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On the production of novel zirconia-reinforced bioactive glass porous structures for bone repair

  • Ceramics
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Abstract

The objective of this study was to develop a replica method for producing zirconia-reinforced bioactive glass (ZRBG) porous structures for bone repair. Four different types of porous structures were produced: zirconia (G1), 58S BG-coated zirconia (G2), zirconia-reinforced BG (G3) and 58S BG-coated zirconia-reinforced BG (G4). A complete characterization of the specimens was performed via SEM-EDS, Archimedes method, 3D X-ray micro-tomography, micro-indentation, compressive strength tests and SBF immersion tests. G3 and G4 specimens presented a BG matrix (~ 33% glassy phase) with dispersed zirconia particles. The porosity of the specimens ranged from 86% up to 93%. BG58S-zirconia groups G3 and G4) exhibited lower YM (38.76 ± 11.20 GPa and 43.49 ± 2.16 GPa) than that of G1 monolithic zirconia specimens (94.39 ± 12.62 GPa), which were more compatible to that of the bone. No significant difference in compressive strength between BG58S-zirconia (G3: 0.41 ± 0.20 MPa; G4: 0.45 ± 0.11 MPa) and zirconia (G1: 0.32 ± 0.11 MPa) was detected observed (p > 0.05). In vitro SBF tests showed a potential bioactivity for ZRBG porous structures.

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References

  1. Perez RA, Mestres G (2016) Role of pore size and morphology in musculo-skeletal tissue regeneration. Mater Sci Eng C 61:922–939

    Article  CAS  Google Scholar 

  2. Shadjou NHM (2015) Bone tissue engineering using silica-based mesoporous nanobiomaterials: recent progress. Mater Sci Eng C 55:401–409

    Article  CAS  Google Scholar 

  3. do Vale Pereira R (2011) Arcabouço compósito biodegradável produzido via sinterização seletiva a laser com matriz de Policaprolactona e partículas dispersas de Biovidro 58S. Universidade Federal de Santa Catarina

  4. Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR (2006) Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 27:3413–3431

    Article  CAS  Google Scholar 

  5. Hing K (2005) Bioceramic bone graft substitutes: influence of porosity and chemistry. Int J Appl Ceram Technol 2(3):184–199

    Article  CAS  Google Scholar 

  6. Loh Q, Choong C (2013) Three-dimensional scaffolds for tissue engi-neering applications: role of porosity and pore size. Tissue Eng B Rev 19(6):485–502

    Article  CAS  Google Scholar 

  7. Tiainen H, Lyngstadaas S, Ellingsen J, Haugen H (2010) Ultra-porous titanium oxide scaffold with high compressive strength. J Mater Sci Mater Med 21(10):2783–2792

    Article  CAS  Google Scholar 

  8. Hutmacher D (2000) Scaffolds in tissue engineering bone and cartilage. Biomaterials 21(24):2529–2543

    Article  CAS  Google Scholar 

  9. Mohamad YD, Bretcanu O, Boccaccini A (2008) Polymer-bioceramic composites for tissue engineering scaffolds. J Mater Sci 43:4433–4442. https://doi.org/10.1007/s10853-008-2552-y

    Article  Google Scholar 

  10. Saiz E, Zimmermann EA, Lee JS et al (2013) Perspectives on the role of nanotechnology in bone tissue engineering. Dent Mater 29:103–115

    Article  CAS  Google Scholar 

  11. Karageorgiou V, Kaplan D (2005) Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 26:5474–5491

    Article  CAS  Google Scholar 

  12. Jones JR, Hench LL (2003) Regeneration of trabecular bone using porous ceramics. Curr Opin Solid State Mater Sci 7:301–307

    Article  CAS  Google Scholar 

  13. Sebdani MM, Fathi MH (2011) Fabrication and characterization of hydroxyapatite-forsterite-bioactive glass composite nanopowder for biomedical applications. Int J Appl Ceram Technol 8:553–559

    Article  CAS  Google Scholar 

  14. Bellucci D, Cannillo V, Sola A (2012) A new highly bioactive composite for bone tissue repair. Int J Appl Ceram Technol 9:455–467

    Article  CAS  Google Scholar 

  15. Oréfice RL, Pereira MDM, Mansur HS (2006) Biomateriais: fundamentos e aplicações. Cultura Médica, Rio de Janeiro

    Google Scholar 

  16. Hench LL (2015) Opening paper 2015-some comments on bioglass: four eras of discovery and development. Biomed Glas 1:1–11

    Google Scholar 

  17. Jones JR (2015) Review of bioactive glass: from hench to hybrids. Acta Biomater 23:S53–S82

    Article  Google Scholar 

  18. Ma J, Chen CZ, Wang DG et al (2010) Influence of the sintering temperature on the structural feature and bioactivity of sol-gel derived SiO2-CaO-P2O5 bioglass. Ceram Int 36:1911–1916

    Article  CAS  Google Scholar 

  19. Hench LL, Splinter RJ, Allen WC, Greenlee TK (1972) Bonding mechanism at interface of ceramic prosthetic materials. Biomed Mater 5(6):117–141

    Article  Google Scholar 

  20. Rahaman MN, Liu X, Bal BS et al (2012) Bioactive glass in bone tissue engineering. Ceram Trans 237:73–82

    Article  CAS  Google Scholar 

  21. Hoppe A, Güldal NS, Boccaccini AR (2011) A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics. Biomaterials 32:2757–2774

    Article  CAS  Google Scholar 

  22. Sepulveda P, Jones JR, Hench LL (2001) Characterization of melt-derived 45S5 and sol-gel-derived 58S bioactive glasses. J Biomed Mater Res 58:734–740

    Article  CAS  Google Scholar 

  23. Zhong J, Greenspan DC (2000) Processing and properties of sol–gel bioactive glasses. J Biomed Mater Res 53(6):696–701

    Article  Google Scholar 

  24. Sepulveda P, Jones JR, Hench LL (2002) In vitro dissolution of melt-derived 45S5 and sol–gel derived 58S bioactive glasses. J Biomed Mater Res 61:301–311

    Article  CAS  Google Scholar 

  25. Fu Q, Saiz E, Rahaman MN, Tomsia AP (2011) Bioactive glass scaffolds for bone tissue engineering: state of the art and future perspectives. Mater Sci Eng C 31(7):1245–1256

    Article  CAS  Google Scholar 

  26. Boccardi E, Philippart A, Melli V et al (2016) Bioactivity and mechanical stability of 45S5 bioactive glass scaffolds based on natural marine sponges. Ann Biomed Eng 44:1881–1893

    Article  CAS  Google Scholar 

  27. Hum J, Boccaccini AR (2018) Collagen as coating material for 45S5 bioactive glass-based scaffolds for bone tissue engineering. Int J Mol Sci 19(6):1807

    Article  Google Scholar 

  28. Lacefield WR, Hench LL (1985) The bonding of bioglass® to a cobalt-chromium surgical implant alloy. Biomaterials 7(2):104–108

    Article  Google Scholar 

  29. Gomez-Vega JM, Saiz E, Tomsia AP et al (2000) Novel bioactive functionally graded coatings on Ti6Al4V. Adv Mater 12:894–898

    Article  CAS  Google Scholar 

  30. Schubert H (1986) Anisotropic thermal expansion coefficients of Y2O3-stabilized tetragonal zirconia. J Am Ceram Soc 69:270–271

    Article  CAS  Google Scholar 

  31. Zhang Y, Legeros R, Kim J (2014). B2-Bioactive graded zirconia-based structures. US 8, 703,294

  32. Chevalier J (2006) What future for zirconia as a biomaterial? Biomaterials 27:535–543

    Article  CAS  Google Scholar 

  33. Denry I, Kelly JR (2008) State of the art of zirconia for dental applications. Dent Mater 24:299–307

    Article  CAS  Google Scholar 

  34. Özkurt Z, Kazazoğlu E (2011) Zirconia dental implants: a literature review. J Oral Implantol 37:367–376

    Article  Google Scholar 

  35. Gouveia PF, Schabbach LM, Souza JCM et al (2017) New perspectives for recycling dental zirconia waste resulting from CAD/CAM manufacturing process. J Clean Prod 152:454–463

    Article  CAS  Google Scholar 

  36. Kelly JR, Denry I (2008) Stabilized zirconia as a structural ceramic: an overview. Dent Mater 24:289–298

    Article  CAS  Google Scholar 

  37. Mesquita-Guimarães J, Leite MA, Souza JCM et al (2017) Processing and strengthening of 58S bioactive glass-infiltrated titania scaffolds. J Biomed Mater Res-Part A 105:590–600

    Article  Google Scholar 

  38. Galarraga-Vinueza ME, Passoni B, Benfatti CAM et al (2017) Inhibition of multi-species oral biofilm by bromide doped bioactive glass. J Biomed Mater Res-Part A 105:1994–2003

    Article  CAS  Google Scholar 

  39. Pereira RDV, Salmoria GV, de Moura MOC et al (2014) Scaffolds of PDLLA/bioglass 58S produced via selective laser sintering. Mater Res 17:33–38

    Article  Google Scholar 

  40. Bettelheim F, Brown W, Campbell M et al (2009) Introduction to general organic and biochemistry, 10th edn. Cengage Learning, Boston

    Google Scholar 

  41. Yin Y, Ma B, Hu C et al (2019) Preparation and properties of porous SiC–Al2O3 ceramics using coal ash. Int J Appl Ceram Technol 16:23–31

    Article  CAS  Google Scholar 

  42. Schindelin J, Arganda-Carreras I, Frise E et al (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9:676–682

    Article  CAS  Google Scholar 

  43. Serra J (1986) Introduction to mathematical morphology. Comput Vision, Graph Image Process 35(3):283–305

    Article  Google Scholar 

  44. Gonzalez R, Woods R (2002) Digital image processing. Prentice Hall, Upper Saddle River

    Google Scholar 

  45. Chassery JM, Montanvert A (1991) Géométrie discrete en analyse d’images, Editions H

  46. Diógenes AN, Dos Santos LOE, Fernandes CP et al (2009) Porous media microstrucutre reconstruction using pixel-based and object-based simulated annealing–comparison with other reconstruction methods. Rev Eng Térmica 8:35

    Google Scholar 

  47. Stochero NP, de Moraes EG, Moreira AC et al (2020) Ceramic shell foams produced by direct foaming and gelcasting of proteins: permeability and microstructural characterization by X-ray microtomography. J Eur Ceram Soc 40(12):4224–4231

    Article  CAS  Google Scholar 

  48. Jain V, Johnson R, Ganesh I et al (2003) Effect of rubber encapsulation on the comparative mechanical behaviour of ceramic honeycomb and foam. Mater Sci Eng A 347:109–122

    Article  Google Scholar 

  49. Mesquita-Guimarães J, Leite MA, Souza JCM et al (2017) Processing and strengthening of 58S bioactive glass-infiltrated titania scaffolds. J Biomed Mater Res Part A 105:590–600

    Article  Google Scholar 

  50. Kokubo T, Takadama H (2006) How useful is SBF in predicting in vivo bone bioactivity? Biomaterials 27:2907–2915

    Article  CAS  Google Scholar 

  51. Chatzistavrou X, Kantiranis N, Kontonasaki E et al (2011) Thermal analysis and in vitro bioactivity of bioactive glass-alumina composites. Mater Charact 62:118–129

    Article  CAS  Google Scholar 

  52. Boccaccini AR, Chen Q, Lefebvre L et al (2007) Sintering, crystallisation and biodegradation behaviour of bioglass s-derived glass–ceramics. Faraday Discuss 136:27–44

    Article  CAS  Google Scholar 

  53. Cannillo V, Pierli F, Sampath S, Siligardi C (2009) Thermal and physical characterisation of apatite/wollastonite bioactive glass-ceramics. J Eur Ceram Soc 29:611–619

    Article  CAS  Google Scholar 

  54. Blaeß C, Müller R, Poologasundarampillai G, Brauer DS (2019) Sintering and concomitant crystallization of bioactive glasses. Int J Appl Glas Sci 10:449–462

    Article  Google Scholar 

  55. Habibe AF, Maeda LD, Souza RC et al (2009) Effect of bioglass additions on the sintering of Y-TZP bioceramics. Mater Sci Eng C 29(6):1959–1964

    Article  CAS  Google Scholar 

  56. Zhu Y, Zhu R, Ma J et al (2015) In vitro cell proliferation evaluation of porous nano-zirconia scaffolds with different porosity for bone tissue engineering. Biomed Mater 10:055009

    Article  Google Scholar 

  57. Chen QZ, Thompson ID, Boccaccini AR (2006) 45S5 Bioglass®-derived glass-ceramic scaffolds for bone tissue engineering. Biomaterials 27:2414–2425

    Article  CAS  Google Scholar 

  58. Chen QZ, Efthymiou A, Salih V, Boccaccini AR (2008) Bioglass®-derived glass-ceramic scaffolds: study of cell proliferation and scaffold degradation in vitro. J Biomed Mater Res-Part A 84(4):1049–1060

    Article  CAS  Google Scholar 

  59. Xia W, Chang J (2010) Bioactive glass scaffold with similar structure and mechanical properties of cancellous bone. J Biomed Mater Res-Part B Appl Biomater 95(2):449–455

    Article  Google Scholar 

  60. Srivastava AK, Pyare R, Sing SP (2012) Elastic properties of substituted 45S5 bioactive glasses and glass-ceramic. Int J Sci Eng Res 3(2):1–13

    Google Scholar 

  61. Chen QZ, Xu JL, Yu LG et al (2012) Spark plasma sintering of sol-gel derived 45S5 Bioglass®-ceramics: mechanical properties and biocompatibility evaluation. Mater Sci Eng C 32(3):494–502

    Article  CAS  Google Scholar 

  62. Thompson ID, Hcnch LL (1998) Mechanical properties of bioactive glasses, glass-ceramics and composites. Proc Inst Mech Eng Part H J Eng Med 212(2):127–136

    Article  CAS  Google Scholar 

  63. Bohner M, Lemaitre J (2009) Can bioactivity be tested in vitro with SBF solution? Biomaterials 30:2175–2179

    Article  CAS  Google Scholar 

  64. Maçon ALB, Kim TB, Valliant EM et al (2015) A unified in vitro evaluation for apatite-forming ability of bioactive glasses and their variants. J Mater Sci Mater Med 26:1–10

    Article  Google Scholar 

Download references

Funding

This study was supported by FCT-Portugal (UID/EEA/04436/2013, NORTE-01-0145-FEDER-000018–HAMaBICo, POCI-01-0145-FEDER-031035_LaserMULTICER) and CNPq-Brazil (CNPq/UNIVERSAL/421229/2018-7; CNPq/INOVSAUDE2018/441457/2018-5). The authors acknowledge the collaboration of Laboratory of Porous Media and Thermophysical Properties (LMPT/UFSC-http://emc.ufsc.br/portal/laboratorios/lmpt/) for the collaboration in performing the X-Ray tomographic analyses.

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Authors and Affiliations

  1. Ceramic and Composite Materials Research Group (CERMAT), Campus Trindade, Federal University of Santa Catarina (UFSC), Florianópolis, SC, 88040-900, Brazil

    Paula F. Gouveia, Joana Mesquita-Guimarães, Márcio C. Fredel & Bruno Henriques

  2. Center for MicroElectroMechanical Systems (CMEMS-UMinho), University of Minho, Campus de Azurém, 4800-058, Guimarães, Portugal

    Joana Mesquita-Guimarães, Júlio C. M. Souza, Filipe S. Silva & Bruno Henriques

  3. Postgraduate Program in Dentistry (PPGO), School of Dentistry (DODT), Campus Trindade, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil

    Maria E. Galarraga-Vinueza & Bruno Henriques

  4. Dept. of Dental Sciences, University Institute of Health Sciences (IUCS), CESPU, Gandra PRD, 4585-116, Portugal

    Júlio C. M. Souza

  5. Laboratory of Porous Media and Thermophysical Properties (LMPT), Dept. of Mechanical Engineering (EMC), PGMAT, Federal University of Santa Catarina (UFSC), Florianópolis, SC, 88040-900, Brazil

    Anderson C. Moreira

  6. School of Dentistry, Universidad de Las Américas (UDLA), Quito, Ecuador

    Maria E. Galarraga-Vinueza

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  1. Paula F. Gouveia
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  2. Joana Mesquita-Guimarães
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  3. Maria E. Galarraga-Vinueza
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  4. Júlio C. M. Souza
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  8. Bruno Henriques
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Correspondence to Bruno Henriques.

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Gouveia, P.F., Mesquita-Guimarães, J., Galarraga-Vinueza, M.E. et al. On the production of novel zirconia-reinforced bioactive glass porous structures for bone repair. J Mater Sci 56, 11682–11697 (2021). https://doi.org/10.1007/s10853-021-06005-x

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  • DOI: https://doi.org/10.1007/s10853-021-06005-x

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