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Metal nanozymes with multiple catalytic activities: regulating strategies and biological applications

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Abstract

Nanozymes with high enzyme-like catalytic activity have been recognized as promising alternatives for nature enzymes and exhibit great potentials in biodetection, disease diagnosis and treatment. Metal nanozyme is an important member of the nanozyme family. When metal nanozymes are controllably regulated by compositions, sizes, morphologies, crystal defects, surface states or stimulated by diversified external fields, they will acquire unique geometric and electronic structures and exhibit various physical/chemical properties in catalytic behaviors. Although significant progress has been made in metal nanozymes, there is still large space for further improving the catalytic efficiency, developing the synthetic process for large-scale production, facilitating the clinical transformation and exploring the untapped applications. Directing at these issues, rational design of novel nanozymes for better applications and deeper understanding of catalytic mechanisms are urgently required. Accordingly, this review focuses on the recent advances on regulating strategies, catalytic mechanisms and relevant biological applications of metal nanozymes with multiple enzyme-like performance. Furthermore, future perspectives are outlooked to inspire more attention and efforts on this interesting multi-disciplinary field.

Graphical abstract

摘要

纳米酶具有优异的类酶催化活性, 有望成为天然酶的良好替代品, 并在生物检测、疾病诊断和治疗方面蕴含着巨 大应用潜力。金属纳米酶是纳米酶家族的重要成员, 对其组成、尺寸、形貌、晶体缺陷、表面状态等进行可控调 节或使其经受外场激发、环境改变时, 可使金属纳米酶获得独特的几何构型与电子结构, 并在催化行为中表现出 不同的物理/化学性质。尽管金属纳米酶研究已经取得显著进展, 但在进一步提升催化效率、开发大规模生产合成 工艺、促进临床转化和拓宽应用范围等方面仍有较大探索空间。面对上述问题, 新型纳米酶的合理设计与催化机 制的深入理解已成为应用提升的迫切需求。本文对具备多类活性的金属纳米酶调控策略、催化机制及相关生物学 应用最新进展进行了综述, 并对其未来研究热点进行了展望, 期望引发对这一有趣、多学科交叉领域的更多关注。.

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Acknowledgements

This work is financially supported by the National Natural Science Foundation of China (No. 62274141) and the Program for Zhongyuan Leading Talents of Science and Technology Innovation in Henan Province (No. 204200510016).

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  1. Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Xuchang, 461000, China

    Qi Yang, Yuan-Yang Mao, Quan Liu & Wei-Wei He

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Yang, Q., Mao, YY., Liu, Q. et al. Metal nanozymes with multiple catalytic activities: regulating strategies and biological applications. Rare Met. 42, 2928–2948 (2023). https://doi.org/10.1007/s12598-023-02309-w

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