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3D Bioprinting Strategies for Articular Cartilage Tissue Engineering

  • S.I. : Bioengineering and Enabling Technologies II
  • Published:
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Abstract

Articular cartilage is the avascular and aneural tissue which is the primary connective tissue covering the surface of articulating bone. Traumatic damage or degenerative diseases can cause articular cartilage injuries that are common in the population. As a result, the demand for new therapeutic options is continually increasing for older people and traumatic young patients. Many attempts have been made to address these clinical needs to treat articular cartilage injuries, including osteoarthritis (OA); however, regenerating highly qualified cartilage tissue remains a significant obstacle. 3D bioprinting technology combined with tissue engineering principles has been developed to create biological tissue constructs that recapitulate the anatomical, structural, and functional properties of native tissues. In addition, this cutting-edge technology can precisely place multiple cell types in a 3D tissue architecture. Thus, 3D bioprinting has rapidly become the most innovative tool for manufacturing clinically applicable bioengineered tissue constructs. This has led to increased interest in 3D bioprinting in articular cartilage tissue engineering applications. Here, we reviewed current advances in bioprinting for articular cartilage tissue engineering.

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Acknowledgements

This review was supported by the National Institutes of Health (1P41EB023833-01), the National Science Foundation (2100739), and the National Research Foundation of Korea (NRF-2022R1A2C1091873).

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  1. Do Young Park and Seon-Hwa Kim have contributed equally to this work.

Authors and Affiliations

  1. Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Do Young Park, Sang-Hyug Park, Ji Su Jang, James J. Yoo & Sang Jin Lee

  2. Department of Orthopedic Surgery, Ajou University Hospital, Suwon, Republic of Korea

    Do Young Park

  3. Department of Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan, Republic of Korea

    Seon-Hwa Kim & Sang-Hyug Park

  4. Department of Anesthesiology and Pain Medicine, College of Medicine, Hallym University, Chuncheon, Republic of Korea

    Ji Su Jang

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  1. Do Young Park
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Park, D.Y., Kim, SH., Park, SH. et al. 3D Bioprinting Strategies for Articular Cartilage Tissue Engineering. Ann Biomed Eng (2023). https://doi.org/10.1007/s10439-023-03236-8

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