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Natural agents as wound-healing promoters

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Abstract

The management of acute and chronic wounds resulting from diverse injuries poses a significant challenge to clinical practices and healthcare providers. Wound healing is a complex biological process driven by a natural physiological response. This process involves four distinct phases, namely hemostasis, inflammation, proliferation, and remodeling. Despite numerous investigations on wound healing and wound dressing materials, complications still persist, necessitating more efficacious therapies. Wound-healing materials can be categorized into natural and synthetic groups. The current study aims to provide a comprehensive review of highly active natural animal and herbal agents as wound-healing promoters. To this end, we present an overview of in vitro, in vivo, and clinical studies that led to the discovery of potential therapeutic agents for wound healing. We further elucidated the effects of natural materials on various pharmacological pathways of wound healing. The results of previous investigations suggest that natural agents hold great promise as viable and accessible products for the treatment of diverse wound types.

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Abbreviations

BV:

Bee venom

IL:

Interleukin

MDA:

Malondialdehyde

MMP:

Matrix metalloproteinase

MRSA:

Methicillin-resistant Staphylococcus aureus

NF-κB:

Nuclear factor-κB

Nrf2:

Nuclear factor erythroid 2-related factor 2

PDGE2:

Palladogermanide

PDGF:

Platelet-derived growth factor

PGE2:

Prostaglandin E2

ROS:

Reactive oxygen species

SCS:

Sulfonated chitosan

SOD:

Superoxide dismutase

TGF β:

Transforming growth factor β

TNF:

Tumor necrosis factor

VEGF:

Vascular endothelial growth factor

References

  • Abdulrhman M, Elbarbary NS, Amin DA, Ebrahim RS (2012) Honey and a mixture of honey, beeswax, and olive oil–propolis extract in treatment of chemotherapy-induced oral mucositis: a randomized controlled pilot study. Pediatr Hematol Oncol 29:285–292

    Article  PubMed  Google Scholar 

  • Abu-Al-Basal MA (2010) Healing potential of Rosmarinus officinalis L. on full-thickness excision cutaneous wounds in alloxan-induced-diabetic BALB/c mice. J Ethnopharmacol 131:443–450

    Article  CAS  PubMed  Google Scholar 

  • Abu-Seida MA (2015) Effect of propolis on experimental cutaneous wound healing in dogs. Vet Med Int 2015(2):2

    Google Scholar 

  • Afkhamizadeh M, Aboutorabi R, Ravari H, Najafi MF, Azimi SA, Langaroodi AJ, Yaghoubi MA, Sahebkar A (2018) Topical propolis improves wound healing in patients with diabetic foot ulcer: a randomized controlled trial. Nat Prod Res 32:2096–2099

    Article  CAS  PubMed  Google Scholar 

  • Ahn C, Mulligan P, Salcido RS (2008) Smoking-the bane of wound healing: biomedical interventions and social influences. Adv Skin Wound Care 21:2

    Article  Google Scholar 

  • Almasaudi S (2021) The antibacterial activities of honey. Saudi J Biol Sci 28:2188–2196

    Article  CAS  PubMed  Google Scholar 

  • Altıparmak M, Eskitaşçıoğlu T (2018) Comparison of systemic and topical Hypericum perforatum on diabetic surgical wounds. J Invest Surg 31:29–37

    Article  PubMed  Google Scholar 

  • Al-Waili N (2018) Mixing two different propolis samples potentiates their antimicrobial activity and wound healing property: a novel approach in wound healing and infection. Vet World 11:1188–1195

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Al-Waili N, Hozzein WN, Badr G, Al-Ghamdi A, Al-Waili H, Al-Waili T, Salom K (2015) Propolis and bee venom in diabetic wounds; a potential approach that warrants clinical investigation. Afr J Tradit Complement Altern Med 12:1–11

    Article  CAS  Google Scholar 

  • Amal B, Veena B, Jayachandran VP, Shilpa J (2015) Preparation and characterisation of Punica granatum pericarp aqueous extract loaded chitosan-collagen-starch membrane: role in wound-healing process. J Mater Sci Mater Med 26:181

    Article  CAS  PubMed  Google Scholar 

  • Aramwit P, Palapinyo S, Srichana T, Chottanapund S, Muangman P (2013) Silk sericin ameliorates wound healing and its clinical efficacy in burn wounds. Arch Dermatol Res 305:585–594

    Article  CAS  PubMed  Google Scholar 

  • Arora D, Rani A, Sharma A (2013) A review on phytochemistry and ethnopharmacological aspects of genus Calendula. Pharmacogn Rev 7:179

    Article  PubMed  PubMed Central  Google Scholar 

  • Asadi SY, Parsaei P, Karimi M, Ezzati S, Zamiri A, Mohammadizadeh F, Rafieian-Kopaei M (2013) Effect of green tea (Camellia sinensis) extract on healing process of surgical wounds in rat. Int J Surg 11:332–337

    Article  PubMed  Google Scholar 

  • Attalla KM, Owayss AA, Mohanny KM (2007) Antibacterial activities of bee venom, propolis, and royal jelly produced by three honey bee, Apis mellifera L., hybrids reared in the same environmental conditions. Anal Agric Sci 45:895–902

    Google Scholar 

  • Bae S, Gu H, Gwon MG, An HJ, Han SM, Lee SJ, Leem J, Park KK (2022) Therapeutic effect of bee venom and melittin on skin infection caused by streptococcus pyogenes. Toxins 14:2

    Article  Google Scholar 

  • Baghel PS, Shukla S, Mathur RK, Randa R (2009) A comparative study to evaluate the effect of honey dressing and silver sulfadiazene dressing on wound healing in burn patients. Indian J Plast Surg 42:176–181

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bano I, Arshad M, Yasin T, Ghauri MA, Younus M (2017) Chitosan: a potential biopolymer for wound management. Int J Biol Macromol 102:380–383

    Article  CAS  PubMed  Google Scholar 

  • Baqer LK, Yaseen RT (2018a) The effect of whole honey bee venom (Apismellifera) on reducing skin infection of rabbits caused by methicillin resistant staphylococcus aureus: an in vivo study. J Pure Appl Microbiol 12:2111–2116

    Article  CAS  Google Scholar 

  • Belkhodja H, Meddah B, Aicha M, Djilali B, Asmaa B (2020) Wound healing activity of the essential oils of Rosmarinus officinalis and Populus alba in a burn wound model in rats. SAR J Pathol Microbiol 1:1–9

    Google Scholar 

  • Bishop A (2008) Role of oxygen in wound healing. J Wound Care 17:399–402

    Article  CAS  PubMed  Google Scholar 

  • Brem H, Tomic-Canic M (2007) Cellular and molecular basis of wound healing in diabetes. J Clin Investig 117:1219–1222

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Buzzi M, De Freitas F, de Barros Winter M (2016a) Therapeutic effectiveness of a Calendula officinalis extract in venous leg ulcer healing. J Wound Care 25:732–739

    Article  CAS  PubMed  Google Scholar 

  • Buzzi M, de Freitas F, Winter M (2016b) A prospective, descriptive study to assess the clinical benefits of using Calendula officinalis hydroglycolic extract for the topical treatment of diabetic foot ulcers. Ostomy Wound Manag 62:8–24

    Google Scholar 

  • Campos ACL, Groth AK, Branco AB (2008) Assessment and nutritional aspects of wound healing. Curr Opin Clin Nutr Metab Care 1:1

    Google Scholar 

  • Catanzano O, Boateng J (2020) Local delivery of growth factors using wound dressings. Therap Dress Wound Heal Appl 2:291–314

    Google Scholar 

  • Cecchini C, Cresci A, Coman MM, Ricciutelli M, Sagratini G, Vittori S, Lucarini D, Maggi F (2007) Antimicrobial activity of seven Hypericum entities from central Italy. Planta Med 73:564–566

    Article  CAS  PubMed  Google Scholar 

  • Chandran PK, Kuttan R (2008) Effect of Calendula officinalis flower extract on acute phase proteins, antioxidant defense mechanism and granuloma formation during thermal burns. J Clin Biochem Nutr 43:58–64

    Article  PubMed  PubMed Central  Google Scholar 

  • Charousaei F, Dabirian A, Mojab F (2011) Using chamomile solution or a 1% topical hydrocortisone ointment in the management of peristomal skin lesions in colostomy patients: results of a controlled clinical study. Ostomy Wound Manag 57:28–36

    Google Scholar 

  • Chong GO, Lee YH, Jeon SY, Yang H-Y, An S-H (2020) Efficacy of a chitosan tampon in the loop electrosurgical excision procedure: a prospective randomized controlled study. Sci Rep 10:6017

    Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

  • Chouhan D, Mandal BB (2020) Silk biomaterials in wound healing and skin regeneration therapeutics: from bench to bedside. Acta Biomater 103:24–51

    Article  CAS  PubMed  Google Scholar 

  • Chouhan D, Lohe T-u, Samudrala PK, Mandal BB (2018) In situ forming injectable silk fibroin hydrogel promotes skin regeneration in full thickness burn wounds. Adv Healthcare Mater 7:1801092

    Article  Google Scholar 

  • Dai T, Tanaka M, Huang Y-Y, Hamblin MR (2011) Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects. Expert Rev Anti Infect Ther 9:857–879

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • de Almeida N, Ana L, MarilenaChinali K, Miguel Angel SDM (2010) Effects of green tea use on wound healing. Int J Morphol 28:905–910

    Google Scholar 

  • Dreifke MB, Jayasuriya AA, Jayasuriya AC (2015) Current wound healing procedures and potential care. Mater Sci Eng C 48:651–662

    Article  CAS  Google Scholar 

  • Duarte CME, Maria Rozelide SQ, Mônica CP, Ana LA (2011) Effects of Chamomilla recutita (L) on oral wound healing in rats

  • Edwards R, Harding KG (2004) Bacteria and wound healing. Curr Opin Infect Dis 17:91–96

    Article  PubMed  Google Scholar 

  • Effect of aloe vera and propolis on wound healing in pressure injuries. 2022

  • El Mihyaoui A, Joaquim CG, da Esteves S, Saoulajan C, María Emilia CC, Ahmed L, Marino BA (2022) Chamomile (Matricaria chamomilla L): a review of ethnomedicinal use, phytochemistry and pharmacological uses. Life 12:479

    Article  PubMed  PubMed Central  ADS  Google Scholar 

  • Elham A, Reyhaneh M, Niki P, Fatemeh GB (2022) Nanotechnology-based therapies for skin wound regeneration. In: Emerging nanomaterials and nano-based drug delivery approaches to combat antimicrobial resistance

  • El-Wahed AA, Abd SAM, Khalifa MH, Elashal SG, Musharraf AS, Khatib A, Tahir HE, Zou X, Naggar YA, Mehmood A (2021) Cosmetic applications of bee venom. Toxins 13:810

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Enhanced secondary intention healing vs. standard secondary intention healing in mohs surgical defects on the head and distal lower extremities. 2022

  • Ernawati DS, Puspa A (2018) Expression of vascular endothelial growth factor and matrix metalloproteinase-9 in Apis mellifera Lawang propolis extract gel-treated traumatic ulcers in diabetic rats. Vet World 11:304

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ersel M, Yigit U, Funda KA, Enver O, Yusuf AA, Fatih K, Turker C, Ayfer M, Gurkan Y, Emel OC (2016) Effects of silk sericin on incision wound healing in a dorsal skin flap wound healing rat model. Med Sci Monit 22:1064

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eskandarinia A, Kefayat A, Rafienia M, Agheb M, Navid S, Ebrahimpour K (2019) Cornstarch-based wound dressing incorporated with hyaluronic acid and propolis: in vitro and in vivo studies. Carbohyd Polym 216:25–35

    Article  CAS  Google Scholar 

  • Eskandarinia A, Kefayat A, Agheb M, Rafienia M, Baghbadorani MA, Navid S, Ebrahimpour K, Khodabakhshi D, Ghahremani F (2020) A novel bilayer wound dressing composed of a dense polyurethane/propolis membrane and a biodegradable polycaprolactone/gelatin nanofibrous scaffold. Sci Rep 10:3063

    Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

  • Franz MG, Steed DL, Robson MC (2007) Optimizing healing of the acute wound by minimizing complications. Curr Probl Surg 44:691–763

    Article  PubMed  Google Scholar 

  • Gilliver SC, Ashworth JJ, Ashcroft GS (2007) The hormonal regulation of cutaneous wound healing. Clin Dermatol 25:56–62

    Article  PubMed  Google Scholar 

  • Giostri GS, Eduardo Murilo N, Marcelo B, Luiz Cesar G-S (2022) Treatment of acute wounds in hand with Calendula officinalis L.: a randomized trial. Tissue Barriers 10:1994822

    Article  PubMed  Google Scholar 

  • Goharshenasan P, Amini S, Atria A, Abtahi H, Khorasani G (2016) Topical application of honey on surgical wounds: a randomized clinical trial. Complement Med Res 23:12–15

    Article  Google Scholar 

  • Gonzalez ACO, Tila Fortuna C, de Zilton AA, Alena RAPM (2016) Wound healing—a literature review. An Bras Dermatol 91:614–620

    Article  PubMed  PubMed Central  Google Scholar 

  • Gosain A, DiPietro LA (2004) Aging and Wound Healing. World J Surg 28:321–326

    Article  PubMed  Google Scholar 

  • Greaves NS, Ashcroft KJ, Baguneid M, Bayat A (2013) Current understanding of molecular and cellular mechanisms in fibroplasia and angiogenesis during acute wound healing. J Dermatol Sci 72:206–217

    Article  CAS  PubMed  Google Scholar 

  • Grenda T, Grabczak M, Sieradzki Z, Kwiatek K, Pohorecka K, Skubida M, Bober A (2018) Clostridium botulinum spores in Polish honey samples. J Vet Sci 19:635–642

    Article  PubMed  PubMed Central  Google Scholar 

  • Guo S, DiPietro LA (2010) Factors affecting wound healing. J Dent Res 89:219–229

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hadizadeh-Talasaz F, Mardani F, Bahri N, Rakhshandeh H, Khajavian N, Taghieh M (2022) Effect of rosemary cream on episiotomy wound healing in primiparous women: a randomized clinical trial. BMC Complement Med Therap 22:1–10

    Article  Google Scholar 

  • Hajhashemi M, Ghanbari Z, Movahedi M, Rafieian M, Keivani A, Haghollahi F (2018) The effect of Achillea millefolium and Hypericum perforatum ointments on episiotomy wound healing in primiparous women. J Matern Fetal Neonatal Med 31:63–69

    Article  PubMed  Google Scholar 

  • Han G, Ceilley R (2017) Chronic wound healing: a review of current management and treatments. Adv Ther 34:599–610

    Article  PubMed  PubMed Central  Google Scholar 

  • Han SangMi, Lee KwangGill, Yeo JooHong, Kim WonTae, Park KwanKyu (2011) Biological effects of treatment of an animal skin wound with honeybee (Apis melifera. L) venom. J Plast Reconstr Aesthet Surg 64:e67–e72

    Article  PubMed  Google Scholar 

  • Hayouni EA, Miled K, Boubaker S, Bellasfar Z, Abedrabba M, Iwaski H, Oku H, Matsui T, Limam F, Hamdi M (2011) Hydroalcoholic extract based-ointment from Punica granatum L. peels with enhanced in vivo healing potential on dermal wounds. Phytomedicine 18:976–984

    Article  CAS  PubMed  Google Scholar 

  • Henshaw FR, Bolton T, Nube V, Hood A, Veldhoen D, Pfrunder L, McKew GL, Macleod C, McLennan SV, Twigg SM (2014) Topical application of the bee hive protectant propolis is well tolerated and improves human diabetic foot ulcer healing in a prospective feasibility study. J Diabetes Complicat 28:850–857

    Article  Google Scholar 

  • Hozzein WN, Badr G, Al Ghamdi AA, Sayed A, Al-Waili NS, Garraud O (2015) Topical application of propolis enhances cutaneous wound healing by promoting TGF-beta/Smad-mediated collagen production in a streptozotocin-induced type I diabetic mouse model. Cell Physiol Biochem 37:940–954

    Article  CAS  PubMed  Google Scholar 

  • Hozzein WN, Badr G, Badr BM, Allam A, Ghamdi AA, Al-Wadaan MA, Al-Waili NS (2018a) Bee venom improves diabetic wound healing by protecting functional macrophages from apoptosis and enhancing Nrf2, Ang-1 and Tie-2 signaling. Mol Immunol 103:322–335

    Article  CAS  PubMed  Google Scholar 

  • Ibrahim NI, SokKuan W, Isa Naina M, Norazlina M, Kok-Yong C, Soelaiman I-N, Ahmad NS (2018) Wound healing properties of selected natural products. Int J Environ Res Public Health 15:2360

    Article  CAS  PubMed  Google Scholar 

  • Ibrahim N, Abbas H, El-Sayed NS, Gad HA (2022) Rosmarinus officinalis L hexane extract: phytochemical analysis, nanoencapsulation, and in silico, in vitro, and in vivo anti-photoaging potential evaluation. Sci Rep 12:13102

    Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

  • Iftikhar F, Arshad M, Rasheed F, Amraiz D, Anwar P, Gulfraz M (2010) Effects of acacia honey on wound healing in various rat models. Phytother Res 24:583–586

    Article  CAS  PubMed  Google Scholar 

  • Jarrahi M (2008) An experimental study of the effects of Matricaria chamomilla extract on cutaneous burn wound healing in albino rats. Nat Prod Res 22:422–427

    Article  CAS  PubMed  Google Scholar 

  • Kamaratos AV, Tzirogiannis KN, Iraklianou SA, Panoutsopoulos GI, Kanellos IE, Melidonis AI (2014) Manuka honey-impregnated dressings in the treatment of neuropathic diabetic foot ulcers. Int Wound J 11:259–263

    Article  PubMed  Google Scholar 

  • Ke C-L, Deng F-S, Chuang C-Y, Lin C-H (2021) Antimicrobial actions and applications of chitosan. Polymers 13:904

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Keylock KT, Vieira VJ, Wallig MA, DiPietro LA, Schrementi M, Woods JA (2008) Exercise accelerates cutaneous wound healing and decreases wound inflammation in aged mice. Am J Physiol Regul Integr Comparat Physiol 294:R179–R184

    Article  CAS  Google Scholar 

  • Kharat Z, Goushki MA, Sarvian N, Asad S, Dehghan MM, Kabiri M (2021) Chitosan/PEO nanofibers containing Calendula officinalis extract: preparation, characterization, in vitro and in vivo evaluation for wound healing applications. Int J Pharm 609:121132

    Article  CAS  PubMed  Google Scholar 

  • Khezri K, Farahpour MR, Rad SM (2019) Accelerated infected wound healing by topical application of encapsulated Rosemary essential oil into nanostructured lipid carriers. Artif Cells Nanomed Biotechnol 47:980–988

    Article  CAS  PubMed  Google Scholar 

  • Khodabakhshi D, Eskandarinia A, Kefayat A, Rafienia M, Navid S, Karbasi S, Moshtaghian J (2019) In vitro and in vivo performance of a propolis-coated polyurethane wound dressing with high porosity and antibacterial efficacy. Colloids Surf B 178:177–184

    Article  CAS  Google Scholar 

  • Kim H, Park S-Y, Lee G (2019) Potential therapeutic applications of bee venom on skin disease and its mechanisms: a literature review. Toxins 11:374

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kurek-Górecka A, Komosinska-Vassev K, Rzepecka-Stojko A, Olczyk P (2020) Bee venom in wound healing. Molecules 26:2

    Article  Google Scholar 

  • Kurek-Górecka A, Komosinska-Vassev K, Rzepecka-Stojko A, Olczyk P (2021) Bee venom in wound healing. Molecules 26:148

    Article  Google Scholar 

  • Lavaf M, Simbar M, Mojab F, Majd HA, Samimi M (2017) Comparison of honey and phenytoin (PHT) cream effects on intensity of pain and episiotomy wound healing in nulliparous women. J Complement Integr Med 15:20160139

    Article  Google Scholar 

  • Le Son H, Thanh Tram N (2013) Preparation and evaluation of Annona glabra L. leaf extract contained alginate film for burn healing. Eur J Med Plants 3:485

    Article  Google Scholar 

  • Li J, Chen J, Kirsner R (2007) Pathophysiology of acute wound healing. Clin Dermatol 25:9–18

    Article  CAS  PubMed  Google Scholar 

  • Liu He, Wang C, Li C, Qin Y, Wang Z, Yang F, Li Z, Wang J (2018) A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing. RSC Adv 8:7533–7549

    Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

  • Liu J, Yan L, Yang W, Lan Y, Zhu Q, Hongjie Xu, Zheng C, Guo R (2019) Controlled-release neurotensin-loaded silk fibroin dressings improve wound healing in diabetic rat model. Bioactive Mater 4:151–159

    Article  Google Scholar 

  • Liu Y, Liu Y, Mi Wu, Zou R, Mao S, Cong P, Hou M, Jin H, Zhao Y, Bao Y (2022) Adipose-derived mesenchymal stem cell-loaded β-chitin nanofiber hydrogel promote wound healing in rats. J Mater Sci Mater Med 33:1–14

    Article  Google Scholar 

  • Lund-Nielsen B, Adamsen L, Kolmos HJ, Rørth M, Tolver A, Gottrup F (2011) The effect of honey-coated bandages compared with silver-coated bandages on treatment of malignant wounds—a randomized study. Wound Repair Regen 19:664–670

    Article  PubMed  Google Scholar 

  • Majtan J (2014) Honey: an immunomodulator in wound healing. Wound Repair Regen 22:187–192

    Article  PubMed  Google Scholar 

  • Martinello M, Mutinelli F (2021) Antioxidant activity in bee products: a review. Antioxidants 10:71

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Martinotti S, Ranzato E (2015) Propolis: a new frontier for wound healing? Burns Trauma 3:9

    Article  PubMed  PubMed Central  Google Scholar 

  • Martins MD, Marques MM, Bussadori SK, Martins MAT, Pavesi VCS, Mesquita-Ferrari RA, Fernandes KPS (2009) Comparative analysis between Chamomilla recutita and corticosteroids on wound healing. An in vitro and in vivo study. Phytotherapy Res 23:274–278

    Article  CAS  Google Scholar 

  • Marucha PT, Kiecolt-Glaser JK, Favagehi M (1998) Mucosal wound healing is impaired by examination stress. Psychosom Med 60:2

    Article  Google Scholar 

  • McDaniel JC, Belury M, Ahijevych K, Blakely W (2008) Omega-3 fatty acids effect on wound healing. Wound Repair Regen 16:337–345

    Article  PubMed  PubMed Central  Google Scholar 

  • Menke NB, Ward KR, Witten TM, Bonchev DG, Diegelmann RF (2007) Impaired wound healing. Clin Dermatol 25:19–25

    Article  PubMed  Google Scholar 

  • Mo X, Cen J, Gibson E, Wang R, Percival SL (2015) An open multicenter comparative randomized clinical study on chitosan. Wound Repair Regen 23:518–524

    Article  PubMed  Google Scholar 

  • Moeini A, Pedram P, Makvandi P, Malinconico M, d’Ayala GG (2020) Wound healing and antimicrobial effect of active secondary metabolites in chitosan-based wound dressings: a review. Carbohyd Polym 233:115839

    Article  CAS  Google Scholar 

  • Mujica V, Orrego R, Fuentealba R, Leiva E, Zúñiga-Hernández J (2019) Propolis as an adjuvant in the healing of human diabetic foot wounds receiving care in the diagnostic and treatment centre from the regional hospital of Talca. J Diabet Res 20:19

    Google Scholar 

  • Naskar D, Barua RR, Ghosh AK, Kundu SC (2014) Introduction to silk biomaterials. Silk biomaterials for tissue engineering and regenerative medicine. Elsevier, Amsterdam

    Google Scholar 

  • Negut I, Dorcioman G, Grumezescu V (2020) Scaffolds for wound healing applications. Polymers 12:2010

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nema N, Saurabh Arjariya S, Bairagi MJ, Kharya MD (2013) In vivo topical wound healing activity of punica granatum peel extract on rats. Am J Phytomed Clin Therap 1:195–200

    Google Scholar 

  • Nematollahi P, Aref NM, Meimandi FZ, Rozei SL, Zareé H, Mirlohi SMJ, Rafiee S, Mohsenikia M, Soleymani A, Ashkani-Esfahani S (2019) Matricaria chamomilla extract improves diabetic wound healing in rat models. Trauma Monthly 24:1–5

    Google Scholar 

  • Nicolaus C, Junghanns S, Hartmann A, Murillo R, Ganzera M, Merfort I (2017) In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts. J Ethnopharmacol 196:94–103

    Article  PubMed  Google Scholar 

  • Niknam S, Tofighi Z, Faramarzi MA, Abdollahifar MA, Sajadi E, Dinarvand R, Toliyat T (2021) Polyherbal combination for wound healing: Matricaria chamomilla L. and Punica granatum L. DARU J Pharmac Sci 29:133–145

    Article  CAS  Google Scholar 

  • Nirwana I, Priyawan R, Devi R (2017) Potential of pomegranate fruit extract (Punica granatum Linn.) to increase vascular endothelial growth factor and platelet-derived growth factor expressions on the post-tooth extraction wound of Cavia cobaya. Vet World 10:999

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ojeh N, Pastar I, Tomic-Canic M, Stojadinovic O (2015) Stem cells in skin regeneration, wound healing, and their clinical applications. Int J Mol Sci 16:25476–25501

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Parente LML, de Ruy Souza LJ, Leonice MFT, Marina CV, de José RP (2012) Wound healing and anti-inflammatory effect in animal models of Calendula officinalis L. growing in Brazil. Evid-Based Complement Alternat Med 2:2

    Google Scholar 

  • Parizi FK, Sadeghi T, Heidari S (2021) The effect of rosemary ointment on the pressure ulcer healing in patients admitted to the intensive care unit: a randomized clinical trial. Nurs Pract Today 2:2

    Google Scholar 

  • Park SY, Lee HU, Lee Y-C, Kim GH, Park EC, Han SH, Lee JG, Choi S, Heo NS, Kim DL (2014) Wound healing potential of antibacterial microneedles loaded with green tea extracts. Mater Sci Eng C 42:757–762

    Article  CAS  Google Scholar 

  • Patrulea V, Ostafe V, Borchard G, Jordan O (2015) Chitosan as a starting material for wound healing applications. Eur J Pharm Biopharm 97:417–426

    Article  CAS  PubMed  Google Scholar 

  • Portela R, Leal CR, Almeida PL, Sobral RG (2019) Bacterial cellulose: a versatile biopolymer for wound dressing applications. Microb Biotechnol 12:586–610

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Preethi KC, Kuttan R (2009) Wound healing activity of flower extract of Calendula officinalis. J Basic Clin Physiol Pharmacol 20:73–79

    Article  PubMed  Google Scholar 

  • Qureshi MA, Khatoon F, Ahmed S (2015) An overview on wounds, their issues and natural remedies for wound healing. Biochem Physiol 4:2–9

    Google Scholar 

  • Rodriguez PG, Felix FN, Woodley DT, Shim EK (2008) The role of oxygen in wound healing: a review of the literature. Dermatol Surg 34:2

    Google Scholar 

  • Saghazadeh S, Rinoldi C, Schot M, Kashaf SS, Sharifi F, Jalilian E, Nuutila K, Giatsidis G, Mostafalu P, Derakhshandeh H (2018a) Drug delivery systems and materials for wound healing applications. Adv Drug Deliv Rev 127:138–166

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Saghazadeh S, Rinoldi C, Schot M, Kashaf SS, Sharifi F, Jalilian E, Nuutila K, Giatsidis G, Mostafalu P, Derakhshandeh H, Yue K, Swieszkowski W, Memic A, Tamayol A, Khademhosseini A (2018b) Drug delivery systems and materials for wound healing applications. Adv Drug Deliv Rev 127:138–166

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Samadi S, Khadivzadeh T, Emami A, Moosavi NS, Tafaghodi M, Behnam HR (2010) The effect of Hypericum perforatum on the wound healing and scar of cesarean. J Alternat Complement Med 16:113–117

    Article  Google Scholar 

  • Sanford JA, Gallo RA (2013) Functions of the skin microbiota in health and disease. Seminars in immunology. Elsevier, Amsterdam, pp 370–377

    Google Scholar 

  • Sen CK (2019) Human wounds and its burden: an updated compendium of estimates. In: Mary Ann Liebert, Inc., publishers 140 Huguenot Street, 3rd Floor New

  • Shahrahmani H, Kariman N, Jannesari S, Rafieian-Kopaei M, Mirzaei M, Ghalandari S, Shahrahmani N, Mardani G (2018) The effect of green tea ointment on episiotomy pain and wound healing in primiparous women: a randomized, double-blind, placebo-controlled clinical trial. Phytother Res 32:522–530

    Article  CAS  PubMed  Google Scholar 

  • Shivananda Nayak B, Sivachandra Raju S, Chalapathi Rao AV (2007) Wound healing activity of Matricaria recutita L. extract. J Wound Care 16:298–302

    Article  PubMed  Google Scholar 

  • Siritientong T, Angspatt A, Ratanavaraporn J, Aramwit P (2014) Clinical potential of a silk sericin-releasing bioactive wound dressing for the treatment of split-thickness skin graft donor sites. Pharm Res 31:104–116

    Article  CAS  PubMed  Google Scholar 

  • Stanojevic LP, Marjanovic-Balaban ZR, Kalaba VD, Stanojevic JS, Cvetkovic DJ (2016) Chemical composition, antioxidant and antimicrobial activity of chamomile flowers essential oil (Matricaria chamomilla L.). J Essent Oil Bear Plants 19:2017–2028

    Article  CAS  Google Scholar 

  • Suarato G, Bertorelli R, Athanassiou A (2018) Borrowing from nature: biopolymers and biocomposites as smart wound care materials. Front Bioeng Biotechnol 6:137

    Article  PubMed  PubMed Central  Google Scholar 

  • Sugihara A, Sugiura K, Morita H, Ninagawa T, Tubouchi K, Tobe R, Izumiya M, Horio T, Abraham NG, Ikehara S (2000) Promotive effects of a silk film on epidermal recovery from full-thickness skin wounds (44552). Proc Soc Exp Biol Med 225:58–64

    CAS  PubMed  Google Scholar 

  • Sun Z, Shi C, Wang X, Fang Q, Huang J (2017) Synthesis, characterization, and antimicrobial activities of sulfonated chitosan. Carbohyd Polym 155:321–328

    Article  CAS  Google Scholar 

  • Sun C, Zeng X, Zheng S, Wang Y, Li Z, Zhang H, Nie L, Zhang Y, Zhao Y, Yang X (2022) Bio-adhesive catechol-modified chitosan wound healing hydrogel dressings through glow discharge plasma technique. Chem Eng J 427:130843

    Article  CAS  Google Scholar 

  • Sungkar A, Doewes M, Purwanto B, Wasita B (2021) The effect of Indonesian propolis dosage on vascularization of skin graft in skin wound of white rat’s skin graft model: molecular studies of malondialdehyde (MDA), nuclear factor-kappa beta (NF-kB), interleukin-6, vascular endothelial growth factor (VEGF). Bali Med J 10:811–820

    Article  Google Scholar 

  • Süntar IP, Akkol EK, Yılmazer D, Baykal T, Kırmızıbekmez H, Alper M, Yeşilada E (2010) Investigations on the in vivo wound healing potential of Hypericum perforatum L. J Ethnopharmacol 127:468–477

    Article  PubMed  Google Scholar 

  • Szabo G, Mandrekar P (2009) A recent perspective on alcohol immunity, and host defense. Alcohol Clin Exp Res 33:220–232

    Article  CAS  PubMed  Google Scholar 

  • Takaki I, Bersani-Amado LE, Vendruscolo A, Sartoretto SM, Diniz SP, Bersani-Amado CA, Cuman RKN (2008) Anti-inflammatory and antinociceptive effects of Rosmarinus officinalis L. essential oil in experimental animal models. J Med Food 11:741–746

    Article  CAS  PubMed  Google Scholar 

  • The effectiveness of stingless bee honey (kelulut honey) versus gel in diabetic wound bed preparation. 2023

  • The Obese Surgical Patient (2006) A susceptible host for infection. Surg Infect 7:473–480

    Article  Google Scholar 

  • Tottoli EM, Dorati R, Genta I, Chiesa E, Pisani S, Conti B (2020) Skin wound-healing process and new emerging technologies for skin wound care and regeneration. Pharmaceutics 12:735

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vidya M, Rajagopal S (2021) Silk fibroin: a promising tool for wound healing and skin regeneration. Int J Polym Sci 2021:9069924

    Article  Google Scholar 

  • Wagih Abd EL, Fattah E, Abd EL (2014) Antimicrobial activity of chamomile acetone extract against some experimentally-induced skin infections in mice. Egypt J Environ Res 2:58–70

    Google Scholar 

  • Xu F-W, Lv Y-L, Zhong Y-F, Xue Y-N, Wang Y, Zhang L-Y, Xian Hu, Tan W-Q (2021) Beneficial effects of green tea EGCG on skin wound healing: a comprehensive review. Molecules 26:6123

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yadollah-Damavandi S, Mehdi Chavoshi-Nejad EJ, NoushinNekouyian SH, Amin Seifaee SR, Hossein Karimi SA-E, Yekta P (2015) Topical Hypericum perforatum improves tissue regeneration in full-thickness excisional wounds in diabetic rat model. Evid-Based Complement Alternat Med 2:2

    Google Scholar 

  • Yalcınkaya E, Basaran MM, Tunckasık ME, Yazici GN, Elmas Ç, Kocaturk S (2022) Efficiency of hypericum perforatum, povidone iodine, tincture benzoin and tretinoin on wound healing. Food Chem Toxicol 166:113209

    Article  PubMed  Google Scholar 

  • Yilmaz R, Zafer Ö, Füsun T, Ali H (2012) The effects of rosemary (Rosemarinus officinalis) extract on wound healing in rabbits. FÜS Ağ Bil Vet Derg 26:105–109

    Google Scholar 

  • YupanquiMieles J, Cian Vyas EA, Gavin Humphreys CD, Paulo B (2022) Honey: an advanced antimicrobial and wound healing biomaterial for tissue engineering applications. Pharmaceutics 14:1663

    Article  CAS  Google Scholar 

  • Zeleníková R, Vyhlídalová D (2019) Applying honey dressings to non-healing wounds in elderly persons receiving home care. J Tissue Viability 28:139–143

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Negin Akhtari & Fatemeh Ghorbani-Bidkorpeh

  2. Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mahnaz Ahmadi

  3. Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran

    Yasaman Kiani Doust Vaghe & Hossein Vatanpour

  4. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Elham Asadian

  5. Evidence-Based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran

    Sahar Behzad

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  1. Negin Akhtari
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  3. Yasaman Kiani Doust Vaghe
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Akhtari, N., Ahmadi, M., Kiani Doust Vaghe, Y. et al. Natural agents as wound-healing promoters. Inflammopharmacol 32, 101–125 (2024). https://doi.org/10.1007/s10787-023-01318-6

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