Abstract
Ischemic stroke (IS) is one of the leading causes of death and morbidity worldwide. As a novel form of cell death, ferroptosis is an important mechanism of ischemic stroke. Nuclear factor E2-related factor 2 (Nrf2) is the primary regulator of cellular antioxidant response. In addition to alleviating ischemic stroke nerve damage by reducing oxidative stress, Nrf2 regulates genes associated with ferroptosis, suggesting that Nrf2 may inhibit ferroptosis after ischemic stroke. However, the specific pathway of Nrf2 on ferroptosis in the field of ischemic stroke remains unclear. Therefore, this paper provides a concise overview of the mechanisms underlying ferroptosis, with a particular focus on the regulatory role of Nrf2. The discussion highlights the potential connections between Nrf2 and the mitigation of oxidative stress, regulation of iron metabolism, modulation of the interplay between ferroptosis and inflammation, as well as apoptosis. This paper focuses on the specific pathway of Nrf2 regulation of ferroptosis after ischemic stroke, providing scientific research ideas for further research on the treatment of ischemic stroke.
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This study was supported by National Natural Science Foundation of China(Grant Numbers: 82174484 and 81973932), the Peak academic Talent of Jiangsu Hospital of Traditional Chinese Medicine (grant number: K2021RC24), Jiangsu University Advantage Discipline Construction Project (grant number: ZYX03KF035), and the sixth phase of the "333 High-level Talents Training Project" of the Jiangsu Province.
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Deng, X., Chu, W., Zhang, H. et al. Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke. Cell Mol Neurobiol 43, 3885–3896 (2023). https://doi.org/10.1007/s10571-023-01411-y
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DOI: https://doi.org/10.1007/s10571-023-01411-y