Nanotechnology: An Emerging Field in Protein Aggregation and Cancer Therapeutics

Jena, Sonali; Mohanty, Sonali; Ojha, Monalisha; Subham, Kumari; Jha, Suman

doi:10.1007/978-981-16-2516-9_11

Sonali Jena⁴,
Sonali Mohanty⁴,
Monalisha Ojha⁴,
Kumari Subham⁴ &
…
Suman Jha⁴

756 Accesses

Abstract

Nanoparticles (NPs) prominence in technological advancements in different fields of biology and medicine are for their tuneable physicochemical properties, like size and surface functionality. For the fact that NP composition can be engineered to exhibit unique functions, it has paved the path for development of novel tools and techniques with better precision and efficacy in different research fields including biomedical research. For instance, single-walled carbon nanotubes have shown an impressive potential as an efficient delivery agent for transportation of biomolecules to cells. Additionally, NPs with size-tuneable light emission property, which made it accessible to relatively non-accessible area, have been implemented to precisely deliver drug and get images of tumour sites. Thus, the primary driving forces behind the progress of nanotechnology in different fields are their surface area to volume ratio and tuneable physicochemical properties. Besides the tuneable accessible surface, NPs also has two other layers, i.e. the shell layer and the core, which have relatively less role in most of the nanotechnology-mediated biological applications. Since accessible surface area credits for most of the application, it is mostly discussed layer than other two layers. Despite knowing the physicochemical properties of NPs, understanding its behaviour to biological surfaces for its multifaceted functions becomes priority for its biological applications. Upon introduction of metallic nanoparticles into biological milieu, its surface interacts with different biological surfaces, including biomolecular surfaces of varying curvatures, to attain a stable local free energy minima state. In doing so, it forms a corona of biomolecular surfaces around it, which in turn further decides the fate of the complex like the agglomeration, molecular stability, core/surface dissolution rate, toxicity. Thus, the chapter evaluated different nanoparticle-based theranostic applications in protein amyloidogenesis and cancer; both are from the group of incurable human diseases.

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Abbreviations

APP:: Amyloid precursor protein
CTC:: Circulating tumour cell
CTL:: Cytotoxic T lymphocytes
DMPC:: Dimyristoylphosphatidylcholine
DMPG:: Dimyristoylphosphatidylglycerol
DMSO:: Dimethyl sulfoxide
FDA:: Food and Drug Administration
hIAPP:: Human islet amyloid polypeptide
MNP:: Magnetic nanoparticle
MRI:: Magnetic resonance imaging
NAC:: Non-amyloid β-peptide component
NFT:: Neurofibrillary tangles
NLS:: Nuclear localization signal
NP:: Nanoparticle
OI:: Optical imaging
PD:: Parkinson’s disease
PEI:: Polyethylenimine
PLGA:: Poly(n-butyl cyanoacrylate)
QD:: Quantum dot
RNAi:: RNA interference
ROS:: Reactive oxygen species
siRNA:: Small interfering RNA
SPIONS:: Supramagnetic iron oxide nanoparticle
TIIDM:: Type 2 diabetes mellitus

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Department of Life Science, National Institute of Technology Rourkela, Rourkela, Odisha, India
Sonali Jena, Sonali Mohanty, Monalisha Ojha, Kumari Subham & Suman Jha

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Sonali Jena
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Sonali Mohanty
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Monalisha Ojha
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Kumari Subham
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Suman Jha
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Correspondence to Suman Jha .

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Centre for Biotechnology, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India
Manoranjan Arakha
Centre for Biotechnology, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India
Arun Kumar Pradhan
Department of Life Science, National Institute of Technology Rourkela, Rourkela, Odisha, India
Suman Jha

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Jena, S., Mohanty, S., Ojha, M., Subham, K., Jha, S. (2022). Nanotechnology: An Emerging Field in Protein Aggregation and Cancer Therapeutics. In: Arakha, M., Pradhan, A.K., Jha, S. (eds) Bio-Nano Interface. Springer, Singapore. https://doi.org/10.1007/978-981-16-2516-9_11

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DOI: https://doi.org/10.1007/978-981-16-2516-9_11
Published: 28 November 2021
Publisher Name: Springer, Singapore
Print ISBN: 978-981-16-2515-2
Online ISBN: 978-981-16-2516-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)

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