Skip to main content
SpringerLink
Log in

Cyclodextrin-based Nanosponges for Drug Delivery

  • Published:
Journal of inclusion phenomena and macrocyclic chemistry Aims and scope Submit manuscript

Abstract

Nanosponges were prepared from β-cyclodextrins as nanoporous materials for possible use as carriers for drug delivery. The structure of β-cyclodextrin-based nanosponges was principally investigated by FT-IR, DSC and RX analyses. Sizes, morphology and toxicity were also examined. The capacity of the nanosponges to incorporate molecules within their structure was evaluated using drugs with different structures and solubilities. The nanosponges were found capable of carrying both lipophilic and hydrophilic drugs and of improving the solubility of poorly water-soluble molecules.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Duchêne D., Ponchel G., Wouassindjewe D., Adv. Drug Del. Rev. 36, 29 (1999)

    Article  Google Scholar 

  2. McCormack B., Gregoriadis G., Int. J. Pharm. 162, 59 (1998)

    Article  CAS  Google Scholar 

  3. Loftsson T., Kristandsottir T., Ingasdottir K., Balvinsdottir J., Olafsdottir B.J., J. Microencapsul. 9, 325 (1992)

    Google Scholar 

  4. Cavalli R., Peira E., Caputo O., Gasco M.R., Int. J. Pharm. 182, 59 (1998)

    Article  Google Scholar 

  5. Silvera A., Ponchel G., Puisieux F., Duchêne D., Pharm. Res. 15, 1051 (1998)

    Article  PubMed  Google Scholar 

  6. Dubes A., Parrot-Lopez H., Dagobert G., Fessi H., Shalgadian P., Coleman A.W., Eur. J. Pharm. Biopharm. 55, 279 (2003)

    Article  PubMed  CAS  Google Scholar 

  7. Memisoglu-Bilensoy E., Vural I., Bochot A., Renoir J.M., Duchêne D., Huncal A., J. Controlled Rel. 104, 489 (2005)

    CAS  Google Scholar 

  8. F. Trotta and W. Tumiatti: Pat. WO 03/085002 (2003)

Download references

Acknowledgements

The authors thank Dr. Loredana Serpe for the cytotoxicity experiments, Prof. Dino Aquilano for the RX analysis and Sea-Marconi Technologies for their generous grant.

Author information

Authors and Affiliations

  1. Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via Pietro Giuria 9, I-10125, Torino, Italy

    Roberta Cavalli

  2. Dipartimento. di Chimica IFM, Università degli Studi di Torino, Via Pietro Giuria 7, I-10125, Torino, Italy

    Francesco Trotta

  3. Sea-Marconi Technologies, Via Crimea 4, 10097, Collegno, Italy

    Wander Tumiatti

Authors
  1. Roberta Cavalli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Francesco Trotta
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Wander Tumiatti
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Francesco Trotta.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cavalli, R., Trotta, F. & Tumiatti, W. Cyclodextrin-based Nanosponges for Drug Delivery. J Incl Phenom Macrocycl Chem 56, 209–213 (2006). https://doi.org/10.1007/s10847-006-9085-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10847-006-9085-2

Keywords

Search

Navigation