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An update on microneedle-based systems for diabetes

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Abstract

Diabetes is one of the most serious chronic diseases today. Patients with diabetes need frequent insulin injections or blood sampling to monitor blood glucose levels. The microneedles are a painless transdermal drug delivery system, which has great advantages in achieving self-management. There have been a lot of researches on microneedles used in diabetes treatment. Microneedle-based treatment of diabetes has also changed from a simple and reliable system to a complex and efficient system. This review introduces microfluidic, glucose response, and other contents based on microneedles, and some challenges in the development of microneedles.

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Funding

This work was financially supported by the National Natural Science Foundation of China (51873015), the Joint Project of BRC-BC (Biomedical Translational Engineering Research Center of BUCT-CJFH) (XK2020-05, RZ2020-01), and the long-term subsidy mechanism from the Ministry of Finance and the Ministry of Education of PRC.

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Authors and Affiliations

  1. Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, People’s Republic of China

    Wen Xuan Li, Xiao Peng Zhang, Bo Zhi Chen & Xin Dong Guo

  2. Department of Dermatology, China-Japan Friendship Hospital, East Street Cherry Park, Chaoyang District, Beijing, 100029, People’s Republic of China

    Wen Min Fei & Yong Cui

  3. Graduate School, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, People’s Republic of China

    Wen Min Fei & Yong Cui

  4. Biopharmaceutical and Health Engineering Division, Tsinghua Shenzhen International Graduate School, Shenzhen, People’s Republic of China

    Can Yang Zhang

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  1. Wen Xuan Li
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Wen Xuan Li, Xiao Peng Zhang, Bo Zhi Chen, and Wen Min Fei: Writing — Original draft preparation. Yong Cui and Can Yang Zhang, Conceptualization. Xin Dong Guo: Conceptualization, Project administration.

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Li, W.X., Zhang, X.P., Chen, B.Z. et al. An update on microneedle-based systems for diabetes. Drug Deliv. and Transl. Res. 12, 2275–2286 (2022). https://doi.org/10.1007/s13346-021-01113-2

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