/10.1016/j.jaim.2016.11.007.
Galehdari H, Negahdari S, Kesmati M, Rezaie A, Shariati G. Effect of the herbal mixture composed of Aloe Vera, Henna, Adiantum capillus-veneris, and Myrrha on wound healing in streptozotocin-induced diabetic rats. BMC Complement Altern Med. 2016;16(1):386. https://doi.org/10.1186/s12906-016-1359-7.
Akgun SG, Aydemir S, Ozkan N, Yuksel M, Sardas S. Evaluation of the wound healing potential of Aloe vera-based extract of Nerium oleander. North Clin Istanb. 2017;4(3):205–12. https://doi.org/10.14744/nci.2017.94914.
Chumpolphant S, Suwatronnakorn M, Issaravanich S, Tencomnao T, Prasansuklab A. Polyherbal formulation exerts wound healing, anti-inflammatory, angiogenic and antimicrobial properties: potential role in the treatment of diabetic foot ulcers. Saudi J Biol Sci. 2022;29(7): 103330. https://doi.org/10.1016/j.sjbs.2022.103330.
Fahimi S, Abdollahi M, Mortazavi SA, Hajimehdipoor H, Abdolghaffari AH, Rezvanfar MA. Wound Healing activity of a traditionally used Poly Herbal product in a burn Wound Model in rats. Iran Red Crescent Med J. 2015;17(9): e19960. https://doi.org/10.5812/ircmj.19960.
Negahdari S, Galehdari H, Kesmati M, Rezaie A, Shariati G. Wound Healing activity of extracts and formulations of Aloe vera, Henna, Adiantum capillus-veneris, and myrrh on mouse dermal fibroblast cells. Int J Prev Med. 2017;8:18. https://doi.org/10.4103/ijpvm.IJPVM_338_16.
Zhang XN, Ma ZJ, Wang Y, Li YZ, Sun B, Guo X, et al. The four-Herb Chinese Medicine Formula Tuo-Li-Xiao-Du-San accelerates cutaneous wound healing in streptozotocin-induced diabetic rats through reducing inflammation and increasing angiogenesis. J Diabetes Res. 2016;2016: 5639129. https://doi.org/10.1155/2016/5639129.
Xu X, Li X, Zhang L, Liu Z, Pan Y, Chen D, et al. Enhancement of wound healing by the traditional Chinese Medicine Herbal Mixture Sophora flavescens in a rat model of Perianal Ulceration. In Vivo. 2017;31(4):543–9. https://doi.org/10.21873/invivo.11092.
Jahandideh M, Hajimehdipoor H, Mortazavi SA, Dehpour A, Hassanzadeh G. Evaluation of the Wound Healing activity of a traditional compound Herbal Product using rat excision wound model. Iran J Pharm Res. 2017;16(Supp):153–63.
Liao J, Azelmat J, Zhao L, Yoshioka M, Hinode D, Grenier D. The Kampo medicine Rokumigan possesses antibiofilm, anti-inflammatory, and wound healing properties. Biomed Res Int. 2014;2014: 436206. https://doi.org/10.1155/2014/436206.
Chaushu L, Weinreb M, Beitlitum I, Moses O, Nemcovsky CE. Evaluation of a topical herbal patch for soft tissue wound healing: an animal study. J Clin Periodontol. 2015;42(3):288–93. https://doi.org/10.1111/jcpe.12372.
Tang N, Zheng Y, Cui D, Haick H. Multifunctional dressing for Wound diagnosis and Rehabilitation. Adv Healthc Mater. 2021;10: e2101292. https://doi.org/10.1002/adhm.202101292.
Kaur G, Narayanan G, Garg D, Sachdev A, Matai I. Biomaterials-based regenerative strategies for skin tissue Wound Healing. ACS Appl Bio Mater. 2022;5:2069–106. https://doi.org/10.1021/acsabm.2c00035.
Joorabloo A, Liu T. Recent advances in nanomedicines for regulation of macrophages in wound healing. J Nanobiotechnol. 2022;20:407. https://doi.org/10.1186/s12951-022-01616-1.
Hawthorne B, Simmons JK, Stuart B, Tung R, Zamierowski DS, Mellott AJ. Enhancing wound healing dressing development through interdisciplinary collaboration. J Biomed Mater Res B Appl Biomater. 2021;109:1967–85. https://doi.org/10.1002/jbm.b.34861.
Blanco-Fernandez B, Castano O, Mateos-Timoneda MA, Engel E, Perez-Amodio S. Nanotechnology approaches in Chronic Wound Healing. Adv Wound Care (New Rochelle). 2021;10:234–56. https://doi.org/10.1089/wound.2019.1094.
Bhadauria SS, Malviya R. Advancement in Nanoformulations for the management of Diabetic Wound Healing. Endocr Metab Immune Disord Drug Targets. 2022;22:911–26. https://doi.org/10.2174/1871530322666220304214106.
Nikam A, Thomas A, Giram P, Nagore D, Chitlange S. Herbal-based dressings in Wound Management. Curr Diabetes Rev. 2022;18. https://doi.org/10.2174/1573399818666220401105256
Banerjee K, Madhyastha R, Nakajima Y, Maruyama M, Madhyastha H. Nanoceutical adjuvants as Wound Healing Material: precepts and prospects. Int J Mol Sci. 2021;22: 4748. https://doi.org/10.3390/ijms22094748.
Dam P, Celik M, Ustun M, Saha S, Saha C, Kacar EA, et al. Wound healing strategies based on nanoparticles incorporated in hydrogel wound patches. RSC Adv. 2023;13(31):21345–64. https://doi.org/10.1039/d3ra03477a.
Chu W, Wang P, Ma Z, Peng L, Guo C, Fu Y, et al. Lupeol-loaded chitosan-Ag+ nanoparticle/sericin hydrogel accelerates wound healing and effectively inhibits bacterial Infection. Int J Biol Macromol. 2023;243: 125310. https://doi.org/10.1016/j.ijbiomac.2023.125310.
Sari MHM, Cobre AF, Pontarolo R, Ferreira LM. Status and future scope of Soft nanoparticles-based hydrogel in Wound Healing. Pharmaceutics. 2023;15(3): 874. https://doi.org/10.3390/pharmaceutics15030874.
Montazeri S, Rastegari A, Mohammadi Z, Nazari M, Yousefi M, Samadi FY, et al. Chitosan nanoparticle loaded by epidermal growth factor as a potential protein carrier for wound healing: in vitro and in vivo studies. IET Nanobiotechnol. 2023;17(3):204–11. https://doi.org/10.1049/nbt2.12116.
Froelich A, Jakubowska E, Wojtylko M, Jadach B, Gackowski M, Gadzinski P, et al. Alginate-based materials loaded with nanoparticles in Wound Healing. Pharmaceutics. 2023;41142. https://doi.org/10.3390/pharmaceutics15041142
Huang C, Dong L, Zhao B, Lu Y, Huang S, Yuan Z, et al. Anti-inflammatory hydrogel dressings and skin wound healing. Clin Transl Med. 2022;12(11): e1094. https://doi.org/10.1002/ctm2.1094.
Zhang X, Wei P, Yang Z, Liu Y, Yang K, Cheng Y, et al. Current Progress and Outlook of Nano-based hydrogel dressings for Wound Healing. Pharmaceutics. 2022;15(1): 68. https://doi.org/10.3390/pharmaceutics15010068.
Chen Z, Wang L, Guo C, Qiu M, Cheng L, Chen K, et al. Vascularized polypeptide hydrogel modulates macrophage polarization for wound healing. Acta Biomater. 2023;155:218–34. https://doi.org/10.1016/j.actbio.2022.11.002.
Guan T, Li J, Chen C, Liu Y. Self-assembling peptide-based hydrogels for Wound tissue repair. Adv Sci (Weinh). 2022;9(10): e2104165. https://doi.org/10.1002/advs.202104165.
Zhang S, Ge G, Qin Y, Li W, Dong J, Mei J, et al. Recent advances in responsive hydrogels for diabetic wound healing. Mater Today Bio. 2022;18: 100508. https://doi.org/10.1016/j.mtbio.2022.100508.
Umar AK, Sriwidodo S, Maksum IP, Wathoni N. Film-forming spray of Water-Soluble Chitosan containing liposome-coated human epidermal growth factor for Wound Healing. Molecules. 2021;26(17): 5326. https://doi.org/10.3390/molecules26175326.
Natsaridis E, Mouzoura P, Gkartziou F, Marazioti A, Antimisiaris SG. Development of growth factor-incorporating liposomes for integration into scaffolds as a method to improve tissue regeneration. Int J Dev Biol. 2022;66(1–2–3):137–54. https://doi.org/10.1387/ijdb.210108sa.
Cardoso-Daodu IM, Ilomuanya MO, Amenaghawon AN, Azubuike CP. Artificial neural network for optimizing the formulation of curcumin-loaded liposomes from statistically designed experiments. Prog Biomater. 2022;11(1):55–65. https://doi.org/10.1007/s40204-022-00179-6.
Eid HM, Ali AA, Ali AMA, Eissa EM, Hassan RM, Abo El-Ela FI, et al. Potential use of tailored citicoline Chitosan-Coated liposomes for Effective Wound Healing in Diabetic Rat Model. Int J Nanomedicine. 2022;17:555–75. https://doi.org/10.2147/IJN.S342504.
Tan G, Wang L, Pan W, Chen K. Polysaccharide Electrospun nanofibers for Wound Healing Applications. Int J Nanomedicine. 2022;17:3913–31. https://doi.org/10.2147/IJN.S371900.
Patel Z, Gharat SA, Al-Tabakha MM, Ashames A, Boddu SHS, Momin MM. Recent advancements in Electrospun nanofibers for Wound Healing: polymers, Clinical and Regulatory Perspective. Crit Rev Ther Drug Carrier Syst. 2022;39:83–118. https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2022039840.
Xu H, Zhang F, Wang M, Lv H, Yu DG, Liu X, et al. Electrospun hierarchical structural films for effective wound healing. Biomater Adv. 2022;136: 212795. https://doi.org/10.1016/j.bioadv.2022.212795.
Behere I, Ingavle G. In vitro and in vivo advancement of multifunctional electrospun nanofiber scaffolds in wound healing applications: innovative nanofiber designs, stem cell approaches, and future perspectives. J Biomed Mater Res. 2022;110:443–61. https://doi.org/10.1002/jbm.a.37290.
Gwon K, Choi WI, Lee S, Lee JS, Shin JH. Biodegradable hyaluronic acid-based, nitric oxide-releasing nanofibers for potential wound healing applications. Biomater Sci. 2021;9:8160–70. https://doi.org/10.1039/d1bm01019k.
Zeng N, Jiang L, Miao Q, Zhi Y, Shan S, Su H. [Preparation and applications of the polymeric micelle/hydrogel nanocomposites as biomaterials]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2021;38(3):609–20. https://doi.org/10.7507/1001-5515.202011024. (Chinese).
Hwang D, Ramsey JD, Kabanov AV. Polymeric micelles for the delivery of poorly soluble Drugs: from nanoformulation to clinical approval. Adv Drug Deliv Rev. 2020;156:80–118. https://doi.org/10.1016/j.addr.2020.09.009.
Kotta S, Aldawsari HM, Badr-Eldin SM, Nair AB, Yt K. Progress in Polymeric Micelles for Drug Delivery Applications. Pharmaceutics. 2022;14(8): 1636. https://doi.org/10.3390/pharmaceutics14081636.
Perumal S, Atchudan R, Lee W. A review of polymeric micelles and their applications. Polym (Basel). 2022;14(12): 2510. https://doi.org/10.3390/polym14122510.
Yoshida C, Uchida Y, Ito T, Takami T, Murakami Y. Chitosan gel sheet containing polymeric micelles: synthesis and Gelation properties of PEG-Grafted Chitosan. Mater (Basel). 2017;10(9): 1075. https://doi.org/10.3390/ma10091075.
Liao JL, Zhong S, Wang SH, Liu JY, Chen J, He G, et al. Preparation and properties of a novel carbon nanotubes/poly(vinyl alcohol)/epidermal growth factor composite biological dressing. Exp Ther Med. 2017;14(3):2341–8. https://doi.org/10.3892/etm.2017.4752.
Ravanbakhsh H, Bao G, Mongeau L. Carbon nanotubes promote cell migration in hydrogels. Sci Rep. 2020;10(1):2543. https://doi.org/10.1038/s41598-020-59463-9.
Kittana N, Assali M, Abu-Rass H, Lutz S, Hindawi R, Ghannam L, et al. Enhancement of wound healing by single-wall/multi-wall carbon nanotubes complexed with chitosan. Int J Nanomedicine. 2018;13:7195–206. https://doi.org/10.2147/IJN.S183342.
Liu J, Ismail NA, Yusoff M, Razali MH. Physicochemical Properties and Antibacterial Activity of Gellan Gum incorporating Zinc Oxide/Carbon nanotubes Bionanocomposite Film for Wound Healing. Bioinorg Chem Appl. 2022;2022: 3158404. https://doi.org/10.1155/2022/3158404.
Zhao P, Feng Y, Zhou Y, Tan C, Liu M. Gold@Halloysite nanotubes-chitin composite hydrogel with antibacterial and hemostatic activity for wound healing. Bioact Mater. 2022;20:355–67. https://doi.org/10.1016/j.bioactmat.2022.05.035.
Ali Zahid A, Chakraborty A, Shamiya Y, Ravi SP, Paul A. Leveraging the advancements in functional biomaterials and scaffold fabrication technologies for chronic wound healing applications. Mater Horiz. 2022;9:1850–65. https://doi.org/10.1039/d2mh00115b.
Zulkiflee I, Masri S, Zawani M, Salleh A, Amirrah IN, Wee MFMR, et al. Silicon-based Scaffold for Wound Healing skin regeneration applications: a concise review. Polym (Basel). 2022;14: 4219. https://doi.org/10.3390/polym14194219.
Sun L, Li L, Wang Y, Li M, Xu S, Zhang C. A collagen-based bi-layered composite dressing for accelerated wound healing. J Tissue Viability. 2022;31:180–9. https://doi.org/10.1016/j.jtv.2021.09.003.
Hao R, Cui Z, Zhang X, Tian M, Zhang L, Rao F, et al. Rational design and preparation of functional hydrogels for skin wound healing. Front Chem. 2022;9:9. https://doi.org/10.3389/fchem.2021.839055.
Sharma A, Puri V, Kumar P, Singh I. Biopolymeric, nanopatterned, fibrous carriers for wound healing applications. Curr Pharm Des. 2020;26:4894–908. https://doi.org/10.2174/1381612826666200701152217.
Gardikiotis I, Cojocaru FD, Mihai CT, Balan V, Dodi G. Borrowing the features of biopolymers for emerging Wound Healing dressings: a review. Int J Mol Sci. 2022;23: 8778. https://doi.org/10.3390/ijms23158778.
Wang C, Shirzaei Sani E, Gao W. Wearable bioelectronics for chronic wound management. Adv Funct Mater. 2022;32:2111022. https://doi.org/10.3760/cma.j.cn501120-20210218-00057.
Veeraraghavan VP, Periadurai ND, Karunakaran T, Hussain S, Surapaneni KM, Jiao X. Green synthesis of silver nanoparticles from aqueous extract of Scutellaria barbata and coating on the cotton fabric for antimicrobial applications and wound healing activity in fibroblast cells (L929). Saudi J Biol Sci. 2021;28:3633–40. https://doi.org/10.1016/j.sjbs.2021.05.007.
Buranasukhon W, Athikomkulchai S, Tadtong S, Chittasupho C. Wound healing activity of Pluchea indica leaf extract in oral mucosal cell line and oral spray formulation containing nanoparticles of the extract. Pharm Biol. 2017;55:1767–74. https://doi.org/10.1080/13880209.2017.1326511.
Jakfar S, Lin TC, Chen ZY, Yang IH, Gani BA, Ningsih DS, et al. A polysaccharide isolated from the Herb Bletilla striata combined with methylcellulose to Form a Hydrogel via Self-Assembly as a Wound Dressing. Int J Mol Sci. 2022;23: 12019. https://doi.org/10.3390/ijms231912019.
Zahedi E, Esmaeili A, Eslahi N, Shokrgozar MA, Simchi A. Fabrication and characterization of Core-Shell electrospun fibrous mats containing medicinal herbs for wound healing and skin tissue engineering. Mar Drugs. 2019;17: 27. https://doi.org/10.3390/md17010027.
Ryall C, Chen S, Duarah S, Wen J. Chitosan-based microneedle arrays for dermal delivery of Centella asiatica. Int J Pharm. 2022;627: 122221. https://doi.org/10.1016/j.ijpharm.2022.122221.
Khezri K, Farahpour MR, Mounesi Rad S. Accelerated infected wound healing by topical application of encapsulated Rosemary essential oil into nanostructured lipid carriers. Artif Cells Nanomed Biotechnol. 2019;47(1):980–8. https://doi.org/10.1080/21691401.2019.1582539.
Parastar H, Farahpour MR, Shokri R, Jafarirad S, Kalantari M. Acceleration in healing of infected full-thickness wound with novel antibacterial γ-AlOOH-based nanocomposites. Prog Biomater. 2023;12(2):123–36. https://doi.org/10.1007/s40204-022-00216-4.
Ali A, Garg P, Goyal R, Kaur G, Li X, Negi P, et al. A Novel Herbal Hydrogel Formulation of Moringa oleifera for Wound Healing. Plants (Basel). 2020;10(1): 25. https://doi.org/10.3390/plants10010025.
Aker SD, Tamburaci S, Tihminlioglu F. Development of Cissus quadrangularis-Loaded POSS-Reinforced Chitosan-based bilayer sponges for Wound Healing Applications: drug release and in Vitro Bioactivity. ACS Omega. 2023;8(22):19674–91. https://doi.org/10.1021/acsomega.3c00999.
Beyranvand F, Gharzi A, Abbaszadeh A, Khorramabadi RM, Gholami M, Gharravi AM. Encapsulation of Satureja Khuzistanica extract in alginate hydrogel accelerate wound healing in adult male rats. Inflamm Regen. 2019;39:2. https://doi.org/10.1186/s41232-019-0090-4.
Rameshk M, Sharififar F, Mehrabani M, Pardakhty A, Farsinejad A, Mehrabani M. Proliferation and in Vitro Wound Healing effects of the microniosomes containing Narcissus tazetta L. Bulb extract on primary human fibroblasts (HDFs). Daru. 2018;26(1):31–42. https://doi.org/10.1007/s40199-018-0211-7.
Namviriyachote N, Lipipun V, Akkhawattanangkul Y, Charoonrut P, Ritthidej GC. Development of polyurethane foam dressing containing silver and asiaticoside for healing of dermal wound. Asian J Pharm Sci. 2019;14(1):63–77. https://doi.org/10.1016/j.ajps.2018.09.001.
Koshak AE, Algandaby MM, Mujallid MI, Abdel-Naim AB, Alhakamy NA, Fahmy UA, et al. Wound Healing activity of Opuntia ficus-indica fixed oil formulated in a self-nanoemulsifying formulation. Int J Nanomedicine. 2021;16:3889–905. https://doi.org/10.2147/IJN.S299696.
Frykberg RG, Banks J. Challenges in the treatment of chronic wounds. Adv Wound Care (New Rochelle). 2015;4(9):560–82. https://doi.org/10.1089/wound.2015.0635.
Sharifi S, Hajipour MJ, Gould L, Mahmoudi M. Nanomedicine in Healing Chronic wounds: opportunities and challenges. Mol Pharm. 2021;18(2):550–75. https://doi.org/10.1021/acs.molpharmaceut.0c00346.
Oguntibeju OO. Medicinal plants and their effects on diabetic wound healing. Vet World. 2019;12(5):653. https://doi.org/10.14202/vetworld.2019.653-663.
Ghomi ER, Shakiba M, Ardahaei AS, Kenari MA, Faraji M, Ataei S, et al. Innovations in drug delivery for chronic wound healing. Curr Pharm Des. 2022;28(5):340–51. https://doi.org/10.2174/1381612827666210714102304.
Han G, Ceilley R. Chronic wound healing: a review of current management and treatments. Adv Ther. 2017;34(3):599–610. https://doi.org/10.1007/s12325-017-0478-y.
Sood A, Granick MS, Tomaselli NL. Wound dressings and comparative effectiveness data. Adv Wound Care (New Rochelle). 2014;3(8):511–29. https://doi.org/10.1089/wound.2012.0401.
Park JW, Hwang SR, Yoon IS. Advanced growth factor delivery systems in wound management and skin regeneration. Molecules. 2017;22(8): 1259. https://doi.org/10.3390/molecules22081259.
Li Z, Yu A. Complications of negative pressure wound therapy: a mini review. Wound Repair Regen. 2014;22(4):457–61. https://doi.org/10.1111/wrr.12190.
Khansa I, Schoenbrunner AR, Kraft CT, Janis JE. Silver in Wound Care-Friend or Foe? A Comprehensive Review. Plast Reconstr Surg Glob Open. 2019;7(8): e2390. https://doi.org/10.1097/GOX.0000000000002390.
Sun BK, Siprashvili Z, Khavari PA. Advances in skin grafting and treatment of cutaneous wounds. Science. 2014;346(6212):941–5. https://doi.org/10.1126/science.1253836.
Borena BM, Martens A, Broeckx SY, Meyer E, Chiers K, Duchateau L, et al. Regenerative skin wound healing in mammals: state-of-the-art on growth factor and stem cell based treatments. Cell Physiol Biochem. 2015;36(1):1–23. https://doi.org/10.1159/000374049.
Duscher D, Barrera J, Wong VW, Maan ZN, Whittam AJ, Januszyk M, et al. Stem cells in wound healing: the future of Regenerative Medicine? A Mini-review. Gerontology. 2016;62(2):216–25. https://doi.org/10.1159/000381877.
Parani M, Lokhande G, Singh A, Gaharwar AK. Engineered nanomaterials for Infection control and Healing Acute and Chronic wounds. ACS Appl Mater Interfaces. 2016;8(16):10049–69. https://doi.org/10.1021/acsami.6b00291.
Sharma A, Khanna S, Kaur G, Singh I. Medicinal plants and their components for wound healing applications. Future J Pharm Sci. 2021;7(1):1–3. https://doi.org/10.1186/s43094-021-00202-w.
Shedoeva A, Leavesley D, Upton Z, Fan C. Wound healing and the use of medicinal plants. Evid-Based Complementary Altern Med. 2019;2019.https://doi.org/10.1155/2019/2684108
Ghuman S, Ncube B, Finnie JF, McGaw LJ, Njoya EM, Coopoosamy RM, et al. Antioxidant, anti-inflammatory and wound healing properties of medicinal plant extracts used to treat wounds and dermatological disorders. South Afr J Bot. 2019;126:232–40. https://doi.org/10.1016/j.sajb.2019.07.013.
Solati K, Karimi M, Rafieian-Kopaei M, Abbasi N, Abbaszadeh S, Bahmani M. Phytotherapy for wound healing: the most important herbal plants in wound healing based on Iranian ethnobotanical documents. Mini Rev Med Chem. 2021;21(4):500–19. https://doi.org/10.2174/1389557520666201119122608.
Malabadi RB, Kolkar KP, Acharya M, Nityasree BR, Chalannavar RK. Wound healing: role of traditional herbal medicine treatment. IJISRR. 2022;4(6):2856–74.
Pereira RF, Bartolo PJ. Traditional therapies for skin Wound Healing. Adv Wound Care (New Rochelle). 2016;5(5):208–29. https://doi.org/10.1089/wound.2013.0506.
Balap AR, Gaikwad AA. Challenges, advances and opportunities of herbal medicines in wound healing:a review. Int J Pharm Sci Rev Res. 2021;71(1):125–36. https://doi.org/10.47583/ijpsrr.2021.v71i01.015.
Monika P, Chandraprabha MN, Rangarajan A, Waiker PV, Chidambara Murthy KN. Challenges in healing wound: role of complementary and alternative medicine. Front Nutr. 2022;8: 791899. https://doi.org/10.3389/fnut.2021.791899.
Ayaz M, Subhan F, Ahmed J, Khan AU, Ullah F, Ullah I, et al. Sertraline enhances the activity of antimicrobial agents against pathogens of clinical relevance. J Biol Res (Thessalon). 2015;22(1):4. https://doi.org/10.1186/s40709-015-0028-1.
Dev SK, Choudhury PK, Srivastava R, Sharma M. Antimicrobial, anti-inflammatory and wound healing activity of polyherbal formulation. Biomed Pharmacother. 2019;111:555–67. https://doi.org/10.1016/j.biopha.2018.12.075.
Lordani TVA, de Lara CE, Ferreira FBP, de Souza Terron Monich M, Mesquita da Silva C, Felicetti Lordani CR, et al. Therapeutic effects of Medicinal plants on Cutaneous Wound Healing in humans: a systematic review. Mediators Inflamm. 2018;2018: 7354250. https://doi.org/10.1155/2018/7354250.
Carvalho AR Jr, Diniz RM, Suarez MA, Figueiredo CS, Zagmignan A, Grisotto MA, et al. Use of some asteraceae plants for the treatment of wounds: from ethnopharmacological studies to scientific evidences. Front Pharmacol. 2018;9: 784. https://doi.org/10.3389/fphar.2018.00784.
Dorjsembe B, Lee HJ, Kim M, Dulamjav B, Jigjid T, Nho CW. Achillea Asiatica extract and its active compounds induce cutaneous wound healing. J Ethnopharmacol. 2017;206:306–14. https://doi.org/10.1016/j.jep.2017.06.006.
Neto JA, Tarôco BR, Dos Santos HB, Thomé RG, Wolfram E, de Ribeiro A. Using the plants of Brazilian cerrado for wound healing: from traditional use to scientific approach. J Ethnopharmacol. 2020;260: 112547. https://doi.org/10.1016/j.jep.2020.112547.
Fazil M, Nikhat S. Topical medicines for wound healing: a systematic review of Unani literature with recent advances. J Ethnopharmacol. 2020;257: 112878. https://doi.org/10.1016/j.jep.2020.112878.
Criollo-Mendoza MS, Contreras-Angulo LA, Leyva-Lopez N, Gutierrez-Grijalva EP, Jimenez-Ortega LA, Heredia JB. Wound healing properties of natural products: mechanisms of action. Molecules. 2023;28(2): 598. https://doi.org/10.3390/molecules28020598.
Carvalho MT, Araújo-Filho HG, Barreto AS, Quintans-Júnior LJ, Quintans JS, Barreto RS. Wound healing properties of flavonoids: a systematic review highlighting the mechanisms of action. Phytomedicine. 2021;90: 153636. https://doi.org/10.1016/j.phymed.2021.153636.
Yazarlu O, Iranshahi M, Kashani HRK, Reshadat S, Habtemariam S, Iranshahy M, et al. Perspective on the application of medicinal plants and natural products in wound healing: a mechanistic review. Pharmacol Res. 2021;174: 105841. https://doi.org/10.1016/j.phrs.2021.105841.
Nejjari R, Benabbes M, Amrani M, Meddah B, Bouatia M, Taoufik J. Phytochemical screening and wound healing activity of Telephium Imperati (L.) in rats. South Afr J Bot. 2019;123:147–51. https://doi.org/10.1016/j.sajb.2019.03.023.
Shrivastav A, Mishra AK, Ali SS, Ahmad A, Abuzinadah MF, Khan NA. In vivo models for assesment of wound healing potential: a systematic review. Wound Med. 2018;20:43–53. https://doi.org/10.1016/j.wndm.2018.01.003.
Mehta P, Shah R, Lohidasan S, Mahadik KR. Pharmacokinetic profile of phytoconstituent(s) isolated from medicinal plants-A comprehensive review. J Tradit Complement Med. 2015;5(4):207–27. https://doi.org/10.1016/j.jtcme.2014.11.041.
Ovais M, Ahmad I, Khalil AT, Mukherjee S, Javed R, Ayaz M, et al. Wound healing applications of biogenic colloidal silver and gold nanoparticles: recent trends and future prospects. Appl Microbiol Biotechnol. 2018;102(10):4305–18. https://doi.org/10.1007/s00253-018-8939-z.
Zohra T, Ovais M, Khalil AT, Qasim M, Ayaz M, Shinwari ZK. Extraction optimization, total phenolic, flavonoid contents, HPLC-DAD analysis and diverse pharmacological evaluations of Dysphania ambrosioides (L.) Mosyakin & Clemants. Nat Prod Res. 2019;33(1):136–42. https://doi.org/10.1080/14786419.2018.1437428.
Jiang T, Li Q, Qiu J, Chen J, Du S, Xu X, et al. Nanobiotechnology: applications in Chronic Wound Healing. Int J Nanomedicine. 2022;17:3125–45. https://doi.org/10.2147/IJN.S372211.
Gobi R, Ravichandiran P, Babu RS, Yoo DJ. Biopolymer and Synthetic polymer-based nanocomposites in Wound dressing applications: a review. Polym (Basel). 2021;13(12): 1962. https://doi.org/10.3390/polym13121962.
Bai Q, Han K, Dong K, Zheng C, Zhang Y, Long Q, et al. Potential applications of nanomaterials and Technology for Diabetic Wound Healing. Int J Nanomedicine. 2020;15:9717–43. https://doi.org/10.2147/IJN.S276001.
Mofazzal Jahromi MA, Sahandi Zangabad P, Moosavi Basri SM, Sahandi Zangabad K, Ghamarypour A, Aref AR, Karimi M, Hamblin MR. Nanomedicine and advanced technologies for Burns: preventing Infection and facilitating wound healing. Adv Drug Deliv Rev. 2018;123:33–64. https://doi.org/10.1016/j.addr.2017.08.001.
Kang HJ, Chen N, Dash BC, Hsia HC, Berthiaume F. Self-assembled nanomaterials for chronic skin Wound Healing. Adv Wound Care (New Rochelle). 2021;10(5):221–33. https://doi.org/10.1089/wound.2019.1077.
Guo S, Wang P, Song P, Li N. Electrospinning of botanicals for skin wound healing. Front Bioeng Biotechnol. 2022;10: 1006129. https://doi.org/10.3389/fbioe.2022.1006129.
Wang W, Lu KJ, Yu CH, Huang QL, Du YZ. Nano-drug delivery systems in wound treatment and skin regeneration. J Nanobiotechnol. 2019;17(1):82. https://doi.org/10.1186/s12951-019-0514-y.
Faraji A, Aghdaki M, Hessami K, Hosseinkhani A, Roozmeh S, Asadi N, et al. Episiotomy wound healing by Commiphora myrrha (Nees) Engl. And Boswellia carteri Birdw. In primiparous women: a randomized controlled trial. J Ethnopharmacol. 2021;264: 113396. https://doi.org/10.1016/j.jep.2020.113396.
Duric K, Kovcic Hadziabdic S, Duric M, Niksic H, Uzunovic A, Dzudzevic Cancar H. Efficacy and safety of three plant extracts based formulations of vagitories in the treatment of vaginitis: a randomized controlled trial. Med Glas (Zenica). 2021;18:47–54. https://doi.org/10.17392/1261-21.
Burusapat C, Supawan M, Pruksapong C, Pitiseree A, Suwantemee C. Topical Aloe Vera Gel for Accelerated Wound Healing of Split-Thickness skin graft Donor sites: a Double-Blind, randomized, controlled trial and systematic review. Plast Reconstr Surg. 2018;142(1):217–26. https://doi.org/10.1097/PRS.0000000000004515.
Mokhtari M, Razzaghi R, Momen-Heravi M. The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot Ulcer: a randomized, double‐blind, placebo‐controlled trial. Phytother Res. 2021;35:2099–107. https://doi.org/10.1002/ptr.6957.
Damkerngsuntorn W, Rerknimitr P, Panchaprateep R, Tangkijngamvong N, Kumtornrut C, Kerr SJ, et al. The effects of a standardized extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: a Split-Face, Double-Blind, randomized, placebo-controlled trial. J Altern Complement Med. 2020;26:529–36. https://doi.org/10.1089/acm.2019.0325.
Toomari E, Hajian S, Mojab F, Omidkhah T, Nasiri M. Evaluation the effect of Silybum marianum ointment on episiotomy wound healing and pain intensity in primiparous women: a randomized triple-blind clinical trial. BMC Complement Med Ther. 2021;21:253. https://doi.org/10.1186/s12906-021-03413-z.
lhashim M, Lombardo J. Effect of Topical Garlic on Wound Healing and Scarring: a clinical trial. Dermatol Surg. 2020;46:618–27. https://doi.org/10.1097/DSS.0000000000002123.
Taleb S, Saeedi M. The effect of the Verbascum Thapsus on episiotomy wound healing in nulliparous women: a randomized controlled trial. BMC Complement Med Ther. 2021;21:166. https://doi.org/10.1186/s12906-021-03339-6.
Tonaco LAB, Gomes FL, Velasquez-Melendez G, Lopes MTP, Salas CE. The proteolytic fraction from latex of Vasconcellea cundinamarcensis (P1G10) enhances wound healing of diabetic foot ulcers: a double-blind Randomized Pilot Study. Adv Ther. 2018;35:494–502. https://doi.org/10.1007/s12325-018-0684-2.
Izadpanah A, Soorgi S, Geraminejad N, Hosseini M. Effect of grape seed extract ointment on cesarean section wound healing: a double-blind, randomized, controlled clinical trial. Complement Ther Clin Pract. 2019;35:323–8. https://doi.org/10.1016/j.ctcp.2019.03.011.
Hemmati AA, Foroozan M, Houshmand G, Moosavi ZB, Bahadoram M, Maram NS. The topical effect of grape seed extract 2% cream on Surgery wound healing. Glob J Health Sci. 2014;7(3):52–8. https://doi.org/10.5539/gjhs.v7n3p52.
Ikarashi N, Kaneko M, Fujisawa I, Fukuda N, Yoshida R, Kon R, et al. Wound-Healing and skin-moisturizing effects of Sasa veitchii Extract. Healthcare. 2021;9:761. https://doi.org/10.3390/healthcare9060761.
Funding
None.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Consent for publication
Not applicable.
Conflict of interest
The authors declare no conflict of interest.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Pathak, D., Mazumder, A. A critical overview of challenging roles of medicinal plants in improvement of wound healing technology. DARU J Pharm Sci 32, 379–419 (2024). https://doi.org/10.1007/s40199-023-00502-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40199-023-00502-x