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The role of long noncoding ribonucleic acids in the central nervous system injury

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Abstract

Central nervous system (CNS) injury involves complex pathophysiological molecular mechanisms. Long noncoding ribonucleic acids (lncRNAs) are an important form of RNA that do not encode proteins but take part in the regulation of gene expression and various biological processes. Multitudinous studies have evidenced lncRNAs to have a significant role in the process of progression and recovery of various CNS injuries. Herein, we review the latest findings pertaining to the role of lncRNAs in CNS, both normal and diseased state. We aim to present a comprehensive clinical application prospect of lncRNAs in CNS, and thus, discuss potential strategies of lncRNAs in treating CNS injury.

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Abbreviations

CNS:

Central nervous system;

lncRNAs:

Long noncoding ribonucleic acids;

TNF-a:

Factors like tumor necrosis factor-a;

ROS:

Reactive oxygen species;

ncRNAs:

Non-coding RNAs;

mRNAs:

Messenger RNAs;

miRNAs:

MicroRNAs;

NGS:

Next-generation sequencing;

TFs:

Transcription factors;

ceRNAs:

Competing endogenous RNAs;

TUG1:

Taurine-upregulated gene 1;

MAPK:

Mitogen-activated protein kinase;

NF-kB:

Nuclear factor kappa-light chain-enhancer of activated B;

FOXO3:

Forkhead box O3;

ROCK1:

Rho-associated coiled-coil-containing protein kinase 1;

SAH:

Subarachnoid hemorrhage;

DC:

Dendritic cells;

NFAT5:

Nuclear factor of activated T cells 5;

NEAT1:

Nuclear enriched abundant transcript 1;

IFG1R:

Insulin-like growth factor 1 receptor;

BDNF-AS:

Brain-derived neurotrophic factor antisense;

P53:

Protein 53;

IL-1β:

Interleukin-1β;

IL-6:

Interleukin-6;

Bax:

BCL-2-associated X protein;

Caspase 3:

Cysteinyl aspartate-specific proteinase-3;

Bcl-2:

B-cell lymphoma-2;

PPARγ:

Peroxisome proliferator-activated receptor γ;

HMGB1:

High mobility group protein B1;

RBFOX2:

RNA binding fox-1 homolog 2

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  1. Min Huang and Xizhi Wang contributed equally to this work.

Authors and Affiliations

  1. Department of Histology and Embryology, School of Medicine, Shaoxing University, Shaoxing City, 312000, China

    Min Huang, Xizhi Wang, Yong Zhang & Xuehong Liu

  2. Department of Cardiology, Lihuili Hospital Affiliated to Ningbo University, Ningbo City, China

    Xizhi Wang

  3. Bupa Cromwell Hospital, London, UK

    Benson O. A. Botchway

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XL designed the study. MH, XW, BOAB, YZ and XL prepared the first draft of the manuscript. MH, XW, BOAB, YZ and XL revised the manuscript. All authors approved the final paper.

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Huang, M., Wang, X., Botchway, B.O.A. et al. The role of long noncoding ribonucleic acids in the central nervous system injury. Mol Cell Biochem (2023). https://doi.org/10.1007/s11010-023-04875-0

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